公开(公告)号：WO2009063426A3

公开(公告)日：2009-05-22

申请号：PCT/IB2008/054774

申请日：2008-11-14

Applicant: UNIVERSITÀ DEGLI STUDI DI ROMA 'LA SAPIENZA' ,  BOZZONI, Irene ,  FATICA, Alessandro ,  ROSA, Alessandro

Inventor： BOZZONI, Irene ,  FATICA, Alessandro ,  ROSA, Alessandro

IPC: C12N15/11

Abstract: The present invention relates to a mixture of molecules comprising at least one miRNA and at least one siRNA, or at least two miRNAs, or at least two siRNAs for inducing hematopoietic differentiation or for treating leukemia wherein the miRNA is able to modulate hematopoietic differentiation and/or to act as oncosuppressor, and the siRNA is able to modulate hematopoietic differentiation or to inhibit the expression of a fusion product deriving from a chromosomic translocation associated to leukemia.

公开(公告)号：WO2009063426A2

公开(公告)日：2009-05-22

申请号：PCT/IB2008054774

申请日：2008-11-14

Applicant: UNIV ROMA ,  BOZZONI IRENE ,  FATICA ALESSANDRO ,  ROSA ALESSANDRO

Inventor： BOZZONI IRENE ,  FATICA ALESSANDRO ,  ROSA ALESSANDRO

IPC: C12N15/113

CPC classification number: C12N15/1135 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present invention relates to a mixture of molecules comprising at least one miRNA and at least one siRNA, or at least two miRNAs, or at least two siRNAs for inducing hematopoietic differentiation or for treating leukemia wherein the miRNA is able to modulate hematopoietic differentiation and/or to act as oncosuppressor, and the siRNA is able to modulate hematopoietic differentiation or to inhibit the expression of a fusion product deriving from a chromosomic translocation associated to leukemia.

Abstract translation: 本发明涉及包含至少一种miRNA和至少一种siRNA，或至少两种miRNA或至少两种用于诱导造血分化或用于治疗白血病的siRNA的分子混合物，其中所述miRNA能够调节造血分化和/ 或充当抑癌抑制因子，并且siRNA能够调节造血分化或抑制源自与白血病相关的染色体易位的融合产物的表达。