公开(公告)号：WO2002087587A2

公开(公告)日：2002-11-07

申请号：PCT/GB2002/002011

申请日：2002-05-02

Applicant: CELLTECH R & D LIMITED ,  MOFFAT, David, Festus, Charles ,  BATCHELLOR, Mark, James ,  BROOKINGS, Daniel, Christopher ,  DAVIS, Peter, David

Inventor： MOFFAT, David, Festus, Charles ,  BATCHELLOR, Mark, James ,  BROOKINGS, Daniel, Christopher ,  DAVIS, Peter, David

IPC: A61K31/517

CPC classification number: C07D401/12 ,  C07D239/93 ,  C07D239/94 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of formula (1) are described wherein Ar is an optionally substituted aryl, heteroaryl, aralkyl, heteroaralkyl or alkyl group, X is a nitrogen atom or a C(R 1a ) group, n is zero or the integer 1 or 2 and R, R 1 , R 2 , R 3 and R 4 are substituents defined in the specification. The compounds are able to inhibit the activity of Class 1 receptor tyrosine kinases and are of use in the treatment of hyperproliferative disorders such as psoriasis.

Abstract translation: 描述式（1）化合物，其中Ar是任选取代的芳基，杂芳基，芳烷基，杂芳烷基或烷基，X是氮原子或C（R 1a）基团，n是0或整数1或2 R 1，R 2，R 2，R 3和R 4是说明书中定义的取代基。 该化合物能够抑制1类受体酪氨酸激酶的活性，并且可用于治疗过度增殖性疾病如牛皮癣。

公开(公告)号：WO02087587A3

公开(公告)日：2003-01-09

申请号：PCT/GB0202011

申请日：2002-05-02

Applicant: CELLTECH R&D LTD ,  MOFFAT DAVID FESTUS CHARLES ,  BATCHELLOR MARK JAMES ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS PETER DAVID

Inventor： MOFFAT DAVID FESTUS CHARLES ,  BATCHELLOR MARK JAMES ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS PETER DAVID

IPC: A61P35/00 ,  C07D239/93 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  A61K31/517

CPC classification number: C07D401/12 ,  C07D239/93 ,  C07D239/94 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of formula (1) are described wherein Ar is an optionally substituted aryl, heteroaryl, aralkyl, heteroaralkyl or alkyl group, X is a nitrogen atom or a C(R ) group, n is zero or the integer 1 or 2 and R, R , R , R and R are substituents defined in the specification. The compounds are able to inhibit the activity of Class 1 receptor tyrosine kinases and are of use in the treatment of hyperproliferative disorders such as psoriasis.

Abstract translation: 描述式（1）化合物，其中Ar是任选取代的芳基，杂芳基，芳烷基，杂芳烷基或烷基，X是氮原子或C（R 1a）基团，n是0或整数1或2 R 1，R 2，R 2，R 3和R 4是说明书中定义的取代基。 该化合物能够抑制1类受体酪氨酸激酶的活性，并且可用于治疗过度增殖性疾病如牛皮癣。