Abstract:
The object of the present invention is to provide a humanized or mouse-human chimeric anti-podoplanin antibody or an antibody fragment containing the antigen-binding region thereof, and the object is achieved by providing an isolated humanized or mouse-human chimeric anti-podoplanin antibody which comprises a predetermined amino acid sequence, or an antibody fragment containing the antigen-binding region thereof.
Abstract:
The object of the present invention is to provide a humanized or mouse-human chimeric anti-podoplanin antibody or an antibody fragment containing the antigen-binding region thereof, and the object is achieved by providing an isolated humanized or mouse-human chimeric anti-podoplanin antibody which comprises a predetermined amino acid sequence, or an antibody fragment containing the antigen-binding region thereof.
Abstract:
The present invention addresses the problem of providing an anti-podoplanin antibody which is a humanized antibody or a mouse-human chimeric antibody, or an antibody fragment containing an antigen binding domain of the anti-podoplanin antibody. The problem can be solved by: an anti-podoplanin antibody which is an isolated humanized antibody or an isolated mouse-human chimeric antibody each comprising a specific amino acid sequence, or an antibody fragment containing an antigen binding domain of the antibody.
Abstract:
PROBLEM TO BE SOLVED: To provide, by targeting a tablet including royal jelly as a main component, a royal jelly-containing tablet capable of enhancing the hardness of the tablet; and a method for manufacturing the same.SOLUTION: The royal jelly-containing tablet of the present invention includes royal jelly as a main component and is obtained by performing a process of wet-compressing, at 10 MPa or above, a royal jelly provided as a raw ingredient of the royal jelly-containing tablet. It is desirable for the hardness of the royal jelly-containing tablet to be 80 N or higher. Moreover, it is also permissible to obtain a coated royal jelly-containing tablet by performing a process of coating the surface of the tablet obtained by such a method.
Abstract:
PROBLEM TO BE SOLVED: To provide a sterile refining apparatus for active pharmaceutical ingredients, the apparatus being able to further reduce the content of impurities.SOLUTION: The sterile refining apparatus for active pharmaceutical ingredients is used for performing a first step in which after a solution of pharmaceutical crude ingredients is prepared by dissolving pharmaceutical crude ingredients in a first solution, the prepared solution is sterilized, a second step in which the pharmaceutical ingredients is crystallized by adding an aseptically filtered second solvent to the sterile prepared solution, and a third step in which the crystallized pharmaceutical ingredients is filtered, dried, and pulverized, and the thus obtained powder of pharmaceutical ingredients is filled into a container. In the sterile refining apparatus, the steps are connected by pipes from a pharmaceutical crude ingredients input part to a container filling device 39 in order to carry out the steps under inert gas atmosphere by use of a series of inline systems. The pharmaceutical ingredients are filtered and dried in the third step is conveyed out from a conveyance port by inert gas flowing downstream from a filtering dryer, is conveyed to a powder transport hopper 31, located below the filtering dryer, by a vibration feeder 29, and is conveyed to a pulverizing device 36 by a screw conveyer.
Abstract:
PROBLEM TO BE SOLVED: To provide a skin fibroblast proliferation-promoting agent and a skin collagen production-promoting agent each capable of being utilized for various uses such as cosmetics, foods, drinks and medicines.SOLUTION: The skin fibroblast proliferation-promoting agent and the skin collagen production-promoting agent each contains apisin as an active ingredient. Preferably, the apisin is separated from royal jelly by liquid chromatography.
Abstract:
PROBLEM TO BE SOLVED: To provide a royal jelly-containing composition prevented from discoloration of outer appearance with age in solid royal jelly. SOLUTION: The royal jelly-containing composition is obtained by dissolving in a solvent, royal jelly and at least one kind selected from starch, and dextrin having a dextrose equivalent of not more than 18, and freeze-drying the product. It is preferable to use starch, and dextrin having a dextrose equivalent of not more than 3. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing retusapurpurin A applicable to the sectors of e.g. food/drink and cosmetics, etc., and to provide a method for assessing propolis extracts. SOLUTION: The method for producing retusapurpurin A includes: the step of conducting an extract treatment, using an extractive solvent, from propolis raw mass made from raw material Dalbergia as the original plant. The method for assessing a propolis extract obtained using an extractive solvent, from propolis raw mass made from raw material Dalbergia as the original plant is characterized in comprising using retusapurpurin A as an indicator. COPYRIGHT: (C)2011,JPO&INPIT