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公开(公告)号：JP2013135677A
公开(公告)日：2013-07-11
申请号：JP2013015172
申请日：2013-01-30
Applicant: Becker David L , デイビツド・エル・ベツカー , Green Colin R , コリン・アール・グリーン
Inventor： BECKER DAVID LAURENCE , GREEN COLIN RICHARD
IPC: C12N15/09 , C12N15/113 , A61K9/06 , A61K9/10 , A61K31/70 , A61K31/711 , A61K38/00 , A61K47/16 , A61K47/34 , A61K47/46 , A61K48/00 , A61P17/02 , A61P17/12 , A61P17/16 , A61P25/00 , A61P29/00 , A61P43/00 , C12N15/11
CPC classification number: C07H21/04 , A61K31/711 , A61K38/00 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2320/32
Abstract: PROBLEM TO BE SOLVED: To provide a formulation that is used in therapeutic and/or cosmetic treatment and comprises at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle.SOLUTION: The connexin 43 anti-sense polynucleotide comprises a specific sequence or a sequence having at least 90% identity to the sequence and has length of 40 nucleotides or less. The formulation comprises the polynucleotide together with a pharmaceutically acceptable carrier or vehicle and is useful in therapeutic and/or cosmetic treatment in which a localized disruption in direct cell-cell communication is desirable.
Abstract translation: 要解决的问题：提供用于治疗和/或美容治疗的制剂，并且包含连接蛋白与药学上可接受的载体或载体的至少一种反义多核苷酸。解决方案：连接蛋白43反义多核苷酸 包括与序列具有至少90％同一性并具有40个核苷酸或更短的长度的特定序列或序列。 制剂包含多核苷酸以及药学上可接受的载体或媒介物，并且可用于治疗和/或美容治疗，其中期望直接细胞 - 细胞通讯中的局部破坏。
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公开(公告)号：JP2012041342A
公开(公告)日：2012-03-01
申请号：JP2011179832
申请日：2011-08-19
Applicant: Becker David L , Green Colin R , コリン・アール・グリーン , デイビツド・エル・ベツカー
Inventor： BECKER DAVID LAURENCE , GREEN COLIN RICHARD
IPC: A61K31/7088 , C12N15/09 , A61K9/06 , A61K9/10 , A61K31/70 , A61K31/711 , A61K38/00 , A61K47/16 , A61K47/34 , A61K47/46 , A61K48/00 , A61P17/00 , A61P17/02 , A61P17/12 , A61P17/16 , A61P25/00 , A61P29/00 , A61P43/00 , C12N15/11 , C12N15/113
CPC classification number: C07H21/04 , A61K31/711 , A61K38/00 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2320/32
Abstract: PROBLEM TO BE SOLVED: To provide a method for site specific down regulation of expression of connexin which is a protein composing a gap junction channel of a cell membrane structure making cell-cell communication easy, for therapy and/or for cosmetic surgery.SOLUTION: The method comprises administrating a formulation containing at least one antisense polynucleotide to a connexin protein on the patient surface site or the patient body internal site. The method is useful particularly in reduction of neuronal cell death, wound healing, reduction of inflammation, decrease of scar formation, and skin rejuvenation and thickening.
Abstract translation: 要解决的问题：提供一种用于局部特异性下调连接蛋白的表达的方法，所述连接蛋白是构成细胞膜结构的间隙连接通道的蛋白质的形成，其使细胞通信容易，用于治疗和/或整容手术 。 解决方案：该方法包括将含有至少一种反义多核苷酸的制剂施用于患者表面部位或患者体内部位置处的连接蛋白。 该方法特别用于减少神经元细胞死亡，伤口愈合，减少炎症，减少瘢痕形成以及皮肤年轻化和增厚。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2013136594A
公开(公告)日：2013-07-11
申请号：JP2013015171
申请日：2013-01-30
Applicant: Becker David L , デイビツド・エル・ベツカー , Green Colin R , コリン・アール・グリーン
Inventor： BECKER DAVID LAURENCE , GREEN COLIN RICHARD
IPC: A61K31/7088 , C12N15/09 , A61K9/06 , A61K9/10 , A61K31/70 , A61K31/711 , A61K38/00 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/16 , A61K47/34 , A61K47/44 , A61K47/46 , A61K48/00 , A61P17/02 , A61P17/12 , A61P17/16 , A61P25/00 , A61P29/00 , A61P43/00 , C12N15/11 , C12N15/113
CPC classification number: C07H21/04 , A61K31/711 , A61K38/00 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2320/32
Abstract: PROBLEM TO BE SOLVED: To provide a production method of a medicine which contains an antisense polynucleotide and is used for treating human or animal wounds.SOLUTION: The method aims to produce a medicine, which comprises connexin 43 antisense polynucleotide and a pharmaceutically acceptable carrier selected from a gel, lanolin, hard paraffin, soft yellow paraffin or soft white paraffin, white beeswax, yellow beeswax, cetostearyl alcohol, cetyl alcohol, dimethicone, emulsifying wax, isopropyl myristate, microcrystalline wax, oleyl alcohol and stearyl alcohol, and which promotes wound healing. A polyoxyethylene-polyoxypropylene copolymer gel is preferably used for an external gel.
Abstract translation: 要解决的问题：提供含有反义多核苷酸并用于治疗人或动物伤口的药物的制备方法。溶液：该方法旨在产生一种药物，其包含连接蛋白43反义多核苷酸和选择的药学上可接受的载体 来自凝胶，羊毛脂，硬石蜡，软黄色石蜡或软白色石蜡，白蜂蜡，黄蜂蜡，鲸蜡硬脂醇，鲸蜡醇，聚二甲基硅氧烷，乳化蜡，肉豆蔻酸异丙酯，微晶蜡，油醇和硬脂醇，并促进伤口 愈合。 聚氧乙烯 - 聚氧丙烯共聚物凝胶优选用于外部凝胶。
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4.发明公开Formulations comprising antisense nucleotides to connexins 有权Formulierungen enthaltend Antisense Nukleotide spezifischfürConnexine
公开(公告)号：EP1621212A1
公开(公告)日：2006-02-01
申请号：EP05016736.0
申请日：2000-01-27
Applicant: Becker, David, Dr. , Green, Colin R., Dr.
Inventor： Becker, David, Dr. , Green, Colin R., Dr.
CPC classification number: C07H21/04 , A61K31/711 , A61K38/00 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2320/32
Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decreases of scar formation and skin rejuvenation and thickening.
Abstract translation: 包含至少一种连接蛋白的反义多核苷酸与药学上可接受的载体或载体的治疗和/或化妆品制剂可用于连接蛋白表达的位点特异性下调，特别是在减少神经元细胞死亡，伤口愈合，还原 的炎症，瘢痕形成减少和皮肤年轻化和增厚。
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公开(公告)号：EP1146908B1
公开(公告)日：2005-08-03
申请号：EP00901236.0
申请日：2000-01-27
Applicant: Becker, David, Dr. , Green, Colin R., Dr.
Inventor： BECKER, David Laurence , GREEN, Colin Richard
CPC classification number: C07H21/04 , A61K31/711 , A61K38/00 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2320/32
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Patent Agency Ranking
公开(公告)号：EP2314321A1
公开(公告)日：2011-04-27
申请号：EP10013180.4
申请日：2000-01-27
Applicant: Becker, David L. , Green, Colin R., Dr.
Inventor： Becker, David L. , Green, Colin R., Dr.
CPC classification number: C07H21/04 , A61K31/711 , A61K38/00 , C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2320/32
Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decreases of scar formation and skin rejuvenation and thickening.
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公开(公告)号：CA2730386C
公开(公告)日：2015-08-11
申请号：CA2730386
申请日：2000-01-27
Applicant: GREEN COLIN R , BECKER DAVID L
Inventor： GREEN COLIN R , BECKER DAVID L
IPC: A61K31/711 , C12N15/09 , A61K9/06 , A61K9/10 , A61K31/70 , A61K38/00 , A61K47/16 , A61K47/34 , A61K47/46 , A61K48/00 , A61L15/44 , A61P17/02 , A61P17/12 , A61P17/16 , A61P25/00 , A61P29/00 , A61P43/00 , C12N15/11 , C12N15/113
Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin, protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.
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公开(公告)号：CA2442620A1
公开(公告)日：2002-10-10
申请号：CA2442620
申请日：2002-03-28
Applicant: BECKER DAVID
Inventor： BECKER DAVID F
Abstract: A method for collaborating remotely that incorporates the use of high- resolution computer imagery, or any other source of high-resolution video, i s provided. The method provides for converting high-resolution video or analog RGB computer video into for example, High Definition Television (HDTV) signa ls or keep the RGB computer signal in its original format but in digital form. These signals are then compressed, encoded and transmitted over a broadband communication network. At a remote location (112), the signals are decompressed, decoded by a decoder (152) and displayed on an HDTV-capable display device (115) or a normal analog-RGB computer monitor.
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公开(公告)号：CA2730386A1
公开(公告)日：2000-08-03
申请号：CA2730386
申请日：2000-01-27
Applicant: GREEN COLIN R , BECKER DAVID L
Inventor： GREEN COLIN R , BECKER DAVID L
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公开(公告)号：DK1146908T3
公开(公告)日：2005-10-10
申请号：DK00901236
申请日：2000-01-27
Applicant: BECKER DAVID DR , GREEN COLIN R DR
Inventor： BECKER DAVID LAURENCE , GREEN COLIN RICHARD
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