公开(公告)号：US10908073B2

公开(公告)日：2021-02-02

申请号：US15507718

申请日：2015-08-27

Applicant: Single Technologies AB

Inventor： Bengt Sahlgren ,  Raoul Stubbe ,  Johan Strömqvist

IPC: G01N21/25 ,  G01N21/64 ,  G02B21/36 ,  G01N35/02 ,  G02B21/00

Abstract: A method and apparatus are provided, in which an observation volume is defined by a volume where light from illumination means and a field of view of detection means overlap. The central axes of said light from the illumination means and said field of view of the detection means are non-parallel, and the sample is transported through the observation volume during imaging, preferably by rotation of a sample container holding the sample.

公开(公告)号：US10732113B2

公开(公告)日：2020-08-04

申请号：US16079900

申请日：2017-02-23

Applicant: Single Technologies AB

Inventor： Raoul Stubbe ,  Bengt Sahlgren ,  Johan Strömqvist

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/26 ,  G02B21/33 ,  G02B19/00 ,  G02B27/10 ,  G02B27/14 ,  G01N21/47 ,  G01N21/51

Abstract: An apparatus for imaging a includes an light source for illuminating the sample simultaneously in a line focus or an array of foci; and a sensor for detecting photons emitted or scattered from the sample simultaneously in an array of fields of view. An array of sub-observation volumes in the sample, from which photons are emitted or scattered during imaging, is defined by the volumes in space where the line focus or array of foci from the light source overlap with the corresponding array of field of views of the sensor. A cylindrical sample holder holds the sample at a surface and is rotatably arranged such that at least a portion of the sample can be transported through at least one of the sub-observation volumes by rotating the sample holder. The apparatus can be used in a high-throughput method of imaging.

公开(公告)号：US20190049382A1

公开(公告)日：2019-02-14

申请号：US16079900

申请日：2017-02-23

Applicant: Single Technologies AB

Inventor： Raoul Stubbe ,  Bengt Sahlgren ,  Johan Strömqvist

IPC: G01N21/64 ,  G01N21/51 ,  G02B19/00 ,  G02B21/00 ,  G02B21/26 ,  G02B21/33 ,  G02B27/10 ,  G02B27/14

CPC classification number: G01N21/6458 ,  G01N21/474 ,  G01N21/51 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/103 ,  G02B19/0019 ,  G02B19/0057 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/33 ,  G02B27/1006 ,  G02B27/141

Abstract: An apparatus for imaging a includes an light source for illuminating the sample simultaneously in a line focus or an array of foci; and a sensor for detecting photons emitted or scattered from the sample simultaneously in an array of fields of view. An array of sub-observation volumes in the sample, from which photons are emitted or scattered during imaging, is defined by the volumes in space where the line focus or array of foci from the light source overlap with the corresponding array of field of views of the sensor. A cylindrical sample holder holds the sample at a surface and is rotatably arranged such that at least a portion of the sample can be transported through at least one of the sub-observation volumes by rotating the sample holder. The apparatus can be used in a high-throughput method of imaging.

公开(公告)号：US20170292907A1

公开(公告)日：2017-10-12

申请号：US15507718

申请日：2015-08-27

Applicant: Single Technologies AB

Inventor： Bengt Sahlgren ,  Raoul Stubbe ,  Johan Strömqvist

IPC: G01N21/25 ,  G02B21/36 ,  G01N21/64

CPC classification number: G01N21/253 ,  G01N21/6452 ,  G01N35/02 ,  G02B21/00 ,  G02B21/36 ,  G02B21/367

Abstract: A method and apparatus are provided, in which an observation volume is defined by a volume where light from illumination means and a field of view of detection means overlap. The central axes of said light from the illumination means and said field of view of the detection means are non-parallel, and the sample is transported through the observation volume during imaging, preferably by rotation of a sample container holding the sample.