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    MULTI-SAMPLE LASER-SCATTER MEASUREMENT INSTRUMENT WITH INCUBATION FEATURE, AND SYSTEMS FOR USING THE SAME
    2.
    发明申请
    MULTI-SAMPLE LASER-SCATTER MEASUREMENT INSTRUMENT WITH INCUBATION FEATURE, AND SYSTEMS FOR USING THE SAME 审中-公开
    具有激光功能的多样本激光扫描仪测量仪器及其使用系统

    公开(公告)号：WO2016088108A1

    公开(公告)日：2016-06-09

    申请号：PCT/IB2015/059385

    申请日：2015-12-04

    Applicant: BACTERIOSCAN LTD.

    Inventor： MARSHALL, Dana, A. ,  MCMINN, Theodore, S. ,  REGELMAN, Dan, Vadim

    IPC: G01N21/00

    CPC classification number: G01N21/51 ,  G01N21/0332 ,  G01N2021/4707

    Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. The instrument can be used for taking measurements of organism concentration in multiple samples as a production tool for microbiology. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples during the test. In another aspect, the instrument can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

    Abstract translation: 光学测量仪器是一种集成的仪器，其包括具有光源的光学腔，样品比色皿和光学传感器。 光源和传感器位于平移或旋转机械平台上的工作台上，使得光束可以移动到多个样品容器。 该仪器可用于测量多个样品中的生物体浓度，作为微生物学的生产工具。 优选地，该仪器保持多个单独加载的独立流体样品，并通过前向散射信号确定细菌浓度。 该仪器可以包含板内孵化，以在测试过程中促进样品中的细菌生长。 另一方面，仪器可以是用于医疗诊断测试数据的网络的一部分，其中数据以由患者可识别信息固有地保持的方式存储。

    PIPETTE HAVING INTEGRATED FILTRATION ASSEMBLY
    4.
    发明申请
    PIPETTE HAVING INTEGRATED FILTRATION ASSEMBLY 审中-公开
    配套集成过滤装置

    公开(公告)号：WO2016108186A1

    公开(公告)日：2016-07-07

    申请号：PCT/IB2015/060033

    申请日：2015-12-29

    Applicant: BACTERIOSCAN LTD.

    Inventor： MARSHALL, Dana, A. ,  BECKMANN, Robert, W.

    IPC: B01L3/02 ,  G01N35/10

    CPC classification number: B01L3/0275 ,  B01L2300/0681 ,  B01L2400/0605

    Abstract: The present invention is a pipette-filtration assembly having a main body defining a first channel, a second channel, a first valve, and a second valve. The first valve is associated with the first channel and permits flow in a first direction while substantially hindering flow in a second direction. The second valve is associated with the second channel and permits flow in the second direction while substantially hindering flow in the first direction. At least one filter is used to filter a fluid sample as the fluid sample flows in the first direction and/or the second direction. The pipette-filtration assembly is preferably disposable and includes one or two stages of integral filtration, primarily for use with an air-displacement pipetting or transfer system.

    Abstract translation: 本发明是一种移液管过滤组件，其具有限定第一通道，第二通道，第一阀和第二阀的主体。 第一阀门与第一通道相关联并且允许沿第一方向流动，同时基本上妨碍沿第二方向的流动。 第二阀与第二通道相关联并且允许沿第二方向的流动，同时基本上妨碍沿第一方向的流动。 当流体样品沿第一方向和/或第二方向流动时，使用至少一个过滤器来过滤流体样品。 移液器 - 过滤组件优选是一次性的并且包括一个或两个阶段的整体过滤，主要用于空气置换移液或转移系统。

    DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS
    5.
    发明申请
    DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS 审中-公开
    检测和计数在生物流体中悬浮的细菌

    公开(公告)号：WO2009083963A2

    公开(公告)日：2009-07-09

    申请号：PCT/IL2008/001663

    申请日：2008-12-24

    Applicant: BACTERIOSCAN LTD. ,  WEICHSELBAUM, Amnon

    Inventor： WEICHSELBAUM, Amnon ,  DE LA ZERDA, Jaime ,  REGEV, Issakhar

    IPC: G01N21/00 ,  G01N1/10

    CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N33/493 ,  G01N2021/0382 ,  G01N2021/4769 ,  G01N2021/479 ,  G01N2021/513 ,  G01N2201/064

    Abstract: System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.

    Abstract translation: 提供了通过光散射测量来检测和计数悬浮在生物流体中的细菌的系统和方法。 根据本发明的方法，在与预定的最大散射相比较小的散射角范围内的向前散射光显着增强了由生物流体样本散射的光的测量强度的信噪比水平 角度。 本发明的系统包括适于容纳生物流体的样本的比色皿，其侧壁和窗口被适当地构造和布置，以显着降低反射光的水平，遮蔽在所考虑的散射角度范围内测量的散射图案。

    SISTEMA PARA RECUENTO DE BACTERIAS Y DETERMINACION DE SU SUSCEPTIBILIDAD A LOS ANTIBIOTICOS.
    6.
    发明专利
    SISTEMA PARA RECUENTO DE BACTERIAS Y DETERMINACION DE SU SUSCEPTIBILIDAD A LOS ANTIBIOTICOS. 未知

    公开(公告)号：ES2370659T3

    公开(公告)日：2011-12-21

    申请号：ES06821599

    申请日：2006-11-29

    Applicant: BACTERIOSCAN LTD

    Inventor： WEICHSELBAUM AMNON ,  DE LA ZERDA JAIME

    IPC: C12Q1/68 ,  C12Q1/04

    Abstract: Un método para recuento de bacterias suspendidas en un fluido, en que una porción de dicho fluido se filtra para excluir partículas mayores que dichas bacterias y una muestra de la porción filtrada se pone en una cubeta que tiene al menos una ventana iluminada con un haz de luz coherente y colimado, comprendiendo el método las etapas de: i. medir repetidamente a una velocidad de repetición predefinida la intensidad de luz dispersada por la muestra a al menos dos ángulos diferentes de dispersión, ii. calcular representaciones gráficas de diferencia de las mediciones de intensidad de la luz a cada uno de los diferentes ángulos de dispersión a los que se mide la intensidad de la luz, comprendiendo cada representación gráfica de diferencia los valores absolutos de diferencias entre niveles de intensidad de luz medidos en dos momentos de tiempo o diferentes al mismo ángulo de dispersión y iii. igualar cada una de dichas representaciones gráficas de diferencia con una curva de calibración para proporcionar una estimación de la concentración de las bacterias en la muestra.

    試料チャンバを有する光学測定キュベット
    7.
    发明专利
    試料チャンバを有する光学測定キュベット 审中-公开

    公开(公告)号：JP2019090829A

    公开(公告)日：2019-06-13

    申请号：JP2019018893

    申请日：2019-02-05

    Applicant: BACTERIOSCAN LTD

    Inventor： DANA A MARSHALL ,  THEODORE S MCMINN ,  DAN VADIM REGELMAN

    IPC: G01N21/03 ,  G01N21/51

    Abstract: 【課題】量産するのが容易であり、操作者による容易な使用を可能にし、液体試料をフィルタを通して光学チャンバ内により容易に供給する改良されたキュベットを提供する。【解決手段】キュベットアセンブリ110は、内壁および外壁を有する本体と、内壁によって少なくとも部分的に画定される、本体内の複数のキュベットを備える。複数のキュベットのそれぞれは複数の液体試料のそれぞれ1つを受け取るための液体入力チャンバ114、フィルタ132、および複数の液体試料のそれぞれ1つをフィルタ132に通過させることによって生ずるそれぞれの濾過された液体試料を受け取るための光学チャンバ112を含む。光学チャンバ112のそれぞれは、濾過された液体試料を通した入力光ビームの透過を可能にするための入射窓116、および濾過された液体試料内の粒子によって引き起こされる前方散乱信号を透過するための出射窓118を含む。【選択図】図3

    LASER-SCATTER MEASUREMENT INSTRUMENT HAVING CAROUSEL-BASED FLUID SAMPLE ARRANGEMENT
    8.
    发明申请
    LASER-SCATTER MEASUREMENT INSTRUMENT HAVING CAROUSEL-BASED FLUID SAMPLE ARRANGEMENT 审中-公开
    具有基于卡路里的流体样品装置的激光扫描仪测量仪器

    公开(公告)号：WO2016120779A1

    公开(公告)日：2016-08-04

    申请号：PCT/IB2016/050364

    申请日：2016-01-25

    Applicant: BACTERIOSCAN LTD.

    Inventor： MARSHALL, Dana, A. ,  MCMINN, Theodore, S. ,  REGELMAN, Dan, Vadim

    IPC: G01N21/47

    CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N2021/513 ,  G01N2201/0231 ,  G01N2201/0415

    Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.

    Abstract translation: 仪器确定多个流体样品中细菌的浓度，并且包括壳体，可旋转平台，多个流体容器，光源，传感器和马达。 可旋转平台位于外壳内。 流体容器位于可旋转平台上。 每个流体容器保持多个流体样本中的相应的一个，并且具有输入窗口和输出窗口。 光源提供输入光束，用于传输到流体容器的输入窗口并通过相应的流体样品。 输入光束产生与细菌浓度相关联的前向散射信号。 马达旋转可旋转平台，使得输入光束顺序地通过每个流体样品。 壳体内的传感器检测从与接收输入光束的流体样品相关联的输出窗口离开的前向散射信号。

    DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS
    9.
    发明申请
    DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS 审中-公开
    检测和计数在生物流体中悬浮的细菌

    公开(公告)号：WO2009083963A3

    公开(公告)日：2010-03-11

    申请号：PCT/IL2008001663

    申请日：2008-12-24

    Applicant: BACTERIOSCAN LTD ,  WEICHSELBAUM AMNON

    Inventor： WEICHSELBAUM AMNON ,  DE LA ZERDA JAIME ,  REGEV ISSAKHAR

    IPC: C12M1/34

    CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N33/493 ,  G01N2021/0382 ,  G01N2021/4769 ,  G01N2021/479 ,  G01N2021/513 ,  G01N2201/064

    Abstract: System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.

    Abstract translation: 提供了通过光散射测量来检测和计数悬浮在生物流体中的细菌的系统和方法。 根据本发明的方法，在与预定的最大散射相比较小的散射角范围内的向前散射光显着增强了由生物流体样本散射的光的测量强度的信噪比水平 角度。 本发明的系统包括适于容纳生物流体的样本的比色皿，其侧壁和窗口被适当地构造和布置，以显着降低反射光的水平，遮蔽在所考虑的散射角度范围内测量的散射图案。

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