公开(公告)号：WO2003013345A3

公开(公告)日：2003-02-20

申请号：PCT/US2002/025366

申请日：2002-08-08

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

Inventor： RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

IPC: A61B6/00

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window (100) is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window (100) effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window (100) is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window (100) will again form an interface between the spectrometer and the same location of skin as before.

公开(公告)号：WO2003005894A1

公开(公告)日：2003-01-23

申请号：PCT/US2002/021888

申请日：2002-07-09

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  CORTELLA, Julian, M. ,  MUNROW, Mike ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  HARTSTEIN, Philip, C. ,  HERRERA, Roger, O. ,  RULE, Peter

Inventor： BRAIG, James, R. ,  CORTELLA, Julian, M. ,  MUNROW, Mike ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  HARTSTEIN, Philip, C. ,  HERRERA, Roger, O. ,  RULE, Peter

IPC: A61B5/00

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0233

Abstract: In accordance with one embodiment there is provided a method of providing a known spectrum to a noninvasive optical detection system of the type having a window for receiving infrared energy. The method comprises affixing a standard to the window. The standard comprises a body formed from a material having known and stable spectral properties. The method further comprises placing at least a portion of the body directly against the window, and operating the optical detection system to detect an emission spectrum of the body. In accordance with another embodiment an infrared spectrometer comprises a window for receiving infrared energy. The window has an exposed surface. The infrared spectrometer further comprises a standard comprising a body formed of a material having known and stable spectral properties. At least part of the body is removably disposed directly against the exposed surface of the window.

Abstract translation: 根据一个实施例，提供了一种向具有用于接收红外能量的窗口的类型的无创光学检测系统提供已知光谱的方法。 该方法包括将标准附加到窗口。 该标准包括由具有已知且稳定的光谱性质的材料形成的主体。 该方法还包括将身体的至少一部分直接放置在窗户上，并且操作光学检测系统以检测身体的发射光谱。 根据另一实施例，红外光谱仪包括用于接收红外能量的窗口。 窗户有一个暴露的表面。 红外光谱仪还包括标准，其包括由具有已知且稳定的光谱性质的材料形成的主体。 身体的至少一部分可拆卸地直接设置在窗户的暴露表面上。

公开(公告)号：WO2004043250A9

公开(公告)日：2004-07-08

申请号：PCT/US0335200

申请日：2003-11-04

Applicant: OPTISCAN BIOMEDICAL CORP ,  BRAIG JAMES R ,  HEWETT GARY E ,  MUNROW MICHAEL E ,  CORTELLA JULIAN M ,  AZIZI KAMRAZA ,  GOLDBERGER DANIEL S

Inventor： BRAIG JAMES R ,  HEWETT GARY E ,  MUNROW MICHAEL E ,  CORTELLA JULIAN M ,  AZIZI KAMRAZA ,  GOLDBERGER DANIEL S

IPC: A61B5/00 ,  G06F19/00

CPC classification number: A61B5/1495 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0271 ,  A61B2562/0295 ,  G06F19/3418 ,  G16H40/40 ,  G16H40/63 ,  Y10S707/99945

Abstract: An analyte concentration monitoring system having network-based communication features (600) which provide a link between an analyte detection system (602) and a centralized computer (604). The analyte detection system has a processor (610) that calculates analyte concentration in accordance with software (612) executable by the processor. Under certain conditions, the software (612) needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update (614) is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.

Abstract translation: 具有基于网络的通信特征（600）的分析物浓度监测系统（600）提供分析物检测系统（602）和集中式计算机（604）之间的链接。 分析物检测系统具有根据处理器可执行的软件（612）计算分析物浓度的处理器（610）。 在某些情况下，软件（612）需要更新。 因此，当分析物检测系统连接到集中式计算机时，集中式计算机确定是否需要软件更新（614）。 如果需要软件更新，那么集中式计算机可方便地将软件更新提供给分析物检测系统，而无需用户介入。

公开(公告)号：WO03013352B1

公开(公告)日：2004-01-08

申请号：PCT/US0225368

申请日：2002-08-08

Applicant: OPTISCAN BIOMEDICAL CORP ,  RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  AGOSTINO MARK D

Inventor： RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  AGOSTINO MARK D

IPC: A61B5/00

CPC classification number: A61B5/6841 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455

Abstract: A device and method are provided for use with a non-invasive optical measurement system. A site selector (100) is secured to a patient's forearm, such as by a fastening strap (112), thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. Protrusions (108, 108') and raised sections (110, 110') can facilitate the attachment. When the spectrometer must be temporarily removed from the patient's skin the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于非侵入式光学测量系统的装置和方法。 站点选择器（100）例如通过紧固带（112）固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。 突起（108,108'）和凸起部分（110,110'）可以便于附接。 当光谱仪必须临时从患者皮肤上取出时，将位置选择器固定在前臂上，以保持皮肤上一致的测量位置。 当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

公开(公告)号：WO03003915A3

公开(公告)日：2003-04-10

申请号：PCT/US0221416

申请日：2002-07-03

Applicant: OPTISCAN BIOMEDICAL ,  RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  SMITH HEIDI M ,  HERRERA ROGER O ,  WITTE KENNETH G ,  HARTSTEIN PHILIP C ,  AGOSTINO MARK D

Inventor： RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  SMITH HEIDI M ,  HERRERA ROGER O ,  WITTE KENNETH G ,  HARTSTEIN PHILIP C ,  AGOSTINO MARK D

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/1491 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6838

Abstract: A device and method for selecting and stabilizing proper sites for the measurement of the concentration of an analyte, for example glucose, within the tissue of a subject or patient are disclosed. One embodiment of the device (440) immobilizes the subject's forearm (462) and finger (460), thereby stabilizing measurement sites thereon for exposure to a noninvasive monitor which captures analyte concentration data within the subject's skin. The method involves the choice of a location on the subject's body at which to take the analyte measurement, preferably based on the amount of time that has elapsed since the last time the subject ate.

Abstract translation: 公开了用于选择和稳定用于测量受试者或患者的组织内的分析物（例如葡萄糖）的浓度的适当位点的装置和方法。 装置（440）的一个实施例使被检者的前臂（462）和手指（460）固定，由此稳定其上的测量位置，以暴露于非侵入性监测器，其捕获受试者皮肤内的分析物浓度数据。 该方法包括在受试者的身体上选择要进行分析物测量的位置，优选地基于自上次被摄体以来经过的时间量。

公开(公告)号：WO2003039362A1

公开(公告)日：2003-05-15

申请号：PCT/US2002/035707

申请日：2002-11-06

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  STERLING, Bernhard, B. ,  HARTSTEIN, Philip, C. ,  LI, Kenneth, I. ,  AGOSTINO, Mark, D. ,  KLONOFF, David, C. ,  GAFFNEY, Robert, D. ,  ZHENG, Peng ,  GABLE, Jennifer, H. ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  SHEILL, Jane, J. ,  MUNROW, Mike, A. ,  HALL, W., Dale ,  GOLDBERGER, Daniel, S. ,  FENNELL, Martin, J. ,  CORTELLA, Julian, M. ,  BRAIG, James, R. ,  RULE, Peter

Inventor： STERLING, Bernhard, B. ,  HARTSTEIN, Philip, C. ,  LI, Kenneth, I. ,  AGOSTINO, Mark, D. ,  KLONOFF, David, C. ,  GAFFNEY, Robert, D. ,  ZHENG, Peng ,  GABLE, Jennifer, H. ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  SHEILL, Jane, J. ,  MUNROW, Mike, A. ,  HALL, W., Dale ,  GOLDBERGER, Daniel, S. ,  FENNELL, Martin, J. ,  CORTELLA, Julian, M. ,  BRAIG, James, R. ,  RULE, Peter

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150213 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/157 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/35

Abstract: A reagentless whole-blood analyte detection system (200, 400, 450, 1000, 1100) that is capable of being deployed near a patient has a source (220) capable of emitting a beam of radiation that includes a spectral band. The whole-blood system (200, 400, 450, 1000, 1100) also has at least one detector (250, 1152, 1154) in an optical path of the beam. The whole-blood system (200, 400, 450, 1000, 1100) also has a housing (402, 452) that is configured to house the source (220) and the detector(s) (250, 1152, 1154). The whole-blood system (200, 400, 450, 1000, 1100) also has a sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) that is situated in the optical path of the beam. The sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) has a sample cell (242, 310, 610, 810) and a sample cell wall (244, 330, 335) that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统（200,400,450,1000,1100）具有能够发射包括光谱带的辐射束的源（220）。 全血系统（200,400,450,1000,1100）还具有在光束的光路中的至少一个检测器（250,1152,1154）。 全血系统（200,400,450,1000,1100）还具有构造成容纳源（220）和检测器（250,1152,1154）的壳体（402,452）。 全血系统（200,400,450,1000,1100）还具有位于光学系统中的样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405） 梁的路径。 样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405）具有样品池（242,310,610,810）和样品池壁（244,330,335） ），其不消除光谱带中的辐射束的透射率。

公开(公告)号：WO2003016865A3

公开(公告)日：2003-02-27

申请号：PCT/US2002/026190

申请日：2002-08-15

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  RULE, Peter ,  STERLING, Bernhard, B. ,  SMITH, Heidi, M. ,  CORTELLA, Julian, M. ,  GABLE, Jennifer, H.

Inventor： BRAIG, James, R. ,  RULE, Peter ,  STERLING, Bernhard, B. ,  SMITH, Heidi, M. ,  CORTELLA, Julian, M. ,  GABLE, Jennifer, H.

IPC: A61B5/00

Abstract: A method calibrates a monitor (100) that comprises a non-invasive blood constituent monitor (102) and a traditional measurement system (116). The non-invasive blood constituent monitor includes a thermal gradient inducing element (110) an analyzer window (108). A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system (116). A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor (102). The traditional monitor output and the non-invasive monitor output is corrected by the amount of error.

公开(公告)号：WO03013345A2

公开(公告)日：2003-02-20

申请号：PCT/US0225366

申请日：2002-08-08

Applicant: OPTISCAN BIOMEDICAL CORP ,  RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  SMITH HEIDI M ,  HERRERA ROGER O ,  WITTE KENNETH G ,  HARTSTEIN PHILIP C ,  AGOSTINO MARK D

Inventor： RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  SMITH HEIDI M ,  HERRERA ROGER O ,  WITTE KENNETH G ,  HARTSTEIN PHILIP C ,  AGOSTINO MARK D

IPC: A61B5/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/35 ,  A61B

CPC classification number: A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/6824 ,  G01J3/0286 ,  G01J3/0291 ,  G01N21/01 ,  G01N21/35 ,  G01N2021/0389 ,  G01N2201/021 ,  G01N2201/0245

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于非侵入性光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。 在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。 当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。 当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

公开(公告)号：WO2003003915A2

公开(公告)日：2003-01-16

申请号：PCT/US2002/021416

申请日：2002-07-03

Applicant: OPTISCAN BIOMEDICAL ,  RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

Inventor： RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/1491 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6838

Abstract: A device and method for selecting and stabilizing proper sites for the measurement of the concentration of an analyte, for example glucose, within the tissue of a subject or patient are disclosed. One embodiment of the device immobilizes the subject's forearm and finger, thereby stabilizing measurement sites thereon for exposure to a noninvasive monitor which captures analyte concentration data within the subject's skin. The method involves the choice of a location on the subject's body at which to take the analyte measurement, preferably based on the amount of time that has elapsed since the last time the subject ate.

Abstract translation: 公开了用于选择和稳定用于测量受试者或患者的组织内的分析物（例如葡萄糖）的浓度的适当位点的装置和方法。 该装置的一个实施例使受试者的前臂和手指固定，由此稳定其上的测量位置以暴露于非侵入性监测器，其捕获受试者皮肤内的分析物浓度数据。 该方法包括在受试者的身体上选择要进行分析物测量的位置，优选地基于自上次被摄体以来经过的时间量。

公开(公告)号：WO2004043250A1

公开(公告)日：2004-05-27

申请号：PCT/US2003/035200

申请日：2003-11-04

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  HEWETT, Gary, E. ,  MUNROW, Michael, E. ,  CORTELLA, Julian, M. ,  AZIZI, Kamraza ,  GOLDBERGER, Daniel, S.

Inventor： BRAIG, James, R. ,  HEWETT, Gary, E. ,  MUNROW, Michael, E. ,  CORTELLA, Julian, M. ,  AZIZI, Kamraza ,  GOLDBERGER, Daniel, S.

IPC: A61B5/00

CPC classification number: A61B5/1495 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0271 ,  A61B2562/0295 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/40 ,  G16H40/63 ,  Y10S707/99945

Abstract: An analyte concentration monitoring system having network-based communication features (600) which provide a link between an analyte detection system (602) and a centralized computer (604). The analyte detection system has a processor (610) that calculates analyte concentration in accordance with software (612) executable by the processor. Under certain conditions, the software (612) needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update (614) is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.

Abstract translation: 一种分析物浓度监测系统，其具有基于网络的通信特征（600），其提供分析物检测系统（602）和集中式计算机（604）之间的链接。 分析物检测系统具有根据可由处理器执行的软件（612）计算分析物浓度的处理器（610）。 在某些条件下，软件（612）需要更新。 因此，当分析物检测系统连接到集中式计算机时，集中式计算机确定是否需要软件更新（614）。 如果需要软件更新，则集中式计算机可方便地向分析物检测系统提供软件更新，而无需用户干预。