公开(公告)号：US07567346B2

公开(公告)日：2009-07-28

申请号：US11363938

申请日：2006-03-01

Applicant: Pavel A. Fomitchov ,  Eugene Barash ,  Ahmad Yetka ,  Joseph Masino, III

Inventor： Pavel A. Fomitchov ,  Eugene Barash ,  Ahmad Yetka ,  Joseph Masino, III

IPC: G01N21/25

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

Abstract translation: 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

公开(公告)号：US20060290345A1

公开(公告)日：2006-12-28

申请号：US11475091

申请日：2006-06-27

Applicant: Yoshiyuki Kunuki

Inventor： Yoshiyuki Kunuki

IPC: G01R31/28

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N2201/0407

Abstract: A measuring cell holding mechanism, comprising a measuring cell which is configured to include a dielectric block in which a flat face on which a ligand to be attached is formed, and a flow path member which constitutes a flow path between it and this flat face; a dielectric block pressing member which presses the dielectric block from the flow path member side; and a flow path member pressing member which presses the flow path member from the side opposite from the side on which the dielectric block is disposed, with a pressing force smaller than that by the dielectric block pressing member.

Abstract translation: 一种测量单元保持机构，包括测量单元，该测量单元被构造成包括其上形成有待附接的配体的平坦面的介质块和构成其与该平坦面之间的流路的流路构件; 介质块挤压构件，其从所述流路构件侧按压所述介质块; 以及流路构件按压构件，其以比所述介质块按压构件的按压力小的方式将所述流路构件从与设置有所述介质块的一侧相反的一侧挤压。

公开(公告)号：US5428696A

公开(公告)日：1995-06-27

申请号：US92162

申请日：1993-07-15

Applicant: Jerry E. Cahill ,  David H. Tracy

Inventor： Jerry E. Cahill ,  David H. Tracy

IPC: G01N21/25 ,  G02B6/32 ,  G02B6/36 ,  G02B6/42 ,  G02B6/26

CPC classification number: G02B6/3604 ,  G01N21/253 ,  G01N2201/0407 ,  G01N2201/084 ,  G02B6/32 ,  G02B6/4214

Abstract: In a spectrophotometer, each of a plurality of source optical fibers is selectively receptive of source radiation and carries the radiation to a corresponding selected liquid sample cell. A corresponding return optical fiber returns transmitted radiation from the sample to a polychromator. For selecting a sample, a switching member holds exposed ends of the optical fibers on a circle coaxial with an axle for rotating to selected positions. Respective optical trains in the instrument direct radiation into and out of the selected pair of fibers. The diameter of a source aperture, the spacing of the aperture from the radiation source, and the source area define a source etendue. The optical fibers have a fiber etendue substantially the same as the source etendue.

Abstract translation: 在分光光度计中，多个源光纤中的每一个选择性地接受源辐射，并将辐射传送到相应的选定液体样品池。 相应的返回光纤将来自样品的透射辐射返回到多色分光器。 为了选择样品，切换构件将光纤的露出端保持在与轴同轴的圆上，以旋转到选定位置。 仪器中的各种光学列车直接辐射进出所选择的一对光纤。 源孔径的直径，孔径与辐射源的距离以及源区域定义了源极化程度。 光纤具有基本上等于光源渗透率的纤维光密度。

公开(公告)号：US5345395A

公开(公告)日：1994-09-06

申请号：US785800

申请日：1991-10-31

Applicant: Christopher D. Griner

Inventor： Christopher D. Griner

IPC: G01N21/17 ,  G01N21/25 ,  G01N21/27 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/253 ,  G01N21/274 ,  G01N35/028 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283

Abstract: A system uses a photometer that establishes an optical channel between a light emitter and a light detector. The photometer analyses a specimen while it occupies a well in a tray. A movable platform transports the tray to the optical channel for analysis and removes the tray from the optical channel after analysis. The system calibrates the movable platform to assure proper alignment between the specimen and the photometric apparatus used to analyzed the specimen. The system also calibrates the optical channel without use of an external reference.

Abstract translation: 系统使用在光发射器和光检测器之间建立光通道的光度计。 光度计分析样品时，它在托盘中占有很好的位置。 可移动平台将托盘运送到光通道进行分析，并在分析后从光通道中移除托盘。 系统校准可移动平台，以确保样品与用于分析样品的光度测量仪器之间的正确对准。 该系统还可以校准光通道而不使用外部参考。

公开(公告)号：US5325295A

公开(公告)日：1994-06-28

申请号：US688220

申请日：1991-04-22

Applicant: Joseph C. Fratantoni ,  Betty J. Poindexter

Inventor： Joseph C. Fratantoni ,  Betty J. Poindexter

IPC: G01N15/00 ,  G01N21/82 ,  G06F15/00 ,  G01N33/48

CPC classification number: G01N21/82 ,  G01N2015/0084 ,  G01N2201/0407 ,  G01N2201/0446

Abstract: A rapid method for the simultaneous measurement of aggregation or agglutination in plurality of microtest wells or other sample-holding vessels comprises providing a plurality of light beams having discrete focal points adapted to be focused on the contents of a plurality of wells or other vessels and a plurality of photodetectors therefor, directing the light beams through the wells or other vessels and contents thereof, continuously agitating the wells or other vessels and contents thereof with a circular movement effective to permit aggregation or agglutination while preserving the integrity of the material, producing a plurality of output signals from the detectors are proportional to the light absorbencies of the beams as they pass through the wells or other vessels and contents thereof, repeatedly sampling the signals at a predetermined time interval and determining changes in optical densities from the signals obtained after each predetermined time interval by comparing each signal sampled after each predetermined time interval with the first signal sampled for the same microtest well or vessel, whereby any change in optical density which is greater than about 0.05 units is said to indicate that aggregation or agglutination occurred in the well or other vessel. The present method is suitably applied to the measurement of aggregation in platelets.

Abstract translation: 用于同时测量多个微测井或其他样品保持容器中的聚集或凝集的快速方法包括提供多个光束，其具有适于聚焦在多个孔或其它容器的内容物上的离散焦点，以及 多个光电检测器，用于引导光束通过孔或其它容器及其内容物，以圆周运动连续地搅动孔或其它容器及其内容物，以有效地允许聚集或凝集，同时保持材料的完整性，产生多个 来自检测器的输出信号与光束在通过孔或其他容器及其内容物时的光吸收率成比例，以预定的时间间隔重复采样信号，并根据每个预定值之后获得的信号确定光密度的变化 通过比较每个信号的时间间隔 在每个预定时间间隔之后采样，对于相同的微测井或容器采样第一信号，由此大于约0.05单位的光密度的任何变化据说表明孔或其它容器中发生聚集或凝集。 本方法适用于血小板聚集的测定。

公开(公告)号：US5073029A

公开(公告)日：1991-12-17

申请号：US481450

申请日：1990-02-16

Applicant: James P. Eberly ,  Ralph A. Magnotti, Jr.

Inventor： James P. Eberly ,  Ralph A. Magnotti, Jr.

IPC: G01N21/27 ,  G01N21/25 ,  G01N21/77

CPC classification number: G01N21/253 ,  G01N21/255 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0621

Abstract: An optoelectronic device is provided which permits rapid sequential measurement of the optical density of multiple samples. The device employs a plurality of light-emitting diodes (LEDs) as light sources and a plurality of photodiodes as light detectors. In a preferred embodiment, arrays of LEDs paired with photodiodes are adapted to measure the optical density of samples contained in multiwell plastic plates (microplates) conventionally used for immunoassays.

Abstract translation: 提供了一种允许快速连续测量多个样品的光密度的光电子器件。 该装置使用多个发光二极管（LED）作为光源和多个光电二极管作为光检测器。 在优选实施例中，与光电二极管配对的LED阵列适于测量通常用于免疫测定的多孔塑料板（微孔板）中包含的样品的光密度。

公开(公告)号：US4892409A

公开(公告)日：1990-01-09

申请号：US218874

申请日：1988-07-14

Applicant: Harry F. Smith

Inventor： Harry F. Smith

IPC: G01N21/25

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/065

Abstract: The invention relates to photometric apparatus and method for determining a characteristic of individual ones of a plurality of samples contained within a plurality of sample chambers. The photometric apparatus includes an enclosure; a substantially uniform source of radiation coupled to the enclosure such that a plurality of sample chambers, disposed within the enclosure, are simultaneously illuminated by the uniform source; and apparatus for detecting an amount of radiation which is transmitted through individual ones of the sample chambers, the detecting apparatus having an output signal having a magnitude which is a function of the amount of radiation which is transmitted through an individual one of the sample chambers. The substantially uniform source of radiation may include at least one source of radiation having an output comprising wavelengths within a first range of wavelengths and an optically integrating sphere having a radiation input port coupled to the output of the source of radiation and a radiation output port coupled to the enclosure. The photometric apparatus may further include radiation directing devices interposed between the radiation output port and the plurality of sample chambers for simultaneously directing radiation emanating from the output port into each of the sample chambers. The directed radiation may be either focussed or collimated.

Abstract translation: 本发明涉及用于确定包含在多个样品室内的多个样品中的各个样品的特性的光度测定装置和方法。 测光装置包括外壳; 耦合到外壳的基本上均匀的辐射源，使得设置在外壳内的多个样品室同时被均匀光源照射; 以及用于检测通过单个样本室传输的辐射量的装置，该检测装置具有输出信号，该输出信号的幅度是通过单独一个样本室传输的辐射量的函数。 基本上均匀的辐射源可以包括至少一个辐射源，其具有包括在第一波长范围内的波长的输出和具有耦合到辐射源的输出的辐射输入端口的光学积分球，以及辐射输出端口 到外壳。 测光装置还可以包括插入在辐射输出端口和多个样品室之间的辐射导向装置，用于同时将从输出端口发出的辐射引导到每个样品室中。 定向辐射可以是聚焦的或准直的。

公开(公告)号：EP2309251A1

公开(公告)日：2011-04-13

申请号：EP10009248.5

申请日：2010-09-06

Applicant: Siemens Healthcare Diagnostics Products GmbH

Inventor： Meller, Paul, Dr. ,  Pufahl, Holger, Dr.

IPC: G01N21/25 ,  G01N35/00 ,  G01N1/38

CPC classification number: G01N21/253 ,  G01N21/0332 ,  G01N21/255 ,  G01N35/02 ,  G01N2021/0325 ,  G01N2021/825 ,  G01N2035/00534 ,  G01N2201/0407 ,  G01N2201/0423 ,  G01N2201/0453 ,  G01N2201/0627

Abstract: Die vorliegende Erfindung bezieht sich auf eine Vorrichtung (10,30,40,50,60) zur photometrischen Untersuchung von Proben. Sie weist eine Probenhalterungseinrichtung (11,31,41,51,61) für mindestens zwei Probengefäße sowie eine Messeinrichtung und eine bewegbare Einrichtung (14,34,44,54) auf. Die Probenhalterungseinrichtung ist dabei stationär ausgebildet, und die Messeinrichtung ist an der bewegbaren Einrichtung angeordnet, so dass sie mittels der bewegbaren Einrichtung verfahrbar ist.

Abstract translation: 装置（10）具有固定的样品保持器装置（11），其包括用于容纳两个样品容器的保持单元（15）。 测量装置布置在可移动装置（14）上并由可移动装置移位。 保持单元以弧形的方式设置在样品保持器装置上，并且测量装置以旋转的方式围绕弧形布置移位。 测量装置包括光源（12） LED或激光二极管，以及光电检测器（13）。 磁力搅拌器设置在样品架上。 还包括以下独立权利要求：（1）样品的光度检测方法（2）用于自动检查液体样品的分析仪器，包括样品的光度检测装置。

公开(公告)号：EP1902306A1

公开(公告)日：2008-03-26

申请号：EP06739501.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: G01N21/64 ,  G01N35/00

CPC classification number: F16K99/003 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/004 ,  F16K2099/0084 ,  G01N21/0332 ,  G01N21/07 ,  G01N21/359 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/00069 ,  G01N35/1097 ,  G01N2021/0325 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00267 ,  G01N2035/00415 ,  G01N2035/0474 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0833 ,  Y10T436/11 ,  Y10T436/111666

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

公开(公告)号：EP1899067A1

公开(公告)日：2008-03-19

申请号：EP06739539.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William D., ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: B01L7/00

CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.