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    CHIP PLATFORMS FOR MICROARRAY 3D BIOPRINTING
    1.
    发明申请
    CHIP PLATFORMS FOR MICROARRAY 3D BIOPRINTING 审中-公开

    公开(公告)号：WO2018094194A1

    公开(公告)日：2018-05-24

    申请号：PCT/US2017/062266

    申请日：2017-11-17

    Applicant: CLEVELAND STATE UNIVERSITY

    Inventor： LEE, Moo-Yeal

    IPC: B01L3/00 ,  B01L9/00 ,  C12M1/36 ,  C12M1/38 ,  C12M3/00

    Abstract: A micropillar and microwell chip and methods of studying cellular environments using micropillar and microwell chips is disclosed. The micropillar chip may include at least one micropillar with a pillar-microwell. The microwell chip may include at least one microwell with an upper and a lower microwell. A perfusion channel chip that may be integrated with a micropillar chip is also disclosed. The perfusion channel chip may include a channel, a pillar- insertion hole, a membrane cassette, and a reservoir well.

    ELECTROCHEMICAL SYSTEM AND METHOD THEREOF
    3.
    发明申请
    ELECTROCHEMICAL SYSTEM AND METHOD THEREOF 审中-公开
    电化学系统及其方法

    公开(公告)号：WO2009062099A1

    公开(公告)日：2009-05-14

    申请号：PCT/US2008/082887

    申请日：2008-11-07

    Applicant: CLEVELAND STATE UNIVERSITY ,  YAU, Siu-Tung

    Inventor： YAU, Siu-Tung

    IPC: G01N27/48 ,  G01N27/49 ,  C12Q1/00 ,  C12Q1/26

    CPC classification number: C12Q1/26 ,  G01N27/3277

    Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10~ 21 M). In embodiments, the invention provides a cyclic voltammetry system comprising a working electrode, an oxidoreductase, and an electric field generator, wherein the oxidoreductase is immobilized on the working electrode; and the electric field generator generates an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by that the electrical field enhances quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.

    Abstract translation: 本发明的一个实施方案提供了一种用于检测由氧化还原酶如葡萄糖和乙醇催化的化学反应的反应物的超灵敏和选择性系统和方法，其浓度水平低至摩尔（10〜21M）。 在实施方案中，本发明提供了包含工作电极，氧化还原酶和电场发生器的循环伏安法系统，其中氧化还原酶固定在工作电极上; 并且所述电场发生器产生渗透至所述氧化还原酶和所述工作电极之间的界面的至少一部分的电场。 相信系统和方法的超灵敏性是由于电场增强了界面中的量子力学隧道效应引起的，因此促进了氧化还原酶和工作电极之间的界面电子转移。

    CONTROL OF MALIGNANT CELLS PROLIFERATION THROUGH THE INHIBITION OF CASEIN KINASE 2
    4.
    发明申请
    CONTROL OF MALIGNANT CELLS PROLIFERATION THROUGH THE INHIBITION OF CASEIN KINASE 2 审中-公开
    通过抑制CASEIN KINASE 2抑制恶性细胞的增殖

    公开(公告)号：WO2008033308A2

    公开(公告)日：2008-03-20

    申请号：PCT/US2007/019676

    申请日：2007-09-11

    Applicant: CLEVELAND STATE UNIVERSITY ,  KALAFATIS, Michael

    Inventor： KALAFATIS, Michael

    IPC: A61K31/4192

    CPC classification number: A61K31/4192

    Abstract: Methods and related compositions are disclosed for treating an array of myeloproliferative disorders and hematological malignancies. In particular, treatment methods and compositions for treating chronic myelogenous leukemia are disclosed. The methods and compositions utilize certain casein kinases, and specifically CK2α agents.

    Abstract translation: 公开了治疗一系列骨髓增生性疾病和血液恶性肿瘤的方法和相关组合物。 特别地，公开了治疗慢性骨髓性白血病的治疗方法和组合物。 方法和组合物利用某些酪蛋白激酶，特别是CK2a剂。

    METHOD FOR DETECTING MUTATED POLYNUCLEOTIDES WITHIN A LARGE POPULATION OF WILD-TYPE POLYNUCLEOTIDES
    6.
    发明申请
    METHOD FOR DETECTING MUTATED POLYNUCLEOTIDES WITHIN A LARGE POPULATION OF WILD-TYPE POLYNUCLEOTIDES 审中-公开
    在大型野生型多核苷酸群体中检测突变多核苷酸的方法

    公开(公告)号：WO2004003173A2

    公开(公告)日：2004-01-08

    申请号：PCT/US2003/020768

    申请日：2003-07-01

    Applicant: CLEVELAND STATE UNIVERSITY ,  GUO, Baochuan

    Inventor： GUO, Baochuan

    IPC: C12N

    CPC classification number: C12Q1/6858 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q2563/131 ,  C12Q2537/163 ,  C12Q2525/107 ,  C12Q2527/107

    Abstract: Methods are provided for detecting a mutant polynucleotide in mixture of mutant polynucleotides, wild-type polynucleotides and unrelated polynucleotides. The method uses an extension primer complementary to a first target sequence in both the wild-type and mutant polynucleotides. The method also uses a probe complementary to a second target sequence in the wild-type polynucleotides but not in the mutant polynucleotides. Extension of the primers annealed to the first target sequence in mutant polynucleotides produces long extension products. Extention of the primers annealed to the first target sequence in wild-type polynucleotides is blocked by the probe annealed to the second target sequence. Short extension products or no extension products are produced. The extension products are isolated and used in a polymerase chain reaction (PCR). The PCR preferentially amplifies long extension products.

    Abstract translation: 提供了用于检测突变体多核苷酸，野生型多核苷酸和不相关多核苷酸的混合物中的突变多核苷酸的方法。 该方法使用与野生型和突变体多核苷酸两者中的第一靶序列互补的延伸引物。 该方法还使用与野生型多核苷酸中的第二靶序列互补但不在突变体多核苷酸中的探针。 在突变体多核苷酸中延伸退火至第一靶序列的引物产生长延伸产物。 在野生型多核苷酸中退火到第一靶序列的引物的扩增被退火到第二靶序列的探针阻断。 生产短延伸产品或无延伸产品。 延伸产物被分离并用于聚合酶链反应（PCR）。 PCR优先扩增长延伸产物。

    ELECTROCHEMICAL SYSTEM AND METHOD THEREOF
    7.
    发明申请
    ELECTROCHEMICAL SYSTEM AND METHOD THEREOF 审中-公开
    电化学系统及其方法

    公开(公告)号：WO2014004670A2

    公开(公告)日：2014-01-03

    申请号：PCT/US2013/047888

    申请日：2013-06-26

    Applicant: CLEVELAND STATE UNIVERSITY

    Inventor： YAU, Siu-Tung

    IPC: G01N33/543

    CPC classification number: C12Q1/001 ,  G01N27/3277 ,  G01N2333/902

    Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10 -21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.

    Abstract translation: 本发明的一个实施方案提供了一种用于检测由氧化还原酶如葡萄糖和乙醇催化的化学/生物化学反应的反应物的超灵敏和选择性系统和方法，其浓度水平低至臼齿摩尔（10-21M）。 在实施方案中，本发明提供了一种包含工作电极，氧化还原酶和外部电压发生器的模拟免疫感测系统，其中氧化还原酶固定在工作电极上; 并且所述电压发生器产生电压以诱导渗透至所述氧化还原酶和所述工作电极之间的界面的至少一部分的电场。 认为系统和方法的超灵敏性是由电场引起的，这增强了界面中的量子力学隧道效应，因此促进了氧化还原酶和工作电极之间的界面电子转移。

    CONTROL OF MALIGNANT CELLS BY KINASE INHIBITION
    8.
    发明申请
    CONTROL OF MALIGNANT CELLS BY KINASE INHIBITION 审中-公开
    通过激酶抑制对恶性细胞的控制

    公开(公告)号：WO2009032213A1

    公开(公告)日：2009-03-12

    申请号：PCT/US2008/010275

    申请日：2008-08-29

    Applicant: CLEVELAND STATE UNIVERSITY ,  KALAFATIS, Michael

    Inventor： KALAFATIS, Michael

    IPC: C12N9/10 ,  C12N15/09

    CPC classification number: A61K31/00 ,  A61K31/4184 ,  A61K31/4192

    Abstract: Inhibitors of casein kinase 2 are described that have been found to arrest uncontrolled cell proliferation, thereby suggesting their use in cancer treatment strategies. Specific applications include treating breast cancer, colon cancer, melanoma, chronic myelogenous leukemia, bladder cancer, renal cancer, and brain cancer. Various methods and compositions utilizing the inhibitors are described.

    Abstract translation: 已经发现已经发现已经发现抑制不受控制的细胞增殖的酪蛋白激酶2的抑制剂，从而表明它们在癌症治疗策略中的应用。 具体应用包括治疗乳腺癌，结肠癌，黑素瘤，慢性骨髓性白血病，膀胱癌，肾癌和脑癌。 描述了利用抑制剂的各种方法和组合物。

    WIND POWERED ELECTRICITY GENERATING SYSTEM
    9.
    发明申请
    WIND POWERED ELECTRICITY GENERATING SYSTEM 审中-公开
    风力发电系统

    公开(公告)号：WO2009009344A1

    公开(公告)日：2009-01-15

    申请号：PCT/US2008/068888

    申请日：2008-07-01

    Applicant: CLEVELAND STATE UNIVERSITY ,  RASHIDI, Majid

    Inventor： RASHIDI, Majid

    IPC: F03B15/20

    CPC classification number: F03D13/20 ,  F03D1/02 ,  F03D3/002 ,  F03D3/02 ,  F03D9/25 ,  F05B2240/13 ,  F05B2240/131 ,  F05B2240/215 ,  Y02E10/74

    Abstract: An electrical energy generating system converts wind power to electrical power with a wind deflecting structure that divides wind impinging on the structure into two separate accelerated flow paths. One or more turbines are positioned in proximity to the wind deflecting structure such that a portion of the vanes of the turbine is placed within one of the accelerated flow paths. An energy converter is coupled to the turbine that converts rotary motion of the turbine into electricity.

    Abstract translation: 电能发电系统将风力转换为风力发电系统，该风力偏转​​结构将撞击在结构上的风分成两个单独的加速流动路径。 一个或多个涡轮机定位在风偏转结构附近，使得涡轮机叶片的一部分被放置在加速流动路径之一内。 能量转换器联接到涡轮机，其将涡轮机的旋转运动转换成电力。

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