公开(公告)号：JP2006201193A

公开(公告)日：2006-08-03

申请号：JP2006119422

申请日：2006-04-24

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： NGUYEN QUAN ,  SONG YONG

IPC: G01N21/64 ,  G01N33/53 ,  G01N21/78 ,  G01N33/531 ,  G01N33/543 ,  G01N33/545 ,  G01N33/552 ,  G01N33/68 ,  G01N37/00

CPC classification number: G01N33/6842 ,  G01N33/6803 ,  G01N33/6854 ,  Y10S435/973

Abstract: PROBLEM TO BE SOLVED: To provide a new means for simultaneously-detecting a plurality of modified proteins in a specimen.
SOLUTION: This is the method for simultaneously detecting a plurality of modified proteins in a sample comprises a process (a) of bringing the specimen into contact with a plurality of primary antibodies that are combinable with specific target proteins, under mild protein denatured conditions, a process (b) of removing unattached matter from conformation of the primary antibodies or a process (c) of bringing one or a plurality of secondary antibodies into contact with the matter from the process (b), and a process (d) of detecting and/or determining the multiple modified proteins in the specimen.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供同时检测样品中多种修饰蛋白质的新方法。 解决方案：这是同时检测样品中多种修饰蛋白质的方法，包括使样品与可与特定靶蛋白组合的多种一级抗体与轻度蛋白质变性接触的方法（a） 条件，将未附着物质从一抗构象中除去的方法（b）或使一种或多种第二抗体与方法（b）接触的方法（c）和方法（d） 检测和/或确定样品中的多个修饰的蛋白质。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2005172838A

公开(公告)日：2005-06-30

申请号：JP2004374257

申请日：2004-12-24

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： WATKINS MICHAEL I ,  CHANG SUKNAN S ,  DEL ROSARIO RENATO B ,  KNIGHT TIMOTHY DARREN ,  MIRANDA PATRICIA A

IPC: G01N33/53 ,  G01N15/00 ,  G01N15/14 ,  G01N33/543 ,  G01N33/78

CPC classification number: G01N33/78 ,  G01N15/14 ,  Y10S435/973

Abstract: PROBLEM TO BE SOLVED: To provide a novel method, by which a single patient sample is analyzed, and the levels of thyrotropic hormones and anti-thyroxine are measured simultaneously.
SOLUTION: The single patient sample is subjected to an incubation process, along with a particulate mixture in a first suspension. The particulate mixture is composed of particles covered by the thyrotropic hormone and a particle covered by the anti-thyroxine, and the particles can be distinguished from each other through a flow cytometry process. The particles are recovered from the first suspension, and the recovered particles are subjected to the incubation process along with a mixture of labeled binding members in a second suspension. The mixture of the labeled binding members is composed of labeled anti-thyrotropic hormone and a labeled analog, toward which the anti-thyroxine has immunological affinity and in which the immunological affinity is less than that of the anti-thyroxine toward thyroxine.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供分析单个患者样品并同时测量促甲状腺激素和抗甲状腺素水平的新方法。 解决方案：将单个患者样品与第一悬浮液中的微粒混合物一起进行孵育过程。 颗粒状混合物由被维生素激素覆盖的颗粒和被抗甲状腺素覆盖的颗粒组成，并且可以通过流式细胞术方法将颗粒彼此区分开。 从第一悬浮液回收颗粒，并将回收的颗粒与第二悬浮液中标记的结合成员的混合物一起进行温育过程。 标记的结合成员的混合物由标记的抗促甲状腺激素和标记的类似物组成，抗甲状腺素具有免疫亲合力，其免疫亲合力小于抗甲状腺素对甲状腺素的免疫亲合力。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2004163441A

公开(公告)日：2004-06-10

申请号：JP2004066394

申请日：2004-03-09

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： HEFFELFINGER DAVID M ,  VAN HORN CRAIG

IPC: G01N21/63 ,  G01N27/447 ,  G01N37/00

CPC classification number: G01N27/44721 ,  G01N27/44726

Abstract: PROBLEM TO BE SOLVED: To provide an improved electrophoretic device capable of accurate quantitative fluorescence measurement. SOLUTION: This system is equipped with a platform for holding electrophoretic gel, a light source 1003 for illuminating the electrophoretic gel, a lens assembly 1023 for imaging radiation from a labeled region of the electrophoretic gel on a detector 1025. a calibration standard 1027 for showing uniform radiation, and a movable stage having at least a first position and a second position, and connected to the calibration standard 1027 so that concerning a stage on the first position, the calibration standard is arranged close to an inlet aperture 1019 of the lens assembly 1023, and that concerning a stage on the second position, the calibration standard 1027 is arranged out of the inlet aperture 1019 of the lens assembly 1023. COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供能够进行准确的定量荧光测量的改进的电泳装置。 解决方案：该系统配备有用于保持电泳凝胶的平台，用于照射电泳凝胶的光源1003，用于在检测器1025上对来自电泳凝胶的标记区域的辐射进行成像的透镜组件1023。校准标准 1027，用于显示均匀的辐射，以及可移动台，具有至少第一位置和第二位置，并且连接到校准标准1027，使得与第一位置的台相关，校准标准被布置在靠近入口孔1019的位置 透镜组件1023，以及关于第二位置的台阶，校准标准1027布置在透镜组件1023的入口孔1019之外。版权所有（C）2004，JPO

公开(公告)号：JP2013055939A

公开(公告)日：2013-03-28

申请号：JP2012222399

申请日：2012-10-04

Applicant: Bio-Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ インコーポレーティッド

Inventor： PFEIFFER INDRIATI ,  HOEOEK FREDRIK

IPC: C12N15/09 ,  C07H21/00 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/68

CPC classification number: B01J19/0046 ,  A61K47/549 ,  A61K47/554 ,  C07H21/00

Abstract: PROBLEM TO BE SOLVED: To provide oligonucleotide structures that are capable of forming more stable bonds to a lipid membrane and thereby generate an improved control of the process whereby oligonucleotide linkers are introduced to lipid membranes.SOLUTION: Methods for forming lipid membrane oligonucleotide attachments are provided including lipid vesicles. The oligonucleotides typically comprise at least two hydrophobic anchoring moieties capable of being attached to a lipid membrane. The moieties may be attached at the terminal ends of an oligonucleotide or, in the case of a first and second strand forming a duplex, at the same terminal end one of the strands other end not being part of the duplex leaving it free to hybridize to additional strands. The lipid vesicles attached with the oligonucleotide can be used in biosensors and may contain membrane proteins.

Abstract translation: 要解决的问题：提供能够在脂质膜上形成更稳定的键的寡核苷酸结构，从而产生对寡核苷酸接头引入脂质膜的方法的改进控制。 提供了形成脂质膜寡核苷酸附着物的方法，包括脂质囊泡。 寡核苷酸通常包含能够连接到脂质膜上的至少两个疏水性锚定部分。 这些部分可以连接在寡核苷酸的末端，或者在第一和第二链形成双链体的情况下，在相同的末端，另一端的另一端不是双链体的一部分，使其自由与 附加股。 与寡核苷酸连接的脂质囊泡可用于生物传感器中并且可以含有膜蛋白质。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2007101559A

公开(公告)日：2007-04-19

申请号：JP2006334777

申请日：2006-12-12

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： NGUYEN QUAN ,  ZHANG AIGUO

IPC: G01N33/50 ,  G01N33/53 ,  B01J20/281 ,  G01N30/88 ,  G01N33/543 ,  G01N33/68 ,  G01N33/96

CPC classification number: G01N33/54393 ,  G01N33/6863 ,  G01N33/96 ,  G01N2496/00

Abstract: PROBLEM TO BE SOLVED: To provide a new standard diluent for use in various assays. SOLUTION: The present invention provides the standard diluents that normally includes two or more different target analytes, but that is substantially free of the two or more different target analytes, as well as kits and methods relating to the standard diluent The standard diluents provide an accurate and reliable means of calibrating the amount of a large number of target analytes in a single assay. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供用于各种测定的新标准稀释剂。 解决方案：本发明提供通常包含两种或更多种不同目标分析物但基本上不含两种或多种不同目标分析物的标准稀释剂，以及与标准稀释剂相关的试剂盒和方法。标准稀释剂 提供在单次测定中校准大量目标分析物的量的准确可靠的方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2007014953A

公开(公告)日：2007-01-25

申请号：JP2006196101

申请日：2006-07-18

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： CHU DANIEL Y M ,  RISING DONALD L ,  CEREMONY JEFF ,  BALDWIN CLIFF

IPC: B01J19/00 ,  F25B21/02 ,  B01L7/00 ,  C12M1/00 ,  G05D23/19

CPC classification number: B01L7/54 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844 ,  G05D23/1919

Abstract: PROBLEM TO BE SOLVED: To provide a device for correctly performing temperature control for a multi-vessel reaction apparatus. SOLUTION: Temperature control in a rectangular array of reaction vessels such as a thermal cycler such as is used for PCR (polymerase chain reaction) procedures is achieved by use of a temperature block 11 that is in contact with a combination of Peltier effect thermoelectric modules 14 and wire heating elements embedded along the edges of the block. The elements can be energized in such a manner as to achieve a constant temperature throughout the array or a temperature gradient. Further control over the temperature and prevention of condensation in the individual reaction vessels is achieved by the use of a glass (or other transparent material) plate positioned above the vessels, with an electrically conductive coating on the upper surface of the glass plate to provide resistance heating. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于正确地进行多容器反应装置的温度控制的装置。 解决方案：使用诸如用于PCR（聚合酶链式反应）程序的热循环仪的反应容器的矩形阵列中的温度控制通过使用与珀尔帖效应的组合接触的温度块11来实现 热电模块14和沿着块的边缘嵌入的线加热元件。 这些元件可以以在整个阵列中达到恒定温度或温度梯度的方式通电。 通过使用位于容器上方的玻璃（或其他透明材料）板，在玻璃板的上表面上具有导电涂层以提供电阻来实现对各个反应容器中的温度和防止冷凝的进一步控制 加热。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2012023736A

公开(公告)日：2012-02-02

申请号：JP2011163419

申请日：2011-07-26

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： DANIEL Y CHOO ,  PAUL J PATT

IPC: H04N1/04 ,  G06T1/00

CPC classification number: G01N21/253 ,  B01L7/52 ,  G01N2201/101

Abstract: PROBLEM TO BE SOLVED: To provide a method for scanning a planar target which can dramatically reduce or eliminate vibrations of a scanning head caused by rapid reversals in direction and rapid back and forth acceleration following the reversals.SOLUTION: Translational motion of a scanning head relative to a planar target, or vice versa, is achieved by a belt and pulley system with a counterweight that is also driven by the belt and pulley system at the same speed but in the opposite direction as the scanning head. The components and the belt and pulley system are oriented such that all moving components remain on one side of the target and remain so during their entire range of movement.

Abstract translation: 要解决的问题：提供一种用于扫描平面目标的方法，其可以显着地减少或消除由于方向上的快速反转和反转之后的快速前后加速而引起的扫描头的振动。 解决方案：扫描头相对于平面目标的平移运动，反之亦然，通过皮带和皮带轮系统实现，其中配重也由皮带和滑轮系统以相同的速度驱动但是在相反的速度 方向作为扫描头。 部件和皮带轮系统被定向成使得所有移动部件保持在目标的一侧并且在其整个移动范围内保持不变。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2010000089A

公开(公告)日：2010-01-07

申请号：JP2009203587

申请日：2009-09-03

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： WANG YONG

IPC: C12N15/09 ,  C07K19/00 ,  C12N1/21 ,  C12N9/12 ,  C12P19/34 ,  C12R1/01

CPC classification number: C12N9/1276 ,  C07K14/00 ,  C07K14/001 ,  C07K19/00 ,  C07K2319/80 ,  C12N9/1252 ,  C12N9/96 ,  C12P19/34 ,  C12Y207/07007 ,  C12Y207/07049 ,  Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide improved generation of a new nucleic acid modifying enzyme. SOLUTION: The improvement is the fusion of a sequence-non-specific nucleic acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：提供改进的新型核酸修饰酶的产生。 解决方案：改进是以提高酶结合和催化修饰核酸的能力的方式将序列非特异性核酸结合结构域与酶的融合。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2006250951A

公开(公告)日：2006-09-21

申请号：JP2006139066

申请日：2006-05-18

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： PEREZ EVELIO ,  FERNWOOD GEORGE

IPC: G01N27/447

CPC classification number: G01N27/44704 ,  G01N27/44743

Abstract: PROBLEM TO BE SOLVED: To provide a method for quickly casting/molding electrophoresis slab gel in the leaktightness state, without causing damages or breakages. SOLUTION: This is the casting/molding method of slab gel in a spacer assembly equipped with a pair of plates having clearance in between, which comprises a mold installation step of installing slab gel mold in a molding machine equipped with frame and cam means, a step of installing gel formation solution in the clearance, and a step of allowing solidification of the gel formation solution into gel. In the frame, a groove is formed in two parallel edges, and the cam means rotates to an elastically-bendable barrier partitioning the groove to engage with the frame, changing width of the groove. In the mold installation step, when the cam means is at an open position, where it release the barrier to enable insertion and removal of the spacer assembly, an edge facing the spacer assembly is mounted in the groove, and then the cam means is rotated, from the open position to the clamp position for sandwiching the spacer assembly in the frame. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种在密封状态下快速浇铸/模塑电泳板状凝胶的方法，而不会造成损坏或破损。 解决方案：这是一种间隔件组件中的板坯凝胶的铸造/模制方法，该间隔件组件装备有一对间隙，其间具有间隙，其包括在安装有框架和凸轮的成型机中安装板坯模具的模具安装步骤 是指将凝胶形成溶液安装在间隙中的步骤，以及允许凝胶形成溶液凝固成凝胶的步骤。 在框架中，凹槽形成在两个平行的边缘中，并且凸轮装置旋转到分隔槽的可弹性弯曲的阻挡件以与框架接合，从而改变槽的宽度。 在模具安装步骤中，当凸轮装置处于打开位置时，其释放屏障以能够插入和移除间隔件组件，将面向间隔件组件的边缘安装在凹槽中，然后凸轮装置旋转 从打开位置到用于将间隔件组件夹在框架中的夹紧位置。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2004347613A

公开(公告)日：2004-12-09

申请号：JP2004239768

申请日：2004-08-19

Applicant: Bio Rad Lab Inc ,  バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： PEREZ EVELIO ,  FERNWOOD GEORGE

IPC: G01N27/447

CPC classification number: G01N27/44704 ,  G01N27/44743

Abstract: PROBLEM TO BE SOLVED: To achieve proper alignment and assembly of the parts in a leak-proof manner, without damaging or breaking in casting stands of many electrophoresis gels. SOLUTION: Flat plates serving as molds and enclosures for slab gels are held together by a clamping frame, in which the side edges of the plates slide into facing channels and are pinched by lever-operated cams that compress the channel walls against the plate surfaces. The joined plates are held on a vertical support rack, containing a finger-operated spring-loaded notched clamp that presses down on the plates, to seal the opening at the bottom edges of the plates against a gasket. A well-forming comb for insertion between the plates contains flexible outwardly angled fingers, to seal against the spacers between the plates. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：以防漏的方式实现零件的正确对准和组装，而不会在许多电泳凝胶的铸造机架中损坏或破裂。

解决方案：用作板坯凝胶的模具和外壳的平板通过夹紧框架保持在一起，其中板的侧边缘滑入相对的通道中并且被杠杆操纵的凸轮挤压，压缩通道壁抵抗 板表面。 接合的板被保持在垂直的支撑架上，其中包含一个手指操作的弹簧加载的切口的夹紧板，该夹钳压在板上，以将板的底部边缘处的开口密封在垫圈上。 用于在板之间插入的形成良好的梳子包含柔性的向外成角度的指状物，以密封板之间的间隔物。 版权所有（C）2005，JPO＆NCIPI