公开(公告)号：US20180169136A1

公开(公告)日：2018-06-21

申请号：US15737312

申请日：2015-06-18

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-ling Ho ,  Je-Ken Chang ,  Shun-Cheng Wu ,  Chih-Hsiang Chang

IPC: A61K31/728 ,  A61K38/39 ,  A61K35/28 ,  A61K31/366 ,  A61K9/16 ,  A61P19/02

CPC classification number: A61K31/728 ,  A61K9/16 ,  A61K31/366 ,  A61K35/28 ,  A61K38/39 ,  A61K2300/00 ,  A61P19/02

Abstract: The present invention relates to a use of a pharmaceutical composition in the preparation of a drug for promoting chondrogenesis, wherein the pharmaceutical composition comprises a hyaluronic acid mixture and a statin compound.

公开(公告)号：US20150157762A1

公开(公告)日：2015-06-11

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/56 ,  A61L27/54

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.

Abstract translation: 一种用于骨再生的方法，其包括将短期释放组合物施用到有需要的受试者的骨区域中，其中所述组合物包含交联的聚（乳酸 - 共 - 乙醇酸）阿仑膦酸钠（PLGA-ALN），其中 组合物将阿仑膦酸盐释放到骨区域中，其中骨区域的骨组织在9天内原位暴露于治疗有效量的阿仑膦酸盐。

公开(公告)号：US09889225B2

公开(公告)日：2018-02-13

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  C08J9/26 ,  C08G63/91 ,  C12N5/0775

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.