公开(公告)号：WO1996029925A3

公开(公告)日：1996-10-03

申请号：PCT/US1996004136

申请日：1996-03-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  BERGER, Andrew, J. ,  BRENNAN, James, F., III ,  DASARI, Ramanchandra, R. ,  FELD, Michael, S. ,  ITZKAN, Irving ,  TANAKA, Kaz ,  WANG, Yang

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

IPC: A61B05/00

公开(公告)号：WO0042912A9

公开(公告)日：2002-03-28

申请号：PCT/US0001967

申请日：2000-01-25

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  BACKMAN VADIM ,  DASARI RAMANCHANDRA R ,  GURJAR RAJAN ,  ITZKAN IRVING ,  PERELMAN LEV ,  FELD MICHAEL S

Inventor： BACKMAN VADIM ,  DASARI RAMANCHANDRA R ,  GURJAR RAJAN ,  ITZKAN IRVING ,  PERELMAN LEV ,  FELD MICHAEL S

IPC: G01N33/48 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  C12Q1/02 ,  G01N21/21 ,  G01N21/27 ,  G01N21/35 ,  G01N33/483

CPC classification number: A61B5/0084 ,  A61B5/0075

Abstract: The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of backscattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.

Abstract translation: 本发明涉及使用偏振光来测量组织的性质。 更具体地，偏振光可用于检测组织中的发育不良，因为来自这些组织的反向散射光的偏振被保留，同时可以去除来自下层组织的漫散射光的贡献。 用于光的传送和收集的光纤系统可用于测量人体内的组织。

公开(公告)号：WO9629925A2

公开(公告)日：1996-10-03

申请号：PCT/US9604136

申请日：1996-03-27

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  BERGER ANDREW J ,  BRENNAN JAMES F III ,  DASARI RAMANCHANDRA R ,  FELD MICHAEL S ,  ITZKAN IRVING ,  TANAKA KAZ ,  WANG YANG

Inventor： BERGER ANDREW J ,  BRENNAN JAMES F III ,  DASARI RAMANCHANDRA R ,  FELD MICHAEL S ,  ITZKAN IRVING ,  TANAKA KAZ ,  WANG YANG

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  G01N21/65

CPC classification number: G01J3/02 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B2562/12 ,  G01J3/021 ,  G01J3/0221 ,  G01N21/65 ,  G01N2021/656

Abstract: The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Methods include in vivo transdermal and continuous monitoring as well as in vitro blood analysis. Furthermore, a compound parabolic concentrator to increase the amount of detected Raman signal is disclosed.

Abstract translation: 本发明涉及使用拉曼光谱法测量血液和组织中选定分析物以帮助诊断的方法的系统。 更具体地，收集和分析拉曼光谱，以测量血液中溶解气体和其他分析物的浓度。 方法包括体内透皮和连续监测以及体外血液分析。 此外，公开了一种用于增加检测到的拉曼信号量的复合抛物面聚光器。