公开(公告)号：WO2010016795A1

公开(公告)日：2010-02-11

申请号：PCT/SE2009/050918

申请日：2009-08-04

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB ,  BARASH, Eugene ,  FINEHOUT, Erin ,  PIETRZYKOWSKI, Matthew, Damian ,  XIA, Hua ,  ZHU, Li

Inventor： BARASH, Eugene ,  FINEHOUT, Erin ,  PIETRZYKOWSKI, Matthew, Damian ,  XIA, Hua ,  ZHU, Li

IPC: G01N27/447 ,  G01N21/64 ,  G01N33/487

CPC classification number: G01N21/645 ,  B01L3/5027 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/08 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fluorescence detection system comprises a light source configured to produce an excitation light, an optical lens and a fiber bundle. The optical lens is configured to focus the excitation light to a sample to emit fluorescence and to collect the fluorescence. The fiber bundle probe comprises a transmitting fiber configured to transmit the excitation light to the optical lens, and a first receiving fiber configured to deliver the collected fluorescence. The fluorescence detection system further comprises a first detector configured to detect the fluorescence delivered by the receiving fiber to generate a response signal, and a processing unit configured to determine information about the samples by analyzing the response signal. Additionally, a fluorescence detection method is also presented.

Abstract translation: 荧光检测系统包括被配置为产生激发光，光学透镜和光纤束的光源。 光学透镜被配置为将激发光聚焦到样品以发射荧光并收集荧光。 纤维束探针包括被配置为将激发光透射到光学透镜的发射光纤和被配置为传送所收集的荧光的第一接收光纤。 荧光检测系统还包括第一检测器，其被配置为检测由接收光纤传送的荧光以产生响应信号;以及处理单元，被配置为通过分析响应信号来确定关于样本的信息。 另外，还提出了荧光检测方法。

公开(公告)号：WO2009060336A2

公开(公告)日：2009-05-14

申请号：PCT/IB2008/054439

申请日：2008-10-28

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  BAKKER, Levinus, P. ,  BRENDEL, Bernhard, J. ,  HARBERS, Rik ,  VAN DER MARK, Martinus., B.

Inventor： BAKKER, Levinus, P. ,  BRENDEL, Bernhard, J. ,  HARBERS, Rik ,  VAN DER MARK, Martinus., B.

CPC classification number: G01N21/4795 ,  A61B5/0091 ,  A61B5/4312 ,  G01N21/15 ,  G01N2021/1787 ,  G01N2021/4719 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A method of controlling a device for imaging the interior of turbid media is provided. The device comprises: a receiving portion (2) for receiving a turbid medium (1) tobe examined; at least one light source (6) optically connected to the receiving portion (2) for irradiating the interior of the receiving portion (2); and at least one detector (7) opticallyconnected to the receiving portion (2) for detecting light emanating from the interior ofthe receiving portion (2). The at least one light source (6) and the at least one detector (7) areoptically connected to the receivingportion (2) such that a plurality of differentsource- detector position combinationsare formedover a complete measurement. The different source-detector position combinations define different light paths through the receiving portion (2). The method comprises a fast-measurement step in which a reduced set of data corresponding to onlya part of the plurality of source-detector position combinations is generated for providing fast-information about the interior of the receiving portion (2).

Abstract translation: 提供了一种控制用于对浑浊介质内部进行成像的装置的方法。 该装置包括：接收部分（2），用于接收待检查的混浊介质（1）; 至少一个光源（6），其光学连接到所述接收部分（2）以照射所述接收部分（2）的内部; 以及光学地连接到接收部分（2）的至少一个检测器（7），用于检测从接收部分（2）的内部发出的光。 所述至少一个光源（6）和所述至少一个检测器（7）光学地连接到所述接收部分（2），使得多个不同的源检测器位置组合形成为完整的测量。 不同的源 - 检测器位置组合限定穿过接收部分（2）的不同光路。 该方法包括快速测量步骤，其中仅生成与多个源 - 检测器位置组合的一部分相对应的数据集合，用于提供关于接收部分（2）的内部的快速信息。

公开(公告)号：WO2004044662A2

公开(公告)日：2004-05-27

申请号：PCT/US2003/035913

申请日：2003-11-12

Applicant: PHILIP MORRIS PRODUCTS S.A. ,  LANIER, Robert, C., Jr. ,  GILL, Tejinder ,  CAMPBELL, Steven, M. ,  BELLAMAH, Stephen, J.

Inventor： LANIER, Robert, C., Jr. ,  GILL, Tejinder ,  CAMPBELL, Steven, M. ,  BELLAMAH, Stephen, J.

IPC: G05B

CPC classification number: G01N21/8903 ,  A24D3/0295 ,  G01N21/952 ,  G01N2021/8416 ,  G01N2021/8444 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A system and process for monitoring a continuous element being incorporated within a cigarette filter includes a light source and a photoresponsive device facing each other and on opposite sides of a measuring gap, and passing the continuous element through the measuring gap and detecting movement of the continuous element by the effect of the movement on at least one light beam present between the light source and the photoresponsive device. Individual lengths of the continuous cigarette filter rod being produced can be selectively rejected based on a determination of whether the continuous element has a break or a knot along its length.

Abstract translation: 用于监测香烟过滤嘴内的连续元件的系统和过程包括彼此面对并且在测量间隙的相对侧面上的光源和光响应装置，并且使连续元件通过测量间隙并检测连续元件的运动 通过运动对光源和光响应装置之间存在的至少一个光束的影响。 根据确定连续元件是否具有断裂或其长度的结，可以选择性地拒绝所生产的连续卷烟过滤棒的单独长度。

公开(公告)号：WO00068668A1

公开(公告)日：2000-11-16

申请号：PCT/JP2000/002996

申请日：2000-05-10

IPC: C40B40/06 ,  G01N21/64 ,  G01N21/78 ,  G01N27/447 ,  G01N33/487 ,  G01N33/58 ,  G01N35/00 ,  G01N37/00

CPC classification number: G01N21/6452 ,  B01J2219/00536 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/06 ,  G01N27/44721 ,  G01N33/487 ,  G01N33/582 ,  G01N35/00069 ,  G01N2201/0833

Abstract: The invention uses a continuous-wave laser as an excitation light source to achieve highly-accurate detection with a simple structure. A sample (11a) is irradiated with excitation light from an excitation light source (30), and then transported to an optical axis of a fluorescence detecting means (50), thereby being detected of its fluorescence intensity.

Abstract translation: 本发明使用连续波激光器作为激发光源，以简单的结构实现高精度的检测。 用来自激发光源（30）的激发光照射样品（11a），然后将其输送到荧光检测装置（50）的光轴，从而检测其荧光强度。

公开(公告)号：WO00005569A1

公开(公告)日：2000-02-03

申请号：PCT/GB1999/002348

申请日：1999-07-20

IPC: G01N21/64 ,  G01N21/76

CPC classification number: G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/0866

Abstract: Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fibre bundle. The cross-sectional area of the optical fibre bundle corresponds to the area of the sample, the end of which is located close to the sample for detecting any light emitted therefrom, and selected fibres (30) of those making up the bundle are separated from the remainder and extend to a source of excitation radiation (76) and serve to convey excitation radiation (if required) directly to a corresponding plurality of points distributed over the area of the end face of the bundle and therefore over the area of the sample. The remaining fibres (32, 38) of the bundle serve to collect emitted light (whether generated by fluorescence caused by excitation or otherwise) and provide a light path to the charge coupled device camera, wherein the ends of the excitation fibres and the ends of the emitted light collecting fibres are distributed uniformly over the area of the fibre bundle presented to the reaction site.

Abstract translation: 提供了用于检测由测定样品发射的光的装置，其中由样品发射的光被收集以通过光纤束传输到电荷耦合器件照相机（74）。 光纤束的横截面积对应于样品的面积，其端部靠近样品，用于检测从其发出的任何光，并且构成束的那些选定的纤维（30）从 剩余部分并延伸到激发辐射源（76）并且用于将激发辐射（如果需要）直接传送到分布在束的端面的区域上并因此在样品的区域上的对应的多个点。 束的剩余纤维（32,38）用于收集发射的光（无论是由激发产生的还是由激发产生的），并且向电荷耦合器件照相机提供光路，其中激发光纤的端部和 发射的聚光纤维均匀地分布在呈现给反应部位的纤维束的区域上。

公开(公告)号：WO98050782A2

公开(公告)日：1998-11-12

申请号：PCT/US1998/009163

申请日：1998-05-05

IPC: G01N21/77 ,  G01N21/64

CPC classification number: G01N21/7703 ,  G01N2201/0833 ,  Y10S977/924

Abstract: The present invention provides biosensors, apparatus and methods for selectively detecting at least one complementary oligonucleotide target specie in a fluid sample containing a mixture of different oligonucleotide fragments. One preferred embodiment of the biosensor is as a unitary fiber optic array having an in-situ hybridization zone comprising not less than one specie of single stranded oligonucleotide disposed as individual deposits in aligned organization upon multiple strand end faces at differing spatial positions on the distal array end surface. In this manner, a collective of deployed, single specie, multiple fixed probes are presented for selective in-situ hybridization on-demand with at least one mobile complementary target specie ultimately bearing a joined identifying label. The biosensor provides for optical detection of in-situ hybridization on the distal end surface via the presence of the concomitantly disposed joined identifying label at the differing spatial positions.

Abstract translation: 本发明提供用于选择性检测含有不同寡核苷酸片段的混合物的流体样品中的至少一种互补寡核苷酸靶物种的生物传感器，装置和方法。 生物传感器的一个优选实施方案是具有原位杂交区的单一光纤阵列，其包含不少于一种单链寡核苷酸，所述单链寡核苷酸作为单个沉积物以对齐的组织形式排列在远端阵列上的不同空间位置的多股端面上 端面。 以这种方式，提供了一组部署的单个物种，多个固定探针，用于选择性原位杂交，其中至少一个移动互补目标物种最终具有连接的鉴定标签。 生物传感器通过在不同的空间位置处存在伴随设置的连接的识别标签，提供在远端表面上的原位杂交的光学检测。

公开(公告)号：US12025499B2

公开(公告)日：2024-07-02

申请号：US17616794

申请日：2020-06-05

Applicant: Aweta G&P B.V.

Inventor： Johannes Cornelis De Geus ,  Valéry Jean Georges Quenon

IPC: G01J3/42 ,  G01J3/02 ,  G01J3/10 ,  G01N21/84 ,  G01N33/02 ,  G01N21/31 ,  G01N21/85

CPC classification number: G01J3/42 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0289 ,  G01J3/10 ,  G01J2003/102 ,  G01N21/31 ,  G01N21/84 ,  G01N2021/845 ,  G01N2021/8466 ,  G01N2021/8592 ,  G01N33/025 ,  G01N2201/0833

Abstract: Apparatus for determining a property of products, in particular plant or animal products, the apparatus comprising: a conveyor configured for conveying products one-by-one along a transport path in a transport direction; a light source configured for illuminating a first illumination area of the transport path, wherein the first illumination area extends substantially across the transverse width of the transport path; and a sensor structure configured for receiving light from a sensing area of the transport path, wherein the sensing area extends substantially across the transverse width of the transport path, wherein the sensing area is adjacent to the first illumination area.

公开(公告)号：US20230313679A1

公开(公告)日：2023-10-05

申请号：US18206828

申请日：2023-06-07

Applicant: Baker Hughes Oilfield Operations LLC

Inventor： Rocco DiFoggio ,  Helene C. Climent

IPC: E21B49/08 ,  G01N33/28 ,  G01N21/43 ,  G01N21/41

CPC classification number: E21B49/08 ,  G01N33/2823 ,  G01N21/431 ,  G01N21/4133 ,  G01N2201/0833 ,  G01N2021/432

Abstract: An apparatus for detecting one or more properties of a downhole fluid includes a housing. The apparatus also includes a location-sensitive optical detector, arranged within a chamber formed by the housing. The apparatus further includes a light source, arranged within the chamber. The apparatus also includes a lens, positioned at an end of the housing, the lens preferably having a flat side and a curved side, the flat side positioned proximate the chamber to position the flat side closer to the light source than the curved side. The apparatus further includes a mirror, arranged outside the housing.

公开(公告)号：US20190049382A1

公开(公告)日：2019-02-14

申请号：US16079900

申请日：2017-02-23

Applicant: Single Technologies AB

Inventor： Raoul Stubbe ,  Bengt Sahlgren ,  Johan Strömqvist

IPC: G01N21/64 ,  G01N21/51 ,  G02B19/00 ,  G02B21/00 ,  G02B21/26 ,  G02B21/33 ,  G02B27/10 ,  G02B27/14

CPC classification number: G01N21/6458 ,  G01N21/474 ,  G01N21/51 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/103 ,  G02B19/0019 ,  G02B19/0057 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/33 ,  G02B27/1006 ,  G02B27/141

Abstract: An apparatus for imaging a includes an light source for illuminating the sample simultaneously in a line focus or an array of foci; and a sensor for detecting photons emitted or scattered from the sample simultaneously in an array of fields of view. An array of sub-observation volumes in the sample, from which photons are emitted or scattered during imaging, is defined by the volumes in space where the line focus or array of foci from the light source overlap with the corresponding array of field of views of the sensor. A cylindrical sample holder holds the sample at a surface and is rotatably arranged such that at least a portion of the sample can be transported through at least one of the sub-observation volumes by rotating the sample holder. The apparatus can be used in a high-throughput method of imaging.

公开(公告)号：US20180294198A1

公开(公告)日：2018-10-11

申请号：US15484985

申请日：2017-04-11

Applicant: Applied Materials, Inc.

Inventor： Tae Seung Cho ,  Soonam Park ,  Junghoon Kim ,  Dmitry Lubomirsky ,  Shankar Venkataraman

IPC: H01L21/66 ,  G01N21/73 ,  H01L21/3065 ,  H01L21/67 ,  H01J37/32

CPC classification number: H01L22/26 ,  G01N21/73 ,  G01N2201/08 ,  G01N2201/0833 ,  H01J37/32082 ,  H01J37/32568 ,  H01J37/32743 ,  H01J2237/3341 ,  H01L21/31116 ,  H01L21/67253

Abstract: Methods and systems for etching substrates using a remote plasma are described. Remotely excited etchants are formed in a remote plasma and flowed through a showerhead into a substrate processing region to etch the substrate. Optical emission spectra are acquired from the substrate processing region just above the substrate. The optical emission spectra may be used to determine an endpoint of the etch, determine the etch rate or otherwise characterize the etch process. A weak plasma may be present in the substrate processing region. The weak plasma may have much lower intensity than the remote plasma. In cases where no bias plasma is used above the substrate in an etch process, a weak plasma may be ignited near a viewport disposed near the side of the substrate processing region to characterize the etchants.