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公开(公告)号：JP2014110804A
公开(公告)日：2014-06-19
申请号：JP2014037417
申请日：2014-02-27
Applicant: Cnrs-Dae , セーエヌエールエス デーアーエー , Inst Curie , アンスティテュ・キュリInstitut Curie , Universite Pierre Et Marie Curie (Paris 6) , ユニヴェルシテ ピエール エ マリー キュリー (パリ 6)
Inventor： JEAN-LOUIS VIOVY , PEYRIN JEAN-MICHEL , BERNARD BRUGG , LAURE SAIAS , PAUL GOUGIS , MAEVA VIGNES
IPC: C12M3/00 , C12N5/0793 , C12Q1/02 , G01N1/00 , G01N37/00
CPC classification number: C12M29/10 , C12M23/16 , C12M23/34 , C12M35/08 , C12N5/0619
Abstract: PROBLEM TO BE SOLVED: To provide a device for cell culture of neuronal cells.SOLUTION: A device comprises: a support defining a first microfluidic chamber intended to be seeded with a first cell culture; and at least a second microfluidic chamber, wherein a fluidic interconnection system connects the first and second microfluidic chambers and enabling cell extensions, in particular axons, to extend from one chamber to the other chamber. In the device, the interconnection system is produced so as to promote the progression of at least one first type of cell extension. The first and second types of cell extension can differ due to the microfluidic chamber from which they originate and/or due to the cell type in which they constitute the extension.
Abstract translation: 要解决的问题：提供用于神经元细胞的细胞培养的装置。解决方案：装置包括：限定要用第一细胞培养物接种的第一微流体室的支架; 和至少第二微流体腔室，其中流体互连系统连接第一和第二微流体腔室，并且使得细胞延伸部分，特别是轴突能够从一个腔室延伸到另一个腔室。 在该装置中，产生互连系统以促进至少一种第一类型的细胞延伸的进展。 第一和第二类型的细胞延伸可以由于它们起源的微流体腔和/或由于它们构成延伸的细胞类型而不同。
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公开(公告)号：CA2739771C
公开(公告)日：2016-03-29
申请号：CA2739771
申请日：2009-10-12
Applicant: CNRS DAE , INST CURIE , UNIV PIERRE ET MARIE CURIE PARIS 6
Inventor： VIOVY JEAN-LOUIS , PEYRIN JEAN-MICHEL , BRUGG BERNARD , SAIAS LAURE , GOUGIS PAUL , VIGNES MAEVA
Abstract: La présente invention concerne un dispositif de culture cellulaire, notamment de cellules neuronales, comportant : un support définissant une première chambre microfluidique destinée à être ensemencée, par une première culture cellulaire, et au moins une deuxième chambre microfluidique, un système d'interconnexion fluidique reliant les première et deuxième chambres et permettant à des extensions cellulaires, notamment dès axones, de s'étendre d'une chambre vers l'autre chambre, dispositif dans lequel le système d'interconnexion est réalisé de manière à privilégier la progression d'au moins un premier type d'extensions cellulaires par rapport à au moins un second type d'extensions cellulaires, lesdits premier et second types d'extensions cellulaires différant soit par la chambre microfluidique dont ils proviennent, soit par le type cellulaire dont ils sont l'extension.
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公开(公告)号：CA2739771A1
公开(公告)日：2010-04-15
申请号：CA2739771
申请日：2009-10-12
Applicant: CNRS DAE , INST CURIE , UNIV PARIS CURIE
Inventor： VIOVY JEAN-LOUIS , PEYRIN JEAN-MICHEL , BRUGG BERNARD , SAIAS LAURE , GOUGIS PAUL
Abstract: La présente invention concerne un dispositif de culture cellulaire, notamment de cellules neuronales, comportant : un support définissant une première chambre microfluidique destinée à être ensemencée, par une première culture cellulaire, et au moins une deuxième chambre microfluidique, un système d'interconnexion fluidique reliant les première et deuxième chambres et permettant à des extensions cellulaires, notamment dès axones, de s'étendre d'une chambre vers l'autre chambre, dispositif dans lequel le système d'interconnexion est réalisé de manière à privilégier la progression d'au moins un premier type d'extensions cellulaires par rapport à au moins un second type d'extensions cellulaires, lesdits premier et second types d'extensions cellulaires différant soit par la chambre microfluidique dont ils proviennent, soit par le type cellulaire dont ils sont l'extension.
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公开(公告)号：EP2331673B1
公开(公告)日：2020-10-28
申请号：EP09752400.3
申请日：2009-10-12
Applicant: CNRS-DAE , Institut Curie , Sorbonne Université
Inventor： VIOVY Jean-Louis , PEYRIN Jean-Michel , BRUGG Bernard , SAIAS Laure , GOUGIS Paul , VIGNES, Maeva
IPC: C12M3/00
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公开(公告)号：EP2346607A2
公开(公告)日：2011-07-27
申请号：EP09807632.6
申请日：2009-10-12
Applicant: CNRS-DAE , Institut Curie , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , Universite Paris Sud XI
Inventor： VIOVY, Jean-Louis , LE NEL, Anne
IPC: B01L3/00 , G01N33/50 , G01N33/543
CPC classification number: G01N33/54333 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0816 , B01L2300/0887 , B01L2400/043 , B03C1/01 , B03C1/288 , B03C2201/20 , B03C2201/26
Abstract: An integrated microsystem (2), comprising: a microchannel (1), a field generator (9) to create a magnetic field in at least one first portion (5) of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally comprises a detection area (7) in fluid connection with the microchannel. A method is also described in which magnetic microparticles are used to intersect with an analyte in the device.
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Patent Agency Ranking
公开(公告)号：EP2331673A2
公开(公告)日：2011-06-15
申请号：EP09752400.3
申请日：2009-10-12
Applicant: CNRS-DAE , Institut Curie , Université Pierre et Marie Curie (Paris VI)
Inventor： VIOVY Jean-Louis , PEYRIN Jean-Michel , BRUGG Bernard , SAIAS Laure , GOUGIS Paul
IPC: C12M3/00
Abstract: The present invention relates to a device for cell culture, in particular of neuronal cells, comprising: a substrate defining a first microfluidic chamber to be seeded with a first cell culture, and at least a second mircofluidic chamber, a fluidic interconnection system connecting the first and second chambers and enabling cellular extensions, in particular axons, to extend from one chamber to the other, wherein the interconnection system of said device is made so as to promote the progression of at least one first type of cellular extension, said first and second types of extension being different either due to the microfluidic chamber from which they originate, or due to the type of cell of which they constitute an extension.
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公开(公告)号：EP2350652A2
公开(公告)日：2011-08-03
申请号：EP09797159.2
申请日：2009-10-12
Applicant: CNRS-DAE , Institut Curie , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , Fluigent
Inventor： VIOVY, Jean-Louis , SAIAS, Laure
CPC classification number: G01N33/54366 , B01L3/502761 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/1822 , B01L2400/0415 , B01L2400/0424 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , C12M47/04 , G01N15/1463 , G01N33/5008 , G01N2015/1006
Abstract: An integrated microsystem, comprising: a microchannel, a field generator to create a magnetic field in at least one first portion of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally comprises a detection area in fluid connection with the microchannel,
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公开(公告)号：WO2010040920A3
公开(公告)日：2010-10-07
申请号：PCT/FR2009001198
申请日：2009-10-12
Applicant: CNRS DAE , INST CURIE , UNIV PARIS CURIE , VIOVY JEAN-LOUIS , PEYRIN JEAN-MICHEL , BRUGG BERNARD , SAIAS LAURE , GOUGIS PAUL
Inventor： VIOVY JEAN-LOUIS , PEYRIN JEAN-MICHEL , BRUGG BERNARD , SAIAS LAURE , GOUGIS PAUL
IPC: C12M3/00
CPC classification number: C12M29/10 , C12M23/16 , C12M23/34 , C12M35/08 , C12N5/0619
Abstract: The present invention relates to a device for cell culture, in particular of neuronal cells, comprising: a substrate defining a first microfluidic chamber to be seeded with a first cell culture, and at least a second mircofluidic chamber, a fluidic interconnection system connecting the first and second chambers and enabling cellular extensions, in particular axons, to extend from one chamber to the other, wherein the interconnection system of said device is made so as to promote the progression of at least one first type of cellular extension, said first and second types of extension being different either due to the microfluidic chamber from which they originate, or due to the type of cell of which they constitute an extension.
Abstract translation: 用于细胞培养的装置技术领域本发明涉及一种用于细胞培养的装置，特别是神经元细胞培养装置，其包括：基底，该基底限定用第一细胞培养物接种的第一微流体室和至少第二微流体室;流体互连系统， 和第二腔室并且使得细胞延伸部，特别是轴突能够从一个腔室延伸到另一个腔室，其中所述设备的互连系统被制造为促进至少一种第一类型的细胞延伸的进展，所述第一和第二 由于其起源的微流体腔室或由于它们构成延伸的细胞类型，延伸类型不同。
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公开(公告)号：WO2010041230A3
公开(公告)日：2010-04-15
申请号：PCT/IB2009/055206
申请日：2009-10-12
Applicant: CNRS-DAE , INSTITUT CURIE , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , UNIVERSITE PARIS SUD XI , VIOVY, Jean-Louis , LE NEL, Anne
Inventor： VIOVY, Jean-Louis , LE NEL, Anne
IPC: B01L3/00 , G01N33/50 , G01N33/543
Abstract: An integrated microsystem (2), comprising: a microchannel (1), a field generator (9) to create a magnetic field in at least one first portion (5) of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally comprises a detection area (7) in fluid connection with the microchannel. A method is also described in which magnetic microparticles are used to intersect with an analyte in the device.
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公开(公告)号：WO2010041231A9
公开(公告)日：2011-04-28
申请号：PCT/IB2009055207
申请日：2009-10-12
Applicant: CNRS DAE , INST CURIE , UNIV PARIS CURIE , FLUIGENT , VIOVY JEAN-LOUIS , SAIAS LAURE , GOULPEAU JACQUES , SALIBA ANTOINE-EMMANUAL , MALAQUIN LAURENT
Inventor： VIOVY JEAN-LOUIS , SAIAS LAURE , GOULPEAU JACQUES , SALIBA ANTOINE-EMMANUAL , MALAQUIN LAURENT
CPC classification number: G01N33/54366 , B01L3/502761 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/1822 , B01L2400/0415 , B01L2400/0424 , B01L2400/043 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , C12M47/04 , G01N15/1463 , G01N33/5008 , G01N2015/1006
Abstract: An integrated microsystem, comprising: a microchannel, a field generator to create a magnetic field in at least one first portion of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally comprises a detection area in fluid connection with the microchannel,
Abstract translation: 一种集成微系统，包括：微通道，场发生器，用于在所述微通道的至少一个第一部分中产生具有与所述微通道的所述部分中的流动方向基本共线的方向的磁场，所述磁场还呈现梯度 ，其中所述微系统还包括与所述微通道流体连接的检测区域，
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