中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

346 records (took 0.023 seconds)

    84.
    发明专利
    未知

    公开(公告)号：DK171698B1

    公开(公告)日：1997-03-24

    申请号：DK398189

    申请日：1989-08-14

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GOBERT JEAN ,  BOYDENS ROLAND ,  MATHIEU JACQUES

    IPC: C07D413/04 ,  A61K31/53 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18 ,  C07D403/04

    Abstract: New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

    86.
    发明专利
    未知

    公开(公告)号：NO179206C

    公开(公告)日：1996-08-28

    申请号：NO893279

    申请日：1989-08-15

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GOBERT JEAN ,  BOYDENS ROLAND ,  MATHIEU JACQUES

    IPC: A61K31/53 ,  C07D413/04 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18

    Abstract: New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

    Substituted 1H-imidazoles
    87.
    发明专利
    Substituted 1H-imidazoles 未知

    公开(公告)号：HK78895A

    公开(公告)日：1995-05-26

    申请号：HK78895

    申请日：1995-05-18

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  MICHEL PHILLIPPE

    IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/58 ,  C07D233/64 ,  C07D405/06 ,  C07D413/06

    Abstract: New substituted 1H-imidazoles and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2, R3 and R5=hydrogen or C1-C4-alkyl; R4=hydrogen, C1-C4-alkyl or C1-C4-alkoxy; Y1=hydrogen and Y2=OZ2 or the reverse; Z1=Z2=hydrogen or C1-C4-alkyl or Z1 and Z2=-CH2- or -C(CH3)2-. These compounds are prepared either by reducing a corresponding imidazole compound having a hydroxyl or alkoxy group on the methyl bridge between the imidazole and phenyl rings, or by hydrolyzing a 4-[[2,2-dimethyl-4H-1,3-benzodioxin-6(or 8)-yl]methyl]-1H-imidazole, or yet by reducing an alkyl 3-[(1H-imidazol-4-yl)methyl]-2-hydroxybenzoate. These compounds have cardiac, cerebral and tissular anti-ischemic activities.

    88.
    发明专利
    未知

    公开(公告)号：PT91438B

    公开(公告)日：1995-05-04

    申请号：PT9143889

    申请日：1989-08-11

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GOBERT JEAN ,  BOYDENS ROLAND ,  MATHIEU JACQUES

    IPC: A61K31/53 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  C07D413/04 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18 ,  A61K31/534

    Abstract: New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

Patent Agency Ranking