公开(公告)号：JP3543263B2

公开(公告)日：2004-07-14

申请号：JP20375899

申请日：1999-07-16

Applicant: エンドーソニックス・コーポレイションEndosonics Corporation ,  ザ・クリーブランド・クリニック・ファンデーションThe Cleveland ClinicFoundation

Inventor： エミン・エム・テュズク ,  エリク・ジェイ・リー ,  ジェイ・ピー・シーズキ ,  ジェイムズ・ディ・サヴェッジ ,  マーティン・エス・ウェインハウス ,  ユージーン・ジェイ・ジャング・ジュニア

IPC: A61M25/01 ,  A61M25/00 ,  A61M36/04 ,  A61M36/12 ,  A61N5/10

CPC classification number: A61N5/1002 ,  A61N2005/1005

公开(公告)号：WO1990006723A1

公开(公告)日：1990-06-28

申请号：PCT/US1989005586

申请日：1989-12-19

Applicant: ENDOSONICS CORPORATION

Inventor： ENDOSONICS CORPORATION ,  ROSE, Luke, E. ,  MARSH, Wilbert, I., Jr.

IPC: A61B05/0215

CPC classification number: G01L19/148 ,  A61B5/0215 ,  A61M2025/0002 ,  G01L9/0042 ,  G01L9/0054 ,  G01L9/06 ,  G01L19/0084 ,  G01L19/147

Abstract: A pressure sensor assembly (11) is provided for placement within the tip of a conventional catheter (15) or the like for insertion into a small cavity such as a human coronary artery. The pressure sensor assembly (11) is comprised of device and backing dies (67 and 75) of crystalline material bonded together without the use of a bonding material, thereby providing direct contact between the two crystalline dies. A diaphragm (25) is etched into one of the dies before it is bonded to the other die. A cavity (26) formed by the diaphragm when the two dies are bonded is vented to a reference atmosphere by a channel or groove (31) in the backing die. During the fabrication of the sensor assembly, small holes (71) are etched completely through the wafer (75) used to form the device dies in order to provide targets for alignment during the fabrication of the sensor assembly. Finally, the fabrication of circuitry on the wafer forming the device dies includes providing complementary temperature coefficients of the nominal piezoresistance and of the piezoresistive coefficient.

Abstract translation: 提供压力传感器组件（11）用于放置在常规导管（15）等的尖端内，以插入诸如人冠状动脉的小空腔中。 压力传感器组件（11）由结晶材料的装置和背衬模具（67和75）组成，而不使用粘合材料，从而提供两个晶体模具之间的直接接触。 在将模板结合到另一个模具之前，将光阑（25）蚀刻到一个模具中。 当两个模具接合时由隔膜形成的空腔（26）通过背模中的通道或槽（31）排放到参考气氛。 在制造传感器组件期间，通过用于形成器件裸片的晶片（75）完全蚀刻小孔（71），以便在传感器组件的制造期间提供用于对准的目标。 最后，形成器件管芯的晶片上的电路的制造包括提供标称压阻和压阻系数的互补温度系数。

公开(公告)号：WO1998019603A1

公开(公告)日：1998-05-14

申请号：PCT/NL1997000504

申请日：1997-09-02

Applicant: ENDOSONICS CORPORATION ,  CESPEDES, Edoardo Ignacio ,  LANCEÉ, Charles, Theodoor ,  VAN DER STEEN, Antonius, Franciscus, Wilhelmus ,  LI, Wenguang ,  BOM, Nicolaas

Inventor： ENDOSONICS CORPORATION

IPC: A61B08/06

CPC classification number: A61B8/06 ,  A61B8/12

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer; and the estimation accuracy is further improved by the use of a reference decorrelation curve obtained from experiments or beam-theory or both.

Abstract translation: 一种通过使用其中通过多个超声波束询问横截面积的超声波来在腔或其它体腔的横截面区域中的多个位置中测量空间流体流动分量及其速度分布的方法; 从轴向，横向和总流量的估计的组合获得空间流分量的估计; 通过询问超声换能器的两个或多个波束信号的时移和去相关分析的任意组合来获得一个或多个流分量的估计; 并且通过使用从实验或束理论或两者获得的参考去相关曲线来进一步提高估计精度。

公开(公告)号：WO1995029633A1

公开(公告)日：1995-11-09

申请号：PCT/US1995004776

申请日：1995-04-19

Applicant: ENDOSONICS CORPORATION

Inventor： ENDOSONICS CORPORATION ,  O'DONNELL, Matthew ,  EBERLE, Michael, J. ,  STEPHENS, Douglas, N. ,  LITZZA, Gerald, L. ,  HAVILAND, Daniel, S.

IPC: A61B08/12

CPC classification number: A61B8/06 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/4488 ,  A61B8/4494 ,  B06B1/0633 ,  B06B1/067 ,  B06B1/0674 ,  B06B2201/76 ,  G01S15/892 ,  G01S15/8979 ,  G01S15/8981 ,  G01S15/899 ,  G10K11/004 ,  G10K11/008 ,  Y10T29/42

Abstract: An apparatus and method are described for imaging blood flow from within a vasculature. An ultrasound catheter probe (20) carrying an ultrasound transducer array (24) is inserted within a blood vessel (14). The transducer array emits ultrasound excitation signals and receives ultrasound echo waveforms reflected from blood and tissue in a region of the vasculature. A series of the echo waveforms resulting from a series of excitation signals are combined in a manner such that the echo signals from static features in the region, such as tissue and plaque (12), are significantly attenuated. The combined signal primarily represents the relatively dynamic features in the region (i.e., the blood flow). A blood flow image is constructed from the combined signal. The blood flow image is colored and combined with an image of the relatively static features in the region. Thereafter the combined image is displayed on a video display (28).

Abstract translation: 描述了用于对脉管系统内的血流进行成像的装置和方法。 携带超声换能器阵列（24）的超声波导管探针（20）插入血管（14）内。 换能器阵列发射超声激发信号并且接收从脉管系统区域中的血液和组织反射的超声回波波形。 由一系列激励信号产生的一系列回波波形以这样的方式组合，使得来自区域中的静态特征（例如组织和斑块（12））的回波信号被显着衰减。 组合信号主要表示该区域中相对动态的特征（即，血流）。 血液流动图像由组合信号构成。 血流图像被着色并与该区域中相对静态特征的图像组合。 此后，组合的图像显示在视频显示器（28）上。

公开(公告)号：WO1993000036A2

公开(公告)日：1993-01-07

申请号：PCT/US1992005156

申请日：1992-06-19

Applicant: ENDOSONICS CORPORATION

Inventor： ENDOSONICS CORPORATION ,  EBERLE, Michael, J.

IPC: A61B0

CPC classification number: A61B8/12 ,  A61B8/445 ,  G01S7/52026

Abstract: An apparatus and method for imaging a small cavity is disclosed wherein reference waveforms to be used in obtaining an improved image are generated in vivo. The reference waveforms are used to strip the imaging signals of noise in an image generated from the signals. The imaging probe (10) is first inserted into a first area of the vascular system (12) to be imaged and reference waveforms are collected. After collecting the reference waveforms, the imaging probe is further inserted into the vascular system to a second area that is to be imaged. If necessary, the reference collecting step may be repeated. The present invention also provides an imaging apparatus capable of imaging close to the surface of the probe and, in this regard, removes artifacts in the imaging waveforms that usually form a corona (62) in the visual image about the perimeter of the probe (44).

公开(公告)号：WO1997023865A1

公开(公告)日：1997-07-03

申请号：PCT/US1996020655

申请日：1996-12-23

Applicant: ENDOSONICS CORPORATION

Inventor： ENDOSONICS CORPORATION ,  EBERLE, Michael, J. ,  STEPHENS, Douglas, N. ,  RIZZUTI, Gary ,  KIEPEN, Horst ,  HODJICOSTIS, Andreas

IPC: G10K11/00

CPC classification number: B06B1/0633 ,  G10K11/004 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49124

Abstract: An ultrasound transducer assembly of the present invention includes a flexible circuit to which an ultrasound transducer array (8) and integrated circuitry (6) are attached during fabrication of the ultrasound transducer assembly. The flexible circuit comprises a flexible substrate (2) to which the integrated circuitry and transducer elements are attached while the flexible substrate is in a substantially flat shape. The flexible circuit further comprises electrically conductive lines that are deposited upon the flexible substrate. The electrically conductive lines transport electrical signals between the integrated circuitry and the transducer elements. After assembly, the flexible circuit is re-shapable into a final form such as, for example, a substantially cylindrical shape.

Abstract translation: 本发明的超声换能器组件包括柔性电路，超声波换能器组件在制造超声换能器组件期间与该超声波换能器阵列（8）和集成电路（6）连接。 柔性电路包括柔性基板（2），其中集成电路和换能器元件被附接到柔性基板上，同时柔性基板处于基本平坦的形状。 柔性电路还包括沉积在柔性基板上的导电线。 导电线传输集成电路和换能器元件之间的电信号。 在组装之后，柔性电路可重新成型为最终形式，例如大致圆柱形的形状。

公开(公告)号：WO1994017734A1

公开(公告)日：1994-08-18

申请号：PCT/US1994000474

申请日：1994-01-14

Applicant: ENDOSONICS CORPORATION

Inventor： ENDOSONICS CORPORATION ,  EBERLE, Michael, J. ,  RIZZUTI, Gary, P. ,  KIEPEN, Horst, F.

IPC: A61B08/12

CPC classification number: A61B8/12 ,  A61B8/06 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/4488 ,  A61B8/4494 ,  B06B1/0633 ,  B06B1/067 ,  B06B1/0674 ,  B06B2201/76 ,  G01S15/8915 ,  G01S15/892 ,  G01S15/8979 ,  G01S15/8981 ,  G01S15/899 ,  G10K11/004 ,  G10K11/008 ,  Y10T29/42

Abstract: An ultrasound catheter (10) is disclosed for providing substantially real-time images of small cavities. The ultrasound catheter (10) is characterized by separate and distinct materials for backing the transducers (22) and for carrying the electronics components (18). The separate materials comprise an electronics carrier (20) meeting the requirements for holding the integrated circuitry (18) of the ultrasound device and a backing material (24) displaying superior characteristics relating to reducing ringing and minimizing the effect of other sources of signal degradation in the transducer assembly. Also, in accordance with the present invention, a technique is described for connecting the conductor lines of the separate transducer assembly and electronics body.

Abstract translation: 公开了一种用于提供基本上实时的小空腔图像的超声波导管（10）。 超声波导管（10）的特征在于用于支撑换能器（22）和用于承载电子部件（18）的独立且不同的材料。 单独的材料包括满足保持超声波装置的集成电路（18）的要求的电子载体（20）和背衬材料（24），其显示与减少振铃有关的优异特性并使其它信号劣化的影响最小化 换能器组件。 此外，根据本发明，描述了用于连接单独的换能器组件和电子体的导体线的技术。

公开(公告)号：WO1992011809A1

公开(公告)日：1992-07-23

申请号：PCT/US1991009821

申请日：1991-12-31

Applicant: ENDOSONICS CORPORATION

Inventor： ENDOSONICS CORPORATION ,  EBERLE, Michael, J. ,  HODGSON, John, M.

IPC: A61B08/12

CPC classification number: A61M25/104 ,  A61B8/12 ,  A61B8/445 ,  A61M2025/1079

Abstract: A dilating and imaging apparatus (10) for attaching to and receiving pressurized fluid from a distal end of a catheter. The apparatus includes an inflatable balloon (18) and an imaging device (44) positioned behind an expandable portion of the balloon and upstream of the flow of pressurized fluid into the balloon so as to enable the balloon to deflate and achieve a smaller diameter than that of the imaging device (44), thus enabling the apparatus to enter a stenosis having a smaller diameter than the imaging device. In one embodiment of the invention, the imaging device can be maneuvered within the balloon while the balloon is inflated and dilating the stenosis.

公开(公告)号：EP0952786A1

公开(公告)日：1999-11-03

申请号：EP97940463.0

申请日：1997-09-02

Applicant: EndoSonics Corporation

Inventor： CESPEDES, Edoardo Ignacio ,  LANCE , Charles, Theodoor ,  VAN DER STEEN, Antonius, Franciscus, Wilhelmus ,  LI, Wenguang ,  BOM, Nicolaas

IPC: G01P5 ,  A61B8 ,  G01F1 ,  G01S15

CPC classification number: A61B8/06 ,  A61B8/12

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer; and the estimation accuracy is further improved by the use of a reference decorrelation curve obtained from experiments or beam-theory or both.

公开(公告)号：EP0920883A1

公开(公告)日：1999-06-09

申请号：EP98309885.6

申请日：1998-12-02

Applicant: EndoSonics Corporation

Inventor： Baker, Bruce A. ,  Varney, Clifford R. ,  Eberle, Michael J.

IPC: A61M29/02 ,  A61M25/10

CPC classification number: A61M25/10 ,  A61B8/00 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/445 ,  A61B2090/3784 ,  A61B2090/3966 ,  Y10T29/42

Abstract: Catheter assembly and method in which an imaging transducer is positioned proximally of a treatment device at the distal end of a catheter. Unrestricted flow between a fluid lumen in the catheter and the treatment device is provided by an annular passageway formed between the walls of a marker tube which extends through the transducer and a guide wire tube which passes through the marker tube, and by a plenum chamber which is formed between the distal end of the catheter and the proximal end of the marker tube in communication with the fluid lumen and the flow passageway. The catheter, the treatment device, and the transducer are all constructed as individual modular units which can be assembled together as desired to form the assembly.