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    METHOD FOR CLASSIFYING A PIXEL TO GROUPS ACCORDING TO SPECTRUM OF PIXEL BY USE OF A PLURALITY OF WIDE BAND FILTERS AND HARDWARE THEREFOR
    1.
    发明专利
    METHOD FOR CLASSIFYING A PIXEL TO GROUPS ACCORDING TO SPECTRUM OF PIXEL BY USE OF A PLURALITY OF WIDE BAND FILTERS AND HARDWARE THEREFOR 失效

    公开(公告)号：JPH11166893A

    公开(公告)日：1999-06-22

    申请号：JP27927698

    申请日：1998-08-25

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： KATZIR NIR ,  WINE DAVID ,  GARINI YUVAL ,  CABIB DARIO

    IPC: G01N21/64 ,  G01N15/14 ,  G01N21/78 ,  G01N33/533 ,  G01N33/566 ,  G01N33/58 ,  G02B21/06

    Abstract: PROBLEM TO BE SOLVED: To classify each pixel to groups by recording the luminance passed through a wide band emission filter of each pixel to show each pixel by a vector of the degree equal to the number of emission filters, and evaluating the presence of a plurality of fluorogens of each pixel. SOLUTION: A colored chromosome 104 is placed under the objective lens 101 of a device 100 and above the support plate 106 thereof, and a light 112 is emitted from a light source 110. A wide band existing filter 114 corrects the emission of the light 112 to a specified wavelength suitable for excitation, and a wide band emission filter 116 corrects the emission of the chromosome 104 to a specified wavelength. A control device 120 selects this filterpair, excites the fluorogen of each pixel, and repeats this procedure in all filter pairs. The emission luminance after passing the emission filter 116 is recorded by a luminance recording device 122, and each pixel is shown by a vector of the degree equal to the number of a plurality of filter pairs. An arithmetic device 124 comprises an algorithm for evaluating each presence of the fluorogen of each pixel, whereby each pixel is classified to groups.

    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL SAMPLES
    3.
    发明申请
    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL SAMPLES 审中-公开
    分析生物样品的方法和系统

    公开(公告)号：WO2007080583A3

    公开(公告)日：2009-02-12

    申请号：PCT/IL2007000034

    申请日：2007-01-09

    Applicant: APPLIED SPECTRAL IMAGING LTD ,  KATZIR NIR ,  KOLATT TSAFRIR ,  BAR-AM IRIT

    Inventor： KATZIR NIR ,  KOLATT TSAFRIR ,  BAR-AM IRIT

    IPC: G01N33/48 ,  C12Q1/68

    CPC classification number: C12Q1/6841 ,  G06K9/00134

    Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.

    Abstract translation: 提供了可用于分析标记的生物样品，识别染色体畸变，识别遗传异常细胞和/或使用随机或随机扫描方法计算扫描样品的方法，计算机可读存储介质和系统。 具体地，本发明可用于分析FISH染色的样品，并自动识别与样品中染色事件的异常强度比相关的染色体畸变。

    METHOD AND ARTICLE FOR IMPROVING OPTICAL DETECTION AND SENSITIVITY
    4.
    发明申请
    METHOD AND ARTICLE FOR IMPROVING OPTICAL DETECTION AND SENSITIVITY 审中-公开
    改进光学检测和灵敏度的方法和文章

    公开(公告)号：WO2002082356A1

    公开(公告)日：2002-10-17

    申请号：PCT/IL2002/000251

    申请日：2002-03-26

    Applicant: APPLIED SPECTRAL IMAGING LTD. ,  GARINI, Yuval

    Inventor： GARINI, Yuval

    IPC: G06K7/04

    CPC classification number: G06K19/06046 ,  G06K7/10801

    Abstract: A light reflecting article (30) is disclosed. The light reflecting article (30) comprises a sample carrying article (32) layered with a light reflecting layer (34). The light reflecting layer (34) serves for allowing an optical collection and detection system (36) to collect both luminescent light emitted from a sample (38) positioned on the light reflecting article (30) in a direction of the optical collection and detection system (36), as well as luminescent light emitted from the sample (38) in a direction away from the optical collection and detection system (36) and reflected in the direction of the optical collection and detection system (36) via the light reflecting layer (34), thereby increasing a sensitivity of luminescent light detection.

    Abstract translation: 公开了一种光反射制品（30）。 光反射制品（30）包括层叠有光反射层（34）的样品携带物品（32）。 光反射层（34）用于允许光学收集和检测系统（36）收集从位于光反射制品（30）上的样品（38）发射的发光光沿光学收集和检测系统 （36），以及从远离光学收集和检测系统（36）的方向从样品（38）发射并沿着光学收集和检测系统（36）的方向经由光反射层反射的发光 （34），从而增加发光光检测的灵敏度。

    METHOD AND DEVICE FOR ANALYZING BIOLOGICAL SAMPLE
    5.
    发明申请
    METHOD AND DEVICE FOR ANALYZING BIOLOGICAL SAMPLE 审中-公开
    用于分析生物样品的方法和装置

    公开(公告)号：WO2013179279A2

    公开(公告)日：2013-12-05

    申请号：PCT/IL2013/050433

    申请日：2013-05-21

    Applicant: APPLIED SPECTRAL IMAGING LTD.

    Inventor： FRONT, Yaron ,  SLUSZNY, Chanan ,  SHIPOSH, Limor

    IPC: G01N33/543

    CPC classification number: G01N33/54366

    Abstract: A device for analyzing a biological sample is disclosed. The device comprises, a substrate having thereon a sample region for carrying the sample and a reference region; and a reference substance being immobilized on the reference region, and being bindable to at least one label that is specific to at least one component of the sample.

    Abstract translation: 公开了用于分析生物样品的装置。 该装置包括：基板，其上具有用于承载样品的样品区域和参考区域; 并且参考物质固定在参考区上，并且可与至少一种对样品的至少一种组分特异的标记结合。

    METHOD FOR REMOTE SENSING ANALYSIS BY DECORRELATION STATISTICAL ANALYSIS AND HARDWARE THEREFOR
    6.
    发明申请
    METHOD FOR REMOTE SENSING ANALYSIS BY DECORRELATION STATISTICAL ANALYSIS AND HARDWARE THEREFOR 审中-公开
    通过装饰统计分析及其硬件进行远程感测分析的方法

    公开(公告)号：WO9901843A9

    公开(公告)日：1999-04-15

    申请号：PCT/US9813524

    申请日：1998-06-29

    Applicant: APPLIED SPECTRAL IMAGING LTD ,  FRIEDMAN MARK M ,  CABIB DARIO

    Inventor： CABIB DARIO

    IPC: G01J3/28 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  G06T1/00 ,  G06K9/62

    CPC classification number: G01J3/12 ,  G01J3/02 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01J2003/2866 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G06K9/00127 ,  G06K9/00201 ,  G06K9/0063 ,  G06K9/76

    Abstract: A method for remote scenes classification comprising the steps of (a) preparing a reference template for classification of the remote scenes via (i) classifying a set of reference scenes via a conventional classification technique for obtaining a set of preclassified reference scenes; (ii) using a first spectral imager for measuring a spectral cube of the preclassified reference scenes; (iii) employing a principal component analysis for extracting the spectral cube for decorrelated spectral data characterizing the reference scenes; and (iv) using at least a part of the decorrelated spectral data for the preparation of the reference template for remote scenes classification; (b) using a second spectral imager for measuring a spectral cube of analyzed remote scenes, such that a spectrum of each pixel in the remote scenes is obtained; (c) employing a decorrelation statistical method for extracting decorrelated spectral data characterizing the pixels; and (d) comparing at least a part of the decorrelated spectral data extracted from the pixels of the remote scenes with the reference template.

    Abstract translation: 一种用于远程场景分类的方法，包括以下步骤：（a）通过（i）通过用于获得一组预分类参考场景的常规分类技术对一组参考场景进行分类，准备用于远程场景分类的参考模板; （ii）使用第一光谱成像仪来测量预分类参考场景的光谱立方体; （iii）采用主成分分析来提取表征参考场景的去相关光谱数据的光谱立方体; 和（iv）使用至少一部分去相关的光谱数据来准备用于远程场景分类的参考模板; （b）使用第二光谱成像仪来测量分析的远程场景的光谱立方体，使得获得远程场景中每个像素的光谱; （c）采用解相关统计方法来提取表征像素的去相关光谱数据; 和（d）将从远程场景的像素提取的去相关光谱数据的至少一部分与参考模板进行比较。

    METHOD AND SYSTEM FOR SPECTRAL IMAGING
    7.
    发明申请
    METHOD AND SYSTEM FOR SPECTRAL IMAGING 审中-公开

    公开(公告)号：WO2014064701A9

    公开(公告)日：2014-05-01

    申请号：PCT/IL2013/050868

    申请日：2013-10-24

    Applicant: APPLIED SPECTRAL IMAGING LTD.

    Inventor： KATZIR, Nir

    IPC: G01B9/02 ,  G02B27/10 ,  G01B11/02 ,  A61B6/00

    Abstract: A method of calibrating a spectral imaging system is disclosed. The spectral imaging system comprises an interferometer having a beam splitter and at least a first reflector and a second reflector. The method comprises: obtaining data pertaining to an interference pattern model, operating the spectral imaging system to provide an interference pattern of a received light beam, and varying a relative orientation between at least two of: the beam splitter, the first reflector and the second reflector, until the interference pattern of the input light beam substantially matches the interference pattern model.

    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL SAMPLES
    8.
    发明申请
    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL SAMPLES 审中-公开
    分析生物样品的方法和系统

    公开(公告)号：WO2007080583A2

    公开(公告)日：2007-07-19

    申请号：PCT/IL2007/000034

    申请日：2007-01-09

    Applicant: APPLIED SPECTRAL IMAGING LTD. ,  KATZIR, Nir ,  KOLATT, Tsafrir ,  BAR-AM, Irit

    Inventor： KATZIR, Nir ,  KOLATT, Tsafrir ,  BAR-AM, Irit

    IPC: C12Q1/68 ,  G06F19/00

    CPC classification number: C12Q1/6841 ,  G06K9/00134

    Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.

    Abstract translation: 提供了可用于分析标记的生物样品，识别染色体畸变，识别遗传异常细胞和/或使用随机或随机扫描方法计算扫描样品的方法，计算机可读存储介质和系统。 具体地，本发明可用于分析FISH染色的样品，并自动识别与样品中染色事件的异常强度比相关的染色体畸变。

    AUTOMATIC CHARACTERIZATION OF PATHOLOGICAL SPECIMEN
    9.
    发明申请
    AUTOMATIC CHARACTERIZATION OF PATHOLOGICAL SPECIMEN 审中-公开
    病理学特征自动表征

    公开(公告)号：WO2007069233A2

    公开(公告)日：2007-06-21

    申请号：PCT/IL2006/001382

    申请日：2006-11-30

    Applicant: APPLIED SPECTRAL IMAGING LTD. ,  KOLATT, Tsafrir

    Inventor： KOLATT, Tsafrir

    IPC: C12Q1/00 ,  G06F19/00

    CPC classification number: G01N33/5082 ,  G01N15/1475 ,  G01N21/31 ,  G06K9/0014 ,  G06T7/0012 ,  G06T2207/30072

    Abstract: A method for characterizing a stained pathological specimen is disclosed. The method comprises obtaining an image of the specimen, classifying the picture-elements of the image into classification groups, and using the classification groups to define at least one set of picture-elements corresponding to at least one tissue region of the pathological specimen. The method further comprises applying, on each set of picture-elements, at least one set-operator so as to characterize the tissue regions according to image data and spatial characteristics of the set.

    Abstract translation: 公开了一种染色病理样本的表征方法。 该方法包括获得样本的图像，将图像的图像元素分类为分类组，并且使用分类组来定义至少一组对应于病理标本的至少一个组织区域的图像元素。 该方法还包括在每组图像元素上应用至少一个集合算子，以便根据该组的图像数据和空间特征来表征组织区域。

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