公开(公告)号：EP1206481A2

公开(公告)日：2002-05-22

申请号：EP00952707.8

申请日：2000-08-10

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Krasutsky, Pavel A. ,  Carlson, Robert M. ,  Nesterenko, Vitaliy V. ,  Kolomitsyn, Igor V. ,  Edwardson, Chris F.

Inventor： KRASUTSKY, Pavel, A. ,  CARLSON, Robert, M. ,  NESTERENKO, Vitaliy, V. ,  KOLOMITSYN, Igor, V. ,  EDWARDSON, Chris, F.

IPC: C07J63/00 ,  D21B1/02 ,  C08L61/06 ,  C07D301/32 ,  C07C59/10 ,  C07C51/367

CPC classification number: C07D303/38 ,  C07C29/86 ,  C07C51/367 ,  C07C51/43 ,  C07C59/01 ,  C07C59/105 ,  C07J63/008 ,  D21B1/023 ,  C07C31/10 ,  C07C31/08 ,  C07C31/04

Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.

公开(公告)号：IL174604D0

公开(公告)日：2006-08-20

申请号：IL17460406

申请日：2006-03-27

Applicant: CHEVRON USA INC ,  LIU SHENGGAO ,  DAHL JEREMY E ,  CARLSON ROBERT M

IPC: C07C35/44 ,  C07C69/00 ,  G03C1/76 ,  G03F20100101 ,  G03F7/039

Abstract: Novel positive-working photoresist compositions are disclosed. The monomers of the base resin of the resist contain diamondoid-containing pendant groups higher than adamantane in the polymantane series; for example, diamantane, triamantane, tetramantane, pentamantane, hexamantane, etc. The diamondoid-containing pendant group may have hydrophilic-enhancing substituents such as a hydroxyl group, and may contain a lactone group. Advantages of the present compositions include enhanced resolution, sensitivity, and adhesion to the substrate.

公开(公告)号：AU6535300A

公开(公告)日：2001-03-05

申请号：AU6535300

申请日：2000-08-10

Applicant: UNIV MINNESOTA ,  KRASUTSKY PAVEL A ,  CARLSON ROBERT M ,  NESTERENKO VITALIY V ,  KOLOMITSYN IGOR V ,  EDWARDSON CHRIS F

Inventor： KRASUTSKY PAVEL A ,  CARLSON ROBERT M ,  NESTERENKO VITALIY V ,  KOLOMITSYN IGOR V ,  EDWARDSON CHRIS F

IPC: C07D301/32 ,  B01D11/00 ,  C07C29/76 ,  C07C29/86 ,  C07C35/44 ,  C07C51/367 ,  C07C51/43 ,  C07C51/47 ,  C07C59/01 ,  C07C59/105 ,  C07C62/06 ,  C07D303/38 ,  C07J63/00 ,  D21B1/02

公开(公告)号：AU2002346248A1

公开(公告)日：2002-12-16

申请号：AU2002346248

申请日：2002-06-05

Applicant: UNIV MINNESOTA ,  KRASUTSKY PAVEL A ,  CARLSON ROBERT M ,  KOLOMITSYN IGOR V ,  WANG HONG

Inventor： WANG HONG ,  CARLSON ROBERT M ,  KRASUTSKY PAVEL A ,  KOLOMITSYN IGOR V

IPC: C07B39/00 ,  C07C409/00 ,  C07C409/34 ,  C07C331/00

Abstract: Methods of making compositions including fluorinated peroxides are disclosed. The compositions are useful, for example, for reacting with organic compounds. In one embodiment, novel peroxides are provided.

公开(公告)号：AU9495901A

公开(公告)日：2002-04-08

申请号：AU9495901

申请日：2001-10-01

Applicant: UNIV MINNESOTA ,  KRASUTSKY PAVEL A ,  CARLSON ROBERT M

Inventor： KRASUTSKY PAVEL A ,  CARLSON ROBERT M

IPC: A61K31/56 ,  A61K31/695 ,  A61K31/704 ,  C07J63/00

Abstract: Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.

公开(公告)号：AU5789601A

公开(公告)日：2001-07-24

申请号：AU5789601

申请日：2001-01-11

Applicant: UNIV MINNESOTA ,  KRASUTSKY PAVEL A ,  CARLSON ROBERT M ,  VITALIY V NESTERENKO

Inventor： KRASUTSKY PAVEL A ,  CARLSON ROBERT M ,  NESTERENKO VITALIY V

IPC: C07C67/29 ,  C07C45/64 ,  C07C47/46 ,  C07C51/16 ,  C07C51/235 ,  C07C51/367 ,  C07C62/06 ,  C07C62/32 ,  C07C69/00 ,  C07C69/16 ,  C07C69/013 ,  C07C67/08 ,  C07C67/03 ,  C07C67/39 ,  C07C69/732

Abstract: The present invention provides a method for preparing an ester of betulin-3-acetate including alcoholyzing betulin 3,28-dibenzoate; a method for preparing betulin-3-acetate including: (1) acylating betulin to provide betulin 3,28-dibenzoate and (2) alcoholyzing betulin 3,28-dibenzoate to provide betulin-3-acetate; and a process for preparing betulinic acid including: (1) acylating betulin to provide betulin 3,28-dibenzoate; (2) alcoholyzsis betulin 3,28-dibenzoate to provide betulin-3-acetate; (3) oxidizing betulin-3-acetate to provide betulinic aldehyde-3-acetate; (4) oxidizing betulinic aldehyde-3-acetate to provide betulinic acid-3-acetate; and (5) deprotecting betulinic acid-3-acetate to provide betulinic acid.

公开(公告)号：WO2009006178A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/068279

申请日：2008-06-26

Applicant: SUB-ONE TECHNOLOGY, INC. ,  CHEVRON U.S.A. INC. ,  TUDHOPE, Andrew, W. ,  BOARDMAN, William, J. ,  SCIAMANNA, Steven, F. ,  CASSERLY, Thomas, B. ,  CARLSON, Robert, M.

Inventor： TUDHOPE, Andrew, W. ,  BOARDMAN, William, J. ,  SCIAMANNA, Steven, F. ,  CASSERLY, Thomas, B. ,  CARLSON, Robert, M.

IPC: C23C16/00

CPC classification number: C23C16/045 ,  C23C16/26 ,  C23C16/50 ,  C23C16/503 ,  C23C16/509 ,  C23C16/52

Abstract: The invention relates to a method for forming high sp 3 content amorphous carbon coatings deposited by plasma enhanced chemical vapor deposition on internal surfaces and employing the hollow-cathode technique. This method allows adjustment of tribological properties, such as hardness, Young's modulus, wear resistance and coefficient of friction as well as optical properties, such as refractive index. In addition the resulting coatings are uniform and have high corrosion resistance. By controlling pressure, type of diamondoid precursor and bias voltage, the new method prevents the diamondoid precursor from fully breaking upon impact with the substrate. The diamondoid retains sp 3 bonds which yields a high sp 3 content film at higher pressure. This enables a faster deposition rate than would be possible without the use of a diamondoid precursor.

Abstract translation: 本发明涉及一种用于形成通过等离子体增强化学气相沉积在内表面上并采用中空阴极技术沉积的高含量无定形碳涂层的方法。 该方法允许调节摩擦学性能，例如硬度，杨氏模量，耐磨性和摩擦系数以及光学性质如折射率。 此外，所得涂层是均匀的并且具有高耐腐蚀性。 通过控制压力，类金刚石前体和偏置电压，新方法可防止金刚石类前体在与基材碰撞时完全破裂。 金刚石保留sp3键，其在较高压力下产生高的sp3含量的膜。 这使得能够在不使用金刚石前体的情况下实现比可能更快的沉积速率。

公开(公告)号：WO2008153779A1

公开(公告)日：2008-12-18

申请号：PCT/US2008/006666

申请日：2008-05-23

Applicant: CHEVRON U.S.A. INC. ,  KONG, Deyuan ,  LAM, Frederick, W. ,  SCIAMANNA, Steven, F. ,  SHELTON, Earl ,  LIU, Shenggao ,  CARLSON, Robert, M.

Inventor： KONG, Deyuan ,  LAM, Frederick, W. ,  SCIAMANNA, Steven, F. ,  SHELTON, Earl ,  LIU, Shenggao ,  CARLSON, Robert, M.

IPC: A01N37/18 ,  A61K31/165

CPC classification number: C07D209/96 ,  C07C211/19 ,  C07C2603/94 ,  C07D221/20

Abstract: This invention relates to diamondoid derivatives which exhibit therapeutic activity. Specifically, the diamondoid derivatives herein exhibit therapeutic effects in the treatment of viral disorders. Also provided are methods of treatment, prevention and inhibition of viral disorders in a subject in need.

Abstract translation: 本发明涉及显示出治疗活性的类金刚石衍生物。 具体地，本文中的类金刚石衍生物在治疗病毒性疾病中表现出治疗效果。 还提供了在需要的受试者中治疗，预防和抑制病毒性疾病的方法。

公开(公告)号：WO2008070347A3

公开(公告)日：2008-08-21

申请号：PCT/US2007082694

申请日：2007-10-26

Applicant: UNIV MINNESOTA ,  CARLSON ROBERT M ,  KRASUTSKY PAVEL A ,  KACHAROVA LILIYA

Inventor： CARLSON ROBERT M ,  KRASUTSKY PAVEL A ,  KACHAROVA LILIYA

IPC: C07K5/06 ,  A61K47/48 ,  A61P31/00 ,  A61P33/06 ,  C07J63/00

CPC classification number: C07K5/0613 ,  A61K47/542 ,  A61K47/62 ,  C07J63/008

Abstract: The present invention provides for novel compounds of formula I, II, III and IV, as described herein. The present invention also provides for novel methods of manufacturing compounds of formula I, II and III from compounds of formula IV, that include contacting the compound of formula IV and an amino acid (or peptide). The present invention also provides for methods of killing or inhibiting a virus, bacteria and/or fungus. The methods include contacting a virus, bacteria and/or fungus, respectively, with a suitable amount of a compound of formula I, II or III. The present invention also provides for a method of treating a mammal afflicted with a viral infection, bacterial infection and/or fungal infection. The method includes administering to a mammal in need of such treatment an effective amount of a compound of formula I, II or III.

Abstract translation: 本发明提供如本文所述的新颖的式I，II，III和IV化合物。 本发明还提供从式IV化合物制备式I，II和III化合物的新方法，包括使式IV化合物与氨基酸（或肽）接触。 本发明还提供杀死或抑制病毒，细菌和/或真菌的方法。 所述方法包括分别将病毒，细菌和/或真菌与合适量的式I，II或III化合物接触。 本发明还提供了治疗患有病毒感染，细菌感染和/或真菌感染的哺乳动物的方法。 该方法包括向需要这种治疗的哺乳动物施用有效量的式I，II或III化合物。

公开(公告)号：WO2005077377A1

公开(公告)日：2005-08-25

申请号：PCT/US2005/003660

申请日：2005-02-07

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  KRASUTSKY, Pavel, A. ,  KHOTKEVYCH, Andriy, B. ,  CARLSON, Robert, M.

Inventor： KRASUTSKY, Pavel, A. ,  KHOTKEVYCH, Andriy, B. ,  CARLSON, Robert, M.

IPC: A61K31/56

CPC classification number: A61K31/56 ,  A61K8/31 ,  A61K8/34 ,  A61K8/345 ,  A61K8/365 ,  A61K8/37 ,  A61K31/137 ,  A61K31/496 ,  A61K31/57 ,  A61K31/704 ,  A61K31/7048 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  A61K2300/00

Abstract: The present invention provides for compositions that includes a triterpene ( e.g., betulin) and a carrier ( e.g., lanolin). The compositions are useful for skin care ( e.g ., as cosmetic formulations), and as therapeutic formulations, e.g., for treating topical fungal infections.

Abstract translation: 本发明提供了包含三萜（例如，桦木醇）和载体（例如羊毛脂）的组合物。 该组合物可用于皮肤护理（例如，作为化妆品制剂），以及用作治疗剂型，例如用于治疗局部真菌感染。