公开(公告)号：WO2013131408A1

公开(公告)日：2013-09-12

申请号：PCT/CN2013/000230

申请日：2013-03-05

Applicant: DR.REDDY'S LABORATORIES LTD. ,  SASMAL, Pradip Kumar ,  VAMSEEKRISHNA, Chintakunta ,  POTLURI, Vijay ,  TEHIM, Ashok ,  GAI, Yonghua ,  ZHANG, Hang

Inventor： SASMAL, Pradip Kumar ,  VAMSEEKRISHNA, Chintakunta ,  POTLURI, Vijay ,  TEHIM, Ashok ,  GAI, Yonghua ,  ZHANG, Hang

IPC: C07D207/12 ,  A61K31/40 ,  C07D207/04 ,  C07D217/12

CPC classification number: C07D417/14 ,  A61K31/404 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/538 ,  A61K31/5415 ,  C07D209/34 ,  C07D215/227 ,  C07D241/52 ,  C07D263/58 ,  C07D265/36 ,  C07D275/06 ,  C07D277/68 ,  C07D279/16 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 . R 4 , R 5 , and R 6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Abstract translation: 本发明涉及一系列具有通式（I）的取代的化合物，其包括它们的重组异构体和/或其药学上可接受的盐，其中R1，R2，R3。 R4，R5和R6如本文所定义。 本发明还涉及制备这些化合物包括中间体的方法。 本发明的化合物在κ（κ）阿片样物质受体（KOR）位点是有效的。 因此，本发明的化合物可用作药物，特别是用于治疗和/或预防各种中枢神经系统疾病（CNS），包括但不限于急性和慢性疼痛以及相关疾病，特别是周边功能 在中枢神经系统。

公开(公告)号：WO2003059894A1

公开(公告)日：2003-07-24

申请号：PCT/IB2003/000071

申请日：2003-01-15

Applicant: DR.REDDY'S LABORATORIES LTD.

Inventor： DAS, Jagattaran ,  NATESAN, Selvakumar ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram,Kumar ,  MAMIDI, Naga,Venkata,Srinivasa,Rao ,  RAMANUJAM, Rajagopalan

IPC: C07D249/06

CPC classification number: C07D249/06 ,  C07D295/135 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D491/10

Abstract: The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

Abstract translation: 本发明涉及式（I）的新型三唑化合物，其衍生物，其类似物，其互变异构形式，其区域异构体，其旋转异构体，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药物组合物 。 更具体地，本发明涉及通式（I）的新型三唑衍生物，其类似物，其互变异构体，其区域异构体，其旋转异构体，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药物 含有它们的组合物。

公开(公告)号：US20160194352A1

公开(公告)日：2016-07-07

申请号：US14988372

申请日：2016-01-05

Applicant: Dr.Reddy's Laboratories Ltd.

Inventor： Venkata Narasayya SALADI ,  Vishweshwar PEDDY

IPC: C07K5/062

CPC classification number: C07K5/06052 ,  A61K38/00 ,  C07K5/06034

Abstract: The present application relates to the amorphous form of Daclatasvir dihydrochloride and the processes for the preparation thereof. The application further provides its solid dispersion having Daclatasvir dihydrochloride in amorphous form and process for its preparation.

Abstract translation: 本申请涉及无定形Daclatasvir二盐酸盐及其制备方法。 该应用进一步提供其具有无定形形式的达卡拉第二盐酸盐的固体分散体及其制备方法。

公开(公告)号：WO2003104212A1

公开(公告)日：2003-12-18

申请号：PCT/US2003/017600

申请日：2003-06-04

Applicant: DR.REDDY'S LABORATORIES LTD. ,  DR.REDDY'S LABORATORIES, INC. ,  REDDY, Manne, Satyanarayana ,  RAJAN, Srinivasan, Thirumalai ,  SHANKAR, Ranga, Ravi ,  VARDHAN, Sunkara, Vishnu

Inventor： REDDY, Manne, Satyanarayana ,  RAJAN, Srinivasan, Thirumalai ,  SHANKAR, Ranga, Ravi ,  VARDHAN, Sunkara, Vishnu

IPC: C07D295/08

CPC classification number: C07D295/088

Abstract: The present invention relates to a novel amorphous form of [2-[4-[(4-Chlorophenyl)-phenyl methyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride suitable for pharmaceutical formulations and process for the preparation thereof.

Abstract translation: 本发明涉及适用于药物制剂的新型无定形形式的[2- [4 - [（4-氯苯基） - 苯基甲基] -1-哌嗪基]乙氧基]乙酸二盐酸盐及其制备方法。

公开(公告)号：WO2003027118A1

公开(公告)日：2003-04-03

申请号：PCT/IB2002/003950

申请日：2002-09-25

Applicant: DR.REDDY'S LABORATORIES LTD. ,  POTHUKUCHI, Sairam ,  DUVVURI, Subrahmanyam ,  RAJAGOPAL, Sriram

Inventor： POTHUKUCHI, Sairam ,  DUVVURI, Subrahmanyam ,  RAJAGOPAL, Sriram

IPC: C07D491/22

CPC classification number: C07D491/22

Abstract: The present invention relates to pharmaceutically acceptable salts formed by the compounds of general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said pharmaceutically acceptable salts, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, and pharmaceutical compositions containing them.

Abstract translation: 本发明涉及由通式（I）的化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物和含有它们的药学上可接受的组合物形成的药学上可接受的盐。 本发明还涉及制备上述药物可接受的盐，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物和含有它们的药物组合物的方法。