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公开(公告)号：JP2015536449A
公开(公告)日：2015-12-21
申请号：JP2015537719
申请日：2013-10-04
Inventor： ジョセフ，デイヴィッド，エス．
IPC: G01N21/359 , G01N21/39 , G01N33/497
CPC classification number: G01N33/0055 , A61B5/082 , A61B5/097 , A61B5/42 , A61K51/1206 , C12Q1/02 , G01N33/497 , G01N33/569 , G01N2458/15
Abstract: 本発明は、13C−同位体で標識された化合物の投与後の対象の呼気試料におけるガス状の二酸化炭素の13CO2/12CO2同位体比率を測定することによる、肺、消化管、および全身感染を検出する方法に関する。
Abstract translation: 本发明是通过测量@ 13 CO 2气态二氧化碳/ @ 12 CO 2同位素比受试者的呼气样品中的标记的化合物的给药后13 C同位素，肺，胃肠道，并检测全身性感染 如何在。
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公开(公告)号：JP2016504581A
公开(公告)日：2016-02-12
申请号：JP2015547534
申请日：2013-12-12
Inventor： パーケット，エリザベス，エー．
IPC: G01N33/497 , A61K45/00 , A61P11/00 , A61P31/04
CPC classification number: C12Q1/04 , G01J3/433 , G01N21/314 , G01N21/3504 , G01N21/39 , G01N33/497 , G01N2021/399 , G01N2201/0221
Abstract: 本発明は、対象の肺における細菌負荷の部位を決定する方法に関する。
Abstract translation: 本发明涉及一种确定在受试者的肺细菌接种量的部位的方法。
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公开(公告)号：JP6364665B2
公开(公告)日：2018-08-01
申请号：JP2015537719
申请日：2013-10-04
Applicant: アヴィサ ファーマ インコーポレイテッド , AVISA PHARMA INC. , サウスウエスト サイエンシーズ インコーポレーテッド
Inventor： ジョセフ,デイヴィッド,エス. , シルバー,ジョエル,エー. , ゴメス,アンソニー,エル. , マシック,スティーブン,エム. , ピーターソン,クリステン,エー.
IPC: G01N33/497 , G01N21/39 , G01N21/359
CPC classification number: G01N33/0055 , A61B5/082 , A61B5/097 , A61B5/42 , A61K51/1206 , C12Q1/02 , G01N33/497 , G01N33/569 , G01N2458/15
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公开(公告)号：US09518972B2
公开(公告)日：2016-12-13
申请号：US14045856
申请日：2013-10-04
Applicant: AVISA PHARMA INC. , SOUTHWEST SCIENCES, INC.
Inventor： David S. Joseph , Steven M. Massick , Kristen A. Peterson , Anthony L. Gomez , Joel A. Silver
IPC: A61B5/08 , G01N33/00 , A61B5/097 , A61B5/00 , A61K51/12 , G01N33/497 , C12Q1/02 , G01N33/569
CPC classification number: G01N33/0055 , A61B5/082 , A61B5/097 , A61B5/42 , A61K51/1206 , C12Q1/02 , G01N33/497 , G01N33/569 , G01N2458/15
Abstract: The invention is directed to methods of detecting lung, gastrointestinal tract, and systemic infections by measuring 13CO2/12CO2 isotopic ratios of gaseous carbon dioxide in exhaled breath samples of a subject after administration of a 13C-isotopically-labeled compound.
Abstract translation: 本发明涉及通过在施用13 C-同位素标记的化合物之后测量受试者呼出的呼吸样本中的气态二氧化碳的13CO 2/12 CO 2同位素比率来检测肺，胃肠道和全身感染的方法。
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公开(公告)号：US20140179809A1
公开(公告)日：2014-06-26
申请号：US14104338
申请日：2013-12-12
Applicant: Avisa Pharma Inc.
Inventor： Elizabeth A. Perkett
IPC: C12Q1/04
CPC classification number: C12Q1/04 , G01J3/433 , G01N21/314 , G01N21/3504 , G01N21/39 , G01N33/497 , G01N2021/399 , G01N2201/0221
Abstract: The present invention is direct to methods of determining the location of a bacterial load in the lungs of a subject.
Abstract translation: 本发明直接涉及确定受试者肺部细菌负荷位置的方法。
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Patent Agency Ranking
公开(公告)号：US20210177304A1
公开(公告)日：2021-06-17
申请号：US17120455
申请日：2020-12-14
Applicant: Avisa Pharma, Inc.
Inventor： David L. KARSHMER
IPC: A61B5/097 , A61B5/08 , G01N33/497
Abstract: Provided herein are systems and methods for collecting breath samples for detection of respiratory infections.
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公开(公告)号：US20140114206A1
公开(公告)日：2014-04-24
申请号：US14045856
申请日：2013-10-04
Applicant: Avisa Pharma Inc.
Inventor： David S. Joseph
CPC classification number: G01N33/0055 , A61B5/082 , A61B5/097 , A61B5/42 , A61K51/1206 , C12Q1/02 , G01N33/497 , G01N33/569 , G01N2458/15
Abstract: The invention is directed to methods of detecting lung, gastrointestinal tract, and systemic infections by measuring 13CO2/12CO2 isotopic ratios of gaseous carbon dioxide in exhaled breath samples of a subject after administration of a 13C-isotopically-labeled compound.
Abstract translation: 本发明涉及通过在施用13 C-同位素标记的化合物之后测量受试者呼出的呼吸样本中的气态二氧化碳的13CO 2/12 CO 2同位素比来检测肺，胃肠道和全身感染的方法。
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公开(公告)号：WO2014093604A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074629
申请日：2013-12-12
Applicant: AVISA PHARMA INC.
Inventor： PERKETT, Elizabeth, A.
IPC: G01N33/497 , G01N21/39
CPC classification number: C12Q1/04 , G01J3/433 , G01N21/314 , G01N21/3504 , G01N21/39 , G01N33/497 , G01N2021/399 , G01N2201/0221
Abstract: The present invention is direct to methods of determining the location of a bacterial load in the lungs of a subject.
Abstract translation: 本发明直接涉及确定受试者肺部细菌负荷位置的方法。
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公开(公告)号：WO2021119395A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/064449
申请日：2020-12-11
Applicant: AVISA PHARMA, INC.
Inventor： KARSHMER, David, L.
Abstract: Provided herein are systems and methods configured for the collection of breath samples to allow for the detection of respiratory and systemic infections in a subject (e.g., a human patient) in conjunction with delivery of a drug to the subject. The drug may be configured t be metabolized by putative urease pathogens colonizing and/or infecting the subject. The metabolism of the drug by the putative urease pathogens produces elevations in the abundance of 13C02 in the patient's breath samples. Further, the described systems and methods involve collection of one or more baseline breath sample before introduction of the drug into the subject's respiratory airway, as well as one or more breath samples collected a selected period or periods after the completion of the drug delivery. Comparing the abundance o 13C02 in the post-administration sample(s) to the abundance of 13C02 in the baseline sample(s) allows for the detection of urea metabolizing infections of interest.
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公开(公告)号：WO2017123582A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/012928
申请日：2017-01-11
Applicant: AVISA PHARMA INC.
Inventor： KARSHMER, David , MAYNARD, John
IPC: C12Q1/02 , C12Q1/58 , G01N33/497 , A61B5/08 , A61B5/083
CPC classification number: C12Q1/02 , A61B5/0813 , A61B5/082 , A61B5/0836 , C12Q1/58 , C12Q2304/46 , G01N33/497 , G01N2800/12
Abstract: The present disclosure is directed to methods of diagnosing bacterial lung infections by administering an effective amount of carbon-13 isotopically labeled urea to a subject and analyzing exhaled breath samples for the presence of 13 CO 2 originating from the lungs of the subject.
Abstract translation: 本公开内容涉及通过向受试者施用有效量的碳-13同位素标记的尿素并分析呼出气样品中存在的β-1,3-葡萄糖苷酶来诊断细菌肺部感染的方法。 sup> CO 2 来自受试者的肺。
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