公开(公告)号：US20100312191A1

公开(公告)日：2010-12-09

申请号：US12853082

申请日：2010-08-09

Applicant: Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

Inventor： Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

IPC: A61M5/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61B2010/008 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B33Y80/00 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

Abstract translation: 提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。 在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。 还提供制造这些装置的方法，其可以包括中空和/或多孔微针。 用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。 在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。 该装置优选地还包括用于控制通过微针的材料流动的装置。 这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

公开(公告)号：US20100305516A1

公开(公告)日：2010-12-02

申请号：US10592559

申请日：2004-03-12

Applicant: Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

Inventor： Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

IPC: A61M5/00 ,  B22C9/22 ,  B29C33/42 ,  C25D1/00

CPC classification number: B29C33/0061 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C33/301 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C33/56 ,  B29C59/026 ,  B29C2791/001 ,  B29C2793/0009 ,  B29L2031/756 ,  B29L2031/759 ,  B81B2201/055 ,  B81C99/009 ,  C25D1/02 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T29/49982 ,  Y10T29/49984 ,  Y10T29/49986 ,  Y10T29/49988

Abstract: Side-ported microneedles are produced from a suitably shaped microneedle mould (40). A microneedle mould base (32) is made with a number of microneedle mould recesses (30) in it. One surface of the microneedle mould base (32) is coated with a seed layer (34). The microneedle mould base (32) contains two microneedle mould sheets (24, 26), which are separated to gain access to an internal surface of one of the microneedle mould sheets (24, 26). Side-port forming channels (38) are formed on one of the internal surfaces, intersecting with the recesses (30) within the relevant microneedle mould sheet (24). The two microneedle mould sheets (24, 26) are placed back together and joined together as a unitary microneedle mould (40). The microneedles are formed in the recesses (30) by depositing a microneedle layer (44) therein and on the surface with the seed layer (34). The microneedle layer (44) fails to deposit at side-port forming holes (42) where the side-port forming channels (38) intersect the recesses (30), which result in side-ports (46) in the moulded microneedles (52).

Abstract translation: 由适当形状的微针模具（40）制造侧端微针。 微针模具基座（32）在其中形成有许多微针模具凹槽（30）。 微针模具基座（32）的一个表面涂覆有种子层（34）。 微针模具基座（32）包含两个微针模具片（24,26），它们分开以进入其中一个微针模板（24,26）的内表面。 侧孔形成通道（38）形成在与相关微针模板（24）内的凹部（30）相交的一个内表面上。 将两个微针模具片（24,26）放置在一起并作为整体式微针模具（40）连接在一起。 通过在其中放置微针层（44）并在种子层（34）的表面上，在凹部（30）中形成微针。 该微针层（44）不能沉积在侧孔形成通道（42）处，其中侧孔形成通道（38）与凹槽（30）相交，这导致模制微针（52）中的侧端口（46） ）。

公开(公告)号：US20100280457A1

公开(公告)日：2010-11-04

申请号：US12599394

申请日：2007-10-18

Applicant: Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

Inventor： Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

IPC: A61M5/00 ,  B05D3/00

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00206

Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).

Abstract translation: 本发明提供了一种涂布微针的方法，通过该方法，安装在微针装置上的微针以可批量生产的方式精确且容易地被涂布。 在该方法中，将具有多个微针（21）的微针装置（22）安装在工作台（23）上，同时具有多个孔（24）的掩模板（25）固定到框架构件（26） ），并且使用刮刀（28）在掩模板（25）上沿箭头A的方向将涂布溶液（27）用涂布溶液填充孔（24）。 在用涂布溶液（27）填充孔（24）之前或之后，将微针（21）插入孔（24）中以涂覆微针（21）。

公开(公告)号：US07763203B2

公开(公告)日：2010-07-27

申请号：US10727124

申请日：2003-12-03

Applicant: Francisco Arias ,  Faiz Feisal Sherman ,  Grover David Owens

Inventor： Francisco Arias ,  Faiz Feisal Sherman ,  Grover David Owens

IPC: B29C35/08

CPC classification number: A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/150984 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/034

Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.

Abstract translation: 公开了使用软光刻和光刻技术制造微针结构的方法，其中制造由光致抗蚀剂材料或PDMS制成的微型结构。 使用廉价的材料和工艺，微型制造相当快速地发生。 一旦模具可用，使用可模塑材料如聚合物，微针阵列可以以相对较快的程序模制或压花。 在一些情况下，为了易于分离，在成形微胶体与其基底层之间提供牺牲层。 微针本身可以是固体突起，中空“微管”或浅“微杯”。电极可以形成在微针阵列上，包括每个中空微管的单个电极。

公开(公告)号：US20100178810A2

公开(公告)日：2010-07-15

申请号：US12110676

申请日：2008-04-28

Applicant: Arno Aarts ,  Hercules Pereira Neves ,  Chris Van Hoof ,  Eric Beyne ,  Patrick Ruther ,  Robert Puers

Inventor： Arno Aarts ,  Hercules Pereira Neves ,  Chris Van Hoof ,  Eric Beyne ,  Patrick Ruther ,  Robert Puers

IPC: H01R24/00 ,  H01R43/00

CPC classification number: B81C3/008 ,  A61B5/04001 ,  A61B5/0478 ,  A61B2562/125 ,  A61N1/0529 ,  A61N1/0531 ,  B81B2201/055 ,  Y10T29/49222

Abstract: In the present disclosure a device for sensing and/or actuation purposes is presented in which microstructures (20) comprising shafts (2) with different functionality and dimensions can be inserted in a modular way. That way, out-of-plane connectivity, mechanical clamping between the microstructures (20) and a substrate (1) of the device, and electrical connection between electrodes (5) on the microstructures (20) and the substrate (1) can be realized. Connections to external circuitry can be realised. Microfluidic channels (10) in the microstructures (20) can be connected to external equipment. A method to fabricate and assemble the device is provided.

Abstract translation: 在本公开中，提出了用于感测和/或致动目的的装置，其中可以以模块化方式插入包括具有不同功能和尺寸的轴（2）的微结构（20）。 这样，平面外连接，微结构（20）和器件的衬底（1）之间的机械夹紧以及微结构（20）和衬底（1）上的电极（5）之间的电连接可以是 实现了 可以实现与外部电路的连接。 微结构（20）中的微流体通道（10）可以连接到外部设备。 提供了一种制造和组装该装置的方法。

公开(公告)号：US07497980B2

公开(公告)日：2009-03-03

申请号：US10505035

申请日：2003-11-10

Applicant: Yuan Xu ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

Inventor： Yuan Xu ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

IPC: B29C33/42

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/3878 ,  B29C33/42 ,  B29C45/00 ,  B29C2045/0094 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C2201/034

Abstract: A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes in the secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.

Abstract translation: 主模具通过在两个或更多个方向上对板进行线切割来制造，以提供具有从其突出的主模具针阵列的基座。 通过改变在两个或更多个方向上的向上和向下切割的角度，可以容易地改变主模具针的尺寸和形状。 主模具用于通过将二次模板热压在主模上来制造二次模具。 这在二次模具中形成通孔。 二次模具镀有一层金属，形成微针阵列。

公开(公告)号：US07416541B2

公开(公告)日：2008-08-26

申请号：US11121291

申请日：2005-05-03

Applicant: Vadim Vladimirovich Yuzhakov ,  Faiz Feisal Sherman ,  Grover David Owens ,  Vladimir Gartstein

Inventor： Vadim Vladimirovich Yuzhakov ,  Faiz Feisal Sherman ,  Grover David Owens ,  Vladimir Gartstein

IPC: A61M5/32 ,  A61B17/20 ,  A61B17/32 ,  A61B17/34

CPC classification number: B81C99/0085 ,  A61M5/1723 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61N1/30 ,  B81B2201/055

Abstract: Improved microneedle arrays are provided having a sufficiently large separation distance between each of the individual microneedles to ensure penetration of the skin while having a sufficiently small separation distance to provide high transdermal transport rates. A very useful range of separation distances between microneedles is in the range of 100-300 microns, and more preferably in the range of 100-200 microns. The outer diameter and microneedle length is also very important, and in combination with the separation distance will be crucial as to whether or not the microneedles will actually penetrate the stratum corneum of skin. For circular microneedles, a useful outer diameter range is from 20-100 microns, and more preferably in the range of 20-50 microns. For circular microneedles that do not have sharp edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 100-150 microns; for use with other biological fluids, a useful length is in the range of 200 microns-3 mm, and more preferably in the range of 200-400 microns. For circular microneedles having sharp side edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns-3 mm, and more preferably in the range of 200-400 microns. For solid microneedles having a star-shaped profile with sharp edges for its star-shaped blades, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns-3 mm, and more preferably in the range of 200-400 microns, while the radius of each of its blades is in the range of 10-50 microns, and more preferably in the range of 10-15 microns.

公开(公告)号：US20080138582A1

公开(公告)日：2008-06-12

申请号：US11807764

申请日：2007-05-29

Applicant: Rajmohan Bhandari ,  Sandeep Negi ,  Florian Solzbacher ,  Richard A. Normann

Inventor： Rajmohan Bhandari ,  Sandeep Negi ,  Florian Solzbacher ,  Richard A. Normann

IPC: H01B13/00 ,  B32B3/00

CPC classification number: B81C1/00111 ,  A61M2037/0053 ,  A61N1/0551 ,  B81B2201/055 ,  Y10T428/24479

Abstract: Methods for wafer-scale fabrication of needle arrays can include mechanically modifying a wafer to produce a plurality of vertically-extending columns. The columns are etched to round and reshape the columns into substantially uniformly shaped needles. Needle arrays having needle width non-uniformity of less than about 3% and length non-uniformity of less than about 2% can be produced.

Abstract translation: 用于晶圆尺寸制造针阵列的方法可以包括机械地改变晶片以产生多个垂直延伸的柱。 将柱蚀刻成圆形并将柱重新形成基本均匀成形的针。 可以制造具有小于约3％的针宽不均匀性和小于约2％的长度不均匀性的针阵列。

公开(公告)号：US20070233016A1

公开(公告)日：2007-10-04

申请号：US11754368

申请日：2007-05-29

Applicant: Shih-Chi Kuo ,  Yu-Kon Chou

Inventor： Shih-Chi Kuo ,  Yu-Kon Chou

IPC: A61M5/32

CPC classification number: B81C1/00111 ,  A61B17/205 ,  A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  Y10T29/302 ,  Y10T29/304 ,  Y10T29/308 ,  Y10T29/49982

Abstract: A microneedle array device and its fabrication method are provided. The microneedle array device comprises a supporting pad and a plurality of microneedles. Each microneedle has a top portion with a via thereon, thereby the microfluid may flow in or out. The intersection between the top portion and the inner tube of a microneedle forms a convex needle structure, and is almost perpendicular to the upper surface. For each microneedle, a hollow closed tube is formed between the top portion and the supporting pad. The fabrication method uses substrates with high transmittance and a plurality of convex area thereon as upper and lower caps, and applies a photolithography process to fabricate a microneedle array mold. It then sputters or electroplates metal material on the mold. The microneedle array is formed after having taken off the mold.

Abstract translation: 提供了一种微针阵列器件及其制造方法。 微针阵列装置包括支撑垫和多个微针。 每个微针具有顶部，其上具有通孔，从而微流体可以流入或流出。 微针的顶部和内管之间的交点形成凸针结构，并且几乎垂直于上表面。 对于每个微针，在顶部和支撑垫之间形成中空封闭的管。 该制造方法使用具有高透射率的衬底和其上的多个凸起区域作为上盖和下盖，并且应用光刻工艺来制造微针阵列模具。 然后将模具上的金属材料溅射或电镀。 在脱模后形成微针阵列。

公开(公告)号：US20070023386A1

公开(公告)日：2007-02-01

申请号：US11542974

申请日：2006-10-04

Applicant: Stanley Kravitz ,  David Ingersoll ,  Carrie Schmidt ,  Jeb Flemming

Inventor： Stanley Kravitz ,  David Ingersoll ,  Carrie Schmidt ,  Jeb Flemming

IPC: C23F1/00 ,  B44C1/22

CPC classification number: C23F1/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  C03C15/00 ,  C03C23/002 ,  C03C23/007

Abstract: An inexpensive and rapid method for fabricating arrays of hollow microneedles uses a photoetchable glass. Furthermore, the glass hollow microneedle array can be used to form a negative mold for replicating microneedles in biocompatible polymers or metals. These microneedle arrays can be used to extract fluids from plants or animals. Glucose transport through these hollow microneedles arrays has been found to be orders of magnitude more rapid than natural diffusion.

Abstract translation: 用于制造中空微针阵列的廉价且快速的方法使用可光取代玻璃。 此外，玻璃中空微针阵列可用于形成用于在生物相容性聚合物或金属中复制微针的负模。 这些微针阵列可用于从植物或动物中提取液体。 已经发现通过这些中空微针阵列的葡萄糖传输比自然扩散更快的数量级。