公开(公告)号：WO1995031468A1

公开(公告)日：1995-11-23

申请号：PCT/US1994005385

申请日：1994-05-16

Applicant: HUMAN GENOME SCIENCES, INC. ,  LI, Haodong ,  FITZGERALD, Lisa, M.

Inventor： HUMAN GENOME SCIENCES, INC.

IPC: C07H17/00

CPC classification number: C07K14/52 ,  A61K38/00

Abstract: The present invention relates to a human MIF-3 and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for treating cancer, infections, acceleration of wound healing, stimulating the immune system, as an anti-inflammatory. Methods of using antibodies and antagonists/inhibitors for therapeutic purposes, is also disclosed, for example, for treating lethal endotoxaemia, ocular inflammation and diagnosing immune diseases.

Abstract translation: 本发明涉及编码这种多肽的人MIF-3和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了使用该多肽治疗癌症，感染，加速伤口愈合，刺激免疫系统作为抗炎剂的方法。 还公开了用于治疗目的的抗体和拮抗剂/抑制剂的方法，例如用于治疗致死性内毒素血症，眼部炎症和诊断免疫疾病。

公开(公告)号：WO2009012245A3

公开(公告)日：2010-01-07

申请号：PCT/US2008070022

申请日：2008-10-01

Applicant: SUNOVIA ENERGY TECHNOLOGIES IN ,  FITZGERALD LISA ,  SMITH CARL III ,  FUGERER ROBERT

Inventor： FITZGERALD LISA ,  SMITH CARL III ,  FUGERER ROBERT

IPC: F21V29/00

CPC classification number: F21V15/01 ,  F21K9/00 ,  F21V7/18 ,  F21V15/015 ,  F21V19/004 ,  F21V23/026 ,  F21V23/0442 ,  F21V29/004 ,  F21V29/507 ,  F21V29/74 ,  F21V29/763 ,  F21V29/83 ,  F21Y2115/10 ,  H05K1/0204 ,  H05K2201/09054 ,  H05K2201/10106

Abstract: The present disclosure provides a lamp assembly that manages thermal energy output from solid state lighting elements An aspect of the present disclosure provides a lamp assembly that achieves enhanced cooling of light elements within the assembly Enhanced cooling is achieved, in this aspect, by providing a lamp assembly including a heat sink having a plurality of thermo bosses protruding therefrom on a first side, and a plurality of heat sink fins on a second side A printed circuit board is secured to the first side of the heat sink, and has a plurality of through holes that correspond to the size and locations of the thermo bosses, such that when the printed circuit board is secured to the heat sink, the thermo bosses extend into the through holes.

Abstract translation: 本公开提供一种管理来自固态照明元件的热能输出的灯组件本发明的一个方面提供了一种灯组件，其实现组件内的轻元件的增强的冷却。在这方面，通过提供灯 组件，其包括具有在第一侧上从其突出的多个热凸起的散热器和在第二侧上的多个散热片。印刷电路板固定到散热片的第一侧，并且具有多个通孔 对应于热凸台的尺寸和位置的孔，使得当印刷电路板固定到散热器时，热凸起延伸到通孔中。

公开(公告)号：WO1997047643A1

公开(公告)日：1997-12-18

申请号：PCT/US1996014026

申请日：1996-08-26

Applicant: SMITHKLINE BEECHAM CORPORATION ,  HUMAN GENOME SCIENCES, INC. ,  THE INSTITUTE FOR GENOMIC RESEARCH ,  DEBOUCK, Christine, Marie ,  DRAKE, Fred ,  GOWEN, Maxine ,  ROOD, Julie ,  HASTINGS, Gregg, A. ,  ADAMS, Mark, D. ,  FRASER, Claire, M. ,  LEE, Norman, H. ,  KIRKNESS, Ewen, F. ,  BLAKE, Judith, A. ,  FITZGERALD, Lisa, M.

Inventor： SMITHKLINE BEECHAM CORPORATION ,  HUMAN GENOME SCIENCES, INC. ,  THE INSTITUTE FOR GENOMIC RESEARCH

IPC: C07H21/04

CPC classification number: C12N9/6472 ,  A61K38/00 ,  C12Y304/22038

Abstract: The invention relates to cathepsin K polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

Abstract translation: 本发明提供了组织蛋白酶K多肽，编码所述多肽的多核苷酸，产生所述多肽的方法，包括所述多核苷酸的表达，以及所述多肽的激动剂和拮抗剂。 本发明还涉及使用这些多核苷酸的方法以及多肽的激动剂和拮抗剂。 本发明还涉及在部分涉及研究，诊断和临床技术的应用中使用这些多核苷酸，多肽，激动剂和拮抗剂的方法。

公开(公告)号：WO1997047642A1

公开(公告)日：1997-12-18

申请号：PCT/US1996010346

申请日：1996-06-14

Applicant: SMITHKLINE BEECHAM CORPORATION ,  HUMAN GENOME SCIENCES, INC. ,  THE INSTITUTE FOR GENOMIC RESEARCH ,  DEBOUCK, Christine, Marie ,  DRAKE, Fred ,  GOWEN, Maxine ,  ROOD, Julie ,  HASTINGS, Gregg, A. ,  ADAMS, Mark, D. ,  FRASER, Claire, M. ,  LEE, Norman, H. ,  KIRKNESS, Ewen, F. ,  BLAKE, Judith, A. ,  FITZGERALD, Lisa, M.

Inventor： SMITHKLINE BEECHAM CORPORATION ,  HUMAN GENOME SCIENCES, INC. ,  THE INSTITUTE FOR GENOMIC RESEARCH

IPC: C07H21/04

CPC classification number: C12N9/6472 ,  A61K38/00 ,  C12Y304/22038

Abstract: The invention relates to cathepsin K polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

Abstract translation: 本发明涉及组织蛋白酶K多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：WO2009012245A9

公开(公告)日：2009-01-22

申请号：PCT/US2008/070022

申请日：2008-10-01

Applicant: SUNOVIA ENERGY TECHNOLOGIES, INC. ,  FITZGERALD, Lisa ,  SMITH, Carl, III ,  FUGERER, Robert

Inventor： FITZGERALD, Lisa ,  SMITH, Carl, III ,  FUGERER, Robert

IPC: F21V29/00

Abstract: The present disclosure provides a lamp assembly that manages thermal energy output from solid state lighting elements An aspect of the present disclosure provides a lamp assembly that achieves enhanced cooling of light elements within the assembly Enhanced cooling is achieved, in this aspect, by providing a lamp assembly including a heat sink having a plurality of thermo bosses protruding therefrom on a first side, and a plurality of heat sink fins on a second side A printed circuit board is secured to the first side of the heat sink, and has a plurality of through holes that correspond to the size and locations of the thermo bosses, such that when the printed circuit board is secured to the heat sink, the thermo bosses extend into the through holes.

公开(公告)号：WO2009012245A2

公开(公告)日：2009-01-22

申请号：PCT/US2008070022

申请日：2008-10-01

Applicant: SUNOVIA ENERGY TECHNOLOGIES IN ,  FITZGERALD LISA ,  SMITH CARL III ,  FUGERER ROBERT

Inventor： FITZGERALD LISA ,  SMITH CARL III ,  FUGERER ROBERT

IPC: F21V13/12

CPC classification number: F21V15/01 ,  F21K9/00 ,  F21V7/18 ,  F21V15/015 ,  F21V19/004 ,  F21V23/026 ,  F21V23/0442 ,  F21V29/004 ,  F21V29/507 ,  F21V29/74 ,  F21V29/763 ,  F21V29/83 ,  F21Y2115/10 ,  H05K1/0204 ,  H05K2201/09054 ,  H05K2201/10106

Abstract: The present disclosure provides a lamp assembly that manages thermal energy output from solid state lighting elements An aspect of the present disclosure provides a lamp assembly that achieves enhanced cooling of light elements within the assembly Enhanced cooling is achieved, in this aspect, by providing a lamp assembly including a heat sink having a plurality of thermo bosses protruding therefrom on a first side, and a plurality of heat sink fins on a second side A printed circuit board is secured to the first side of the heat sink, and has a plurality of through holes that correspond to the size and locations of the thermo bosses, such that when the printed circuit board is secured to the heat sink, the thermo bosses extend into the through holes.

Abstract translation: 本公开提供一种管理来自固态照明元件的热能输出的灯组件本发明的一个方面提供了一种灯组件，其实现组件内的轻元件的增强的冷却。在这方面，通过提供灯 组件，其包括具有在第一侧上从其突出的多个热凸起的散热器和在第二侧上的多个散热片。印刷电路板固定到散热片的第一侧，并且具有多个通孔 对应于热凸台的尺寸和位置的孔，使得当印刷电路板固定到散热器时，热凸起延伸到通孔中。