公开(公告)号：WO2007128000A3

公开(公告)日：2008-03-20

申请号：PCT/US2007067837

申请日：2007-04-30

Applicant: MEDTRONIC INC ,  NAT INST HEALTH ,  CROSS THOMAS E JR ,  WILLIAMS MICHAELENE M ,  OLSON ROBERT L ,  JAGLER ROBYN L ,  LUDLOW CHRISTY

Inventor： CROSS THOMAS E JR ,  WILLIAMS MICHAELENE M ,  OLSON ROBERT L ,  JAGLER ROBYN L ,  LUDLOW CHRISTY

IPC: A61N1/05 ,  A61N1/36 ,  H01B7/04

CPC classification number: A61N1/0558

Abstract: Implantable medical leads that are customizable and that are flexible and extensible in a controllable manner to facilitate subject body movements. In particular, implantable medical leads include the ability to be customized by selective and controllable separation of lead bodies from one another, which leads are also able to permit and withstand multiple degree of freedom of movement that are useful for use in the neck region of a subject body and other regions of any subject's body that may benefit from increased flexibility and extensibility.

Abstract translation: 可植入的医用引线是可定制的，并且以可控的方式灵活和可扩展以便于受试者的身体运动。 特别地，可植入医疗引线包括通过铅体彼此的选择性和可控的分离来定制的能力，这些引导也能够允许和承受可用于颈部区域中的多个运动自由度 受试者身体和任何受试者身体的其他区域可能受益于增加的灵活性和可扩展性。

公开(公告)号：WO2007127997A3

公开(公告)日：2008-02-28

申请号：PCT/US2007067834

申请日：2007-04-30

Applicant: MEDTRONIC INC ,  CROSS THOMAS E JR ,  WILLIAMS MICHAELENE M

Inventor： CROSS THOMAS E JR ,  WILLIAMS MICHAELENE M

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0551

Abstract: Implantable medical leads that are flexible and extensible in a controllable manner to facilitate subject body movements, able to permit and withstand multiple degree of freedom of movement that are useful for use in the neck region of a subject body and other regions of any subject's body that may benefit from increased flexibility and extensibility. Features of medical leads are utilized to permit extensibility and are based upon the provision of shaped features that controllably permit lead extension under low load, but that maintain a desired shape under no load. The shaped lead portions provide extensibility to the lead as the shapes elastically deform under load. A shaping element, such as an elongate element or a tube defines and holds the lead in the desired shape, which may comprise one or more series of sigmoid shapes as a pattern.

Abstract translation: 可植入的医疗引线，以可控制的方式灵活和可扩展，以便于受试者的身体移动，能够允许和承受可用于主体和受试者身体其他区域的颈部区域的多个运动自由度， 可能会受益于增加的灵活性和可扩展性。 医疗引线的特征被用于允许可扩展性，并且基于提供可控制地允许在低负载下引线延伸但是在无负载下保持期望形状的成形特征。 当形状在负载下弹性变形时，成形的引线部分向引线提供延展性。 诸如细长元件或管的成形元件将引线限定和保持为期望形状，其可以包括一个或多个S形作为图案。

公开(公告)号：WO2007149635A1

公开(公告)日：2007-12-27

申请号：PCT/US2007/067838

申请日：2007-04-30

Applicant: MEDTRONIC, INC. ,  NATIONAL INSTITUTE OF HEALTH ,  LUDLOW, Christy ,  KEARNEY, Pamela, Reed ,  CROSS, Thomas E., Jr. ,  JAGLER, Robyn, L. ,  OLSON, Robert, L. ,  HISSONG, James, Britton

Inventor： LUDLOW, Christy ,  KEARNEY, Pamela, Reed ,  CROSS, Thomas E., Jr. ,  JAGLER, Robyn, L. ,  OLSON, Robert, L. ,  HISSONG, James, Britton

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0551

Abstract: Implantable leads implantable in a patient, such as patient's neck. The lead includes a first lead segment and a second lead segment. The second lead segment extends from the first lead segment at a first junction point and includes first, second, and third legs each defining a longitudinal length in extension from the first junction point to a distal end. A length of the first leg is greater than a length of the second leg, and a length of the second leg is greater than a length of the third leg. With this configuration, each of the legs are adapted to support at least one electrode at the distal end thereof, and are appropriately dimensioned relative to one another for locating the corresponding electrode at a desired target tissue site in the patient's neck. Targeted tissue can include, for example, muscles of the neck.

Abstract translation: 可植入的导线植入患者，如病人的颈部。 引线包括第一引线段和第二引线段。 第二引线段在第一连接点处从第一引线段延伸并且包括第一，第二和第三引脚，每个引脚限定从第一连接点延伸到远端的纵向长度。 第一腿部的长度大于第二腿部的长度，并且第二腿部的长度大于第三腿部的长度。 利用这种构造，每个腿适于在其远端处支撑至少一个电极，并且相对于彼此适当地确定尺寸，以将相应的电极定位在患者颈部中期望的目标组织部位。 目标组织可以包括例如颈部的肌肉。

公开(公告)号：WO2006133445A3

公开(公告)日：2007-02-08

申请号：PCT/US2006022721

申请日：2006-06-09

Applicant: MEDTRONIC INC ,  ROONEY ETHAN A ,  WAHLSTRAND CARL D ,  KING GARY W ,  CROSS THOMAS E ,  STONE RICHARD T

Inventor： ROONEY ETHAN A ,  WAHLSTRAND CARL D ,  KING GARY W ,  CROSS THOMAS E ,  STONE RICHARD T

IPC: A61N1/05

CPC classification number: A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/37211

Abstract: The disclosure describes an implantable medical lead for delivering stimulation to a patient. Electrodes may be located on two or more surfaces of the lead to, for example, selectively deliver stimulation to one or more tissue layers within the patient. The lead may be implanted within or between intra-dermal, deep dermal, or subcutaneous tissue layers, and may be used to, for example, deliver peripheral nerve field stimulation to treat pain experienced by the patient at the site at which the lead is implanted. The lead may comprise a paddle lead or a multiple level lead, e.g., a lead having a plurality of flat or paddle shaped lead bodies arranged in substantially parallel planes. Further, the lead may include fixation structures on the distal end, proximal end, or both ends to prevent migration.

Abstract translation: 本公开描述了用于将刺激递送给患者的可植入医疗引线。 电极可以位于引线的两个或更多个表面上，以例如选择性地将刺激递送到患者体内的一个或多个组织层。 铅可以植入在真皮内，深层皮肤或皮下组织层之内或之间，并且可以用于例如递送周围神经区域刺激以治疗患者在植入铅的部位所经历的疼痛 。 引线可以包括桨引线或多级引线，例如具有布置在基本上平行的平面中的多个扁平或桨状引线的引线。 此外，引线可以包括远端，近端或两端的固定结构，以防止迁移。

公开(公告)号：WO2006135753A1

公开(公告)日：2006-12-21

申请号：PCT/US2006/022494

申请日：2006-06-09

Applicant: MEDTRONIC, INC. ,  ROONEY, Ethan, A. ,  KING, Gary, W. ,  CROSS, Thomas, E., Jr. ,  STONE, Richard, T.

Inventor： ROONEY, Ethan, A. ,  KING, Gary, W. ,  CROSS, Thomas, E., Jr. ,  STONE, Richard, T.

IPC: A61M25/06 ,  A61N1/05

CPC classification number: A61M25/0662 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/3756

Abstract: The disclosure describes an introducer for facilitating implantation of therapy elements into a patient. The introducer has an elongated body that defines a lumen for advancement of a therapy element to an implant site, and includes a curved portion medially located between substantially straight proximal and distal portions. As an example, the shape of the introducer may allow a clinician to more easily, and without substantially damaging surrounding tissue, find the correct tissue depth and follow that tissue depth to the implant site. For example, the introducer may facilitate implantation of a therapy element within or between desired layers of tissue of the patient. In some embodiments, fluid may be injected through the introducer to create a space within the tissue to implant the therapy element. Fluid may also be evacuated through the introducer prior to implantation.

Abstract translation: 本公开描述了一种用于促进将治疗元件植入患者体内的引导器。 导引器具有细长体，其限定用于将治疗元件推进到植入位置的内腔，并且包括中间位于基本上直的近端部分和远端部分之间的弯曲部分。 作为示例，引导器的形状可以允许临床医生更容易地并且不会对周围组织造成实质的伤害，找到正确的组织深度并且将该组织深度跟随到植入部位。 例如，导引器可以有助于将治疗元件植入患者组织的期望层之内或之间。 在一些实施例中，流体可以通过导引器注入，以在组织内产生植入治疗元件的空间。 在植入之前，流体也可以通过导引器排空。

公开(公告)号：WO2006133444A2

公开(公告)日：2006-12-14

申请号：PCT/US2006022718

申请日：2006-06-09

Applicant: MEDTRONIC INC ,  ROONEY ETHAN A ,  WAHLSTRAND CARL D ,  KING GARY W ,  CROSS THOMAS E ,  STONE RICHARD T

Inventor： ROONEY ETHAN A ,  WAHLSTRAND CARL D ,  KING GARY W ,  CROSS THOMAS E ,  STONE RICHARD T

IPC: A61N1/375 ,  A61N1/34 ,  A61N1/36

CPC classification number: A61N1/375 ,  A61N1/0504 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/3756

Abstract: An implantable medical device (IMD) with a housing and electrodes on at least two surfaces of the housing is described. The surfaces may be, for example, opposed, substantially parallel surfaces, e.g., top and bottom surfaces. Location of electrodes on multiple surfaces of the housing may allow the IMD to deliver stimulation to a variety of tissues and with a variety of current field configurations. For example, the IMD may deliver peripheral nerve field stimulation (PNFS) to one or more tissue areas via electrodes selected from one or both of the surfaces to, for example, reduce the sensation of pain in a tissue area proximate to an implantation site of the IMD without targeting a specific nerve. The IMD may be implanted between or within intra-dermal, deep dermal, or subcutaneous layers of the tissue of the patient to deliver PNFS to any one or more of these layers.

Abstract translation: 描述了在壳体的至少两个表面上具有壳体和电极的可植入医疗装置（IMD）。 表面可以是例如相对的基本上平行的表面，例如顶部和底部表面。 电极在壳体的多个表面上的位置可允许IMD将刺激递送到各种组织以及各种当前的现场配置。 例如，IMD可以通过选自一个或两个表面的电极将外周神经区域刺激（PNFS）递送到一个或多个组织区域，以例如减少接近植入部位的组织区域中的疼痛感觉 IMD没有针对特定的神经。 IMD可以植入在患者组织的真皮内，深层皮肤或皮下层之间或内，以将PNFS递送到这些层中的任何一个或多个层。

公开(公告)号：WO2007127998A3

公开(公告)日：2007-12-27

申请号：PCT/US2007067835

申请日：2007-04-30

Applicant: MEDTRONIC INC ,  CROSS THOMAS E JR ,  WILLIAMS MICHAELENE M

Inventor： CROSS THOMAS E JR ,  WILLIAMS MICHAELENE M

IPC: A61N1/05

CPC classification number: A61N1/05

Abstract: Implantable medical leads that are flexible and extensible in a controllable manner with a substantially two-dimensional profile to fit between adjacent tissue layers and to facilitate subject body movements. In particular, implantable medical leads able to permit and withstand multiple degree of freedom of movement that are useful for use in the neck region of a subject body and other regions of any subject's body that may benefit from increased flexibility and extensibility. Features of medical leads are utilized to permit extensibility and are based upon the provision of shaped features that controllably permit lead extension under low load, but that maintain a desired shape under no load. The shaped lead portions provide extensibility to the lead as the shapes elastically deform under load.

Abstract translation: 可植入的医疗导线是柔性的并且以可控的方式可扩展，具有基本上二维的轮廓以适合相邻的组织层并且便于受试者身体运动。 具体而言，可植入的医疗引线能够允许并承受多个运动自由度，这对于在受试者身体的颈部区域和任何受试者身体的其他区域中使用是有用的，这可能受益于增加的灵活性和可延展性。 医疗引线的特点被用来允许延伸性，并且基于提供可控地允许在低负载下引线延伸的成形特征，但是在空载下保持期望的形状。 随着负载下形状弹性变形，成形引线部分为引线提供可延展性。

公开(公告)号：WO2007128002A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/067840

申请日：2007-04-30

Applicant: MEDTRONIC, INC. ,  CROSS, Thomas, E., Jr. ,  WILLIAMS, Michaelene, M.

Inventor： CROSS, Thomas, E., Jr. ,  WILLIAMS, Michaelene, M.

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0551

Abstract: Implantable lead assembly including a lead body, an elongated conductor, a coiled electrode, and a tether line. The lead body maintains the conductor. The electrode is coupled to the conductor, defining proximal and distal ends. The tether line defines a trailing segment and a leading segment terminating in a leading end. The tether line is coupled to the coiled electrode at a point proximal the distal end, and the leading end extends distal the distal end. With this configuration, a pulling force applied to the leading segment is transferred to the electrode at a point proximal the distal end as a pushing force, thereby minimizing an opportunity for overt stretching of the coiled electrode during implantation. The lead assembly can further include a needle connected to the tether line.

Abstract translation: 可植入引线组件，包括引线体，细长导体，线圈电极和系绳。 导体保持导体。 电极耦合到导体，限定近端和远端。 系绳线定义了一个尾部段和一个终端在前端的前导段。 系绳线在靠近远端的点处联接到线圈电极，并且前端延伸到远端。 利用这种构造，作用在前端的拉力作为推力在靠近远端的点转移到电极，从而最小化植入期间线圈电极的明显拉伸的机会。 导线组件还可以包括连接到系绳线的针。

公开(公告)号：WO2006135751A3

公开(公告)日：2007-02-15

申请号：PCT/US2006022490

申请日：2006-06-09

Applicant: MEDTRONIC INC ,  ROONEY ETHAN A ,  WAHLSTRAND CARL D ,  KING GARY W ,  CROSS THOMAS E JR ,  HERUTH KENNETH T ,  WACNIK PAUL W ,  EVANSON JEFFREY S

Inventor： ROONEY ETHAN A ,  WAHLSTRAND CARL D ,  KING GARY W ,  CROSS THOMAS E JR ,  HERUTH KENNETH T ,  WACNIK PAUL W ,  EVANSON JEFFREY S

IPC: A61N1/34

CPC classification number: A61N1/36021 ,  A61M5/14 ,  A61M5/142 ,  A61M2205/054 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36071 ,  A61N1/37211 ,  A61N1/375

Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

Abstract translation: 描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。 与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。 包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。 此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。

公开(公告)号：WO2005102446A1

公开(公告)日：2005-11-03

申请号：PCT/US2004/041201

申请日：2004-12-10

Applicant: MEDTRONIC, INC. ,  WAHLSTRAND, Carl, D. ,  HOEGH, Thomas, Barry ,  HRDLICKA, Gregory, A. ,  CROSS, Thomas, E., Jr. ,  OLSEN, James, M.

Inventor： WAHLSTRAND, Carl, D. ,  HOEGH, Thomas, Barry ,  HRDLICKA, Gregory, A. ,  CROSS, Thomas, E., Jr. ,  OLSEN, James, M.

IPC: A61N1/05

CPC classification number: A61N1/0529 ,  A61N1/05 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/086 ,  A61N1/3718

Abstract: A pulse stimulation system configured for implantation into a patient's body (28) comprises a pulse stimulator (102), a conductive stimulation lead (104) having a proximal end electrically coupled to the pulse simulator (102) and having a distal end, and an electrode assembly (122) coupled to the distal end of the stimulation lead. The electrode assembly comprises an electrode body having a therapy electrode (124) thereon that is electrically coupled to the stimulation lead for delivering therapy to the patient. A floating electrode (126) is configured to contact the patient's body tissue and has a surface area substantially larger than that of the therapy electrode. A filter (132) is coupled between the therapy electrode (124) and the floating electrode (126) for diverting RF energy toward the floating electrode (126) and away from the therapy electrode (124).

Abstract translation: 构造成用于植入患者身体（28）的脉冲刺激系统包括脉冲刺激器（102），具有电耦合到脉冲模拟器（102）并具有远端的近端的导电刺激引线（104），以及 电极组件（122），其耦合到刺激引线的远端。 电极组件包括其上具有治疗电极（124）的电极体，其电耦合到刺激引线以将治疗递送给患者。 浮动电极（126）被配置为接触患者的身体组织，并且其表面积基本上大于治疗电极的表面积。 过滤器（132）耦合在治疗电极（124）和浮动电极（126）之间，用于将RF能量朝向浮动电极（126）转移并远离治疗电极（124）。