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公开(公告)号：US11978269B2
公开(公告)日：2024-05-07
申请号：US18210911
申请日：2023-06-16
Applicant: Becton, Dickinson and Company
Inventor： Paul Barclay Purcell
CPC classification number: G06V20/698 , G01N21/01 , G01N21/17 , G01N21/84 , G06N3/08 , G01N2021/0112 , G01N2021/0181 , G01N2021/0193 , G01N2021/1765 , G01N2021/845 , G01N2201/125
Abstract: Aspects of the present disclosure include reconfigurable integrated circuits for characterizing particles of a sample in a flow stream. Reconfigurable integrated circuits according to certain embodiments are programmed to calculate parameters of a particle in a flow stream from detected light; compare the calculated parameters of the particle with parameters of one or more particle classifications; classify the particle based on the comparison between the parameters of the particle classifications and the calculated parameters of the particle; and adjust one or more parameters of the particle classifications based on the calculated parameters of the particle. Methods for characterizing particles in a flow stream with the subject integrated circuits are also described. Systems and integrated circuit devices programmed for practicing the subject methods, such as on a flow cytometer, are also provided.
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82.发明公开公开(公告)号：US20240068943A1
公开(公告)日：2024-02-29
申请号：US18500999
申请日：2023-11-02
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Thomas Raymond Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
CPC classification number: G01N21/6402 , G01N21/6486 , G06F1/08 , G01N2021/6495 , G01N2201/125 , G01N2201/126
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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83.发明授权公开(公告)号：US11808700B2
公开(公告)日：2023-11-07
申请号：US16442206
申请日：2019-06-14
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Tom Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
CPC classification number: G01N21/6402 , G01N21/6486 , G06F1/08 , G01N2021/6495 , G01N2201/125 , G01N2201/126
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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84.发明授权公开(公告)号：US09983135B2
公开(公告)日：2018-05-29
申请号：US14543888
申请日：2014-11-17
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid
CPC classification number: G01N21/6486 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q1/6869 , C12Q1/6874 , C12Q2521/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q2525/101
Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.
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公开(公告)号：US09863880B2
公开(公告)日：2018-01-09
申请号：US14543867
申请日：2014-11-17
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence West , Michael Ferrigno , Paul E. Glenn , Adam E. Cohen , Anthony Bellofiore
CPC classification number: G01N21/6486 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q1/6869 , C12Q1/6874 , C12Q2521/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q2525/101
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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Patent Agency Ranking
公开(公告)号：US09841371B2
公开(公告)日：2017-12-12
申请号：US14516772
申请日：2014-10-17
Inventor： Kevin J. Knopp , Robert L. Green , Brendon D. Tower , Christopher D. Brown , Gregory H. Vander Rhodes
IPC: G01N21/17 , G01J3/02 , G01J3/44 , G01N21/47 , G01N21/65 , G01J3/42 , G01N21/55 , G01N21/59 , G01N21/35
CPC classification number: G01N21/17 , G01J3/02 , G01J3/0232 , G01J3/0262 , G01J3/0264 , G01J3/0272 , G01J3/0289 , G01J3/0291 , G01J3/42 , G01J3/44 , G01J3/4412 , G01N21/47 , G01N21/4738 , G01N21/55 , G01N21/59 , G01N21/65 , G01N2021/3595 , G01N2201/0221 , G01N2201/0612 , G01N2201/062 , G01N2201/105 , G01N2201/125
Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine information about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.
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87.发明授权公开(公告)号：US09702859B2
公开(公告)日：2017-07-11
申请号：US15187852
申请日：2016-06-21
Applicant: Zoetis Services LLC
Inventor： Joel James Walukas , Ramin Karimpour
IPC: G01J5/02 , G01N33/08 , A01K43/00 , A61B5/024 , G01N21/3563 , G01N21/59 , A01K45/00 , A61B5/00 , G01N21/95 , G01N21/84
CPC classification number: G01N33/085 , A01K43/00 , A01K45/007 , A61B5/024 , A61B5/704 , A61B2503/40 , G01N21/3563 , G01N21/59 , G01N21/85 , G01N21/951 , G01N33/08 , G01N2021/845 , G01N2201/062 , G01N2201/125
Abstract: An egg identification system for determining viability of an avian egg is provided. Such a system includes an emitter assembly configured to emit electromagnetic radiation toward an egg. A detector assembly is axially aligned with the emitter assembly to detect electromagnetic radiation transmitted through the egg. The detector assembly is spaced-apart from the egg during operation thereof such that the detector assembly does not contact the egg. The detected electromagnetic radiation is used to generate an output signal. The output signal is processed to determine whether there exists a periodic variation or an aperiodic perturbation in an intensity of the electromagnetic radiation transmitted through the egg corresponding to action of a heart or embryo movement, wherein the existence of the periodic variation or aperiodic perturbation indicates that the egg is viable. An associated method is also provided.
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公开(公告)号：US09606066B2
公开(公告)日：2017-03-28
申请号：US14206289
申请日：2012-09-10
Applicant: Yuji Ikeda , Ryoji Tsuruoka
Inventor： Yuji Ikeda , Ryoji Tsuruoka
CPC classification number: G01N21/718 , G01J3/443 , G01N2201/06113 , G01N2201/08 , G01N2201/125
Abstract: The objective of the present invention is to reduce the dispersion of a powdered substance, which is the target substance, during the analysis period in an analyzing device that analyzes the target substance by analyzing the light originated from the substance which is in the plasma state. The present invention relates to an analyzing device including a plasma generation means which generates plasma in the space and maintains plasma using the energy of EM radiation emitted from a radiation antenna; and an optical analysis means which analyzes a target substance by analyzing the plasma light generated from target substance of plasma state in the plasma area during the plasma maintenance period where the plasma is maintained by the plasma generation means using the energy of EM radiation. The plasma generation means emits the EM radiation from the radiation antenna in continuous waves during the plasma maintenance period.
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公开(公告)号：US20160202190A1
公开(公告)日：2016-07-14
申请号：US14912695
申请日：2014-08-18
Inventor： Wilko HEIN , Grigorios BARBOUTIS
CPC classification number: G01N21/8483 , G01N21/78 , G01N2021/7759 , G01N2201/125
Abstract: A device for photometric qualification of lateral flow quick tests by means of camera imaging includes an arrangement which manages with a pinhole aperture with a slot-shaped opening, which has been integrated into the basic housing body, in which the imaging has been optimised with a view to diffraction, imaging scale and integration behaviour and in which the illumination and all the components are arranged in a housing which can be produced at a reasonable price, with the result that the quantifiability of customary LFA quick tests is made possible for the user with a sufficient precision. The device can transmit test-specific data automatically and contact-free with the help of electromagnetic waves via a transponder (RFID) and is thus suited for various tests and for quantification of LFA's. The device may work autonomously with an internal microcontroller (embedded system). The figures can be stored and optionally transmitted to a computer via an interface.
Abstract translation: 用于通过照相机成像进行横向流快速测试的光度鉴定装置包括利用具有狭缝形开口的针孔开始管理的装置，其已经集成到基本壳体中，其中成像已经被优化为 考虑到衍射，成像尺度和整合行为，其中照明和所有部件布置在可以以合理价格生产的外壳中，结果是可以使用户进行常规LFA快速测试的可量化性， 足够的精度。 该设备可以通过应答器（RFID）通过电磁波自动和无接触地发送测试专用数据，因此适用于各种测试和量化LFA。 该器件可以与内部微控制器（嵌入式系统）自主工作。 这些图可以被存储并且可选地通过接口传送到计算机。
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公开(公告)号：US20150097941A1
公开(公告)日：2015-04-09
申请号：US14572969
申请日：2014-12-17
Applicant: Pioneer Hi-Bred International, Inc.
Inventor： Adda Sayers , Dean M. Tranel , Travis A. Hanselman , Stephen D. Strachan
CPC classification number: G01N21/17 , A01G7/00 , G01N1/4077 , G01N15/06 , G01N15/10 , G01N15/1463 , G01N33/0098 , G01N2021/1765 , G01N2201/02 , G01N2201/125 , G06K9/00134 , G06Q99/00
Abstract: An apparatus and method of quantitatively obtaining a measurement of pollen of a plant. One method of counting comprises imaging the sample with the pollen well-distributed in the focal plane of the imager. Image evaluation software can identify and count objects in the image that are consistent with pollen. Total pollen count for the plant can be derived from the count of pollen of the sample, proportionality of the sample volume to the starting volume, and proportionality of area of sample imaged to total area of sample. Pollen quantification can be used for research or commercial production decisions relative to the plant or its seed.
Abstract translation: 一种定量获得植物花粉测量的装置和方法。 一种计数方法包括用分布在成像器的焦平面中的花粉成像样品。 图像评估软件可以识别和计数与花粉一致的图像中的对象。 植物的总花粉计数可以从样品的花粉计数，样品体积与起始体积的比例以及样品的面积与样品总面积的比例来得出。 花粉量化可用于相对于植物或其种子的研究或商业生产决策。
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