公开(公告)号：WO1991016852A1

公开(公告)日：1991-11-14

申请号：PCT/SE1991000338

申请日：1991-05-08

Applicant: CHISCAN AB ,  ROS, Mikael ,  STRIDSBERG, Lennart

Inventor： CHISCAN AB

IPC: A61B05/055

CPC classification number: G01R33/465

Abstract: A method is proposed for detecting cancer and particularly malign tumors in a person by using the NMR spectrum of blood plasma. In a recorded spectrum the resonances are determined and for these values mathematically defineable properties are calculated such as in the simplest case the height of the resonance and the value of the width of the resonance at half height. Advantageously at least two different mathematically defineable properties are used and the corresponding values are considered as entered in a multidimensional space. In this there are defined regions of expected and not expected malignancy and if the values are located within either region the corresponding conclusion can be obtained in regard of the fact if the person has or has not cancer. If the values are located outside these regions a safe conclusion cannot be obtained. Further, as a criterion can be used the difference and/or the quotient of the values determined for some characteristic property of these resonances. As a characteristic property the peak value, the width at half height of the area can be chosen. Instead of the width at half height the value can be used which is obtained by first determining the total area of a resonance over a particular level and by dividing this area by the height of the resonance line over the underlying resonances.

Abstract translation: 提出了一种通过使用血浆的NMR光谱来检测人类癌症，特别是恶性肿瘤的方法。 在记录的频谱中，确定共振，并且对于这些值，计算数学上可定义的性质，例如在最简单的情况下，谐振的高度和在一半高度处的共振的宽度的值。 有利地，使用至少两个不同的可数学定义的属性，并将相应的值视为输入到多维空间中。 在这种情况下，存在预期和未预期的恶性肿瘤的确定区域，如果这些值位于任一区域内，则可以获得关于如果该人具有或没有癌症的事实的相应结论。 如果值位于这些区域之外，则无法获得安全的结论。 此外，作为标准，可以使用为这些谐振的一些特性所确定的值的差值和/或商。 作为特征属性，可以选择峰值，该区域的半高处的宽度。 代替半高的宽度，可以使用通过首先确定在特定水平上的共振的总面积并且通过将该面积除以基础谐振之上的谐振线的高度而获得的值。

公开(公告)号：SE9001698L

公开(公告)日：1991-11-11

申请号：SE9001698

申请日：1990-05-10

Applicant: CHISCAN AB

Inventor： ROS M

IPC: G01N24/00 ,  G01N33/50 ,  G01R33/465

公开(公告)号：SE9001698D0

公开(公告)日：1990-05-10

申请号：SE9001698

申请日：1990-05-10

Applicant: CHISCAN AB

Inventor： ROS M

IPC: G01N24/00 ,  G01N33/50 ,  G01R33/465