公开(公告)号：JP2012107065A

公开(公告)日：2012-06-07

申请号：JP2012047133

申请日：2012-03-02

Applicant: Coda Therapeutics Ltd ,  コーダ セラピューティクス リミテッド

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K45/00 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K38/00 ,  A61K38/22 ,  A61K38/43 ,  A61K48/00 ,  A61P1/02 ,  A61P1/04 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/02 ,  C07K14/475 ,  C07K14/52 ,  C12N15/113

CPC classification number: A61K38/177 ,  A61K31/70 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2320/30 ,  Y02P20/582 ,  A61K2300/00

Abstract: PROBLEM TO BE SOLVED: To provide anti-connexin compounds and compositions useful for the treatment of various diseases, conditions and disorders in which modulation of connexins, hemichannels, and gap junctions would be benefit, and to provide methods for using these compounds and compositions as well as pharmaceutical formulations, kits, and medical devices.SOLUTION: There are provided methods and compositions for modulating the activity of connexins, for example, for use for the treatment of cardiovascular, vascular, neurological, wounds and other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated with diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable. In one aspect, compounds, compositions and methods for treating a subject with a vascular disorder are provided.

Abstract translation: 要解决的问题：提供用于治疗连接蛋白，半通道和间隙连接的调节将受益的各种疾病，病症和障碍的抗连接蛋白化合物和组合物，以及提供使用这些化合物的方法 和组合物以及药物制剂，试剂盒和医疗装置。 解决方案：提供了调节连接蛋白活性的方法和组合物，例如用于治疗心血管，血管，神经系统，创伤和其他适应症。 这些化合物和方法可以在治疗上使用，例如降低与直接细胞 - 细胞通信中局部破坏或预防半通道开放是有希望的疾病和病症相关的不良反应的严重性。 在一方面，提供了用于治疗患有血管疾病的受试者的化合物，组合物和方法。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：WO2006134494A3

公开(公告)日：2008-07-03

申请号：PCT/IB2006001961

申请日：2006-02-03

Applicant: CODA THERAPEUTICS LTD ,  GREEN COLIN R ,  BECKER DAVID L

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K38/08 ,  A61K31/70 ,  A61K38/10 ,  A61P9/10 ,  A61P17/02 ,  A61P29/00 ,  C12N15/11

CPC classification number: A61K38/177 ,  A61K31/70 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2320/30 ,  Y02P20/582 ,  A61K2300/00

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

Abstract translation: 提供了调节连接蛋白活性的方法和组合物，包括例如用于治疗心血管，血管，神经系统，伤口和其他适应症的治疗。 这些化合物和方法可以在治疗上使用，例如降低相关疾病和病症的不良反应的严重性，其中需要直接细胞 - 细胞通信或预防半通道开放的局部破坏。

公开(公告)号：DK1959981T3

公开(公告)日：2020-01-27

申请号：DK06795121

申请日：2006-02-03

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K31/70 ,  A61K38/17 ,  A61P17/02

公开(公告)号：AU2016203204A1

公开(公告)日：2016-06-09

申请号：AU2016203204

申请日：2016-05-17

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K38/08 ,  A61K31/70 ,  A61K38/10 ,  A61P9/10 ,  A61P17/02 ,  A61P29/00 ,  C12N15/11

Abstract: ANTI-CONNEXIN COMPOUNDS AND USES THEREOF Abstract Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

公开(公告)号：ES2766549T3

公开(公告)日：2020-06-12

申请号：ES06795121

申请日：2006-02-03

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K31/70 ,  A61K38/17 ,  A61P17/02

Abstract: Un compuesto anticonexina 43 para usar en un método de tratamiento de una herida crónica en un sujeto que comprende administrarle al sujeto de 0,1 μg a 1 gramo del compuesto anticonexina 43.

公开(公告)号：AU2011200924A1

公开(公告)日：2011-03-24

申请号：AU2011200924

申请日：2011-03-02

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K38/08 ,  A61K31/70 ,  A61K38/10 ,  A61P9/10 ,  A61P17/02 ,  A61P29/00 ,  C12N15/11

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

公开(公告)号：AU2018200149B2

公开(公告)日：2020-03-19

申请号：AU2018200149

申请日：2018-01-08

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K38/08 ,  A61K31/70 ,  A61K38/10 ,  A61P9/10 ,  A61P17/02 ,  A61P29/00 ,  C12N15/11

Abstract: ANTI-CONNEXIN COMPOUNDS AND USES THEREOF Abstract Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

公开(公告)号：AU2018200149A1

公开(公告)日：2018-02-01

申请号：AU2018200149

申请日：2018-01-08

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K38/08 ,  A61K31/70 ,  A61K38/10 ,  A61P9/10 ,  A61P17/02 ,  A61P29/00 ,  C12N15/11

Abstract: ANTI-CONNEXIN COMPOUNDS AND USES THEREOF Abstract Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

公开(公告)号：ZA200605305B

公开(公告)日：2007-04-25

申请号：ZA200605305

申请日：2006-06-27

Applicant: NZ CODA THERAPEUTICS LTD

Inventor： WILDA LAUX ,  GREEN COLIN R

IPC: A61K20090101 ,  A61P20090101 ,  C12N15/113

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

公开(公告)号：AU2006257283A1

公开(公告)日：2006-12-21

申请号：AU2006257283

申请日：2006-02-03

Applicant: CODA THERAPEUTICS LTD

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: C12N15/11

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.