公开(公告)号：WO2020152563A1

公开(公告)日：2020-07-30

申请号：PCT/IB2020/050407

申请日：2020-01-20

Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA ,  AB ANALITICA S.R.L. ,  INSTITUTE DE BIOLOGIE INTEGRATIVE DE LA CELLULE (12BC), CNRS/UNIVERSITÉ PARIS SUD/CEA ,  ALACRIS THERANOSTICS GMBH

Inventor： DE ANGELIS, Francesco ,  GAROLI, Denis ,  ROCCHIA, Walter ,  SPITALERI, Andrea ,  HILDEBRANDT, Niko ,  PALADIN, Dino ,  SCHUETTE, Moritz ,  LEHRACH, Hans Rudolf

IPC: G01N33/542 ,  G01N33/68 ,  C12Q1/6869 ,  B82B1/00 ,  B82Y15/00

Abstract: The present invention relates to a method, an apparatus and a nanopore for optical recognition of molecules, wherein said method comprises a step wherein a molecule (4) to be recognized passes through a nanopore (1), and is characterized in that the nanopore (1) comprises at least one flexible element (10) configured substantially as an appendix or the like, extending within the nanopore (1), and wherein the recognition step is effected in relation to the displacement and/or deformation of the flexible element (10) induced by the passage of the molecule (4).