公开(公告)号：WO2004099253A1

公开(公告)日：2004-11-18

申请号：PCT/EP2004/005092

申请日：2004-05-12

Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  KLEMT, Volker ,  BORGYA, Anneliese ,  GALLUSSER, Andreas ,  GROL, Michael ,  HALLERMAYER, Klaus ,  SEIDEL, Christoph

Inventor： KLEMT, Volker ,  BORGYA, Anneliese ,  GALLUSSER, Andreas ,  GROL, Michael ,  HALLERMAYER, Klaus ,  SEIDEL, Christoph

IPC: C07K16/26

CPC classification number: C07K16/26 ,  A61K39/00 ,  C07K14/58 ,  C07K2317/10 ,  C07K2317/34 ,  Y10S435/975 ,  Y10S436/811

Abstract: The present invention relates to antibodies binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.

Abstract translation: 本发明涉及结合天然proBNP的抗体，特异性检测天然proBNP的方法，将天然proBNP水平与心力衰竭诊断相关联的方法，用于检测天然proBNP的试剂盒和产生杂交瘤细胞系的方法 对天然proBNP的抗体。

公开(公告)号：WO2004099252A1

公开(公告)日：2004-11-18

申请号：PCT/EP2004/005091

申请日：2004-05-12

Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LAROCHE AG ,  KLEMT, Volker ,  BORGYA, Anneliese ,  GALLUSSER, Andreas ,  GROL, Michael ,  HALLERMAYER, Klaus ,  SEIDEL, Christoph

Inventor： KLEMT, Volker ,  BORGYA, Anneliese ,  GALLUSSER, Andreas ,  GROL, Michael ,  HALLERMAYER, Klaus ,  SEIDEL, Christoph

IPC: C07K16/26

CPC classification number: C07K16/26 ,  A61K39/00 ,  C07K14/58 ,  C07K2317/10 ,  C07K2317/34 ,  Y10S435/975 ,  Y10S436/811

Abstract: The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.

Abstract translation: 本发明涉及特异性结合天然proBNP的抗体，特异性检测天然proBNP的方法，将天然proBNP水平与心力衰竭诊断相关联的方法，用于检测天然proBNP的试剂盒和杂交瘤细胞系 产生对天然proBNP的抗体。

公开(公告)号：WO0045176A3

公开(公告)日：2001-07-26

申请号：PCT/EP0000602

申请日：2000-01-27

Applicant: ROCHE DIAGNOSTICS GMBH ,  KARL JOHANN ,  LILL HELMUT ,  STAHL PETER ,  KRUEGER KERSTIN ,  BORGYA ANNELIESE ,  GALLUSSER ANDREAS

Inventor： KARL JOHANN ,  LILL HELMUT ,  STAHL PETER ,  KRUEGER KERSTIN ,  BORGYA ANNELIESE ,  GALLUSSER ANDREAS

IPC: G01N33/53 ,  C07K14/575 ,  C07K16/26 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08 ,  C12R1/91 ,  G01N20060101 ,  G01N33/68 ,  C07K14/58 ,  C07K16/18 ,  C12N15/06

CPC classification number: G01N33/6887 ,  C07K16/26 ,  C07K2317/34

Abstract: The invention relates to a method of identifying N-terminal proBNP in a sample with at least two antibodies that detect different epitopes of the N-terminal proBNP. The method is used to differentiate or classify samples of healthy individuals and samples of patients of NYHA classes I to I. The invention further relates to recombinant N-terminal proBNP, its use as standard in a method of identifying N-terminal proBNP, to antibodies that detect recombinant N-terminal proBNP and to their production.

Abstract translation: 本发明涉及一种用于检测N-端proBNP的样品中与识别N末端proBNP的不同表位的至少两种抗体的方法。 该方法可用于区分或从NYHA类I至IV的患者划分来自健康受试者的样品和样品。 本发明还包括重组N-端proBNP的，承认其用作用于检测N-端proBNP的方法的标准，和抗体的重组N末端proBNP水平，以及它们的制备有关。

公开(公告)号：WO1994015217A1

公开(公告)日：1994-07-07

申请号：PCT/EP1993003661

申请日：1993-12-22

Applicant: BOEHRINGER MANNHEIM GMBH ,  LILL, Helmut ,  DONIÉ, Frédéric ,  BORGYA, Anneliese ,  SEIDEL, Christoph

Inventor： BOEHRINGER MANNHEIM GMBH

IPC: G01N33/68

CPC classification number: C07K14/4716 ,  C07K16/18

Abstract: In a process for the immunological detection of heart muscle necroses a blood sample is allowed to react with at least one antibody which recognizes the N-terminal peptide of cardiac troponine I and can be obtained by immunization with an immunogene containing the amino acid sequence SEQ ID NO 1 or partial sequences thereof at least 6 amino acids in length, the polyclonal or monoclonal antibody being extracted by known methods from the serum or from the immortalized and cloned spleen cells of the immunized animals. The complex which then forms is detected in the appropriate way.