公开(公告)号：WO2010151541A8

公开(公告)日：2010-12-29

申请号：PCT/US2010/039488

申请日：2010-06-22

Applicant: WYETH LLC ,  ANDREELLA, Paolo ,  BRESCELLO, Roberto ,  MICHIELETTO, Ivan ,  MAFFINI, Mauro ,  CATOZZI, Nicola ,  NICOLI, Andrea ,  FORNASARI, Paolo ,  VERZINI, Massimo ,  COTARCA, Livius ,  BRAZZAROLA, Franco

Inventor： ANDREELLA, Paolo ,  BRESCELLO, Roberto ,  MICHIELETTO, Ivan ,  MAFFINI, Mauro ,  CATOZZI, Nicola ,  NICOLI, Andrea ,  FORNASARI, Paolo ,  VERZINI, Massimo ,  COTARCA, Livius ,  BRAZZAROLA, Franco

IPC: C07D209/12 ,  A61K31/55 ,  A61P35/00

Abstract: The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.

公开(公告)号：WO2010151541A1

公开(公告)日：2010-12-29

申请号：PCT/US2010039488

申请日：2010-06-22

Applicant: WYETH LLC ,  ANDREELLA PAOLO ,  BRESCELLO ROBERTO ,  MICHIELETTO IVAN ,  MAFFINI MAURO ,  CATOZZI NICOLA ,  NICOLI ANDREA ,  FORNASARI PAOLO ,  VERZINI MASSIMO ,  COTARCA LIVIUS ,  BRAZZAROLA FRANCO

Inventor： ANDREELLA PAOLO ,  BRESCELLO ROBERTO ,  MICHIELETTO IVAN ,  MAFFINI MAURO ,  CATOZZI NICOLA ,  NICOLI ANDREA ,  FORNASARI PAOLO ,  VERZINI MASSIMO ,  COTARCA LIVIUS ,  BRAZZAROLA FRANCO

IPC: C07D209/12 ,  A61K31/55 ,  A61P35/00

CPC classification number: C07D209/12

Abstract: The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.

Abstract translation: 本公开涉及乙酸巴多昔芬的多晶型D，药物组合物及其使用方法及其制备方法。

公开(公告)号：WO2009102773A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033772

申请日：2009-02-11

Applicant: WYETH ,  ANDREELLA, Paolo ,  BARRECA, Giuseppe ,  TASINATO, Francesco ,  VERZINI, Massimo ,  DEMO, Marco ,  BASSAN, Fabio ,  CANNATA, Vincenzo ,  SORIATO, Giorgio ,  BRESCELLO, Roberto ,  ALLEGRINI, Pietro ,  COTARCA, Livius

Inventor： ANDREELLA, Paolo ,  BARRECA, Giuseppe ,  TASINATO, Francesco ,  VERZINI, Massimo ,  DEMO, Marco ,  BASSAN, Fabio ,  CANNATA, Vincenzo ,  SORIATO, Giorgio ,  BRESCELLO, Roberto ,  ALLEGRINI, Pietro ,  COTARCA, Livius

IPC: C07D209/12 ,  A61K31/404 ,  A61P19/10

CPC classification number: C07D209/12

Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate, and increasing its stability, and polymorphic Form A prepared by such methods.

Abstract translation: 本发明涉及制备乙酸巴多昔芬的多晶型A，提高其稳定性的方法，以及通过这些方法制备的多晶型A.