公开(公告)号：WO2009098516A2

公开(公告)日：2009-08-13

申请号：PCT/GB2009/050118

申请日：2009-02-06

Applicant: UNIVERSITY OF KENT ,  ADRIAN, Podoleanu

Inventor： ADRIAN, Podoleanu

IPC: G02B21/00 ,  G01B9/00

CPC classification number: H04N5/232 ,  A61B3/102 ,  A61B3/14 ,  G01B9/02007 ,  G01B9/0203 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/0064 ,  H04N5/2252 ,  H04N5/33

Abstract: The invention describes several embodiments of an adapter which can make use of the devices in any commercially available digital cameras to accomplish different functions, such as a fundus camera, as a microscope or as an en-face optical coherence tomography (OCT) to produce constant depth OCT images or as a Fourier domain (channelled spectrum) optical coherence tomography to produce a reflectivity profile in the depth of an object or cross section OCT images, or depth resolved volumes,. The invention admits addition of confocal detection and provides simultaneous measurements or imaging in at least two channels, confocal and OCT, where the confocal channel provides an en-face image simultaneous with the acquisition of OCT cross sections, to guide the acquisition as well as to be used subsequently in the visualisation of OCT images.Different technical solutions are provided for the assembly of one or two digital cameras which together with such adapters lead to modular and portable high resolution imaging systems which can accomplish various functions with a minimum of extra components while adapting the elements in the digital camera. The cost of such adapters is comparable with that of commercial digital cameras, i.e. the total cost of such assemblies of commercially digital cameras and dedicated adapters to accomplish high resolution imaging are at a fraction of the cost of dedicated stand alone instruments. Embodiments and methods are presented to employ colour cameras and their associated optical sources to deliver simultaneous signals using their colour sensor parts to provide spectroscopic information, phase shifting interferometry in one step, depth range extension, polarisation, angular measurements and spectroscopic Fourier domain (channelled spectrum) optical coherence tomography in as many spectral bands simultaneously as the number of colour parts of the photodetector sensor in the digital camera. In conjunction with simultaneous acquisition of a confocal image, at least 4 channels can simultaneously be provided using the three color parts of conventional color cameras to deliver three OCT images in addition to the confocal image.

Abstract translation: 本发明描述了适配器的几个实施例，其可以利用任何市售的数码相机中的装置来实现不同的功能，例如眼底照相机，显微镜或作为面内光学相干断层摄影（OCT）以产生恒定的 深度OCT图像或作为傅里叶域（通道光谱）光学相干断层扫描，以在物体的深度或横截面OCT图像或深度分辨体积上产生反射率分布。 本发明允许加入共聚焦检测，并且在至少两个通道，共聚焦和OCT中同时进行测量或成像，其中共聚焦通道与OCT截取的采集同时提供了一个面部图像，以指导采集以及 随后用于OCT图像的可视化。提供了用于组装一个或两个数字照相机的不同技术方案，其中这些数字照相机与这种适配器一起导致模块化和便携式的高分辨率成像系统，其可以利用最少的额外组件来完成各种功能， 适应数码相机中的元素。 这种适配器的成本与商业数码相机的成本相当，即商业数字照相机和专用适配器的这种组件的总成本用于实现高分辨率成像仅占专用独立工具的成本的一小部分。 呈现实施例和方法以使用彩色照相机及其相关联的光源来使用其颜色传感器部分提供同步信号，以提供光谱信息，一步中的相移干涉测量，深度范围扩展，极化，角度测量和分光傅里叶域（通道频谱 ）光学相干断层扫描与数字照相机中的光电检测器传感器的颜色部分的数量同时存在许多光谱带。 结合共焦图像的同时采集，可以使用常规彩色相机的三色部分同时提供至少4个通道，以提供除了共聚焦图像之外的三个OCT图像。

公开(公告)号：WO2009098516A3

公开(公告)日：2009-10-22

申请号：PCT/GB2009050118

申请日：2009-02-06

Applicant: UNIV KENT CANTERBURY ,  ADRIAN PODOLEANU

Inventor： ADRIAN PODOLEANU

IPC: G02B21/00 ,  G01B9/00

CPC classification number: H04N5/232 ,  A61B3/102 ,  A61B3/14 ,  G01B9/02007 ,  G01B9/0203 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/0064 ,  H04N5/2252 ,  H04N5/33

Abstract: The invention describes several embodiments of an adapter which can make use of the devices in any commercially available digital cameras to accomplish different functions, such as a fundus camera, as a microscope or as an en-face optical coherence tomography (OCT) to produce constant depth OCT images or as a Fourier domain (channelled spectrum) optical coherence tomography to produce a reflectivity profile in the depth of an object or cross section OCT images, or depth resolved volumes,. The invention admits addition of confocal detection and provides simultaneous measurements or imaging in at least two channels, confocal and OCT, where the confocal channel provides an en-face image simultaneous with the acquisition of OCT cross sections, to guide the acquisition as well as to be used subsequently in the visualisation of OCT images.Different technical solutions are provided for the assembly of one or two digital cameras which together with such adapters lead to modular and portable high resolution imaging systems which can accomplish various functions with a minimum of extra components while adapting the elements in the digital camera. The cost of such adapters is comparable with that of commercial digital cameras, i.e. the total cost of such assemblies of commercially digital cameras and dedicated adapters to accomplish high resolution imaging are at a fraction of the cost of dedicated stand alone instruments. Embodiments and methods are presented to employ colour cameras and their associated optical sources to deliver simultaneous signals using their colour sensor parts to provide spectroscopic information, phase shifting interferometry in one step, depth range extension, polarisation, angular measurements and spectroscopic Fourier domain (channelled spectrum) optical coherence tomography in as many spectral bands simultaneously as the number of colour parts of the photodetector sensor in the digital camera. In conjunction with simultaneous acquisition of a confocal image, at least 4 channels can simultaneously be provided using the three color parts of conventional color cameras to deliver three OCT images in addition to the confocal image.

Abstract translation: 本发明描述了适配器的几个实施例，该适配器可以利用任何市售数字照相机中的装置来完成不同的功能，诸如眼底照相机，显微镜或作为光学相干断层扫描（OCT）以产生恒定 深度OCT图像或作为傅立叶域（通道光谱）光学相干断层扫描术来产生物体或横截面OCT图像或深度分辨体积的深度中的反射率分布。 本发明允许增加共焦检测并且在至少两个通道中共焦和OCT提供同时测量或成像，其中共焦通道提供与OCT截面的采集同时的正面图像，以指导采集以及 随后用于OCT图像的可视化。为装配一个或两个数码相机提供了不同的技术解决方案，这些相机与这些适配器一起导致模块化和便携式高分辨率成像系统，其能够以最少的额外组件实现各种功能，同时 调整数码相机中的元素。 这种适配器的成本与商用数码相机的成本相当，即商业数码相机和专用适配器的这些组件的总成本是完成高分辨率成像的总成本的一小部分是专用独立仪器的成本。 提出了实施例和方法以使用彩色摄像机及其相关联的光源来使用它们的颜色传感器部件来提供同时的信号，以提供光谱信息，一步中的相移干涉测量，深度范围扩展，偏振，角度测量和光谱傅里叶域（通道频谱 ）光学相干层析成像，与数码相机中的光电探测器传感器的彩色部分的数量一样多。 结合共焦图像的同时采集，可以使用常规彩色相机的三个颜色部分同时提供至少4个通道，以提供除共焦图像之外的三个OCT图像。

公开(公告)号：US08422023B2

公开(公告)日：2013-04-16

申请号：US12307072

申请日：2007-06-28

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: G01N21/4795 ,  A61B3/102 ,  G01B9/0203 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/70

Abstract: An optical coherence tomography (OCT) apparatus includes an optical source, an interferometer generating an object beam and a reference beam, a transverse scanner for scanning an object with said object beam, and a processor for generating an OCT image from an OCT signal returned by said interferometer. At least the optical source, the interferometer, and the scanner are mounted on a common translation stage displaceable towards and away from said object. A dynamic focus solution is provided when the scanner and a folded object path are placed on the translation stage.

Abstract translation: 光学相干断层摄影（OCT）装置包括光源，产生物体光束和参考光束的干涉仪，用于用所述物体光束扫描物体的横向扫描仪，以及用于从OCT信号产生OCT图像的处理器， 所述干涉仪。 至少光源，干涉仪和扫描仪安装在可朝向和远离所述物体移动的公共平移台上。 当扫描仪和折叠对象路径放置在平移台上时，提供动态聚焦解决方案。

公开(公告)号：US20120013849A1

公开(公告)日：2012-01-19

申请号：US12835221

申请日：2010-07-13

Applicant: Adrian Podoleanu ,  Michael Leitner

Inventor： Adrian Podoleanu ,  Michael Leitner

IPC: A61B3/10 ,  G01B11/02

CPC classification number: G01B9/02057 ,  A61B3/1005 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02021 ,  G01B9/02044 ,  G01B9/02064 ,  G01B9/0209

Abstract: A spectral interferometry apparatus and method are disclosed, that can be used to monitor or measure an unknown length by following a characteristic of an indicating signal. The measurement is performed by adjusting an optical path difference (OPD) in an interferometer until sound or light or both are obtained with the desired strength and pitch. Embodiments are presented where the unknown length is the eye length. Sound of different pitches are produced by scanning the channeled spectrum output of an interferometer with the object returning at least one of the interferometer optical signals. The scanning is performed by reading the signal of an analogue photodetector array driven by a nonlinear clock or by tuning a low cost swept source using a distorted driving signal.

Abstract translation: 公开了一种光谱干涉测量装置和方法，其可以用于通过遵循指示信号的特性来监视或测量未知长度。 通过调整干涉仪中的光程差（OPD）来进行测量，直到以期望的强度和间距获得声音或光或者两者。 呈现其中未知长度是眼睛长度的实施例。 通过用对象返回干涉仪光信号中的至少一个来扫描干涉仪的信道频谱输出来产生不同音调的声音。 通过读取由非线性时钟驱动的模拟光电检测器阵列的信号或通过使用失真的驱动信号调谐低成本扫频源来执行扫描。

公开(公告)号：US20110109911A1

公开(公告)日：2011-05-12

申请号：US12919026

申请日：2009-02-24

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: G01B9/02014 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

Abstract: The invention discloses an optical interferometer which can be used to provide simultaneous measurements over multiple path lengths and methods to employ such an interferometer as to achieve a variety of functions covering simultaneous measurements at different depths separated by an increment of a multiple differential delay matched in the interferometer as well as imaging. Optical sensors, optical coherence tomography (OCT) set-ups, optical sensing methods and OCT methods are disclosed which can provide: (i) multiple en-face images at several depths with dynamic dispersion compensation, (ii) fast acquisition of cross sections, (iii) fast acquisition of 3D volumes of a scattering object while maintaining dynamic focus; (iv) fast acquisition of long axial measurement profiles, non mechanical, with dynamic focus, range scalable, with applications in tracking and OTDR. Methods are disclosed on the combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. A method for elimination of axial movement effects in measuring the flow profile is also disclosed.

Abstract translation: 本发明公开了一种光干涉仪，其可用于提供多路径长度上的同时测量以及采用这种干涉仪的方法，以实现各种功能，覆盖在不同深度处的同时测量，所述多个不同深度由在 干涉仪以及成像。 公开了光学传感器，光学相干断层扫描（OCT）设置，光学感测方法和OCT方法，其可以提供：（i）在几个深度处具有动态色散补偿的多个面部图像，（ii）快速获取横截面， （iii）快速获取散射物体的3D体积，同时保持动态聚焦; （iv）快速获取长轴向测量轮廓，非机械，具有动态聚焦，范围可扩展，应用于跟踪和OTDR。 在扫描方式和操作模式的组合中公开了方法，以在测量中进行多功能功能，在移动组织例如眼睛，心脏或移动胚胎或功能/低噪声成像的3D成像中，通过使用角配合或 极化。 还公开了一种在测量流动剖面中消除轴向运动效应的方法。

公开(公告)号：US07466423B2

公开(公告)日：2008-12-16

申请号：US11239677

申请日：2005-09-30

Applicant: Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

Inventor： Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

IPC: G01B9/02

CPC classification number: A61B3/102 ,  A61B3/1025 ,  A61B3/14

Abstract: Optical mapping apparatus for imaging an object, comprising an optical coherence tomography (OCT) system including an OCT source, an OCT reference path leading from the OCT source to an OCT receiver, an OCT object path leading from the object to the OCT coupler, an OCT depth scanner adapted to alter at least one of the OCT reference path and the OCT receiver path. A confocal system is provided including a confocal optical receiver a confocal path leading from the object to the confocal optical receiver via a confocal input aperture. An adaptive optics (AO) system is provided to correct optical aberrations in the OCT object path and the confocal path.

Abstract translation: 用于对物体成像的光学映射设备，包括包括OCT源，从OCT源引导到OCT接收器的OCT参考路径的光学相干断层摄影（OCT）系统，从对象引导到OCT耦合器的OCT对象路径， OCT深度扫描器适于改变OCT参考路径和OCT接收器路径中的至少一个。 提供了共焦系统，其包括共聚焦光学接收器，其经由共焦输入孔从物体引导到共焦光学接收器。 提供自适应光学（AO）系统来校正OCT对象路径和共焦路径中的光学像差。

公开(公告)号：US20070076223A1

公开(公告)日：2007-04-05

申请号：US11561682

申请日：2006-11-20

Applicant: Adrian Podoleanu ,  David Jackson ,  John Rogers ,  George Dobre ,  Radu Cucu

Inventor： Adrian Podoleanu ,  David Jackson ,  John Rogers ,  George Dobre ,  Radu Cucu

IPC: G01B9/02 ,  G01B11/02

CPC classification number: A61B3/102 ,  A61B5/0066 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/4795

Abstract: OCT apparatus includes an interferometer, having an input beam splitter and a 50/50 output splitter. The splitting ratio of the input splitter may be optimized depending on the source power of light source and on the mismatch of the balanced receiver. The input splitter is a plate beam-splitter to minimize the stray reflected light in the interferometer and allow sequential operation of the apparatus in the OCT or in the confocal regime. The switching between the two regimes may be at will, or synchronous with the en-face scanning which results in quasi-simultaneous OCT/confocal imaging or in alternatives frames, confocal and OCT. By using polarization sensitive elements, two channels are provided in each regime, OCT and confocal. The two confocal polarization sensitive channels may allow adjustments of compensators prior to OCT measurements or OCT imaging.

Abstract translation: OCT设备包括具有输入分束器和50/50输出分离器的干涉仪。 输入分路器的分频比可以根据光源的功率和平衡接收机的不匹配进行优化。 输入分路器是平板分光器，以最小化干涉仪中的杂散反射光，并允许在OCT或共聚焦状态下对装置的顺序操作。 两种方案之间的切换可以是随意的，或者与进行准同时OCT /共聚焦成像或替代帧，共聚焦和OCT的正面扫描同步。 通过使用极化敏感元件，在每个方案中提供了两个通道，OCT和共聚焦。 两个共焦极化敏感通道可以允许在OCT测量或OCT成像之前调整补偿器。

公开(公告)号：US08451452B2

公开(公告)日：2013-05-28

申请号：US12764510

申请日：2010-04-21

Applicant: Adrian Podoleanu ,  Simon Tuohy

Inventor： Adrian Podoleanu ,  Simon Tuohy

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02004 ,  A61B3/1015 ,  A61B3/102 ,  A61B3/156 ,  G01B9/02002 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02038 ,  G01B9/02063 ,  G01B9/02068 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70

Abstract: Methods and devices are disclosed for acquiring depth resolved aberration information using principles of low coherence interferometry and perform coherence gated wavefront sensing (CG-WFS). The wavefront aberrations is collected using spectral domain low coherence interferometry (SD-LCI) or time domain low coherence interferometry (TD-LCI) principles. When using SD-LCI, chromatic aberrations can also be evaluated. Methods and devices are disclosed in using a wavefront corrector to compensate for the aberration information provided by CG-WFS, in a combined imaging system, that can use one or more channels from the class of (i) optical coherence tomography (OCT), (ii) scanning laser ophthalmoscopy, (iii) microscopy, such as confocal or phase microscopy, (iv) multiphoton microscopy, such as harmonic generation and multiphoton absorption. For some implementations, simultaneous and dynamic aberration measurements/correction with the imaging process is achieved. The methods and devices disclosed can provide wavefront sensing in the presence of stray reflections from optical interfaces.

Abstract translation: 公开了使用低相干干涉测量原理获取深度分辨像差信息并执行相干门控波前检测（CG-WFS）的方法和装置。 使用频域低相干干涉测量（SD-LCI）或时域低相干干涉测量（TD-LCI）原理收集波前像差。 当使用SD-LCI时，也可以评估色差。 在使用波前校正器来补偿在组合成像系统中由CG-WFS提供的像差信息的方法和装置被公开，该组合成像系统可以使用来自（i）光学相干断层扫描（OCT）的一个或多个通道， ii）扫描激光眼底镜检查，（iii）显微镜，如共焦或相位显微镜，（iv）多光子显微镜，如谐波产生和多光子吸收。 对于一些实施方案，实现了通过成像过程的同步和动态像差测量/校正。 所公开的方法和装置可以在存在来自光学接口的杂散反射的情况下提供波前感测。

公开(公告)号：US07995207B2

公开(公告)日：2011-08-09

申请号：US10576069

申请日：2004-10-14

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: A61B3/102 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/441 ,  A61B5/7203 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01N21/4795

Abstract: A spectral interferometry apparatus and method is provided to supply unambiguous profiles (A—scans free of mirror terms) of the reflectivity versus optical path difference and make difference between the positive and negative optical path difference or provide output in a selected interval of optical path differences. The apparatus comprises object optics that transfer a beam from an optical source to a target object (55) to produce an object beam and reference optics that produce a reference beam. Displacing means (57) are provided to produce a gap (g) between the object beam (41′) and the reference beam (42′). Optical spectrum dispersing means (7) such as a grating or a prism receive the two relatively displaced beams, and disperse their spectral content onto a reading element such as a CCD. The combination of the displacing means and the optical spectrum dispersing means creates an intrinsic optical delay between the wavetrains of the object beam and the reference beam which can be used with the optical path difference in the interferometer to generate a channeled spectrum for the optical path difference in the interferometer on the reading element.

Abstract translation: 提供了一种光谱干涉测量装置和方法来提供反射率相对于光程差的明确分布（无镜像的A扫描），并使得在正和负光程差之间产生差异，或者在所选择的光程差间隔中提供输出 。 该装置包括将光束从光源传输到目标物体（55）以产生物体光束和产生参考光束的参考光学器件的物体光学器件。 设置位移装置（57）以在物体光束（41'）和参考光束（42'）之间产生间隙（g）。 诸如光栅或棱镜的光谱分散装置（7）接收两个相对移动的光束，并将其光谱含量分散到诸如CCD的读取元件上。 位移装置和光谱分散装置的组合在物体光束的波长与参考光束之间产生固有的光学延迟，该参考光束可与干涉仪中的光程差用于产生用于光程差的通道光谱 在干涉仪上读取元件。

公开(公告)号：US20080013078A1

公开(公告)日：2008-01-17

申请号：US11828764

申请日：2007-07-26

Applicant: Adrian Podoleanu ,  David Jackson ,  John Rogers ,  George Dobre ,  Radu Cucu

Inventor： Adrian Podoleanu ,  David Jackson ,  John Rogers ,  George Dobre ,  Radu Cucu

IPC: G01N21/00 ,  G01B11/02

CPC classification number: A61B3/102 ,  A61B5/0066 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/4795

Abstract: OCT apparatus includes an interferometer, having an input beam splitter and a 50/50 output splitter. The splitting ratio of the input splitter may be optimized depending on the source power of light source and on the mismatch of the balanced receiver. The input splitter is a plate beam-splitter to minimize the stray reflected light in the interferometer and allow sequential operation of the apparatus in the OCT or in the confocal regime. The switching between the two regimes may be at will, or synchronous with the en-face scanning which results in quasi-simultaneous OCT/confocal imaging or in alternatives frames, confocal and OCT. By using polarization sensitive elements, two channels are provided in each regime, OCT and confocal. The two confocal polarization sensitive channels may allow adjustments of compensators prior to OCT measurements or OCT imaging.

Abstract translation: OCT设备包括具有输入分束器和50/50输出分离器的干涉仪。 输入分路器的分频比可以根据光源的功率和平衡接收机的不匹配进行优化。 输入分路器是平板分光器，以最小化干涉仪中的杂散反射光，并允许在OCT或共聚焦状态下对装置的顺序操作。 两种方案之间的切换可以是随意的，或者与进行准同时OCT /共聚焦成像或替代帧，共聚焦和OCT的en-face扫描同步。 通过使用极化敏感元件，在每个方案中提供了两个通道，OCT和共聚焦。 两个共焦极化敏感通道可以允许在OCT测量或OCT成像之前调整补偿器。