公开(公告)号：TW575417B

公开(公告)日：2004-02-11

申请号：TW092101918

申请日：2003-01-23

Applicant: 馬克 伊 安德森 ANDERSON MARK E. ,  唐納得 伊 安德森 ANDERSON DONALD E.

Inventor： 馬克 伊 安德森 ANDERSON MARK E. ,  唐納得 伊 安德森 ANDERSON DONALD E.

IPC: A61D

CPC classification number: A61D19/027 ,  Y10S604/906

Abstract: 本發明係關於一種提供更安全、更有效的縱深式經子宮頸之子宮內人工受孕〔AI〕之方法及裝置。這樣的一縱深式人工受孕導管係可將不適感及受傷風險減至最小，且不需由技術純熟的人工受孕專家操作。首先，一導管插入該動物的子宮頸。一薄膜最初位於該導管之一管體內部，但隨後可由該管體之一開口伸出，並在受壓下進入該子宮頸內。該薄膜不發生摩擦的伸入該子宮頸，因此能減少動物之不適感或受傷風險。當該薄膜完全進入該子宮頸，壓力將造成該薄膜的尖端開裂，因而釋放人工受孕的液體，以將懸浮於液體中的遺傳物質置入該生殖管道中。除了人工受孕及胚胎移植之外，該途徑亦可應用於其他治療、診斷或程序，例如螢光鏡照相機、儀器及藥物傳送。五、(一)、本案代表圖為：第 4F 圖
(二)、本案代表圖之元件代表符號簡單說明：
300 導管 412 導緣
430 子配件 440 噴頭
442 內定位環

Abstract in simplified Chinese: 本发明系关于一种提供更安全、更有效的纵深式经子宫颈之子宫内人工受孕〔AI〕之方法及设备。这样的一纵深式人工受孕导管系可将不适感及受伤风险减至最小，且不需由技术纯熟的人工受孕专家操作。首先，一导管插入该动物的子宫颈。一薄膜最初位于该导管之一管体内部，但随后可由该管体之一开口伸出，并在受压下进入该子宫颈内。该薄膜不发生摩擦的伸入该子宫颈，因此能减少动物之不适感或受伤风险。当该薄膜完全进入该子宫颈，压力将造成该薄膜的尖端开裂，因而释放人工受孕的液体，以将悬浮于液体中的遗传物质置入该生殖管道中。除了人工受孕及胚胎移植之外，该途径亦可应用于其他治疗、诊断或进程，例如萤光镜照相机、仪器及药物发送。五、(一)、本案代表图为：第 4F 图 (二)、本案代表图之组件代表符号简单说明： 300 导管 412 导缘 430 子配件 440 喷头 442 内定位环

公开(公告)号：TW200304793A

公开(公告)日：2003-10-16

申请号：TW092101918

申请日：2003-01-23

Applicant: 馬克 伊 安德森 ANDERSON MARK E. ,  唐納得 伊 安德森 ANDERSON DONALD E.

Inventor： 馬克 伊 安德森 ANDERSON MARK E. ,  唐納得 伊 安德森 ANDERSON DONALD E.

IPC: A61D

CPC classification number: A61D19/027 ,  Y10S604/906

Abstract: 本發明係關於一種提供更安全、更有效的縱深式經子宮頸之子宮內人工受孕〔AI〕之方法及裝置。這樣的一縱深式人工受孕導管係可將不適感及受傷風險減至最小，且不需由技術純熟的人工受孕專家操作。首先，一導管插入該動物的子宮頸。一薄膜最初位於該導管之一管體內部，但隨後可由該管體之一開口伸出，並在受壓下進入該子宮頸內。該薄膜不發生摩擦的伸入該子宮頸，因此能減少動物之不適感或受傷風險。當該薄膜完全進入該子宮頸，壓力將造成該薄膜的尖端開裂，因而釋放人工受孕的液體，以將懸浮於液體中的遺傳物質置入該生殖管道中。除了人工受孕及胚胎移植之外，該途徑亦可應用於其他治療、診斷或程序，例如螢光鏡照相機、儀器及藥物傳送。

Abstract in simplified Chinese: 本发明系关于一种提供更安全、更有效的纵深式经子宫颈之子宫内人工受孕〔AI〕之方法及设备。这样的一纵深式人工受孕导管系可将不适感及受伤风险减至最小，且不需由技术纯熟的人工受孕专家操作。首先，一导管插入该动物的子宫颈。一薄膜最初位于该导管之一管体内部，但随后可由该管体之一开口伸出，并在受压下进入该子宫颈内。该薄膜不发生摩擦的伸入该子宫颈，因此能减少动物之不适感或受伤风险。当该薄膜完全进入该子宫颈，压力将造成该薄膜的尖端开裂，因而释放人工受孕的液体，以将悬浮于液体中的遗传物质置入该生殖管道中。除了人工受孕及胚胎移植之外，该途径亦可应用于其他治疗、诊断或进程，例如萤光镜照相机、仪器及药物发送。

公开(公告)号：EP0251631A1

公开(公告)日：1988-01-07

申请号：EP87305540.4

申请日：1987-06-22

Applicant: Anderson, Mark E., M.D.

Inventor： Anderson, Mark E., M.D.

IPC: A61K45/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61K9/58 ,  A61K9/50 ,  A61K37/02

CPC classification number: A61K9/1647 ,  A61K9/204 ,  A61K9/5031 ,  A61K38/2013 ,  Y10S514/885 ,  Y10S514/965

Abstract: A biocompatible, biodegradable, bioerodible composite polymer matrix comprising interleukin-2 in an appropriate polymer. The polymer may be a polymer of copolymer of lactic acid, lactide, glycolide, glutamic acid, or it may be collagen or albumin. The material contains from 10² to 10⁸ U IL-2/g of polymer. Also disclosed is a method for making the composite polymer matrix and a method for implanting the material. A soft, malleable controlled-­release composite material may be used for intracranial or other implantation and may be shaped or molded to fit the site from which the malignant tissue has been removed, opposing the residual tumor, complementing hemostasis, compatible with anatomical structure, and functioning as an implantable immunotherapeutic adjuvant.

Abstract translation: 在适当的聚合物中包含白细胞介素-2的生物相容性，可生物降解的生物可腐蚀的复合聚合物基质。 聚合物可以是乳酸，丙交酯，乙交酯，谷氨酸的共聚物的聚合物，也可以是胶原蛋白或白蛋白。 该材料含有10 2至10 8 U IL-2 / g的聚合物。 还公开了制备复合聚合物基质的方法和用于植入材料的方法。 柔软的，可延展的控释复合材料可用于颅内或其他植入，并且可以被成形或模制以适合恶性组织已被去除的部位，与残留肿瘤相对的位置，补体止血，与解剖结构相容，以及 用作可植入免疫治疗佐剂。

公开(公告)号：EP1494524A2

公开(公告)日：2005-01-12

申请号：EP03703960.9

申请日：2003-01-23

Applicant: Anderson, Mark E. ,  Anderson, Glenn M. ,  Lim, Kang S.

Inventor： Anderson, Donald, E. ,  ANDERSON, Mark, E. ,  ANDERSON, Glenn, M. ,  LIM, Kang, S.

IPC: A01K29/00

CPC classification number: A61M25/0119 ,  A61D19/027

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter (300) causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter (300) is inserted into the cervical tract of the animal. A membrane (410), initially positioned inside a tube section (420) of the catheter (300), is then extended from an opening (440) in the tube (420) and into the tract under pressure. The membrane (410) extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane (410) is fully extended into the tract, pressure causes the tip (418) of the membrane (410) to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. Deployment of the membrane (410) is facilitated by tapering its wall thickness towards its tip (418). In addition to AI and embryo transplant, other applications for the pathway include therapeutic, diagnostic, or other procedures such as introducing fluoroscopic cameras, instruments, and drug delivery.

公开(公告)号：AU2003205284A1

公开(公告)日：2003-10-20

申请号：AU2003205284

申请日：2003-01-23

Applicant: ANDERSON DONALD E ,  ANDERSON MARK E ,  ANDERSON GLENN M ,  LIM KANG S

Inventor： ANDERSON DONALD E ,  ANDERSON MARK E ,  ANDERSON GLENN M ,  LIM KANG S

IPC: A61B17/425 ,  A61D19/02 ,  A61D19/04 ,  A61M25/01

公开(公告)号：WO2011094309A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/022575

申请日：2011-01-26

Applicant: WESTMARK MEDICAL, LLC. ,  ANDERSON, Mark E. ,  MUNOZ, Janette L.

Inventor： ANDERSON, Mark E.

IPC: A61B17/58

CPC classification number: A61B17/7059 ,  A61B17/8047 ,  A61B17/8052

Abstract: A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.

Abstract translation: 提供骨稳定系统，其具有具有顶表面和底表面的平板和沿着纵向轴线延伸穿过的孔。 顶表面中的环形槽围绕轴线并且限定与板成一体的多个弹簧构件的面向外侧。 多个槽限定弹簧构件的侧面，弹簧构件的向内侧形成孔的上部，其包括第一球形部分。 在紧固件头部上具有球形部分的紧固件延伸到孔中，弹簧构件被推开以允许头部通过，但是限制去除，直到克服了由弹簧构件提供的阻力。

公开(公告)号：WO2011059685A2

公开(公告)日：2011-05-19

申请号：PCT/US2010053950

申请日：2010-10-25

Applicant: BAKER HUGHES INC ,  MOSS WILLIAM A ,  RICKABAUGH DAVID L ,  ANDERSON MARK E

Inventor： MOSS WILLIAM A ,  RICKABAUGH DAVID L ,  ANDERSON MARK E

CPC classification number: E21B10/26 ,  E21B10/43

Abstract: An apparatus for engaging a subterranean borehole includes a bi-center bit having backup cutting elements thereon. The bi-center bit includes a pilot bit section and a reamer bit section adjacent to the pilot bit section. The pilot bit section includes at least one primary cutting element and at least one backup cutting element rotationally trailing and laterally offset from the at least one primary cutting element. Methods of drilling a subterranean borehole include engaging a first portion of a borehole with a reamer bit section of a drill bit and simultaneously engaging a second, opposing portion of the borehole with a pilot bit section adjacent to the reamer bit section.

公开(公告)号：WO2011041432A2

公开(公告)日：2011-04-07

申请号：PCT/US2010/050744

申请日：2010-09-29

Applicant: BAKER HUGHES INCORPORATED ,  RICKABAUGH, David, L. ,  PESSIER, Rudolf, Carl ,  ANDERSON, Mark, E. ,  MOSS, William, A.

Inventor： RICKABAUGH, David, L. ,  PESSIER, Rudolf, Carl ,  ANDERSON, Mark, E. ,  MOSS, William, A.

IPC: E21B10/54 ,  E21B10/60

CPC classification number: E21B10/602 ,  B22D19/14 ,  C22C1/1036 ,  C22C9/00

Abstract: Earth-boring drill bits include a bit body including a blockage-resistant internal fluid passageway. The blockage-resistant internal fluid passageway includes at least one internal fluid passageway formed in the bit body and a cuttings filtering feature formed in the at least one internal fluid passageway configured to prevent at least some cuttings from flowing through the at least one internal fluid passageway. In one embodiment, the cuttings filtering feature includes at least one lateral member extending transversely across the at least one internal fluid passageway. In another embodiment, the cuttings filtering feature includes forming a central portion of the at least one internal fluid passageway with a width along a lateral axis thereof less than an average width of a fluid path extending through a nozzle disposed at least partially within the at least one internal fluid passageway. Methods of forming the blockage-resistant internal fluid passageway are also disclosed.

Abstract translation: 钻地钻头包括具有防堵塞内部流体通道的钻头本体。 所述防阻塞内部流体通路包括形成在所述钻头本体中的至少一个内部流体通路和形成在所述至少一个内部流体通路中的切屑过滤特征，所述切屑过滤特征构造成防止至少一些切屑流过所述至少一个内部流体通路 。 在一个实施例中，切屑过滤特征包括横向延伸穿过至少一个内部流体通路的至少一个横向构件。 在另一个实施例中，切屑过滤特征包括形成至少一个内部流体通路的中心部分，其沿着其横向轴线的宽度小于延伸穿过喷嘴的流体路径的平均宽度，所述喷嘴至少部分地设置在至少一个 一个内部流体通道。 还公开了形成阻塞性内部流体通路的方法。

公开(公告)号：WO2011041432A3

公开(公告)日：2011-07-14

申请号：PCT/US2010050744

申请日：2010-09-29

Applicant: BAKER HUGHES INC ,  RICKABAUGH DAVID L ,  PESSIER RUDOLF CARL ,  ANDERSON MARK E ,  MOSS WILLIAM A

Inventor： RICKABAUGH DAVID L ,  PESSIER RUDOLF CARL ,  ANDERSON MARK E ,  MOSS WILLIAM A

IPC: E21B10/54 ,  E21B10/60

CPC classification number: E21B10/602 ,  B22D19/14 ,  C22C1/1036 ,  C22C9/00

Abstract: Earth-boring drill bits include a bit body including a blockage-resistant internal fluid passageway. The blockage-resistant internal fluid passageway includes at least one internal fluid passageway formed in the bit body and a cuttings filtering feature formed in the at least one internal fluid passageway configured to prevent at least some cuttings from flowing through the at least one internal fluid passageway. In one embodiment, the cuttings filtering feature includes at least one lateral member extending transversely across the at least one internal fluid passageway. In another embodiment, the cuttings filtering feature includes forming a central portion of the at least one internal fluid passageway with a width along a lateral axis thereof less than an average width of a fluid path extending through a nozzle disposed at least partially within the at least one internal fluid passageway. Methods of forming the blockage-resistant internal fluid passageway are also disclosed.

Abstract translation: 钻孔钻头包括具有阻塞内部流体通道的钻头体。 防堵塞的内部流体通道包括形成在钻头体中的至少一个内部流体通道和形成在至少一个内部流体通道中的切屑过滤特征，该内部流体通道构造成防止至少一些切屑流过至少一个内部流体通道 。 在一个实施例中，切屑过滤特征包括横向穿过至少一个内部流体通道延伸的至少一个横向构件。 在另一个实施例中，切屑过滤特征包括形成至少一个内部流体通道的中心部分，其宽度沿着其横向轴线小于延伸穿过喷嘴的平均宽度，喷嘴至少部分地至少设置在至少 一个内部流体通道。 还公开了形成耐阻塞内部流体通道的方法。

公开(公告)号：WO2011059685A4

公开(公告)日：2011-09-29

申请号：PCT/US2010053950

申请日：2010-10-25

Applicant: BAKER HUGHES INC ,  MOSS WILLIAM A ,  RICKABAUGH DAVID L ,  ANDERSON MARK E

Inventor： MOSS WILLIAM A ,  RICKABAUGH DAVID L ,  ANDERSON MARK E

IPC: E21B10/54 ,  E21B10/42

CPC classification number: E21B10/26 ,  E21B10/43

Abstract: An apparatus for engaging a subterranean borehole includes a bi-center bit having backup cutting elements thereon. The bi-center bit includes a pilot bit section and a reamer bit section adjacent to the pilot bit section. The pilot bit section includes at least one primary cutting element and at least one backup cutting element rotationally trailing and laterally offset from the at least one primary cutting element. Methods of drilling a subterranean borehole include engaging a first portion of a borehole with a reamer bit section of a drill bit and simultaneously engaging a second, opposing portion of the borehole with a pilot bit section adjacent to the reamer bit section.

Abstract translation: 用于接合地下钻孔的装置包括在其上具有备用切割元件的双中心钻头。 双中心位包括导频位部分和与引导位部分相邻的扩孔器位部分。 导向钻头部分包括至少一个主切割元件和至少一个备用切割元件，该至少一个备用切割元件与所述至少一个主切割元件旋转地后退和横向地偏移。 钻探地下钻孔的方法包括将钻孔的第一部分与钻头的铰刀钻头部分接合，并且同时将钻孔的第二相对部分与邻近铰刀钻头部分的导向钻头部分接合。