公开(公告)号：EP1996643A1

公开(公告)日：2008-12-03

申请号：EP07711258.9

申请日：2007-03-07

Applicant: Coloplast A/S

Inventor： VANGE, Jakob ,  SCHWACH-ABDELLAOUI, Khadija ,  EVERLAND, Hanne ,  NIELSEN, Peter, Sylvest ,  NIELSEN, Brian ,  JESPERSEN, Lene, Karin ,  NIELSEN, Lene, Feldskov

IPC: C08G63/664 ,  C08G81/00 ,  C08J9/00 ,  C08J9/28 ,  A61L27/18 ,  A61L15/26 ,  A61L27/56

CPC classification number: C08G63/664 ,  A61L15/26 ,  A61L15/425 ,  A61L27/18 ,  A61L27/56 ,  C08G2261/126 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2367/04 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/40 ,  Y10T428/249958 ,  C08L67/04

Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH3)-COO-] and (ii) glycolide units [-CH2-COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

公开(公告)号：US09963571B2

公开(公告)日：2018-05-08

申请号：US15616458

申请日：2017-06-07

Applicant: BLUESHIFT INTERNATIONAL MATERIALS, INC.

Inventor： Alan D. Sakaguchi ,  Garrett D. Poe ,  David J. Irvin ,  Alysa M. Joaquin ,  Janae D. Manning

IPC: C08J9/00 ,  C08J9/28 ,  C08G73/10

CPC classification number: C08J9/28 ,  B01J13/0091 ,  C08G73/10 ,  C08G73/1071 ,  C08J2201/0482 ,  C08J2201/0502 ,  C08J2205/024 ,  C08J2205/026 ,  C08J2205/028 ,  C08J2205/042 ,  C08J2205/044 ,  C08J2205/05 ,  C08J2207/00 ,  C08J2207/10 ,  C08J2300/202 ,  C08J2379/08

Abstract: Aerogel compositions that include polyamic amides, methods for preparing the aerogel compositions, and articles of manufacture that include or manufactured from the aerogel compositions are described.

公开(公告)号：US20170121483A1

公开(公告)日：2017-05-04

申请号：US15297276

申请日：2016-10-19

Applicant: BLUESHIFT INTERNATIONAL MATERIALS, INC.

Inventor： Garrett POE ,  Alan SAKAGUCHI ,  Nicole LAMBDIN ,  Kenneth KOLDAN

IPC: C08J9/28 ,  C08J9/26

CPC classification number: C08J9/286 ,  B01D71/64 ,  C08G73/10 ,  C08G73/1046 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/048 ,  C08J2201/0482 ,  C08J2201/0502 ,  C08J2205/026 ,  C08J2205/05 ,  C08J2300/202 ,  C08J2379/08

Abstract: Aerogel compositions, methods for preparing the aerogel compositions, articles of manufacture that include or are made from the aerogel compositions are described and uses thereof. The aerogels include a branched polyimide matrix with little to no crosslinked polymers.

公开(公告)号：US09562141B2

公开(公告)日：2017-02-07

申请号：US14950522

申请日：2015-11-24

Applicant: NeXolve Corporation

Inventor： David L. Rodman ,  Garrett D. Poe ,  Brandon S. Farmer ,  Joseph C. Smith

IPC: C08J9/26 ,  C08J9/28

CPC classification number: C08J9/286 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0502 ,  C08J2201/0543 ,  C08J2205/026 ,  C08J2379/08

Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.

Abstract translation: 本公开提供了一种制备气凝胶的方法，该方法包括使至少一种酸单体与至少一种二氨基单体在第一溶剂中在适于形成聚酰亚胺聚合物的条件下反应; 进行溶剂交换，其中第一溶剂被更换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换还包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2） 压力容器内的高压环境第一个时间段; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 并在第二温度下将冷却的聚酰亚胺聚合物经受第一个真空第二个时间段。

公开(公告)号：US09206298B2

公开(公告)日：2015-12-08

申请号：US13901453

申请日：2013-05-23

Applicant: NeXolve Corporation

Inventor： David L. Rodman ,  Garrett D. Poe ,  Brandon S. Farmer ,  Joseph C. Smith

IPC: C08J9/00 ,  C08J9/28 ,  C08G73/10

CPC classification number: C08J9/286 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0502 ,  C08J2201/0543 ,  C08J2205/026 ,  C08J2379/08

Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.

Abstract translation: 本公开提供了一种制备气凝胶的方法，该方法包括使至少一种酸单体与至少一种二氨基单体在第一溶剂中在适于形成聚酰亚胺聚合物的条件下反应; 进行溶剂交换，其中第一溶剂被更换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换还包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2） 压力容器内的高压环境第一个时间段; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 并在第二温度下将冷却的聚酰亚胺聚合物经受第一个真空第二个时间段。

公开(公告)号：US20140350134A1

公开(公告)日：2014-11-27

申请号：US13901453

申请日：2013-05-23

Applicant: David L. Rodman ,  Garrett D. Poe ,  Brandon S. Farmer ,  Joseph C. Smith

Inventor： David L. Rodman ,  Garrett D. Poe ,  Brandon S. Farmer ,  Joseph C. Smith

IPC: C08J9/28

CPC classification number: C08J9/286 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0502 ,  C08J2201/0543 ,  C08J2205/026 ,  C08J2379/08

Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.

Abstract translation: 本公开提供了一种制备气凝胶的方法，该方法包括使至少一种酸单体与至少一种二氨基单体在第一溶剂中在适于形成聚酰亚胺聚合物的条件下反应; 进行溶剂交换，其中第一溶剂被更换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换还包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2） 压力容器内的高压环境第一个时间段; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 并在第二温度下将冷却的聚酰亚胺聚合物经受第一个真空第二个时间段。

公开(公告)号：US20130171439A1

公开(公告)日：2013-07-04

申请号：US13821192

申请日：2011-09-07

Applicant: Oded Shoseyov ,  Arnon Heyman ,  Shaul Lapidot ,  Sigal Meirovitch ,  Yuval Nevo ,  Tord Gustafsson

Inventor： Oded Shoseyov ,  Arnon Heyman ,  Shaul Lapidot ,  Sigal Meirovitch ,  Yuval Nevo ,  Tord Gustafsson

IPC: C08B15/00 ,  C08L1/00

CPC classification number: C08B15/00 ,  B82Y30/00 ,  C08J9/0061 ,  C08J9/28 ,  C08J9/365 ,  C08J9/42 ,  C08J2201/026 ,  C08J2201/048 ,  C08J2201/0482 ,  C08J2205/026 ,  C08J2205/042 ,  C08J2205/05 ,  C08J2301/00 ,  C08J2461/00 ,  C08L1/00

Abstract: Provided are cellulose nano-material based composite and foam articles.

Abstract translation: 提供了基于纤维素纳米材料的复合材料和泡沫制品。

公开(公告)号：US20090047322A1

公开(公告)日：2009-02-19

申请号：US12224891

申请日：2007-03-07

Applicant: Jakob Vange ,  Khadija Schwach-Abdellaoui ,  Hanne Everland ,  Peter Sylvest Nielsen ,  Brian Nielsen ,  Lene Karin Jespersen ,  Lene Feldskov Nielsen

Inventor： Jakob Vange ,  Khadija Schwach-Abdellaoui ,  Hanne Everland ,  Peter Sylvest Nielsen ,  Brian Nielsen ,  Lene Karin Jespersen ,  Lene Feldskov Nielsen

IPC: C08F283/01 ,  B32B5/22 ,  A61F2/02 ,  C12N5/06 ,  A61C13/00

CPC classification number: C08G63/664 ,  A61L15/26 ,  A61L15/425 ,  A61L27/18 ,  A61L27/56 ,  C08G2261/126 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2367/04 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/40 ,  Y10T428/249958 ,  C08L67/04

Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A—O—(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

Abstract translation: 本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长的用途。 聚合物具有式AO-（CHR1CHR2O）nB，其中A是聚（丙交酯 - 共 - 乙交酯）残基，（i）丙交酯单元[-CH（CH 3）-COO-]和（ii）乙交酯的摩尔比 聚丙交酯 - 共 - 乙交酯残基中的单元[-CH2-COO-]为80:20至10:90，B为聚（丙交酯 - 共 - 乙交酯）残基或氢，C1- 6-烷基或羟基保护基，R1和R2之一是氢或甲基，另一个是氢，n是10-1000，（iii）聚亚烷基二醇单元[ - （CHR1CHR2O） - ]与组合的摩尔比 （I）丙交酯单元和（ii）聚（丙交酯 - 共 - 乙交酯）残基中的乙交酯单元的量最多为14:86，共聚物的分子量为至少20,000g / mol。

公开(公告)号：US20080095823A1

公开(公告)日：2008-04-24

申请号：US11925635

申请日：2007-10-26

Applicant: Simon Williams ,  David Martin ,  Frank Skraly

Inventor： Simon Williams ,  David Martin ,  Frank Skraly

IPC: A61F2/82

CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Abstract translation: 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。 聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

公开(公告)号：US20070135929A1

公开(公告)日：2007-06-14

申请号：US11623593

申请日：2007-01-16

Applicant: Simon Williams ,  David Martin ,  Frank Skraly

Inventor： Simon Williams ,  David Martin ,  Frank Skraly

IPC: A61F2/02

CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, would dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rats. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Abstract translation: 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 器械，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，敷料和止血剂。 聚羟基链烷酸酯可以含有由单体混合物形成的添加剂，或者包括其主链中的侧基或修饰，或者可以化学改性，以改变降解大鼠。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。