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1.发明申请THERAPEUTIC POLYMERIC NANOPARTICLE COMPOSITIONS WITH HIGH GLASS TRANSITION TEMPERATURE OR HIGH MOLECULAR WEIGHT COPOLYMERS 审中-公开具有高玻璃化转变温度或高分子量共聚物的治疗性聚合纳米微粒组合物
公开(公告)号：WO2011084513A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060564
申请日：2010-12-15
Applicant: BIND BIOSCIENCES, INC. , ALI, Mir, Mukkaram , SABNIS, Abhimanyu , DEWITT, David , TROIANO, Greg , WRIGHT, James , FIGUEIREDO, Maria , FIGA, Michael , VAN GEEN HOVEN, Tina , SONG, Young-Ho , AUER, Jason , CAMPBELL, Tarikh, Christopher
Inventor： ALI, Mir, Mukkaram , SABNIS, Abhimanyu , DEWITT, David , TROIANO, Greg , WRIGHT, James , FIGUEIREDO, Maria , FIGA, Michael , VAN GEEN HOVEN, Tina , SONG, Young-Ho , AUER, Jason , CAMPBELL, Tarikh, Christopher
CPC classification number: G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
Abstract: The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
Abstract translation: 本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米粒子的药物组合物。 本发明的其他方面包括制造这种纳米颗粒的方法。
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2.发明申请LONG CIRCULATING NANOPARTICLES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS 审中-公开用于持续释放治疗药物的长期循环纳米颗粒
公开(公告)号：WO2010075072A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/068028
申请日：2009-12-15
Applicant: BIND BIOSCIENCES , ZALE, Stephen, E. , TROIANO, Greg , ALI, Mir, Mukkaram , HRKACH, Jeff , WRIGHT, James , LOW, Susan
Inventor： ZALE, Stephen, E. , TROIANO, Greg , ALI, Mir, Mukkaram , HRKACH, Jeff , WRIGHT, James , LOW, Susan
CPC classification number: A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
Abstract: The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
Abstract translation: 本公开部分地涉及包含多个非胶体长循环纳米颗粒的生物相容性纳米颗粒组合物，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。
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3.发明申请THERAPEUTIC PARTICLES SUITABLE FOR PARENTERAL ADMINISTRATION AND METHODS OF MAKING AND USING SAME 审中-公开适用于肠胃外给药的治疗性颗粒及其制备和使用方法
公开(公告)号：WO2010068866A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067672
申请日：2009-12-11
Applicant: BIND BIOSCIENCES , GRAYSON, Amy , ZALE, Stephen, E. , DEWITT, David
Inventor： GRAYSON, Amy , ZALE, Stephen, E. , DEWITT, David
CPC classification number: A61K47/48346 , A61K9/0019 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/00 , A61K31/21 , A61K31/337 , A61K31/4353 , A61K47/62 , A61K47/66 , A61K47/6937 , B82Y5/00
Abstract: Disclosed herein are therapeutic compositions for treating and preventing diseases such as neointimal hyperplasia (NIH), where the compositions comprise a therapeutic particle that has a localized association with a blood vessel and a therapeutic agent, such as an anti-NIH agent. Methods of use of the therapeutic compositions are also disclosed.
Abstract translation: 本文公开用于治疗和预防诸如新内膜增生（NIH）的疾病的治疗组合物，其中所述组合物包含与血管和治疗剂具有局部结合的治疗性颗粒，例如 抗NIH剂。 还公开了治疗组合物的使用方法。
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公开(公告)号：US20130243863A1
公开(公告)日：2013-09-19
申请号：US13664133
申请日：2012-10-30
Applicant: BIND BIOSCIENCES, INC.
Inventor： Greg Troiano , Young-Ho Song , Stephen E. Zale , James Wright , Christina Van Geen Hoven
IPC: A61K9/19 , A61K31/337
CPC classification number: A61K31/337 , A61K9/0019 , A61K9/16 , A61K9/19 , A61K9/5123 , A61K9/5153 , A61K9/5161 , A61K9/5192 , A61K31/335 , A61K47/26 , A61K47/34 , A61K47/40 , C08G63/664 , Y10S977/906
Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.
Abstract translation: 本公开一般涉及包含聚合物纳米颗粒的冻干药物组合物，其在重构时具有低水平的大于10微米尺寸的颗粒。 本发明的其它方面包括制备这种纳米颗粒的方法。
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5.发明授权公开(公告)号：US08609142B2
公开(公告)日：2013-12-17
申请号：US13713553
申请日：2012-12-13
Applicant: BIND Biosciences, Inc.
Inventor： Greg Troiano , Michael Figa , Abhimanyu Sabnis
CPC classification number: A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.
Abstract translation: 本公开一般涉及制备具有约0.2至约35重量％的治疗剂的纳米颗粒的方法; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。
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Patent Agency Ranking
公开(公告)号：US20130123351A1
公开(公告)日：2013-05-16
申请号：US13716275
申请日：2012-12-17
Applicant: BIND BIOSCIENCES, INC.
Inventor： DAVID M. DEWITT
IPC: A61J3/00
CPC classification number: A61K9/1682 , A61J3/00 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/6951 , B82Y5/00 , Y10S977/773 , Y10S977/906
Abstract: This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).
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公开(公告)号：US20130251757A1
公开(公告)日：2013-09-26
申请号：US13713553
申请日：2012-12-13
Applicant: BIND BIOSCIENCES, INC.
Inventor： Gregory Troiano , Michael Figa , Abhimanyu Sabnis
IPC: A61K9/14 , A61K31/704 , A61K31/4355 , A61K31/7068 , A61K31/337 , A61K31/437
CPC classification number: A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.
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8.发明申请公开(公告)号：US20130115192A1
公开(公告)日：2013-05-09
申请号：US13667299
申请日：2012-11-02
Applicant: BIND BIOSCIENCES, INC
Inventor： Mir M. ALI , Jeff HRKACH , Stephen E. ZALE , Luis ALVAREZ DE CIENFUEGOS
IPC: A61K47/34
CPC classification number: A61K47/34 , A61K9/5153 , A61K47/60 , A61K47/6911
Abstract: This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling to” that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonal” chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.
Abstract translation: 本申请提供纳米颗粒和使用预官能化聚（乙二醇）（也称为PEG）作为二嵌段共聚物合成的大分子引发剂制备纳米颗粒的方法。 开环聚合产生用于赋予治疗性纳米颗粒靶向能力的所需聚（酯） - 聚（乙二醇） - 靶向剂聚合物。 这种“聚合”方法通常使用靶向剂的前体，其中靶向剂的官能团的反应性使用保护基掩蔽。 还描述了使用聚（乙二醇） - 靶向剂缀合物的“偶联”，其中靶向剂保持其天然未保护形式。 该方法使用对正常感兴趣的靶向剂中通常发现的官能团没有交叉反应性的“正交”化学。
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公开(公告)号：US09358215B2
公开(公告)日：2016-06-07
申请号：US14499599
申请日：2014-09-29
Applicant: BIND BIOSCIENCES, INC.
Inventor： David M. Dewitt
IPC: A61K9/51 , A61K47/48 , B82Y5/00 , A61J3/00 , A61K31/337
CPC classification number: A61K9/1682 , A61J3/00 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/6951 , B82Y5/00 , Y10S977/773 , Y10S977/906
Abstract: This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).
Abstract translation: 该应用提供了制造使用包含孔（例如，96孔板）的板的纳米颗粒的高通量方法。
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公开(公告)号：US20150018412A1
公开(公告)日：2015-01-15
申请号：US14499599
申请日：2014-09-29
Applicant: BIND BIOSCIENCES, INC.
Inventor： DAVID M. DEWITT
IPC: A61K9/51 , A61K31/337
CPC classification number: A61K9/1682 , A61J3/00 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/6951 , B82Y5/00 , Y10S977/773 , Y10S977/906
Abstract: This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).
Abstract translation: 该应用提供了制造使用包含孔（例如96孔板）的板的纳米颗粒的高通量方法。
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