公开(公告)号：US20220184009A1

公开(公告)日：2022-06-16

申请号：US17679842

申请日：2022-02-24

Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION ,  DOMPE FARMACEUTICI S.P.A.

Inventor： Paolo FIORINA ,  Roberto BASSI ,  Andrea VERGANI ,  Marcello ALLEGRETTI

IPC: A61K31/18 ,  A61K45/06 ,  A61P3/10 ,  A61P13/12 ,  A61K31/426

Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.

公开(公告)号：US11324630B2

公开(公告)日：2022-05-10

申请号：US16313514

申请日：2017-06-29

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Alfredo Ricci

IPC: A61F9/00

Abstract: A medical device (100) for the instillation of medical products in droplet form is described, said device comprising a hollow cylindrical body (10) and a rod (20) slidably mobile inside the hollow cylindrical body (10) and provided with a head (21) on which a rubber washer (40) is fixed, which washer, during the sliding of the rod (20), is in contact with an inner surface of the hollow cylindrical body (10). The rod (20) is formed as two portions (22, 24) of different diameter and the device (100) further comprises a sealing bush (30) between the hollow cylindrical body (10) and the rod (20), wherein there is provided a stop (32) which prevents the passage of the portion (22) with a larger circular section of the rod (20).

公开(公告)号：US20220112244A1

公开(公告)日：2022-04-14

申请号：US17555154

申请日：2021-12-17

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Marcello Allegretti ,  Andrea Aramini ,  Andrea Beccari ,  Marica Gemei ,  Flavio Mantelli

IPC: C07K7/08

Abstract: The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.

公开(公告)号：US11236129B2

公开(公告)日：2022-02-01

申请号：US17158728

申请日：2021-01-26

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Marcello Allegretti ,  Andrea Aramini ,  Andrea Beccari ,  Marica Gemei ,  Flavio Mantelli

IPC: C07K7/08 ,  A61K38/00

Abstract: The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.

公开(公告)号：US20250082719A1

公开(公告)日：2025-03-13

申请号：US18722415

申请日：2022-12-22

Applicant: DOMPE' FARMACEUTICI S.P.A.

Inventor： Ilaria MACCHI

IPC: A61K38/13 ,  A61K9/00 ,  A61K45/06 ,  A61P29/00

Abstract: The present invention relates to isocyclosporin A, salts and ophthalmic compositions thereof for ophthalmic topical use in the prevention or treatment in an individual of an ophthalmic inflammatory and/or autoimmune disease, preferably selected from corneal and ocular surface inflammatory and/or autoimmune diseases and eyelid margin inflammatory diseases.

公开(公告)号：US12102607B2

公开(公告)日：2024-10-01

申请号：US16769892

申请日：2018-12-11

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Laura Brandolini ,  Thiago Mattar Cunha ,  Marcello Allegretti ,  Andrea Aramini ,  Gianluca Bianchini

IPC: A61P25/02 ,  A61K31/145 ,  A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/337 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4406 ,  A61K31/445

CPC classification number: A61K31/145 ,  A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/337 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4406 ,  A61K31/445 ,  A61P25/02

Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).

公开(公告)号：US20230226256A1

公开(公告)日：2023-07-20

申请号：US18009495

申请日：2021-06-09

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Giuseppina ACERRA ,  Nicola DETTA ,  Assunta PANDOLFI ,  Leonardo MASTROPASQUA ,  Mario NUBILE ,  Domitilla MANDATORI

IPC: A61L27/36 ,  A61K38/18 ,  A61L27/54 ,  A61K9/16 ,  A61K9/00

CPC classification number: A61L27/3604 ,  A61K38/185 ,  A61L27/54 ,  A61K9/1647 ,  A61L27/3687 ,  A61K9/1682 ,  A61L27/3641 ,  A61K9/0051 ,  A61L2300/414 ,  A61L2430/16 ,  A61L2430/40

Abstract: Object of the present invention is a drug delivery system comprising a decellularized corneal stroma scaffold having dispersed within and/or bound to its surface microparticles containing at least one pharmaceutically active molecule dispersed in a matrix having a composition consisting for at least 70% of polylactic co-glycolic acid (PLGA).

公开(公告)号：US11660291B2

公开(公告)日：2023-05-30

申请号：US16764270

申请日：2018-10-23

Applicant: Dompe' Farmaceutici S.P.A. ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

Inventor： Ryan David Roberts ,  Laura Brandolini

IPC: A61P35/00 ,  A61K31/18 ,  C07C311/03 ,  C07C311/08 ,  A61K31/426 ,  A61K33/243 ,  A61K31/475 ,  A61K31/519 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/12

CPC classification number: A61K31/426 ,  A61K31/18 ,  A61K31/475 ,  A61K31/519 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/243 ,  A61K38/12 ,  A61P35/00

Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of some sarcomas, preferably in the treatment and/or prevention of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or lung metastasis associated thereof.

公开(公告)号：US20200170836A1

公开(公告)日：2020-06-04

申请号：US16313514

申请日：2017-06-29

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Alfredo RICCI

IPC: A61F9/00

Abstract: A medical device (100) for the instillation of medical products in droplet form is described, said device comprising a hollow cylindrical body (10) and a rod (20) slidably mobile inside the hollow cylindrical body (10) and provided with a head (21) on which a rubber washer (40) is fixed, which washer, during the sliding of the rod (20), is in contact with an inner surface of the hollow cylindrical body (10). The rod (20) is formed as two portions (22, 24) of different diameter and the device (100) further comprises a sealing bush (30) between the hollow cylindrical body (10) and the rod (20), wherein there is provided a stop (32) which prevents the passage of the portion (22) with a larger circular section of the rod (20).

公开(公告)号：US20240398731A1

公开(公告)日：2024-12-05

申请号：US18799076

申请日：2024-08-09

Applicant: Dompe' Farmaceutici S.P.A.

Inventor： Laura BRANDOLINI ,  Thiago Mattar CUNHA ,  Marcello ALLEGRETTI ,  Andrea ARAMINI ,  Gianluca BIANCHINI

IPC: A61K31/145 ,  A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/337 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4406 ,  A61K31/445 ,  A61P25/02

Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).