公开(公告)号：CA2377648A1

公开(公告)日：2000-12-28

申请号：CA2377648

申请日：2000-06-23

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： PARAMITHIOTIS EUSTACHE ,  LAWTON TREBOR ,  PINARD MARC ,  HAGHIGHAT ASHKAN ,  CASHMAN NEIL R ,  SLON-USAKIEWICZ JACEK

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61P25/28 ,  A61P31/00 ,  A61P43/00 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/00 ,  C07K14/47 ,  C07K14/76 ,  C07K14/765 ,  C07K14/795 ,  C07K16/00 ,  C07K16/18 ,  C07K16/44 ,  C07K19/00 ,  C12N5/10 ,  C12N9/36 ,  C12P21/08 ,  G01N33/15 ,  G01N33/53 ,  G01N33/577 ,  A61K38/06 ,  A61K39/395 ,  A61K39/40 ,  C12N5/06

Abstract: In general, the invention features antibodies specific for PrPSc and diagnostic, therapeutic, and decontamination uses thereof. The invention als o features synthetic peptides useful as immunogens for generating antibodies specific for PrPSc and therapeutic for the treatment of prion diseases.

公开(公告)号：DE60032486D1

公开(公告)日：2007-02-01

申请号：DE60032486

申请日：2000-06-23

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： CASHMAN R ,  PARAMITHIOTIS EUSTACHE ,  SLON-USAKIEWICZ JACEK ,  HAGHIGHAT ASHKAN ,  PINARD MARC ,  LAWTON TREBOR

IPC: A61K39/00 ,  G01N33/50 ,  A61K38/00 ,  A61K38/06 ,  A61K39/395 ,  A61K39/40 ,  A61K49/00 ,  A61P25/28 ,  A61P31/00 ,  A61P43/00 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/00 ,  C07K14/47 ,  C07K14/76 ,  C07K14/765 ,  C07K14/795 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/44 ,  C07K19/00 ,  C12N5/06 ,  C12N5/10 ,  C12N9/36 ,  C12P21/08 ,  G01N33/15 ,  G01N33/53 ,  G01N33/577

公开(公告)号：AU2003294165A1

公开(公告)日：2004-06-18

申请号：AU2003294165

申请日：2003-11-21

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： KEARNEY PAUL EDWARD ,  JAITLY NAVDEEP ,  ENG KEVIN

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/68 ,  G06F19/22 ,  G06G7/48 ,  G06G7/58 ,  H01J49/00

Abstract: The present invention features computer methods and systems for comparing biomolecules across biological samples. In these methods, mass spectrometry measurements are obtained on biomolecules in two or more samples. These measurements are then processed and analyzed by the methods described herein to render them more comparable. We refer to this technology as "Constellation Mapping" (CM). The resulting data, constellation maps, can be used to compare the abundance of biomolecules across samples, and, when done in real time, can be used to select differentially abundant biomolecules for subsequent LC/MS-MS.

公开(公告)号：CA2503292A1

公开(公告)日：2004-06-10

申请号：CA2503292

申请日：2003-11-21

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： ENG KEVIN ,  JAITLY NAVDEEP ,  KEARNEY PAUL EDWARD

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/68 ,  G06F19/22 ,  G06G7/48 ,  G06G7/58 ,  H01J49/00

Abstract: The present invention features computer methods and systems for comparing biomolecules across biological samples. In these methods, mass spectrometry measurements are obtained on biomolecules in two or more samples. These measurements are then processed and analyzed by the methods described herein to render them more comparable. We refer to this technology as ~Constellatio n Mapping~ (CM). The resulting data, constellation maps, can be used to compar e the abundance of biomolecules across samples, and, when done in real time, c an be used to select differentially abundant biomolecules for subsequent LC/MS- MS.

公开(公告)号：AU783484B2

公开(公告)日：2005-11-03

申请号：AU5637500

申请日：2000-06-23

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： CASHMAN NEIL R ,  PARAMITHIOTIS EUSTACHE ,  SLON-USAKIEWICZ JACEK ,  HAGHIGHAT ASHKAN ,  PINARD MARC ,  LAWTON TREBOR

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61P25/28 ,  A61P31/00 ,  A61P43/00 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/00 ,  C07K14/47 ,  C07K14/76 ,  C07K14/765 ,  C07K14/795 ,  C07K16/00 ,  C07K16/18 ,  C07K16/44 ,  C07K19/00 ,  C12N5/10 ,  C12N9/36 ,  C12P21/08 ,  G01N33/15 ,  G01N33/53 ,  G01N33/577 ,  A61K38/06 ,  A61K39/395 ,  A61K39/40 ,  C12N5/06

公开(公告)号：AU2004203724A1

公开(公告)日：2004-07-22

申请号：AU2004203724

申请日：2004-01-05

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： SWAMY SAJANI ,  JAITLY NAVDEEP ,  FURTOS-MATEL ALEXANDRA ,  KEARNEY PAUL EDWARD ,  THIBAULT PIERRE

IPC: G01N24/00 ,  G01N33/68 ,  G06F19/00 ,  H01J49/00

Abstract: The invention described herein is a tool developed for the analysis of proteomic mass spectrometry (MS) data to identify and characterize glycoproteins. The tool is designed to perform four main tasks, separately, or as needed: optimize the selection of glycopeptides for MS/MS, identify glycopeptide spectra from MS/MS data, characterize the sugar moieties of identified glycopeptide spectra, and match the glycosylated precursor to its parent protein. The design and implementation for each of these components is described in more depth in this patent application.

公开(公告)号：AU6887101A

公开(公告)日：2002-01-02

申请号：AU6887101

申请日：2001-06-12

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： CASHMAN NEIL R ,  PINARD MARC ,  LEDEBUR HARRY JR

IPC: A61K31/785 ,  A61P25/00 ,  C07K14/00 ,  C07K14/47 ,  C08G69/10 ,  A61K31/00

Abstract: The use of a pharmaceutical composition comprising a peptide copolymer of lysine and tyrosine (e.g. copaxone) in combatting prion-related diseases is described.

公开(公告)号：CA2508829A1

公开(公告)日：2004-07-22

申请号：CA2508829

申请日：2004-01-05

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： SWAMY SAJANI ,  THIBAULT PIERRE ,  KEARNEY PAUL EDWARD ,  FURTOS-MATEI ALEXANDRA ,  JAITLY NAVDEEP

IPC: G01N24/00 ,  G01N33/68 ,  G06F19/00 ,  H01J49/00 ,  G01N30/00 ,  G01N30/72

Abstract: The invention described herein is a tool developed for the analysis of proteomic mass spectrometry (MS) data to identify and characterize glycoproteins. The tool is designed to perform four main tasks, separately, or as needed: optimize the selection of glycopeptides for MS/MS, identify glycopeptide spectra from MS/MS data, characterize the sugar moieties of identified glycopeptide spectra, and match the glycosylated precursor to its parent protein. The design and implementation for each of these components i s described in more depth in this patent application.

公开(公告)号：CA2466837A1

公开(公告)日：2003-05-22

申请号：CA2466837

申请日：2002-11-13

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： KEARNEY PAUL EDWARD ,  THIBAULT PIERRE ,  HU MICHAEL ,  OSTERMANN JOACHIM BERNHARD ,  AGUILERA FRANK REINALDO MORALE ,  FAUBERT DENIS ,  BOULOS MARGUERITE ,  TSANG JOHN SHING-CHUN

IPC: G01N27/62 ,  B01J20/283 ,  G01N30/26 ,  G01N30/34 ,  G01N30/72 ,  G01N30/88 ,  G01N33/48 ,  G01N33/68 ,  G06F19/00 ,  H01J49/04

Abstract: The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are couple with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecule s from multiple biological samples.

公开(公告)号：AU2002310497A1

公开(公告)日：2003-01-08

申请号：AU2002310497

申请日：2002-06-20

Applicant: CAPRION PHARMACEUTICALS INC

Inventor： KONDEJEWSKI LES ,  QI XIAO-FEI ,  CHAKRABARTTY AVIJIT ,  CASHMAN NEIL

IPC: G01N33/68 ,  G01N21/76 ,  C12Q1/26 ,  G01N33/00 ,  G01N33/53