公开(公告)号：JP2014169325A

公开(公告)日：2014-09-18

申请号：JP2014121150

申请日：2014-06-12

Applicant: Coda Therapeutics (Nz) Ltd ,  コーダ セラピューティクス (エヌゼット) リミテッド

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K45/00 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/713 ,  A61K38/00 ,  A61K45/06 ,  A61K48/00 ,  A61P1/04 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07K7/00 ,  C12N15/113

CPC classification number: A61K38/177 ,  A61K31/70 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2320/30 ,  Y02P20/582 ,  A61K2300/00

Abstract: PROBLEM TO BE SOLVED: To provide an anti-connexin compound and composition advantageous for regulation of connexin, hemichannel and gap junction and useful for therapy of various diseases, conditions and disorders; and a use method of these compound and composition, a pharmaceutical formulation, a kit and a medical device.SOLUTION: A method and composition for regulating connexin activity for therapy of, for example, cardiovascular, vessel, nerve, wound and other indications are provided. These compound and method can be therapeutically used to alleviate seriousness of adverse effect related to a disease and a disorder where topical destruction of direct cell-cell communication or prevention of hemichannel opening is desired. One aspect provides a compound, composition and method for therapy of a subject affected with vessel disorders.

Abstract translation: 要解决的问题：提供有利于调节连接蛋白，半通道和间隙连接的抗连接蛋白化合物和组合物，并且可用于治疗各种疾病，病症和病症; 以及这些化合物和组合物的使用方法，药物制剂，试剂盒和医疗装置。解决方案：提供了用于调节例如心血管，血管，神经，伤口和其他适应症的治疗的连接蛋白活性的方法和组合物 。 这些化合物和方法可以在治疗上用于减轻与需要局部破坏直接细胞 - 细胞通信或预防半通道开放的疾病和障碍有关的不利影响的严重性。 一方面提供用于治疗受血管障碍影响的受试者的化合物，组合物和方法。

公开(公告)号：JP2011201926A

公开(公告)日：2011-10-13

申请号：JP2011154922

申请日：2011-07-13

Applicant: Coda Therapeutics (Nz) Ltd ,  コーダ セラピューティクス (エヌゼット) リミテッド

Inventor： LAUX WILDA ,  GREEN COLIN R

IPC: A61K48/00 ,  A61K31/7105 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K38/00 ,  A61K38/22 ,  A61K38/48 ,  A61K45/00 ,  A61P17/02 ,  A61P27/02 ,  A61P27/06 ,  A61P27/10 ,  A61P27/12 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: PROBLEM TO BE SOLVED: To provide compounds (including antisense compounds) useful in tissue engineering.SOLUTION: A method and composition for modulating the activities of connexins are provided (for example, including the use in post-surgical trauma or tissue engineering application). These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable. A method for reducing tissue damage is associated with an ophthalmic procedure in a subject, comprising administering an antisense compound to the eye of the subject in conjunction with the procedure in an amount sufficient to modulate the expression of a connexin protein in the eye or in cells associated with the eye of the subject.

Abstract translation: 要解决的问题：提供可用于组织工程的化合物（包括反义化合物）。解决方案：提供调节连接蛋白活性的方法和组合物（例如，包括在手术后创伤或组织工程应用中的用途）。 这些化合物和方法可以在治疗上使用，例如，降低相关疾病和病症的不良反应的严重性，其中期望直接细胞 - 细胞通讯的局部中断。 减少组织损伤的方法与受试者的眼科手术相关，包括以足以调节眼睛或细胞中连接蛋白的蛋白质的表达量的方式向受试者的眼睛施用反义化合物 与受试者的眼睛相关联。

公开(公告)号：JP2014122248A

公开(公告)日：2014-07-03

申请号：JP2014075147

申请日：2014-04-01

Applicant: Coda Therapeutics (Nz) Ltd ,  コーダ セラピューティクス (エヌゼット) リミテッド

Inventor： LAUX WILDA ,  GREEN COLIN R

IPC: A61K48/00 ,  A61K31/7088 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P43/00 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: PROBLEM TO BE SOLVED: To provide a compound (including an antisense compound) useful for tissue engineering.SOLUTION: Provided are methods and compositions for modulating the activities of connexins (for example, for use in post-surgical trauma or tissue engineering applications). These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct-cell to cell communication is desirable. Further provided is a method for reducing tissue damage associated with an ophthalmic procedure in a subject, comprising administering an antisense compound to the eye of said subject in conjunction with said procedure in an amount sufficient to inhibit the expression of a connexin protein in the eye or in cells associated with the eye of said subject.

Abstract translation: 要解决的问题：提供可用于组织工程的化合物（包括反义化合物）。解决方案：提供用于调节连接蛋白活性的方法和组合物（例如，用于手术后创伤或组织工程应用）。 这些化合物和方法可用于治疗，例如降低相关疾病和病症的不良反应的严重性，其中期望直接细胞与细胞通讯的局部中断。 还提供了一种用于减少与受试者相关的眼科手术的组织损伤的方法，包括以足以抑制眼睛中连接蛋白表达的量与所述方法一起向所述受试者的眼睛施用反义化合物，或 在与所述受试者的眼睛相关联的细胞中。

公开(公告)号：WO2005053600A3

公开(公告)日：2005-06-16

申请号：PCT/IB2004/004431

申请日：2004-12-03

Applicant: CODA THERAPEUTICS (NZ) LTD ,  LAUX, Wilda ,  GREEN, Colin, R.

IPC: C12N15/11

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

公开(公告)号：WO2005053600A2

公开(公告)日：2005-06-16

申请号：PCT/IB2004004431

申请日：2004-12-03

Applicant: CODA THERAPEUTICS NZ LTD ,  LAUX WILDA ,  GREEN COLIN R

IPC: C12N15/113 ,  A61K

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract translation: 提供了用于调节连接蛋白活性的方法和组合物，包括例如用于手术后外伤，创伤或组织工程应用。 这些化合物和方法可以在治疗上使用，例如，降低相关疾病和病症的不良反应的严重性，其中期望直接细胞 - 细胞通讯的局部中断。

公开(公告)号：EP1699924A2

公开(公告)日：2006-09-13

申请号：EP04817632.5

申请日：2004-12-03

Applicant: Coda Therapeutics (NZ) Ltd

Inventor： LAUX, Wilda ,  GREEN, Colin, R.

IPC: C12N15/11 ,  A61K31/7088 ,  A61P25/00 ,  A61P27/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract translation: 提供了方法和组合物用于调节连接蛋白的活性，包括，例如，在手术后，外伤或组织工程应用中使用。 这些化合物和方法可用于治疗，例如，以减少相关的疾病和病症，其中在直接的细胞 - 细胞通信的本地化破坏期望的不利影响的严重性。

公开(公告)号：EP2311949A3

公开(公告)日：2012-11-21

申请号：EP10015438.4

申请日：2004-12-03

Applicant: Coda Therapeutics (NZ) Ltd

Inventor： Laux, Wilda ,  Green, Colin R.

IPC: C12N15/113 ,  A61K31/7088 ,  A61P25/00 ,  A61P27/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

公开(公告)号：EP2311949A2

公开(公告)日：2011-04-20

申请号：EP10015438.4

申请日：2004-12-03

Applicant: Coda Therapeutics (NZ) Ltd

Inventor： Laux, Wilda ,  Green, Colin R.

IPC: C12N15/113 ,  A61K31/7088 ,  A61P25/00 ,  A61P27/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract translation: 提供了方法和组合物用于调节连接蛋白的活性，包括，例如，在手术后，外伤或组织工程应用中使用。 这些化合物和方法可用于治疗，例如，以减少相关的疾病和病症，其中在直接的细胞 - 细胞通信的本地化破坏期望的不利影响的严重性。

公开(公告)号：EP2314689A3

公开(公告)日：2012-12-19

申请号：EP10015439.2

申请日：2004-12-03

Applicant: Coda Therapeutics (NZ) Ltd

Inventor： Laux, Wilda ,  Green, Colin R.

IPC: C12N15/113 ,  A61K31/7088 ,  A61P25/00 ,  A61P27/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

公开(公告)号：EP2314689A2

公开(公告)日：2011-04-27

申请号：EP10015439.2

申请日：2004-12-03

Applicant: Coda Therapeutics (NZ) Ltd

Inventor： Laux, Wilda ,  Green, Colin R.

IPC: C12N15/11 ,  A61K31/7088 ,  A61P25/00 ,  A61P27/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2320/31 ,  Y02P20/582

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract translation: 提供了方法和组合物用于调节连接蛋白的活性，包括，例如，在手术后，外伤或组织工程应用中使用。 这些化合物和方法可用于治疗，例如，以减少相关的疾病和病症，其中在直接的细胞 - 细胞通信的本地化破坏期望的不利影响的严重性。