公开(公告)号：WO2006083440A3

公开(公告)日：2007-06-21

申请号：PCT/US2005047297

申请日：2005-12-29

Applicant: 3M INNOVATIVE PROPERTIES CO ,  GRIESGRABER GEORGE W ,  KSHIRSAGAR TUSHAR A ,  JOHANNESSEN SARAH C ,  DANIELSON MICHAEL E

Inventor： GRIESGRABER GEORGE W ,  KSHIRSAGAR TUSHAR A ,  JOHANNESSEN SARAH C ,  DANIELSON MICHAEL E

IPC: C07D471/14 ,  A61K31/437 ,  C07D471/22

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R 1 )- group in the fused ring at the 1-position of the imidazo ring, wherein R l includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在稠环中具有-CH（-R 1 SUB） - 基团 咪唑环的1位，其中R 1包括官能团，例如酰胺，磺酰胺，脲，氨基甲酸酯，酯，酮，醚，前述砜的硫代类似物 ，肟或羟胺，公开了含有化合物的药物组合物，制备该化合物的中间体，使用这些化合物作为免疫调节剂的方法，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。 。

公开(公告)号：WO2013165591A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/031606

申请日：2013-03-14

Applicant: BIOTHERA, INC. ,  GROSSMAN, William, J. ,  ANTONYSAMY, Mary, A. ,  WALSH, Richard, M. ,  NELSON, Mariana, I. ,  BOSE, Nandita ,  DANIELSON, Michael, E. ,  MICHEL, Kyle, S.

Inventor： GROSSMAN, William, J. ,  ANTONYSAMY, Mary, A. ,  WALSH, Richard, M. ,  NELSON, Mariana, I. ,  BOSE, Nandita ,  DANIELSON, Michael, E. ,  MICHEL, Kyle, S.

IPC: A61K31/716 ,  C07K16/18 ,  G01N33/53

CPC classification number: A61K39/39583 ,  A61K31/716 ,  A61K39/39 ,  A61K39/39558 ,  A61K39/39575 ,  A61K45/06 ,  A61K47/6835 ,  A61K2039/55583 ,  C07K16/12 ,  C07K16/14 ,  G01N33/554 ,  G01N33/56966 ,  G01N2400/24 ,  A61K2300/00

Abstract: This disclosure describes, in one aspect, a method for identifying β-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble β-glucan to at least a portion of the blood sample and incubating the mixture under conditions allowing the soluble β-glucan to bind to the immune cells, and detecting soluble β-glucan bound to the immune cells. In another aspect, this disclosure describes a method that generally includes identifying the subject as a low binder of β-glucan, and co-administering to the subject a soluble β-glucan and an antibody preparation capable of converting the subject from a low binder to a high binder.

Abstract translation: 本公开在一个方面描述了鉴定β-葡聚糖结合受试者的免疫细胞的方法。 通常，该方法包括获得来自受试者的血液样品，血液样品包含免疫细胞，向至少一部分血液样品中加入可溶性β-葡聚糖，并在允许可溶性β-葡聚糖结合到血液样品的条件下孵育该混合物 免疫细胞，并检测结合免疫细胞的可溶性β-葡聚糖。 在另一方面，本公开描述了一种方法，其通常包括将所述受试者识别为β-葡聚糖的低粘合剂，并且向受试者共同施用可溶性β-葡聚糖和能够将受试者从低粘合剂转化为 高粘合剂。

公开(公告)号：WO2012154818A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037073

申请日：2012-05-09

Applicant: BIOTHERA, INC. ,  BOSE, Nandita ,  CHAN, Anissa S.H. ,  DANIELSON, Michael E. ,  ANTONYSAMY, Mary A. ,  VASILAKOS, John P. ,  GORDEN, Keith B. ,  LEONARDO, Steven M. ,  GROSSMAN, William J.

Inventor： BOSE, Nandita ,  CHAN, Anissa S.H. ,  DANIELSON, Michael E. ,  ANTONYSAMY, Mary A. ,  VASILAKOS, John P. ,  GORDEN, Keith B. ,  LEONARDO, Steven M. ,  GROSSMAN, William J.

IPC: A61K39/39

CPC classification number: A61K47/643 ,  A61K31/716 ,  A61K39/39

Abstract: Described herein are beta-glucan compounds, compositions, and methods. Generally, the methods exploit the observation that beta-glucan compounds can bind to B cells. Thus, the methods generally include administering a beta-glucan compound to a subject in an amount effective for the beta-glucan compound to bind to a B cell and modulate at least one biological function of the B cell.

Abstract translation: 本文描述的是β-葡聚糖化合物，组合物和方法。 通常，该方法利用β-葡聚糖化合物可以结合B细胞的观察。 因此，所述方法通常包括向对象施用β-葡聚糖化合物结合B细胞并调节B细胞的至少一种生物学功能的量的β-葡聚糖化合物。

公开(公告)号：WO2006091567A3

公开(公告)日：2006-08-31

申请号：PCT/US2006/006042

申请日：2006-02-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  MERRILL, Bryon, A. ,  NIWAS, Shri ,  LUNDQUIST, Gregory, D., Jr. ,  HEPPNER, Philip, D. ,  DANIELSON, Michael, E.

Inventor： KSHIRSAGAR, Tushar, A. ,  MERRILL, Bryon, A. ,  NIWAS, Shri ,  LUNDQUIST, Gregory, D., Jr. ,  HEPPNER, Philip, D. ,  DANIELSON, Michael, E.

IPC: C07D471/04 ,  A61K31/4162

Abstract: Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

公开(公告)号：WO2006074003A3

公开(公告)日：2007-11-22

申请号：PCT/US2005047258

申请日：2005-12-29

Applicant: 3M INNOVATIVE PROPERTIES CO ,  GRIESGRABER GEORGE W ,  KSHIRSAGAR TUSHAR A ,  CELEBI AZIM A ,  SLANIA SARAH J ,  DANIELSON MICHAEL E ,  RICE MICHAEL J ,  WURST JOSHUA R

Inventor： GRIESGRABER GEORGE W ,  KSHIRSAGAR TUSHAR A ,  CELEBI AZIM A ,  SLANIA SARAH J ,  DANIELSON MICHAEL E ,  RICE MICHAEL J ,  WURST JOSHUA R

IPC: A61K31/4745 ,  C07D487/22

CPC classification number: C07D498/14 ,  C07D471/14 ,  C07D498/22

Abstract: Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-X 1 -R 1 )-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 熔融[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[4 ，5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）与-CH（-X 1 R 1 -R 1） >） - 咪唑环1位的稠合环中的基团，含有化合物的药物组合物，中间体，制备化合物的方法，以及这些化合物作为免疫调节剂的方法，用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：WO2006091647A3

公开(公告)日：2007-10-18

申请号：PCT/US2006006222

申请日：2006-02-22

Applicant: COLEY PHARM GROUP INC ,  KSHIRSAGAR TUSHAR A ,  MERRILL BRYON A ,  LANGER SCOTT E ,  LINDSTROM KYLE J ,  JOHANNESSEN SARAH C ,  MARSZALEK GREGORY J ,  WURST JOSHUA R ,  MANSKE KARL J ,  NIWAS SHRI ,  LUNDQUIST GREGORY D JR ,  HEPPNER PHILIP D ,  GRIESGRABER GEORGE W ,  DANIELSON MICHAEL E

Inventor： KSHIRSAGAR TUSHAR A ,  MERRILL BRYON A ,  LANGER SCOTT E ,  LINDSTROM KYLE J ,  JOHANNESSEN SARAH C ,  MARSZALEK GREGORY J ,  WURST JOSHUA R ,  MANSKE KARL J ,  NIWAS SHRI ,  LUNDQUIST GREGORY D JR ,  HEPPNER PHILIP D ,  GRIESGRABER GEORGE W ,  DANIELSON MICHAEL E

IPC: C07D471/02 ,  A61K31/4353 ,  A61K31/437 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14

CPC classification number: A61K31/4745 ,  C07D471/04 ,  C07D471/14

Abstract: A method of preferentially inducing IFN-a biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-a biosynthesis in an animal are disclosed.

Abstract translation: 一种在动物中优先诱导IFN-a生物合成的方法，包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物，中间体，制备方法和 公开了使用这些化合物的免疫调节剂用于治疗包括病毒和肿瘤疾病在内的疾病的方法，其包括在动物中优先诱导IFN-α生物合成。

公开(公告)号：WO2006107771A2

公开(公告)日：2006-10-12

申请号：PCT/US2006/012031

申请日：2006-03-31

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  MERRILL, Bryon, A. ,  DANIELSON, Michael, E. ,  HAYS, David, S. ,  AMOS, David, T. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  MOSER, William, H.

Inventor： MERRILL, Bryon, A. ,  DANIELSON, Michael, E. ,  HAYS, David, S. ,  AMOS, David, T. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  MOSER, William, H.

IPC: A61K31/4745 ,  C07D471/14

CPC classification number: C07D471/04

Abstract: Pyrazolo[3,4- c ]quinolines, pyrazolo[4,5- c ]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4- c ]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.

Abstract translation: 吡唑并[3,4-c]喹啉，吡唑并[4,5-c]萘啶及其类似物，例如6,7,8,9-四氢吡唑并[3,4-c]喹啉，以及药物组合物 公开了含有化合物，中间体，制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于抑制动物中的细胞因子生物合成以及通过抑制细胞因子生物合成来治疗或预防性治疗疾病。

公开(公告)号：WO2005079195A3

公开(公告)日：2005-09-01

申请号：PCT/US2004/032480

申请日：2004-10-01

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  HAYS, David, S. ,  DANIELSON, Michael, E. ,  GERSTER, John, F. ,  NIWAS, Shri, ,  PRINCE, Ryan, B. ,  KSHIRSAGAR, Tushar, A. ,  HEPPNER, Philip, D. ,  MOSER, William, H. ,  MOSEMAN, Joan, T. ,  RADMER, Matthew, R. ,  KAVANAGH, Maureen, A. ,  STRONG, Sarah, A. ,  BONK, Jason, D.

Inventor： HAYS, David, S. ,  DANIELSON, Michael, E. ,  GERSTER, John, F. ,  NIWAS, Shri, ,  PRINCE, Ryan, B. ,  KSHIRSAGAR, Tushar, A. ,  HEPPNER, Philip, D. ,  MOSER, William, H. ,  MOSEMAN, Joan, T. ,  RADMER, Matthew, R. ,  KAVANAGH, Maureen, A. ,  STRONG, Sarah, A. ,  BONK, Jason, D.

IPC: A61K31/437 ,  C07D471/04 ,  C07D471/14 ,  C07D487/02 ,  C07D487/12

Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

公开(公告)号：WO2013165593A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/031625

申请日：2013-03-14

Applicant: BIOTHERA, INC. ,  GROSSMAN, William J. ,  ANTONYSAMY, Mary A. ,  WALSH, Richard M. ,  NELSON, Mariana I. ,  BOSE, Nandita ,  DANIELSON, Michael E. ,  MICHEL, Kyle S.

Inventor： GROSSMAN, William J. ,  ANTONYSAMY, Mary A. ,  WALSH, Richard M. ,  NELSON, Mariana I. ,  BOSE, Nandita ,  DANIELSON, Michael E. ,  MICHEL, Kyle S.

IPC: A01N43/04 ,  A61K39/40 ,  C07K16/00 ,  C12P21/08

CPC classification number: A61K39/39583 ,  A61K31/716 ,  A61K39/39 ,  A61K39/39558 ,  A61K39/39575 ,  A61K45/06 ,  A61K47/6835 ,  A61K2039/55583 ,  C07K16/12 ,  C07K16/14 ,  G01N33/554 ,  G01N33/56966 ,  G01N2400/24 ,  A61K2300/00

Abstract: This disclosure describes, in one aspect, a composition that includes a β-glucan component and an antibody component that specifically binds to the β-glucan. In another aspect, this disclosure describes a method of increasing a subject's response to β-glucan immunotherapy. Generally, the method includes identifying the subject as a low binder of β-glucan and administering to the subject a composition that comprises a β-glucan moiety conjugated to the therapeutic antibody. In some cases, the therapeutic antibody can be an anti-tumor antibody.

Abstract translation: 本公开在一个方面描述了包含β-葡聚糖组分和特异性结合β-葡聚糖的抗体组分的组合物。 在另一方面，本公开描述了增加受试者对β-葡聚糖免疫治疗的反应的方法。 通常，该方法包括将该受试者识别为β-葡聚糖的低粘合剂，并向受试者施用包含与治疗性抗体缀合的β-葡聚糖部分的组合物。 在一些情况下，治疗性抗体可以是抗肿瘤抗体。

公开(公告)号：WO2008134462A1

公开(公告)日：2008-11-06

申请号：PCT/US2008/061484

申请日：2008-04-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  PARTHASARATHY, Ranjani ,  DANIELSON, Michael, E. ,  FALETTI, John, C. ,  BEDINGHAM, William

Inventor： PARTHASARATHY, Ranjani ,  DANIELSON, Michael, E. ,  FALETTI, John, C. ,  BEDINGHAM, William

IPC: G01N35/00 ,  B01L3/00

CPC classification number: B01L3/5027 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0887 ,  G01N33/54366 ,  G01N33/54393

Abstract: Methods of providing at least one reagent for use in a device for processing sample material, delivering at least one reagent to a device for processing sample material, and adding at least one reagent to at least one of the steps in a process for detecting or assaying a nucleic acid; a support film coated with a dry reagent layer; and a device for processing sample material having a support film coated with a dry reagent layer contained within at least one chamber of the device are disclosed.

Abstract translation: 提供用于处理样品材料的装置中的至少一种试剂，将至少一种试剂输送到用于处理样品材料的装置，以及在检测或测定方法中至少一个步骤中加入至少一种试剂的方法 核酸; 涂覆有干试剂层的支撑膜; 并且公开了一种用于处理样品材料的装置，其具有涂覆有包含在该装置的至少一个室中的干试剂层的支撑膜。