公开(公告)号：WO2007009388A1

公开(公告)日：2007-01-25

申请号：PCT/CN2006/001782

申请日：2006-07-20

Applicant: 中国科学院上海药物研究所 ,  李英 ,  左建平 ,  杨忠顺 ,  周文亮 ,  隋毅 ,  王峻霞 ,  张瑜 ,  周宇 ,  吴锦明

Inventor： 李英 ,  左建平 ,  杨忠顺 ,  周文亮 ,  隋毅 ,  王峻霞 ,  张瑜 ,  周宇 ,  吴锦明

IPC: C07D493/18 ,  A61K31/357 ,  C07D323/00 ,  C07D321/00 ,  C07D311/00 ,  A61P37/06

CPC classification number: C07D493/18

Abstract: Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions containing them and the use thereof are disclosed. The artemisinin derivatives have the structure as following(formula I): These compounds and compositions have immuno-suppressive activities which has been proved by pharmacological test, and may be used to prepare novel immuno-suppressants for treating the diseases caused by hypofunction of human immunity( e. g. auto-immune diseases such as lupus erythematosus, rheumatoid arthritis, multiple sclerosis and the like), and may be useful as anti-rejection agents in organ transplantation.

公开(公告)号：WO2006081771A1

公开(公告)日：2006-08-10

申请号：PCT/CN2006/000182

申请日：2006-01-27

Applicant: 中国科学院上海药物研究所 ,  李英 ,  左建平 ,  杨忠顺 ,  周文亮 ,  隋毅 ,  王峻霞 ,  张瑜 ,  周宇 ,  吴锦明

Inventor： 李英 ,  左建平 ,  杨忠顺 ,  周文亮 ,  隋毅 ,  王峻霞 ,  张瑜 ,  周宇 ,  吴锦明

IPC: C07D493/18 ,  A61K31/335 ,  C07D323/00 ,  C07D321/00 ,  C07D311/00 ,  A61P37/00

CPC classification number: C07D493/18

Abstract: The invention provides a artemisine derivative of the following formula I, its preparation method and use, as well as a pharmaceutical composition containing such artemisine derivative and its use. The artemisinin derivatives of the present invetion and the pharmaceutical compositions containing the same have immunosuppressive activities and can be used safely. The compositions which comprise the artemisine derivatives can be made into long-term dosage forms such as tablet, pellet and the like, and have widely productive and use value.