公开(公告)号：WO2015148915A9

公开(公告)日：2016-12-22

申请号：PCT/US2015022977

申请日：2015-03-27

Applicant: ACAD SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  SHIE JIUN-JIE

IPC: G01N21/64 ,  C07K7/08

CPC classification number: G01N33/582 ,  C07D309/14 ,  C07D311/02 ,  C07F5/027 ,  C07K7/08 ,  G01N21/64 ,  G01N2333/924 ,  G01N2458/30

Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

Abstract translation: 提供式（I）的叠氮基-BODIPY化合物，式（IV）的基于环辛烯的荧光探针和式（VI）的基于活性的探针。 这些化合物经历叠氮炔环加成反应（AAC）以形成三唑基产物。 所提供的化合物可用于检测和成像含炔或叠氮化物的分子。 公开了使用本公开的化合物检测和成像生物分子的方法。

公开(公告)号：WO2016137992A3

公开(公告)日：2016-10-27

申请号：PCT/US2016019128

申请日：2016-02-23

Applicant: YANG AN-SUEI ,  ACAD SINICA

Inventor： YANG AN-SUEI ,  CHEN HONG-SEN ,  CHEN ING-CHIEN ,  TUNG CHAO-PING ,  HOU SHIN-CHEN ,  YU CHUNG-MING ,  YANG CHI-KAI ,  CHIU YI-KAI

IPC: C40B40/08 ,  C07K16/00 ,  C07K16/10 ,  C07K16/22 ,  C12N15/10 ,  C12N15/73 ,  C40B50/06

CPC classification number: C07K16/005 ,  A61K48/00 ,  C07K16/1018 ,  C07K16/18 ,  C07K16/22 ,  C07K16/245 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12N15/1037

Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1 ) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

Abstract translation: 本文公开了噬菌体展示的单链可变片段（scFv）文库，其包含多个噬菌体展示的scFv，其特征在于（1）特定的CS组合; （2）每个CDR中芳香残基的特异性分布; 和（3）每个CDR中的特定序列。 本发明的scFv文库可用于有效地产生具有与不同抗原结合亲和力的不同抗体。 因此，本公开提供了根据实验研究和/或临床应用中的需要迅速产生不同抗原特异性抗体的潜在手段。

公开(公告)号：WO2016123591A3

公开(公告)日：2016-12-15

申请号：PCT/US2016015856

申请日：2016-01-30

Applicant: ACAD SINICA ,  WONG CHI-HUEY

Inventor： WONG CHI-HUEY ,  HSU TSUI-LING ,  LOU YI-WEI ,  LIN CHIH-WEI ,  YEH SHIH-CHI ,  WU CHUNG-YI ,  WU HAN-CHUNG

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C12N5/07 ,  G01N33/53

CPC classification number: C07K16/32 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2887 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.

Abstract translation: 本文公开了包含与Globo H，SSEA3和SSEA-4结合的抗体或其抗原结合片段的药物组合物，以及其使用方法。 使用方法包括但不限于癌症治疗和诊断。 本公开的抗体可以结合某些癌细胞表面。 本文公开的抗体的示例性靶标可以包括癌，例如脑，皮肤，骨，肺，乳房，食道，胃，肝，胆管，胰腺，结肠，肾，宫颈癌，卵巢癌和/或前列腺癌中的癌。

公开(公告)号：WO2016040369A3

公开(公告)日：2016-09-15

申请号：PCT/US2015049014

申请日：2015-09-08

Applicant: ACAD SINICA ,  WONG CHI-HUEY

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: C07H15/18 ,  A61K39/39

CPC classification number: C07H15/18 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/585 ,  C07H15/04 ,  C07H17/02

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

Abstract translation: 公开了用于iNKT非依赖性诱导趋化因子的糖鞘脂（GSL）组合物和方法。

公开(公告)号：EP3244925A4

公开(公告)日：2018-06-06

申请号：EP16737095

申请日：2016-01-18

Applicant: ACAD SINICA

Inventor： CHANG TSE-WEN ,  CHU HSING-MAO ,  CHEN JOU-HAN ,  LIN CHUN-YU ,  LIN CHIEN-JEN

IPC: A61K39/395 ,  A61K39/00 ,  A61K47/58 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/68 ,  C07K14/485 ,  C07K14/655 ,  C07K14/705 ,  C07K14/715 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46 ,  C12P21/08

CPC classification number: A61K47/6803 ,  A61K31/397 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/537 ,  A61K31/739 ,  A61K47/48215 ,  A61K47/48246 ,  A61K47/48538 ,  A61K47/48561 ,  A61K47/48692 ,  A61K47/58 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/6801 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6883 ,  A61K51/065 ,  A61K51/088 ,  A61K2039/505 ,  C07K14/485 ,  C07K14/655 ,  C07K14/70578 ,  C07K14/7151 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2863 ,  C07K16/2875 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/33

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

公开(公告)号：EP3188600A4

公开(公告)日：2018-04-25

申请号：EP15837670

申请日：2015-09-01

Applicant: ACAD SINICA

Inventor： SHEN CHE-KUN JAMES ,  SHYU YU-CHIAU

IPC: C12N15/00 ,  A61K38/17 ,  A61P35/00 ,  A61P43/00

CPC classification number: C07K14/4702 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/1709 ,  A61K45/06 ,  C07K14/4703 ,  Y02A50/402

Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.

公开(公告)号：EP3174985A4

公开(公告)日：2018-04-04

申请号：EP15828285

申请日：2015-07-31

Applicant: ACAD SINICA ,  UNIV NAT TAIWAN

Inventor： YANG PAN CHYR ,  CHANG YI CHUNG ,  LAI WEI YUN

IPC: C12N15/115 ,  A61K31/7088 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C12N15/113

CPC classification number: C12N15/115 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/48215 ,  A61K47/60 ,  C12N15/1138 ,  C12N15/117 ,  C12N2310/16 ,  C12N2310/17 ,  C12N2310/351

Abstract: Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.

公开(公告)号：EP3174984A4

公开(公告)日：2018-02-21

申请号：EP15827848

申请日：2015-07-31

Applicant: ACAD SINICA ,  NATIONAL TAIWAN UNIV ,  TAIPEI MEDICAL UNIV

Inventor： PECK KONAN ,  YANG PAN-CHYR ,  CHANG YI-CHUNG ,  HUANG BO-TSANG ,  YEH SHAUH-DER

IPC: C12N15/115 ,  A61K31/711 ,  A61K31/713 ,  A61P35/00 ,  A61P37/00

CPC classification number: C12N15/115 ,  A61K9/0019 ,  A61K31/711 ,  A61K31/713 ,  A61K47/48215 ,  A61K47/60 ,  C12N15/1138 ,  C12N2310/16 ,  C12N2310/351

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

公开(公告)号：EP3126398A4

公开(公告)日：2017-11-01

申请号：EP15759030

申请日：2015-03-02

Applicant: ACAD SINICA ,  UNIV KAOHSIUNG MEDICAL ,  ROFFLER STEVEN R

Inventor： ROFFLER STEVEN R ,  CHENG TIAN-LU ,  KAO CHIEN-HAN ,  CHEN BING-MAE ,  SU YU-CHENG ,  TUNG HSIN-YI ,  CHUANG KUO-HSIANG

IPC: C07K16/46 ,  A61K39/395 ,  A61K47/50 ,  A61K49/00

CPC classification number: A61K47/48746 ,  A61K47/6879 ,  A61K47/6897 ,  A61K49/0002 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/73

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：EP3099703A4

公开(公告)日：2017-08-09

申请号：EP15743950

申请日：2015-01-26

Applicant: ACAD SINICA

Inventor： LI TSUNG-LIN ,  LYU SYUE-YI ,  LIU YU-CHEN ,  CHANG CHIN-YUAN

IPC: C07K9/00 ,  A61K38/14

CPC classification number: C07K9/008 ,  A61K38/00 ,  C12P19/60

Abstract: Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the compounds for treating and/or preventing bacterial infection as well as methods of preparing the compounds are also described.

Abstract translation: 本文描述了式（I）的化合物或其药学上可接受的盐及其药物组合物。 本发明的化合物可用于抑制细菌生长。 还描述了使用该化合物治疗和/或预防细菌感染的方法以及制备该化合物的方法。