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    BIODEGRADABLE FLEXOGRAPHIC INK
    1.
    发明申请
    BIODEGRADABLE FLEXOGRAPHIC INK 审中-公开
    可生物降解的柔性墨水

    公开(公告)号：WO2003062334A1

    公开(公告)日：2003-07-31

    申请号：PCT/CA2003/000088

    申请日：2003-01-23

    Applicant: BIOMATERA INC. ,  MASARO, Laurent ,  LAPOINTE, Patrick ,  JACQUES-GAYET, Jean-Charles

    Inventor： MASARO, Laurent ,  LAPOINTE, Patrick ,  JACQUES-GAYET, Jean-Charles

    IPC: C09D11/10

    CPC classification number: C09D11/102 ,  C09D11/08

    Abstract: The present invention relates to a flexographic water based ink in which a biodegradable polymer, such a polyhydroxyalkanoate (PHA), replaces conventional poorly or non-biodegradable organic polymeric resins for example. PHAs are used as a latex suspension in water, thus the present invention relates to a novel pigment/latex mixture. PHA in a latex form is a fluid vehicle in which all the other components necessary to provide a flexographic ink are added, i.e., pigments, wax and/or binder, as well as a solvent, if necessary. The PHAs are mainly responsible for the biodegradability of the flexographic water based ink. The present invention relates also a method to produce a flexographic water based composition with enhanced biodegradability properties.

    Abstract translation: 本发明涉及柔性水性油墨，其中可生物降解的聚合物，例如聚羟基链烷酸酯（PHA））代替例如常规的不良或不可生物降解的有机聚合物树脂。 PHA用作水中的胶乳悬浮液，因此本发明涉及新型颜料/胶乳混合物。 胶乳形式的PHA是流体载体，其中如果需要，添加所需的所有其它提供柔性油墨的组分，即颜料，蜡和/或粘合剂以及溶剂。 PHA主要负责柔性水性油墨的生物降解性。 本发明还涉及生产具有增强的生物降解性能的柔性水性组合物的方法。

    METHOD FOR PREPARING GELS
    2.
    发明申请
    METHOD FOR PREPARING GELS 审中-公开
    制备凝胶的方法

    公开(公告)号：WO2003042300A1

    公开(公告)日：2003-05-22

    申请号：PCT/CA2002/001745

    申请日：2002-11-14

    Applicant: BIOMATERA INC. ,  MASARO, Laurent ,  LAPOINTE, Patrick ,  JACQUES-GAYET, Jean-Charles

    Inventor： MASARO, Laurent ,  LAPOINTE, Patrick ,  JACQUES-GAYET, Jean-Charles

    IPC: C08L67/04

    CPC classification number: C08J3/075 ,  A61K9/06 ,  A61K47/34 ,  C08J2367/04 ,  C08L67/04 ,  C08L71/02 ,  C08L2201/52 ,  Y10S514/944 ,  C08L71/00 ,  C08L2666/14

    Abstract: The formation of a cream and gel is described using a biopolymer, such as a polyhydroxyalkanoate (PHA), a polylactide (PLA), a polylactideglycolide (PLGA) and a polyglycoside (PGA), or a derivative thereof, in a latex form with the addition of a binder, which is generally an amphiphilic chemical entity. An hydrophobic domain of the amphiphilic chemical entity interacts with at least one biopolymer forming a water soluble complex, while the hydrophilic domain of the amphiphilic chemical entity maintains the soluble complex in suspension in an aqueous solution, which after proper heating becomes a gel or a cream. As a result, a versatile gel or cream is created with different compositions and textures that are obtained based on the nature of the binder used and the ratio of biopolymers and binder(s).

    Abstract translation: 使用乳液形式的生物聚合物如聚羟基链烷酸酯（PHA），聚丙交酯（PLA），聚丙交酯聚乙交酯（PLGA）和聚糖苷（PGA）或其衍生物）来描述乳膏和凝胶的形成，其中 添加通常是两亲化学实体的粘合剂。 两亲化学实体的疏水结构域与形成水溶性络合物的至少一种生物聚合物相互作用，而两亲性化学实体的亲水结构域将可溶性络合物保持在水溶液中，该水溶液在适当加热后成为凝胶或奶油 。 结果，产生了基于所使用的粘合剂的性质和生物聚合物和粘合剂的比例而获得的具有不同组成和结构的多功能凝胶或乳膏。

    METHOD FOR CONTROLLING MOLECULAR WEIGHT AND DISTRIBUTION OF BIOPOLYMERS
    3.
    发明申请
    METHOD FOR CONTROLLING MOLECULAR WEIGHT AND DISTRIBUTION OF BIOPOLYMERS 审中-公开
    用于控制分子量和生物聚合物分布的方法

    公开(公告)号：WO2004067756A1

    公开(公告)日：2004-08-12

    申请号：PCT/CA2004/000132

    申请日：2004-01-29

    Applicant: BIOMATERA INC. ,  MASARO, Laurent ,  LAPOINTE, Patrick ,  GAYET, Jean-Charles, Jacques

    Inventor： MASARO, Laurent ,  LAPOINTE, Patrick ,  GAYET, Jean-Charles, Jacques

    IPC: C12P7/62

    CPC classification number: C08G69/10 ,  C08G63/88 ,  C08G63/91 ,  C08L67/04 ,  C12P7/625 ,  C08L2666/18

    Abstract: A method has been developed for the control of both molecular weight and molecular weight distribution of polyhydroxyalkanoates (PHAs) produced by bacterial strains. The control is exerted once the biopolymer has been accumulated intracellularly through a fermentation process by a chemical, enzymatic or irradiation treatment. More particularly, the control of both molecular weight and molecular weight dispersity is achieved by keeping the biopolymer in its native state during the whole process. This implies that no or little or no crystallization has occurred. In another embodiment, the decrease of the molecular weight can be achieved during the extraction and purification process.

    Abstract translation: 已经开发了用于控制由细菌菌株产生的聚羟基链烷酸酯（PHA）的分子量和分子量分布的方法。 一旦生物聚合物通过化学，酶促或辐射处理的发酵过程在细胞内积累，则产生对照。 更具体地，分子量和分子量分散度的控制通过在整个过程中保持生物聚合物处于其天然状态来实现。 这意味着没有发生或很少或没有发生结晶。 在另一个实施方案中，可以在提取和纯化过程中实现分子量的降低。

    BIODEGRADABLE BONE IMPLANT
    8.
    发明申请
    BIODEGRADABLE BONE IMPLANT 审中-公开
    可生物降解的骨植入物

    公开(公告)号：WO2003070292A1

    公开(公告)日：2003-08-28

    申请号：PCT/CA2003/000227

    申请日：2003-02-19

    Applicant: BIOMATERA INC. ,  MASARO, Laurent ,  LAPOINTE, Patrick

    Inventor： MASARO, Laurent ,  LAPOINTE, Patrick

    IPC: A61L27/58

    CPC classification number: A61L27/58 ,  A61L24/0042 ,  A61L24/043 ,  A61L27/26 ,  A61L2430/02 ,  C08L67/04 ,  C08L71/02

    Abstract: The present invention provides a method for making biodegradable and bioresorbable biomaterials that are also characterized by its malleability. Any desired shape can be obtained from this material, resulting from the specific composition of this invention. Therefore, the biomaterial of the present invention is very well suited to be used as in preparation of implants for dental applications, or as in the case of difficult accessible sites such as bone cavities. Composition of the biomaterial comprises an hydrophobic biopolymer, a compound having both hydrophilic and hydrophobic properties, bone regenerative entity that help in the bone regeneration. In addition, these biomaterials can be used as vehicle for the release of biologically active entities or drugs, such as growth factors or analgesics for example.

    Abstract translation: 本发明提供了一种制造可生物降解和生物可吸收的生物材料的方法，其特征还在于其可塑性。 根据本发明的具体组成可以从该材料获得任何所需的形状。 因此，本发明的生物材料非常适合用于在牙科应用的植入物的制备中，或者在诸如骨腔的困难可及位点的情况下使用。 生物材料的组成包括疏水生物聚合物，具有亲水和疏水性质的化合物，有助于骨再生的骨再生实体。 此外，这些生物材料可以用作释放生物活性物质或药物的载体，例如生长因子或止痛剂。

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