公开(公告)号：US10124078B2

公开(公告)日：2018-11-13

申请号：US15797816

申请日：2017-10-30

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  ALZECA BIOSCIENCES, LLC

Inventor： Ananth V. Annapragada ,  Jason L. Eriksen ,  Eric A. Tanifum ,  Indrani Dasgupta ,  Stephen C. Cook

IPC: A61K9/127 ,  A61K49/18 ,  C08G65/335

Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.

公开(公告)号：US20180043039A1

公开(公告)日：2018-02-15

申请号：US15797816

申请日：2017-10-30

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  ALZECA BIOSCIENCES, LLC

Inventor： Ananth V. Annapragada ,  Jason L. Eriksen ,  Eric A. Tanifum ,  Indrani Dasgupta ,  Stephen C. Cook

IPC: A61K49/18 ,  C08G65/335 ,  A61K9/127

CPC classification number: A61K49/1812 ,  A61K9/1273 ,  A61K47/6911 ,  A61K49/0466 ,  C08G65/3353

Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.

公开(公告)号：WO2018204913A1

公开(公告)日：2018-11-08

申请号：PCT/US2018/031370

申请日：2018-05-07

Applicant: TRACT PHARMACEUTICALS, INC. ,  BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM

Inventor： XIAN, Wa ,  MCKEON, Frank ,  VINCENT, Matthew P.

IPC: A61K35/38 ,  C12N5/07 ,  A61K38/18 ,  A61P1/00

Abstract: The present invention addresses IBD from the standpoint of mucosal stem cells cloned from defined regions of the gastrointestinal tract. In the case of pediatric Crohn's disease, for example, isolation of those stem cells according to the methods of the present invention reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.

公开(公告)号：WO2019133810A1

公开(公告)日：2019-07-04

申请号：PCT/US2018/067858

申请日：2018-12-28

Applicant: TRACT PHARMACEUTICALS, INC. ,  BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM

Inventor： XIAN, Wa ,  MCKEON, Frank ,  DULEBA, Marcin ,  VINCENT, Matthew P.

IPC: C12N5/071

CPC classification number: C12N5/068 ,  C12N2500/38 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/415 ,  C12N2501/42 ,  C12N2501/603 ,  C12N2501/727

Abstract: The present invention relates to a culture media system that is useful for the isolation and epigenetically stable propagation of normal stem cells in culture which are derived from columnar epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.

公开(公告)号：WO2012139080A3

公开(公告)日：2012-10-11

申请号：PCT/US2012/032649

申请日：2012-04-06

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  Alzeca Biosciences, LLC ,  Board Of Regents of the University of Houston System ,  Texas Children's Hospital ,  ANNAPRAGADA, Ananth ,  ERIKSEN, Jason, L. ,  TANIFUM, Eric, A. ,  DASGUPTA, Indrani ,  COOK, Stephen, C.

Inventor： ANNAPRAGADA, Ananth ,  ERIKSEN, Jason, L. ,  TANIFUM, Eric, A. ,  DASGUPTA, Indrani ,  COOK, Stephen, C.

IPC: A61K49/18

Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions comprising, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease. One such method for imaging amyloid deposits in a patient is provided, the method comprising: introducing into the patient a detectable quantity of a liposomal composition comprising a lipid-hydrophilic polymer-Formula I ligand conjugate.

公开(公告)号：EP3638267A1

公开(公告)日：2020-04-22

申请号：EP18794115.8

申请日：2018-05-07

Applicant: Tract Pharmaceuticals, Inc. ,  Board of Regents of the University of Houston System

Inventor： MCKEON, Frank ,  VINCENT, Matthew P.

IPC: A61K35/38 ,  C12N5/07 ,  A61K38/18 ,  A61P1/00

公开(公告)号：EP2694116A2

公开(公告)日：2014-02-12

申请号：EP12767275.6

申请日：2012-04-06

Applicant: Board of Regents of the University of Texas System ,  Alzeca Biosciences, Llc ,  Board of Regents of the University of Houston System ,  Texas Children's Hospital

Inventor： ANNAPRAGADA, Ananth ,  ERIKSEN, Jason, L. ,  TANIFUM, Eric, A. ,  DASGUPTA, Indrani ,  COOK, Stephen, C.

IPC: A61K49/00 ,  A61K49/04 ,  A61K49/18

CPC classification number: A61K49/1812 ,  A61K47/6911 ,  A61K49/0466

Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer- amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer' s Disease.

Abstract translation: 提供了基于脂质的纳米颗粒组合物。 组合物通常包含脂质亲水性聚合物 - 淀粉样蛋白结合配体缀合物，并且可以是脂质体组合物。 组合物，包括脂质体组合物，可用于淀粉样蛋白的成像和/或治疗。 阿尔茨海默病特征斑块沉积。

公开(公告)号：EP3366313A1

公开(公告)日：2018-08-29

申请号：EP18167725.3

申请日：2012-04-06

Applicant: Board Of Regents Of the University Of Texas System ,  Alzeca Biosciences, Llc ,  Board of Regents of the University of Houston System ,  Texas Children's Hospital

Inventor： Annapragada, Ananth ,  Eriksen, Jason, L. ,  Tanifum, Eric, A. ,  Dasgupta, Indrani ,  Cook, Stephen, C.

IPC: A61K49/18 ,  A61K49/04 ,  A61K47/69

CPC classification number: A61K49/1812 ,  A61K47/6911 ,  A61K49/0466

Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.

公开(公告)号：EP2694116B1

公开(公告)日：2018-06-13

申请号：EP12767275.6

申请日：2012-04-06

Applicant: Board of Regents of the University of Texas System ,  Alzeca Biosciences, Llc ,  Board of Regents of the University of Houston System ,  Texas Children's Hospital

Inventor： ANNAPRAGADA, Ananth ,  ERIKSEN, Jason, L. ,  TANIFUM, Eric, A. ,  DASGUPTA, Indrani ,  COOK, Stephen, C.

IPC: A61K49/18 ,  A61K49/04 ,  A61K47/69

CPC classification number: A61K49/1812 ,  A61K47/6911 ,  A61K49/0466

Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.