公开(公告)号：WO9918434A9

公开(公告)日：1999-08-05

申请号：PCT/US9821193

申请日：1998-10-06

Applicant: TUFTS COLLEGE ,  WALT DAVID R ,  DICKINSON TODD A

Inventor： WALT DAVID R ,  DICKINSON TODD A

IPC: G01N21/62 ,  C12M1/34 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/00 ,  G01N33/50

CPC classification number: G01N21/6452 ,  B01J2219/00317 ,  B01J2219/00524 ,  B01J2219/00648 ,  B01J2219/00659 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/54393 ,  G01N2021/6484 ,  G01N2021/7786

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbrs of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identifies of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的识别通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：WO0013004A2

公开(公告)日：2000-03-09

申请号：PCT/US9919624

申请日：1999-08-26

Applicant: TUFTS COLLEGE ,  WALT DAVID R ,  DICKINSON TODD A

Inventor： WALT DAVID R ,  DICKINSON TODD A

IPC: B01J19/00 ,  C40B40/14 ,  C40B70/00 ,  G01N21/77 ,  G01N21/64

CPC classification number: G01N21/7703 ,  B01J19/0046 ,  B01J2219/005 ,  B01J2219/00513 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  C40B70/00 ,  G01N2201/0833

Abstract: A combinatorial synthesis method for fabricating unique families of discrete copolymer sensors and copolymer gradient sensors is provided. The method employs combinatorial copolymer synthesis of discrete monomer or oligomer combinations as well as spatially-varying combinations for generating large numbers of analyte-discriminating sensors from a limited selection of initial monomer and oligomer compositions. The method can be applied to either analyte-specific sensors or sensor arrays or semi-selective sensors and cross-reactive sensor arrays which employ virtually any known physicochemical transduction mechanism for detecting analytes. Since the analyte response characteristics of such copolymer sensors are not limited to a linear proportional ratio of the monomer or oligomer combinations employed, the resulting copolymer sensors provide for increased diversity in sensor and sensor array response characteristics for discriminating between a variety of materials and for detecting and identifying analytes in fluid samples.

公开(公告)号：WO0013004A9

公开(公告)日：2000-10-05

申请号：PCT/US9919624

申请日：1999-08-26

Applicant: TUFTS COLLEGE ,  WALT DAVID R ,  DICKINSON TODD A

Inventor： WALT DAVID R ,  DICKINSON TODD A

IPC: B01J19/00 ,  C40B40/14 ,  C40B70/00 ,  G01N21/77 ,  G01N21/64

CPC classification number: G01N21/7703 ,  B01J19/0046 ,  B01J2219/005 ,  B01J2219/00513 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  C40B70/00 ,  G01N2201/0833

Abstract: A combinatorial synthesis method for fabricating unique families of discrete copolymer sensors and copolymer gradient sensors is provided. The method employs combinatorial copolymer synthesis of discrete monomer or oligomer combinations as well as spatially-varying combinations for generating large numbers of analyte-discriminating sensors from a limited selection of initial monomer and oligomer compositions. The method can be applied to either analyte-specific sensors or sensor arrays or semi-selective sensors and cross-reactive sensor arrays which employ virtually any known physicochemical transduction mechanism for detecting analytes. Since the analyte response characteristics of such copolymer sensors are not limited to a linear proportional ratio of the monomer or oligomer combinations employed, the resulting copolymer sensors provide for increased diversity in sensor and sensor array response characteristics for discriminating between a variety of materials and for detecting and identifying analytes in fluid samples.

公开(公告)号：WO0013004B1

公开(公告)日：2000-08-17

申请号：PCT/US9919624

申请日：1999-08-26

Applicant: TUFTS COLLEGE ,  WALT DAVID R ,  DICKINSON TODD A

Inventor： WALT DAVID R ,  DICKINSON TODD A

IPC: B01J19/00 ,  C40B40/14 ,  C40B70/00 ,  G01N21/77 ,  G01N21/64

CPC classification number: G01N21/7703 ,  B01J19/0046 ,  B01J2219/005 ,  B01J2219/00513 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  C40B70/00 ,  G01N2201/0833

Abstract: A combinatorial synthesis method for fabricating unique families of discrete copolymer sensors and copolymer gradient sensors is provided. The method employs combinatorial copolymer synthesis of discrete monomer or oligomer combinations as well as spatially-varying combinations for generating large numbers of analyte-discriminating sensors from a limited selection of initial monomer and oligomer compositions. The method can be applied to either analyte-specific sensors or sensor arrays or semi-selective sensors and cross-reactive sensor arrays which employ virtually any known physicochemical transduction mechanism for detecting analytes. Since the analyte response characteristics of such copolymer sensors are not limited to a linear proportional ratio of the monomer or oligomer combinations employed, the resulting copolymer sensors provide for increased diversity in sensor and sensor array response characteristics for discriminating between a variety of materials and for detecting and identifying analytes in fluid samples.

Abstract translation: 提供了用于制造离散共聚物传感器和共聚物梯度传感器的独特族的组合合成方法。 该方法采用离散单体或低聚物组合的组合共聚物合成以及空间变化组合以从有限选择的初始单体和低聚物组合物中产生大量分析物识别传感器。 该方法可应用于分析物特异性传感器或传感器阵列或半选择性传感器和交叉反应传感器阵列，其实际上使用任何已知的用于检测分析物的物理化学转换机制。 由于这种共聚物传感器的分析物响应特性不限于所用单体或低聚物组合的线性比例比率，所得共聚物传感器提供了传感器和传感器阵列响应特性的增加的多样性，用于区分各种材料和用于检测 并识别流体样本中的分析物。