公开(公告)号：WO1991005241A1

公开(公告)日：1991-04-18

申请号：PCT/US1990005591

申请日：1990-10-01

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  BUSCH, Kenneth, W. ,  HUDSON, Keith, M. ,  BUSCH, Marianna, A. ,  KUBALA, Sidney, Wayne, Jr. ,  TILOTTA, David, Charles ,  LAM, Christopher, Kwok, Yin ,  SRINIVASAN, Ravishankar

IPC: G01N21/72

CPC classification number: G01N21/72

Abstract: The apparatus and method for observing infrared emission from excited molecules in samples of interest was investigated. Over the wavelength interval from 1 to 5 mu m, two strong emission bands were observed with a PbSe detector (429) when organic compounds were introduced into a hydrogen/air flame (421). The band at 4.3 mu m (2326 cm ) was due to the asymmetric stretch of carbon dioxide while the band at 2.7 mu m was due to both water and carbon dioxide emission. The carbon dioxide emission at 4.3 mu m was found to be most intense at the tip of the flame (421), and was found to increase with the amount of organic compound introduced into the flame (421). For chromatographic application, an optical filter (428) was used to isolate the 4.3 mu m emission band. The infrared emission detection system finds application in the determination of total inorganic carbon, chloride and available chlorine in aqueous samples. The detector is optimized by use of a dual beam system with background subtraction capabilities thereby eliminating background noise and the fluctuations therein.

Abstract translation: 研究了用于观察感兴趣样品中激发分子的红外发射的装置和方法。 在1〜5μm的波长间隔内，当将有机化合物引入氢气/空气火焰中时，PbSe检测器（429）观察到两个强烈的发射带（421）。 4.3米（2326厘米-1）的带是由于二氧化碳的拉伸不对称，而2.7米的波段是由于水和二氧化碳的排放。 发现在火焰尖端（421），4.3μm的二氧化碳排放最强烈，发现随着引入火焰的有机化合物的量而增加（421）。 对于色谱应用，使用滤光器（428）隔离4.3μm的发射带。 红外发射检测系统应用于水样品中总无机碳，氯化物和有效氯的测定。 通过使用具有背景消除能力的双光束系统来优化检测器，从而消除背景噪声及其中的波动。

公开(公告)号：WO1990009637A1

公开(公告)日：1990-08-23

申请号：PCT/US1990000818

申请日：1990-02-13

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  FEDDERSEN, Brett, A. ,  GRATTON, Enrico ,  PISTON, David, W. ,  VANDE VEN, Martin

IPC: G06F15/20

CPC classification number: G01J3/4406 ,  G01N21/6408

Abstract: A digital frequency domain fluorometer utilizing a computer-controlled digital data acquisition system is used for the study of fluorescence and phosphorescence phenomena in the bio-chemical, biological and bio-physics arts. The computer (808) is used for the direct collection of data, as well as for the filtering and calculation of the phase and modulation values of the sample under study. From these values, fluorescence lifetimes can be determined. The digital data acquisition system (702 and 808) provides for the simultaneous collection and processing of several modulation frequencies. In addition, the digital frequency domain fluorometer can utilize an array detector (72) for detecting the modulated light from the various samples under study. The use of the array detector (72) provides a means for independently collecting data over a large number of pixels. This configuration allows for a time resolved image to be collected at once.

公开(公告)号：WO1989010813A1

公开(公告)日：1989-11-16

申请号：PCT/US1989002066

申请日：1989-05-12

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  BHALLA, Amar, S. ,  CROSS, Leslie, E. ,  SHROUT, Thomas, R.

IPC: B23B03/00

CPC classification number: H01G4/0085 ,  B06B1/0644 ,  C04B35/4504 ,  C04B35/4512 ,  C04B35/4521 ,  H01L41/0471 ,  H01L41/0478

Abstract: Ceramic electrode materials (14, 16) of the invention include ceramic compositions having significant electrical conductivity at room temperature. The ceramic electrodes (14, 16) are coupled to a dielectric (12) to provide electrical devices such as capacitors(10) and transducers (10). The presently known ceramic compositions having room temperature conductivity are ceramic materials that are superconductors at low temperatures and include compositions of the formula: ZBa2-xAxO9-y, where Z is Y, La or any of the lanthanide series elements; A is Na, K, Rb, Cs or Pb; x is in the range 0.0 to 0.2; and y is about 2.0. Compositions having the formula: Bi2Sr3-xCaxCu2Oy, where x is in the range 0.0 to 2.0 and y is in the range 5.0 to 8.0 may also be used as ceramic electrodes (14, 16). The ceramic electrodes (14, 16) have similar perovskite crystalline structures to the dielectrics (12) forming the electrical devices (10) of the invention.

Abstract translation: 本发明的陶瓷电极材料（14,16）包括在室温下具有显着导电性的陶瓷组合物。 陶瓷电极（14,16）耦合到电介质（12）以提供诸如电容器（10）和换能器（10）的电气装置。 目前已知的具有室温导电性的陶瓷组合物是在低温下是超导体的陶瓷材料，并且包括下式的组成：ZBa2-xAxO9-y，其中Z是Y，La或任何镧系元素; A是Na，K，Rb，Cs或Pb; x在0.0〜0.2的范围内; y约为2.0。 具有式Bi2Sr3-xCaxCu2Oy的组合物也可用作陶瓷电极（14,16），其中x在0.0至2.0范围内且y在5.0至8.0的范围内。 陶瓷电极（14,16）具有与形成本发明的电气装置（10）的电介质（12）类似的钙钛矿晶体结构。

公开(公告)号：WO1988003888A1

公开(公告)日：1988-06-02

申请号：PCT/US1987002979

申请日：1987-11-05

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  SIEGWART, John, T., Jr.

IPC: B62M09/12

CPC classification number: B62M9/16 ,  F16H2007/0893

Abstract: An assembly comprising a pulley sub assembly (104) and a shift sub assembly (106). The pulley sub assembly includes a plurality of pulleys (116, 120, 122, 124, 126, 130), each pulley includes a plurality of sections (134, 136, 140, 142), and at least one section of each pulley is axially moveable. The shift sub assembly has a disengaged position to maintain the pulleys in normal positions, and an engaged position. With one embodiment (100), when the shift sub-assembly is in the engaged position, it slides a section of a first pulley from the plane thereof, into the plane of a second pulley, and then back into the plane of the first pulley. With an alternate embodiment (400), when the first sub-assembly is in the engaged position, it slides all of the sections of a pulley, one at a time, into the plane of another pulley.

公开(公告)号：WO1998024793A1

公开(公告)日：1998-06-11

申请号：PCT/US1997022123

申请日：1997-12-05

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC. ,  BUYNAK, John, D. ,  RAO, Akireddy, Srinivasa ,  ADAM, Greg, C.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC.

IPC: C07D501/00

CPC classification number: C07D501/00 ,  A61K31/545 ,  A61K31/546

Abstract: The invention provides a compound of formula (I) wherein R to R , n, X, Y and Z have any of the values defined in the specification; or a pharmaceutically acceptable salt thereof; for use in medical therapy, and in particular, for use in treating an elastase-mediated pathology. The invention also provides novel compounds of formula (I), and their pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising compounds of formula (I) and their pharmaceutically acceptable salts. The invention also provides the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, to prepare a medicament for treating an elastase-mediated pathology.

Abstract translation: 本发明提供式（I）化合物，其中R 1至R 5，n，X，Y和Z具有说明书中定义的任何值; 或其药学上可接受的盐; 用于医学治疗，特别是用于治疗弹性蛋白酶介导的病理学。 本发明还提供新的式（I）化合物及其药学上可接受的盐，以及包含式（I）化合物及其药学上可接受的盐的药物组合物。 本发明还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗弹性蛋白酶介导的病理学的药物中的用途。

公开(公告)号：WO1998011918A1

公开(公告)日：1998-03-26

申请号：PCT/US1997016321

申请日：1997-09-17

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  LAZAROVITS, Andrew, I. ,  POPPEMA, Sibrand

IPC: A61K39/395

CPC classification number: C07K16/289 ,  A61K38/00 ,  A61K39/395 ,  A61K39/39541 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  A61K2300/00

Abstract: A method for the prevention or reversal of transplant rejection, or for therapy for autoimmune diseases, is provided comprising administering compounds such as monoclonal antibodies, that bind specifically to one or more preselected CD45R leukocyte antigens.

Abstract translation: 提供了用于预防或逆转移植排斥反应或用于自身免疫性疾病的治疗的方法，其包括施用特异性结合一种或多种预选的CD45R白细胞抗原的化合物，例如单克隆抗体。

公开(公告)号：WO1998006751A1

公开(公告)日：1998-02-19

申请号：PCT/US1997014485

申请日：1997-08-18

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  CLARK-LEWIS, Ian ,  GONG, Jiang-Hong

IPC: C07K14/52

CPC classification number: C07K14/523 ,  A61K38/00

Abstract: The present invention is directed towards NH2-terminally truncated analogs of three human chemokines: MCP-3, RANTES and MIP-1 alpha having highly potent anti-inflammatory activity and anti-autoimmune activity. The present invention is also directed to inhibiting the biological activities of three native, mammalian chemokines: MCP-3, RANTES and MIP-1 alpha . The present invention is further directed to treating inflammatory diseases and autoimmune disorders such as rheumatoid arthritis, for example. The present invention is also directed to pharmaceutical compositions comprising NH2-terminally truncated chemokine analogs.

Abstract translation: 本发明涉及三种人趋化因子的NH2-末端截短类似物：MCP-3，RANTES和MIP-1α，其具有高度有效的抗炎活性和抗自身免疫活性。 本发明还涉及抑制三种天然哺乳动物趋化因子MCP-3，RANTES和MIP-1α的生物学活性。 本发明进一步涉及治疗炎性疾病和自身免疫性疾病如类风湿性关节炎。 本发明还涉及包含NH 2 - 末端截短的趋化因子类似物的药物组合物。

公开(公告)号：WO1997033625A2

公开(公告)日：1997-09-18

申请号：PCT/US1997004064

申请日：1997-03-06

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  ELGAVISH, Gabriel, A.

IPC: A61K49/00

CPC classification number: A61K49/06 ,  Y10S514/836

Abstract: The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using these contrast-enhancing agents. The water-soluble, lipophilic contrast-enhancing agents are chelates of a paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with complexing acids which contain at least one short-chain fatty acyl moiety having from about 0 to about 6 carbon atoms in its structure.

Abstract translation: 本发明涉及水溶性，亲脂性对比增强剂，其药物组合物和诊断分析方法，特别是使用这些对比度增强剂的NMR或MRI分析。 水溶性亲脂性对比增强剂是与其中含有至少一个具有约0至约6个碳原子的至少一个短链脂肪酰基部分的配位酸络合的顺磁性，铁磁性或抗磁性金属离子的螯合物， 结构体。

公开(公告)号：WO1997026537A1

公开(公告)日：1997-07-24

申请号：PCT/US1996020465

申请日：1996-12-13

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  KAY, Marguerite, M., B.

IPC: G01N33/564

CPC classification number: G01N33/6896 ,  G01N2800/2821

Abstract: The present invention is directed to methods of detection of Alzheimer's disease. In particular, the present invention provides antibodies to the band 3 protein capable of differentiating Alzheimer's disease tissue from normal tissue. In addition, the invention provides a method of detection of Alzheimer's disease comprising determining differential band 3 phosphorylation.

Abstract translation: 本发明涉及阿尔茨海默病的检测方法。 特别地，本发明提供能够将阿尔茨海默氏病组织与正常组织分化的带3蛋白质的抗体。 此外，本发明提供了一种检测阿尔茨海默病的方法，包括确定差异带3磷酸化。

公开(公告)号：WO1997022406A1

公开(公告)日：1997-06-26

申请号：PCT/US1996019316

申请日：1996-12-05

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  KLEIN, Elias ,  BALACHANDER, Natarajan

IPC: B01D71/80

CPC classification number: B01D69/08 ,  B01D67/0011 ,  B01D71/52 ,  B01D71/68 ,  B01D71/80 ,  B01D2325/08 ,  B01D2325/12 ,  B01D2325/36 ,  C08L71/02 ,  C08L81/06 ,  C08L2205/05 ,  C08L81/00 ,  C08L2666/22

Abstract: A water wettable permselective membrane for use in hemodialysis, ultrafiltration and microfiltration applications and a device containing the same are provided. The membrane having the above properties comprises a hydrophobic-base polymer, such as a polysulfone or polyethersulfone polymer, and a block copolymer additive wherein one of the blocks of the copolymer additive is a hydrophilic polymer and the other block is a hydrophobic polymer that is analogous in structure to the hydrophobic-base polymer.

Abstract translation: 提供了用于血液透析，超滤和微滤应用的水可湿性渗透选择性膜和含有其的装置。 具有上述性质的膜包括疏水基聚合物，例如聚砜或聚醚砜聚合物，和嵌段共聚物添加剂，其中共聚物添加剂的嵌段之一是亲水性聚合物，另一嵌段是类似的疏水性聚合物 在结构上与疏水基聚合物。