公开(公告)号：WO2008002614A3

公开(公告)日：2008-03-06

申请号：PCT/US2007014921

申请日：2007-06-27

Applicant: FLORIDA INTERNAT UNIVERSITY BO ,  BECKER DAVID A ,  KOLHE AMOLKUMAR

Inventor： BECKER DAVID A ,  KOLHE AMOLKUMAR

IPC: C07D221/04 ,  A61K31/435 ,  C07D311/04 ,  C07D335/04

CPC classification number: C07D221/04 ,  C07D311/94 ,  C07D401/06 ,  C07D417/12

Abstract: Disclosed herein are pseudoazulenyl nitrone compounds of general structural formula: (I) or formula (II) and methods of using these compounds to trap free radicals and to treat, prevent, or ameliorate various diseases associated with free radicals.

Abstract translation: 本文公开的具有通式结构式（I）或式（II）的假薁基硝酮化合物以及使用这些化合物捕获自由基并治疗，预防或改善与自由基相关的各种疾病的方法。

公开(公告)号：WO2010110853A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/000830

申请日：2010-03-19

Applicant: GEA FARM TECHNOLOGIES, INC. ,  KASTENSCHMIDT, Kevin, M. ,  STUESSEL, Matthew, J. ,  BECKER, David, A. ,  BUCK, Robert, L. ,  ROTTIER, Ralph, A.

Inventor： KASTENSCHMIDT, Kevin, M. ,  STUESSEL, Matthew, J. ,  BECKER, David, A. ,  BUCK, Robert, L. ,  ROTTIER, Ralph, A.

IPC: A23K1/08 ,  A23K1/18 ,  A23C3/07 ,  A23L3/28

CPC classification number: A23C3/076 ,  A23K10/28 ,  A23K50/10 ,  A23K50/60 ,  A23L3/003 ,  A23L3/28 ,  Y02P60/875

Abstract: The present invention is directed to a system and method for pasteurizing milk and colostrum for feeding to calves. The system includes a vat for storing milk or colostrum, a circulation pump and piping system, a heat exchanger for adjusting and/or maintaining milk temperature, and an ultraviolet light pasteurizing unit ("UV reactor") that treats the milk without damaging important immunoglobulins.

Abstract translation: 本发明涉及一种用于将牛奶和初乳进行巴氏杀菌以供给小牛的系统和方法。 该系统包括用于储存牛奶或初乳的容器，循环泵和管道系统，用于调节和/或维持乳温的热交换器，以及在不损害重要免疫球蛋白的情况下处理牛奶的紫外线杀菌单元（“UV反应器”） 。

公开(公告)号：WO1997019054A1

公开(公告)日：1997-05-29

申请号：PCT/US1996018570

申请日：1996-11-15

Applicant: FLORIDA INTERNATIONAL UNIVERSITY ,  BECKER, David, A.

Inventor： FLORIDA INTERNATIONAL UNIVERSITY

IPC: C07C251/14

CPC classification number: C07C291/02 ,  C07C291/04 ,  C07C2602/30

Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be colorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g., structural and the like) about the original reactive free radical species.

Abstract translation: 本发明涉及发色性硝酮自旋捕获剂，制备这些试剂的方法，包含它们的组合物及其使用方法。 特别地，本发明的薁基硝酸盐是捕获自由基物质的有效试剂，可用作物理化学和生物体系中的有效抗氧化剂。 因此，本发明还涉及由薁基硝酮与自由基的组合形成的旋转加合物。 本发明的化合物可以容易地从可得到的起始原料制备，并进一步用于测定和许多诊断，预防和治疗应用，包括但不限于缓解，调节和抑制碳中心的负面作用 或氧中心的自由基物质和其他氧化产物。 此外，可以比色测定组合加合物，并且任选地分离和表征组合加合物以获得有关初始反应性自由基物质的有价值的信息（例如结构等）。

公开(公告)号：WO2008076903A1

公开(公告)日：2008-06-26

申请号：PCT/US2007/087614

申请日：2007-12-14

Applicant: CATACEL CORP. ,  BECKER, David, A. ,  BARTOS, Randall, J. ,  WHITTENBERGER, William, A.

Inventor： BECKER, David, A. ,  BARTOS, Randall, J. ,  WHITTENBERGER, William, A.

IPC: F28F1/40 ,  F28F1/10

CPC classification number: F23C13/00 ,  B01J10/007 ,  B01J12/007 ,  B01J19/242 ,  B01J19/244 ,  B01J19/2485 ,  B01J2219/00094 ,  B01J2219/2408 ,  B01J2219/2411 ,  B01J2219/2419 ,  B01J2219/2428 ,  B01J2219/2434 ,  B01J2219/2443 ,  B01J2219/2448 ,  F28F1/40 ,  Y10T29/49345 ,  Y10T29/49352 ,  Y10T29/49872 ,  Y10T29/49938

Abstract: A reactor including a monolith having a plurality of fins in an annular arrangement for receiving fluid flow through the reactor. The monolith is disposed within a generally cylindrical outer tube, and around a corrugated inner tube. The reactor includes a device for urging the monolith radially outward, so as to maintain contact between the monolith and the outer tube.

Abstract translation: 一种反应器，包括具有多个翅片的整料件，环形装置用于接收通过反应器的流体流动。 整体件设置在大致圆柱形的外管内，并且围绕波纹内管。 反应器包括用于将整体径向向外推动的装置，以便保持整料和外管之间的接触。

公开(公告)号：WO2008002614A2

公开(公告)日：2008-01-03

申请号：PCT/US2007/014921

申请日：2007-06-27

Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES ,  BECKER, David, A. ,  KOLHE, Amolkumar

Inventor： BECKER, David, A. ,  KOLHE, Amolkumar

CPC classification number: C07D221/04 ,  C07D311/94 ,  C07D401/06 ,  C07D417/12

Abstract: Disclosed herein are pseudoazulenyl nitrone compounds and methods of using these compounds to trap free radicals and to treat, prevent, or ameliorate various diseases associated with free radicals.

Abstract translation: 本文公开的是假薁基硝酮化合物和使用这些化合物捕获自由基并治疗，预防或改善与自由基相关的各种疾病的方法。