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    SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME
    1.
    发明申请
    SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME 审中-公开
    酶或底物结合剂的特定活性位点抑制剂及其生产方法

    公开(公告)号：WO2012020289A2

    公开(公告)日：2012-02-16

    申请号：PCT/IB2011/001663

    申请日：2011-06-08

    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  SIDHU, Sachdev ,  BEATTY, Linda ,  ERNST, Andreas

    Inventor： SIDHU, Sachdev ,  BEATTY, Linda ,  ERNST, Andreas

    IPC: C07K14/47

    CPC classification number: C07K14/435 ,  A61K38/17 ,  C07K14/47

    Abstract: The present disclosure provides a method of producing enzyme- specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.

    Abstract translation: 本公开提供了生产酶特异性抑制剂或底物结合配偶体的方法，包括：鉴定酶底物复合物或底物结合配偶体 - 底物复合物中底物的活性位点残基; 使活性位点残基随机化以产生底物变体的组合文库; 并选择抑制酶活性或结合底物作为底物特异性结合配偶体的底物变体。 本公开还提供泛素酶特异性抑制剂和结合泛素相互作用基序的泛素变体。

    METHOD AND DEVICE FOR MANAGING OBJECT VIEW DATA IN AN OBJECT DATABASE
    2.
    发明申请
    METHOD AND DEVICE FOR MANAGING OBJECT VIEW DATA IN AN OBJECT DATABASE 审中-公开
    用于管理对象数据库中的对象视图数据的方法和设备

    公开(公告)号：WO2011039184A2

    公开(公告)日：2011-04-07

    申请号：PCT/EP2010064356

    申请日：2010-09-28

    Applicant: FRAUNHOFER GES FORSCHUNG ,  ERNST ANDREAS ,  RUF TOBIAS ,  KUEBLBECK CHRISTIAN

    Inventor： ERNST ANDREAS ,  RUF TOBIAS ,  KUEBLBECK CHRISTIAN

    IPC: G06K9/62

    CPC classification number: G06K9/00295 ,  G06K9/6255

    Abstract: A method for managing object view data in an object database comprises detecting a view of an object in an image and comparing view data of the detected view to object view data of object views of objects in an object database on the basis of a comparison criterion. The method further comprises storing the view data of the detected view together with time information in the object database as new object view data when the comparison shows that the detected view does not correspond to any object view in the object database, or changing time information of existing object view data of an object view in the object database when the comparison shows that the detected view corresponds to the object view. The method further comprises managing the object view data in the object database on the basis of the time information of the object view data.

    Abstract translation: 一种用于在对象数据库管理对象视图的数据的方法包括：检测图像中的对象的视图和视图通过基于比较标准的在对象数据库中的对象的对象视图的对象视图数据捕获的视图的数据进行比较。 此外，该方法包括存储连同时间信息在对象数据库作为新的对象视图的数据中获取的视图的视图数据，当所述比较指示对应于在对象数据库中没有对象视图所获取的视图，或从在对象视图的现有对象视图数据变更的时间的信息 对象数据库如果比较显示捕获的视图对应于对象视图。 另外，该方法包括基于对象视图数据的时间信息来管理对象数据库中的对象视图数据。

    DISPENSING ASSEMBLY
    8.
    发明申请
    DISPENSING ASSEMBLY 审中-公开
    分配总成

    公开(公告)号：WO2013167594A1

    公开(公告)日：2013-11-14

    申请号：PCT/EP2013/059492

    申请日：2013-05-07

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F.HOFFMANN-LA ROCHE AG ,  BAMMESBERGER, Stefan Borja ,  ERNST, Andreas ,  KOLTAY, Peter ,  LOSLEBEN, Nadine ,  TANGUY, Laurent

    Inventor： BAMMESBERGER, Stefan Borja ,  ERNST, Andreas ,  KOLTAY, Peter ,  LOSLEBEN, Nadine ,  TANGUY, Laurent

    IPC: B01L3/02 ,  G01N35/10 ,  B05C5/02

    CPC classification number: G01N35/1016 ,  B01L3/0268 ,  B01L2200/143 ,  B05B1/02 ,  B05B17/06 ,  B05C5/0225 ,  B05C5/0291 ,  G01N35/1002 ,  G01N35/1009 ,  G01N2035/1025

    Abstract: The invention provides for a dispensing assembly (100, 100', 100", 200, 300, 500, 600, 700, 900) comprising a cartridge holder (102). The cartridge holder is operable for receiving a cartridge (108, 108', 108") operable for dispensing a fluid (206). The cartridge comprises a reservoir (114, 804, 908) operable for receiving the fluid. The reservoir comprises an outlet (115, 806). The reservoir has an adjustable volume for forcing the fluid through the outlet. The cartridge further comprises a nozzle (116, 912) for dispensing the fluid. The nozzle is connected to the outlet. The dispensing assembly further comprises an actuator (104) for actuating the adjustable volume. The dispensing assembly further comprises an impulse generator (106) for imparting an impulse to the nozzle. The impulse generator comprises an actor (118) for contacting the nozzle. The dispenser assembly further comprises a controller (202, 420) for controlling the actor and the impulse generator.

    Abstract translation: 本发明提供了一种包括盒保持器（102）的分配组件（100,100'，100“，200,300,500,600,700,900），所述盒保持器可操作用于接收盒（108,108' ，108“），其可操作用于分配流体（206）。 墨盒包括可操作以接收流体的储存器（114,804,908）。 储存器包括出口（115,806）。 储存器具有可调节的体积，用于迫使流体通过出口。 墨盒还包括用于分配流体的喷嘴（116,912）。 喷嘴连接到出口。 分配组件还包括用于致动可调节体积的致动器（104）。 分配组件还包括用于向喷嘴施加脉冲的脉冲发生器（106）。 脉冲发生器包括用于接触喷嘴的动作（118）。 分配器组件还包括用于控制演员和脉冲发生器的控制器（202,420）。

    DETERMINING MODEL PARAMETERS BASED ON TRANSFORMING A MODEL OF AN OBJECT
    9.
    发明申请
    DETERMINING MODEL PARAMETERS BASED ON TRANSFORMING A MODEL OF AN OBJECT 审中-公开
    基于变换对象模型确定模型参数

    公开(公告)号：WO2012113732A1

    公开(公告)日：2012-08-30

    申请号：PCT/EP2012/052798

    申请日：2012-02-17

    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  ERNST, Andreas ,  RUF, Tobias ,  LAUTENSCHLAGER, Felix ,  PAPST, Anton ,  THIELECKE, Jörn ,  KÜBLBECK, Christian

    Inventor： ERNST, Andreas ,  RUF, Tobias ,  LAUTENSCHLAGER, Felix ,  PAPST, Anton ,  THIELECKE, Jörn ,  KÜBLBECK, Christian

    IPC: G06T7/00

    CPC classification number: G06K9/6202 ,  G06T7/251 ,  G06T7/80 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/30241 ,  G06T2207/30244

    Abstract: Apparatus for determining model parameters, the apparatus comprising an object model transformer, a region comparator, and a model parameter determiner. The object model transformer is configured to receive an object model of a known object and to transform the object model based on a set of model parameters from a first frame of reference to a second frame of reference. The object model transformer is further configured to determine as result of this transformation a transformed object model comprising at least one region, the at least one region being associated to an object region of the object. The region comparator is configured to receive the transformed object model and an image depicting the object, to determine for a selected region of the transformed object model a region-related similarity measure representative of a similarity between the selected region and an image section of the image associated to the selected region via a transformation-dependent mapping. The model parameter determiner is configured to determine an updated set of model parameters on the basis of the region-related similarity measure and an optimization scheme.

    Abstract translation: 用于确定模型参数的装置，所述装置包括对象模型变换器，区域比较器和模型参数确定器。 对象模型变换器被配置为接收已知对象的对象模型，并且基于来自第一参考系的第一参考系的一组模型参数来变换对象模型。 对象模型变换器还被配置为确定作为该变换的结果的变换对象模型包括至少一个区域，所述至少一个区域与对象的对象区域相关联。 区域比较器被配置为接收变换的对象模型和描绘对象的图像，以便为所选择的变换对象模型的区域确定表示所选择的区域和图像的图像部分之间的相似度的区域相关性度量 通过变换依赖映射与所选区域相关联。 模型参数确定器被配置为基于区域相关相似性度量和优化方案来确定更新的模型参数集合。

    SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME
    10.
    发明申请
    SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME 审中-公开
    酶或底物结合的特定活性位点抑制剂及其生产方法

    公开(公告)号：WO2012020289A3

    公开(公告)日：2012-05-18

    申请号：PCT/IB2011001663

    申请日：2011-06-08

    Applicant: UNIV TORONTO ,  SIDHU SACHDEV ,  BEATTY LINDA ,  ERNST ANDREAS

    Inventor： SIDHU SACHDEV ,  BEATTY LINDA ,  ERNST ANDREAS

    IPC: C07K14/47

    CPC classification number: C07K14/435 ,  A61K38/17 ,  C07K14/47

    Abstract: The present disclosure provides a method of producing enzyme- specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.

    Abstract translation: 本公开提供了生产酶特异性抑制剂或底物结合配偶体的方法，包括：鉴定酶底物复合物或底物结合配偶体 - 底物复合物中底物的活性位点残基; 使活性位点残基随机化以产生底物变体的组合文库; 并选择抑制酶活性或结合底物作为底物特异性结合配偶体的底物变体。 本公开还提供了结合遍在蛋白相互作用基序的遍在蛋白酶特异性抑制剂和泛素变体。

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