-
公开(公告)号：WO2011002684A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/039976
申请日：2010-06-25
Applicant: TETRALOGIC PHARMACEUTICALS CORP. , CONDON, Stephen, M. , DENG, Yijun , LAPORTE, Matthew, G. , RIPPIN, Susan, R.
Inventor： CONDON, Stephen, M. , DENG, Yijun , LAPORTE, Matthew, G. , RIPPIN, Susan, R.
IPC: C07D217/00
CPC classification number: A61K38/05 , A61K31/404 , A61K31/555 , A61K38/00 , A61K38/07 , A61K45/06 , A61N5/062 , A61N5/10 , C07D403/06 , C07D403/14 , C07K5/02 , C07K5/06 , C07K5/06026 , C12N5/0693 , C12N2500/46 , Y02P20/55
Abstract: A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
Abstract translation: 一种SMAC模拟物及其药物组合物及其使用方法。
-
公开(公告)号：WO2008014229A3
公开(公告)日：2008-05-08
申请号：PCT/US2007074173
申请日：2007-07-24
Applicant: TETRALOGIC PHARMACEUTICALS COR , CONDON STEPHEN M
Inventor： CONDON STEPHEN M
Abstract: Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases.
Abstract translation: 本文提供了使用这些化合物调节凋亡的化合物，组合物和方法，包括IAP拮抗剂。 包括本发明的模拟物和任选的第二试剂的组合物可用于治疗增殖性疾病如癌症和自身免疫性疾病。
-
公开(公告)号：WO2008014238A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/074183
申请日：2007-07-24
Inventor： CONDON, Stephen, M.
IPC: C07K7/00
Abstract: Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases.
-
公开(公告)号：WO2006020060A3
公开(公告)日：2007-02-15
申请号：PCT/US2005025208
申请日：2005-07-15
Applicant: TETRALOGIC PHARM CORP , CONDON STEPHEN M , LAPORTE MATTHEW G , DENG YIJUN , RIPPIN SUSAN R
Inventor： CONDON STEPHEN M , LAPORTE MATTHEW G , DENG YIJUN , RIPPIN SUSAN R
IPC: C07D207/00 , A61K31/00 , A61P35/00
CPC classification number: C07D207/08 , A61K31/395 , C07D207/09 , C07D207/10 , C07D207/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/04 , C07D491/14 , C07D491/147 , C07D491/18 , C07D498/16 , C07K5/06026 , C07K5/06034
Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
Abstract translation: 公开了包括这些的IAP结合分子和组合物。 IAP结合分子与细胞中的IAP（凋亡蛋白的抑制剂）相互作用，并且可用于修饰用这种分子处理的细胞中的凋亡。 这些化合物的实施方案的Kd小于0.1微摩尔。 还公开了将这些IAP结合分子用于治疗，诊断和测定目的的方法。
-
5.发明申请PYRANOINDOLE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTION OR DISEASE 审中-公开吡哆醇衍生物及其用于治疗丙型肝炎病毒感染或疾病的用途
公开(公告)号：WO2005084315A3
公开(公告)日：2007-02-08
申请号：PCT/US2005006645
申请日：2005-03-01
Applicant: VIROPHARMA INC , WYETH CORP , CONDON STEPHEN M , JACKSON RANDY WILLIAM , LAPORTE MATTHEW G , BURNS CHRISTOPHER J , HERBERTZ TORSTEN , GABOURY JANET A
Inventor： CONDON STEPHEN M , JACKSON RANDY WILLIAM , LAPORTE MATTHEW G , BURNS CHRISTOPHER J , HERBERTZ TORSTEN , GABOURY JANET A
IPC: A61K31/407 , C07D491/02 , C07D491/04
CPC classification number: C07D491/04
Abstract: The invention is directed to novel pyranoindole derivatives and analogs as well as compositions containing the same and to the use thereof for the treatment, prevention or inhibition of viral infections and associated diseases caused by the Hepatitis C virus.
Abstract translation: 本发明涉及新的吡喃吲哚衍生物和类似物以及含有该吡喃并吲哚衍生物和类似物的组合物及其用于治疗，预防或抑制由丙型肝炎病毒引起的病毒感染和相关疾病的用途。
-
Patent Agency Ranking
公开(公告)号：WO2010033531A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057070
申请日：2009-09-16
Inventor： CONDON, Stephen, M. , LAPORTE, Matthew, G.
IPC: A01N43/40
CPC classification number: C07D487/04
Abstract: The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
Abstract translation: 本发明描述了化合物，其制备方法，含有它们的药物组合物以及它们在治疗中的用途。
-
公开(公告)号：WO2008014263A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074225
申请日：2007-07-24
Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION , CONDON, Stephen, M. , LAPORTE, Matthew, G. , DENG, Yijun , RIPPIN, Susan, R.
Inventor： CONDON, Stephen, M. , LAPORTE, Matthew, G. , DENG, Yijun , RIPPIN, Susan, R.
CPC classification number: C07K5/06191 , A61K38/00 , C07K5/06026 , C07K5/06034 , Y02A50/411 , Y02A50/414
Abstract: Smac mimetics that Inhibit IAPs.
Abstract translation:
Smac模拟物抑制IAPs。
-
公开(公告)号：WO2008014236A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/074181
申请日：2007-07-24
Inventor： CONDON, Stephen, M.
IPC: C07D471/04 , C07D487/04 , C07D403/12 , A61K31/407 , A61P35/00
CPC classification number: C07D471/04 , C07D403/12 , C07D487/04
Abstract: Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases.
-
公开(公告)号：WO2008014229A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074173
申请日：2007-07-24
Inventor： CONDON, Stephen, M.
Abstract: Compounds, compositions, and methods of using such compounds to modulate apoptosis including IAP antagonists are provided herein. Compositions including mimetics of the invention and, optionally, secondary agents, may be used to treat proliferative disorders such as, cancer and autoimmune diseases.
Abstract translation: 本文提供了化合物，组合物和使用这些化合物来调节凋亡的方法，包括IAP拮抗剂。 包括本发明的模拟物和任选的第二试剂的组合物可以用于治疗增殖性疾病，例如癌症和自身免疫性疾病。
-
公开(公告)号：WO2006020060A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025208
申请日：2005-07-15
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY , CONDON, Stephen, M. , LAPORTE, Matthew, G. , DENG, Yijun , RIPPIN, Susan, R.
Inventor： CONDON, Stephen, M. , LAPORTE, Matthew, G. , DENG, Yijun , RIPPIN, Susan, R.
CPC classification number: C07D207/08 , A61K31/395 , C07D207/09 , C07D207/10 , C07D207/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/04 , C07D491/14 , C07D491/147 , C07D491/18 , C07D498/16 , C07K5/06026 , C07K5/06034
Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
Abstract translation: 公开了包括这些的IAP结合分子和组合物。 IAP结合分子与细胞中的IAP（凋亡蛋白的抑制剂）相互作用，并且可用于修饰用这种分子处理的细胞中的凋亡。 这些化合物的实施方案的Kd小于0.1微摩尔。 还公开了将这些IAP结合分子用于治疗，诊断和测定目的的方法。
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.04 seconds)
