公开(公告)号：WO2012118903A3

公开(公告)日：2013-03-14

申请号：PCT/US2012027154

申请日：2012-02-29

Applicant: AMGEN INC ,  FLORIO MONICA ,  ARORA TARUNA ,  PASZTY CHRISTOPHER J R ,  RICHARDS WILLIAM G

Inventor： FLORIO MONICA ,  ARORA TARUNA ,  PASZTY CHRISTOPHER J R ,  RICHARDS WILLIAM G

IPC: C07K16/22 ,  A61K39/395 ,  A61P19/08 ,  C07K16/18

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/76

Abstract: The invention relates to bispecific anti-sclerostin/anti-DKK1 binding agents and combinations of anti-sclerostin and anti-DKK1 binding agents, and related methods of treatment.

Abstract translation: 本发明涉及双特异性抗硬化蛋白/抗DKK1结合剂以及抗硬化蛋白和抗DKK1结合剂的组合以及相关的治疗方法。

公开(公告)号：WO2012118903A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/027154

申请日：2012-02-29

Applicant: AMGEN INC. ,  FLORIO, Monica ,  ARORA, Taruna ,  PASZTY, Christopher, J., R. ,  RICHARDS, William, G.

Inventor： FLORIO, Monica ,  ARORA, Taruna ,  PASZTY, Christopher, J., R. ,  RICHARDS, William, G.

IPC: G21C17/01 ,  G21C17/017 ,  G21C19/14

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/76

Abstract: The invention relates to bispecific anti-sclerostin/anti-DKK1 binding agents and combinations of anti-sclerostin and anti-DKK1 binding agents, and related methods of treatment.

Abstract translation: 本发明涉及双特异性抗硬化蛋白/抗DKK1结合剂以及抗硬化蛋白和抗DKK1结合剂的组合以及相关的治疗方法。

公开(公告)号：WO2007084730A3

公开(公告)日：2007-12-27

申请号：PCT/US2007001555

申请日：2007-01-18

Applicant: AMCYTE INC ,  FLORIO MONICA ,  FRANCKI ALEKSANDAR ,  TSANG WEN-GHIH

Inventor： FLORIO MONICA ,  FRANCKI ALEKSANDAR ,  TSANG WEN-GHIH

IPC: C12N5/00 ,  C12N5/071

CPC classification number: C12N5/0676 ,  A61K2035/126 ,  C12N5/0677 ,  C12N2501/105 ,  C12N2501/135 ,  C12N2501/48 ,  C12N2501/70 ,  C12N2509/00 ,  C12N2533/32 ,  C12N2533/74

Abstract: The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.

Abstract translation: 本发明涉及这样的发现，即通过使细胞与（1）足以减少胰腺内分泌细胞凋亡的半胱天冬酶抑制剂接触，可以增强胰腺祖细胞的增殖和存活; 和（2）足以增加胰腺内分泌细胞中活化的Akt水平的量的生长因子。

公开(公告)号：WO2007084730A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/001555

申请日：2007-01-18

Applicant: AMCYTE INC. ,  FLORIO, Monica ,  FRANCKI, Aleksandar ,  TSANG, Wen-Ghih

Inventor： FLORIO, Monica ,  FRANCKI, Aleksandar ,  TSANG, Wen-Ghih

IPC: C12N5/08

CPC classification number: C12N5/0676 ,  A61K2035/126 ,  C12N5/0677 ,  C12N2501/105 ,  C12N2501/135 ,  C12N2501/48 ,  C12N2501/70 ,  C12N2509/00 ,  C12N2533/32 ,  C12N2533/74

Abstract: The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.

Abstract translation: 本发明涉及通过使细胞与（1）足以减少胰腺内分泌细胞凋亡的半胱天冬酶抑制剂接触的细胞增强胰腺祖细胞的增殖和存活的发现; 和（2）足以增加胰腺内分泌细胞中活化的Akt水平的生长因子。