公开(公告)号：WO2015192158A1

公开(公告)日：2015-12-23

申请号：PCT/AT2015/050151

申请日：2015-06-16

Applicant: UNIVERSITÄT LINZ ,  BIOMED-ZET LIFE SCIENCE GMBH

Inventor： TEASDALE, Ian ,  WILFERT, Sandra ,  AIGNER, Tamara ,  ITURMENDI, Aiztiber ,  BRUEGGEMANN, Oliver ,  SCHROEDER, Klaus ,  OLAWALE, Gbenga ,  HILDNER, Florian ,  RIGAU DE LLOBET, Maria

IPC: C08G79/02 ,  A61L27/52 ,  A61F2/28 ,  A61K47/48 ,  C08L85/02

CPC classification number: C08G79/025 ,  A61L27/18 ,  A61L27/52 ,  A61L27/56 ,  C08G79/02 ,  C08G2230/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/10 ,  C08J2207/10 ,  C08J2385/02 ,  C08L85/02

Abstract: Die Erfindung betrifft ein Polymer für die Gewebezüchtung aus bioabbaubaren Polyphosphazenen mit photopolymerisierbaren Seitengruppen, wobei die Seitengruppen der Polyphosphazene ausschließlich aus Aminosäuren und/oder Aminosäurederivaten gebildet sind, wobei diese über die Aminogruppe der Aminosäure am Rückgrat des Polyphosphazens gebunden sind und einen an der Säuregruppe gebundenen Abstandhalter mit einer Kohlenstoffkette der Länge m aufweisen, welcher am freien Ende eine Vinylgruppe aufweist, wobei gilt m = 0 bis m = 10.

Abstract translation: 本发明涉及一种用于具有可光聚合侧基的可生物降解的聚磷腈，其中所述的聚磷腈的侧基的排他的氨基酸和/或氨基酸衍生物形成的，这是在所述的聚磷腈的主链通过氨基的氨基酸接合并且接合到酸基间隔物的组织工程的聚合物 具有长度为m，其在自由端部乙烯基，其中m = 0到m = 10度的碳链。

公开(公告)号：WO2011076971A2

公开(公告)日：2011-06-30

申请号：PCT/ES2010/070867

申请日：2010-12-23

Applicant: FUNDACION INASMET ,  OLALDE GRAELLS, Beatriz ,  JURADO OÑATE, María, Jesús

Inventor： OLALDE GRAELLS, Beatriz ,  JURADO OÑATE, María, Jesús

IPC: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28

CPC classification number: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0422 ,  C08J2201/0444 ,  C08J2201/0446 ,  C08J2201/052 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249986 ,  C08L71/00

Abstract: La presente invención se refiere a un artículo de polímero de tipo PEEK poroso que comprende una estructura de polímero de tipo PEEK porosa y que presenta al menos una distribución de poros trimodal. La invención describe un procedimiento para la producción de dicho artículo de polímero de tipo PEEK poroso que comprende: a) poner en contacto un polímero de tipo PEEK con una composición que comprende al menos un disolvente orgánico, b) calentar a una temperatura a la que se disuelve el polímero de tipo PEEK, c) añadir al menos un agente porógeno, d) enfriar la mezcla obtenida en c) a una temperatura al menos igual o menor que la temperatura a la que precipita el polímero de tipo PEEK, e) conformar dicha mezcla enfriada para dar un artículo conformado, f) retirar el disolvente orgánico y el agente porógeno, y g) recuperar el artículo de polímero de tipo PEEK.

Abstract translation: 本发明涉及具有多孔PEEK聚合物结构和至少一个三峰孔分布的多孔PEEK聚合物元件。 本发明还涉及一种生产所述多孔PEEK聚合物元件的方法，其中：a）使PEEK聚合物与包含至少一种有机溶剂的组合物接触，b）将聚合物和组合物加热至 其中PEEK聚合物溶解，c）加入至少一种成孔剂，d）将c​​）中制得的混合物冷却至至少等于或低于PEEK聚合物沉淀的温度的温度，e ）所述冷却的混合物成形为形成成形物体，f）除去有机溶剂和成孔剂，g）回收PEEK聚合物元素。

公开(公告)号：WO2010062678A3

公开(公告)日：2011-04-07

申请号：PCT/US2009062744

申请日：2009-10-30

Applicant: LIU DAVID

Inventor： LIU DAVID

IPC: C08J9/28 ,  A61L27/18 ,  A61L27/56 ,  C08J9/26

CPC classification number: C08J9/26 ,  A61K9/0019 ,  A61K9/5031 ,  A61K9/5089 ,  A61K48/00 ,  A61K51/1255 ,  A61L24/0036 ,  A61L27/38 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/56 ,  A61L2430/36 ,  C08J9/28 ,  C08J2201/0446 ,  C08J2201/0544 ,  C08J2207/10 ,  C12N15/88

Abstract: Provided herein are bimodal porous polymer microspheres comprising macropores and micropores. Also provided herein are methods and apparatus for fabrication such microspheres. Further provided herein are methods of using bimodal porous polymer microspheres.

Abstract translation: 本文提供了包含大孔和微孔的双峰多孔聚合物微球。 本文还提供了用于制造这种微球的方法和装置。 本文还提供了使用双峰多孔聚合物微球的方法。

公开(公告)号：WO2007051307A2

公开(公告)日：2007-05-10

申请号：PCT/CA2006001808

申请日：2006-11-06

Applicant: PPD MEDITECH ,  MORRISSETTE DANIEL ,  CROTEAU PATRICK

Inventor： MORRISSETTE DANIEL ,  CROTEAU PATRICK

IPC: C08J9/26 ,  A61L31/06

CPC classification number: B32B5/145 ,  A61L27/18 ,  A61L27/48 ,  A61L27/56 ,  B32B5/22 ,  B32B27/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249981 ,  Y10T428/249991 ,  C08L71/00

Abstract: A method for fabricating a porous structure from a first material. The method comprises the acts of mixing the first material with a second material to form a mixture, the first material having a melting point which is lower than the second material, heating the mixture under pressure to a temperature between a melting point of the first material and a melting point of the second material, cooling the molten mixture until it hardens and removing the second material from the first material. The method may also include a subsequent annealing step. There is also described a material suitable for implant, illustratively vertebral or spinal implants, comprising a rigid biocompatible polymer such as PEEK comprising a plurality of interconnected pores. The polymer illustratively has a porosity of between 50% and 85% by volume and in a particular embodiment is able to withstand pressures of up to 20 MPa. The porous PEEK material may also have a minimum thickness in any dimension of one (1 ) inch.

Abstract translation: 一种从第一材料制造多孔结构的方法。 该方法包括将第一材料与第二材料混合以形成混合物的行为，第一材料具有低于第二材料的熔点，将压力下的混合物加热到第一材料的熔点之间的温度 和所述第二材料的熔点，冷却所述熔融混合物直到其硬化并从所述第一材料除去所述第二材料。 该方法还可以包括随后的退火步骤。 还描述了适合于植入物，例如脊椎或脊髓植入物的材料，其包含刚性生物相容性聚合物，例如包含多个互连孔的PEEK。 该聚合物示例性地具有50体积％至85体积％之间的孔隙率，并且在特定实施方案中能够承受高达20MPa的压力。 多孔PEEK材料也可以具有一（1）英寸的任何尺寸的最小厚度。

公开(公告)号：WO2006055940A3

公开(公告)日：2006-08-24

申请号：PCT/US2005042240

申请日：2005-11-18

Applicant: MAYO FOUNDATION ,  WANG SHANGFENG ,  YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L

Inventor： WANG SHANGFENG ,  YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L

IPC: C08F20/00 ,  A61F2/00 ,  A61K31/77 ,  B32B27/00 ,  C08G63/02 ,  C08G65/332 ,  C08J9/26 ,  C08K3/32 ,  C12N5/06

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

Abstract: Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in­ situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

Abstract translation: 聚（丙烯酸富马酸酯）与聚（己内酯）二醇共聚以制备聚（丙烯酸富马酸酯）和聚（己内酯）的嵌段共聚物。 聚（丙烯酸富马酸酯）和聚（己内酯）的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。 嵌段共聚物可以通过氧化还原或光引发交联，具有或不具有另外的交联剂。 因此，共聚物既可自交联（不使用任何交联剂）和光可交联（在诸如紫外光的光子存在下）。

公开(公告)号：US11958036B1

公开(公告)日：2024-04-16

申请号：US18241387

申请日：2023-09-01

Applicant: King Faisal University

Inventor： Junaid Saleem ,  Safdar Hossain Sk ,  Zubair Khalid Baig Moghal ,  Gordon McKay

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C02F1/28 ,  C02F1/40 ,  C08J5/18 ,  C08J9/26 ,  C02F101/32 ,  C02F103/00

CPC classification number: B01J20/261 ,  B01J20/28004 ,  B01J20/28033 ,  B01J20/3007 ,  B01J20/3064 ,  B01J20/3071 ,  C02F1/285 ,  C02F1/40 ,  C08J5/18 ,  C08J9/26 ,  C02F2101/32 ,  C02F2103/007 ,  C02F2303/16 ,  C08J2201/0446 ,  C08J2205/044 ,  C08J2323/06

Abstract: Freestanding porous polyethylene thin film, and a method for preparing a freestanding porous polyethylene thin film. The method includes dissolving polyethylene in an organic solvent to form a solution under reflux conditions; adding a swellable pocket forming agent to the solution and mixing the solution until the swellable pocket forming agent is well-dispersed therein; applying the well-dispersed solution onto a solid substrate through spin coating to form a thin film on the solid substrate; peeling the thin film off the solid substrate; and extracting the swellable pocket forming agent from the peeled thin film by washing the peeled thin film in water, thereby obtaining a freestanding porous polyethylene thin film with swellable pockets, macro-voids, and micropores. The freestanding porous polyethylene thin film can be used as an oil sorbent. The freestanding porous polyethylene thin film has about 500 to about 800 swellable cavities per cm2.

公开(公告)号：US11883792B1

公开(公告)日：2024-01-30

申请号：US18241612

申请日：2023-09-01

Applicant: KING FAISAL UNIVERSITY

Inventor： Junaid Saleem ,  Safdar Hossain S K ,  Zubair Khalid Baig Moghal ,  Gordan McKay

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C02F1/28 ,  C08J5/18 ,  C08J9/26 ,  C09K103/00 ,  C09K3/32 ,  C02F103/00 ,  C02F101/32

CPC classification number: B01J20/261 ,  B01J20/28004 ,  B01J20/28033 ,  B01J20/3007 ,  B01J20/3064 ,  B01J20/3071 ,  C02F1/285 ,  C08J5/18 ,  C08J9/26 ,  C02F2101/32 ,  C02F2103/007 ,  C02F2303/16 ,  C08J2201/0446 ,  C08J2323/12 ,  C09K3/32

Abstract: Sponge-like porous polypropylene thin film, and a method for preparing a sponge-like porous polypropylene thin film. The method includes dissolving polypropylene in an organic solvent to form a solution under reflux condition; adding a cavity forming agent to the solution and mixing the solution until the cavity forming agent is well-dispersed therein; applying the well-dispersed solution onto the solid substrate through spin coating to form a thin film on the solid substrate; peeling the thin film off the solid substrate; extracting the cavity forming agent from the peeled thin film by washing the peeled thin film in an aqueous or nonaqueous solvent, thereby obtaining a sponge-like porous polypropylene thin film with cavities, macro-voids, and micropores. The sponge-like porous polypropylene thin film is used as an oil sorbent. The sponge-like porous polypropylene thin film has about 400 to about 700 swellable cavities per cm2.

公开(公告)号：US11772306B2

公开(公告)日：2023-10-03

申请号：US17374521

申请日：2021-07-13

Applicant: NuVasive, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee

IPC: B29C43/04 ,  B29C67/20 ,  B29C44/58 ,  C08J9/26 ,  B29C33/00 ,  B29K71/00 ,  B29L31/00

CPC classification number: B29C43/04 ,  B29C33/00 ,  B29C44/58 ,  B29C67/202 ,  C08J9/26 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7532 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2300/22 ,  C08J2371/00

Abstract: In general, in various embodiments, the present disclosure is directed systems and methods for producing a porous surface from a solid piece of polymer. In particular, the present disclosure is directed to systems that include a track assembly, mold assembly, press assembly, and methods for using the same for producing a porous surface from a solid piece of polymer. In some embodiments, the present systems and methods are directed to processing a polymer at a temperature below a melting point of the polymer to produce a solid piece of polymer with an integrated a porous surface.

公开(公告)号：US20180193126A1

公开(公告)日：2018-07-12

申请号：US15854748

申请日：2017-12-26

Applicant: Vertera Inc.

Inventor： Wei-Hsang CHANG ,  Stephen Lee LAFFOON ,  Christopher S.D. LEE ,  David Lee SAFRANSKI

IPC: A61F2/00 ,  B29C44/34 ,  A61B6/12 ,  A61B6/00 ,  A61F2/44 ,  B29C67/20 ,  C08J9/26 ,  A61L27/56 ,  A61B90/00 ,  A61L27/18 ,  A61L27/50 ,  B29C44/04 ,  C08J9/00 ,  A61L31/06 ,  C08L71/00 ,  B29K71/00 ,  B29L31/00

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

公开(公告)号：US09889225B2

公开(公告)日：2018-02-13

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  C08J9/26 ,  C08G63/91 ,  C12N5/0775

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.