Abstract:
A drill bit assembly for boring including a drill bit and a bit sub. A front bit end has a plurality cutting elements at a forward face of the front bit end and a first fluid return passage extending through the drill bit to a rear bit end. The bit sub couples to the rear bit end. The bit sub includes a bore disposed at a front sub end sized and shaped to receive the rear bit end of the drill bit. A plurality of legs extends from a mid-sub region toward the front sub end between pairs of cutting elements. The plurality of legs has a fluid delivery passage disposed therein with the fluid delivery passage extending from the plurality of legs to a rear sub bit end. The bit sub has a second fluid return passage connecting the first fluid return passage to the rear sub bit end.
Abstract:
A drill bit assembly for boring including a drill bit and a bit sub. A front bit end has a plurality cutting elements at a forward face of the front bit end and a first fluid return passage extending through the drill bit to a rear bit end. The bit sub couples to the rear bit end. The bit sub includes a bore disposed at a front sub end sized and shaped to receive the rear bit end of the drill bit. A plurality of legs extends from a mid-sub region toward the front sub end between pairs of cutting elements. The plurality of legs has a fluid delivery passage disposed therein with the fluid delivery passage extending from the plurality of legs to a rear sub bit end. The bit sub has a second fluid return passage connecting the first fluid return passage to the rear sub bit end.
Abstract:
Membranes useful for amperometric sensors are described. The membranes allow continuous and real time in vivo measurements of a variety of redox active chemical species present in a fluid sample. In some embodiments, the membrane comprises a redox mediator, a redox reactive species, and conductive nanostructures, such as carbon nanotubes. The membrane can be provided on a working electrode of the sensor. Amperometric sensors incorporating the membranes and methods of treatment using the sensors are also described.
Abstract:
A single or multilumen intravenous catheter that may include an integral biosensor having an active portion exposed through a sensing port formed in a distal portion of an outer wall of the catheter. The biosensor may be formed on a flex circuit mounted to a support member or probe that displaces the active portion from an inner wall of the catheter for protection from friction during installation through a lumen. The support member or probe may position the biosensor concentrically within the lumen or against an inner diameter of the outer wall. The biosensor may be sealed about the sensing port to prevent passage of fluid therethrough, or a proximal end of the sensing port may remain open to allow flushing of the biosensor with saline infused through the lumen.
Abstract:
A method of creating a sensor that may include applying a first conductive material on a first portion of a substrate (110) to form a reference electrode (125) and depositing a first mask (130) over the substrate, the first mask (130) having an opening that exposes the reference electrode and a second portion of the substrate. The method may also include depositing a second conductive material (140) into the opening in the first mask, the second conductive material (140) being in direct contact with the reference electrode (125) and depositing a second mask (150) over the second conductive material, the second mask having an opening (160) over the second portion of the substrate, the opening exposing a portion of the second conductive material, which forms a working surface to receive a fluid of interest. The sensor is also described.
Abstract:
A drill bit for drilling a hole through earth and hard materials, the drill bit including a bit body having an inner bore and a cutting head at a cutting end, the cutting head including a center portion with one or more apertures extending from the cutting end to the inner bore, a perimeter portion projecting radially outward to form a plurality of blades divided by a plurality of junk slots, a cutting face, and a plurality of cutter receptacles spaced about the cutting face. A plurality of cutters with cutter tips terminating in points are in mounted into the cutter receptacles at a pitch angle relative to the cutting face, and with the plurality of cutter points together defining a projected cutting surface.
Abstract:
The present invention is directed to a sensing element that comprises a flexible substrate having first and second opposite surfaces; at least one sensor disposed on the first surface of the flexible substrate; an adhesive layer substantially covering the second surface of the flexible substrate; and a release liner releasably adhered to the adhesive layer so that upon removal of the release liner the adhesive layer is exposed for securing the sensing element to the catheter. The release liner permits the sensing element to be positioned at a desired location within the catheter after which the release liner can be removed to expose the adhesive layer. The adhesive layer can then be used to attach and secure the sensing element at a desired location on the catheter. As a result, the need for additional adhesives can be reduced or eliminated.
Abstract:
A single or multilumen intravenous catheter that may include an integral biosensor having an active portion exposed through a sensing port formed in a distal portion of an outer wall of the catheter. The biosensor may be formed on a flex circuit mounted to a support member or probe that displaces the active portion from an inner wall of the catheter for protection from friction during installation through a lumen. The support member or probe may position the biosensor concentrically within the lumen or against an inner diameter of the outer wall. The biosensor may be sealed about the sensing port to prevent passage of fluid therethrough, or a proximal end of the sensing port may remain open to allow flushing of the biosensor with saline infused through the lumen.
Abstract:
A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.
Abstract:
A method of creating an active electrode that may include providing a flex circuit having an electrode made of a first material and providing a first mask over the flex circuit, the first mask having an offset region and an opening that exposes the electrode. The method may also include depositing a second material over the offset region and the opening, the second material being different from the first material an providing a second mask over the second material, the second mask having a opening over a portion of the second material that is over the offset region.