公开(公告)号：WO2005123069A2

公开(公告)日：2005-12-29

申请号：PCT/US2005/020519

申请日：2005-06-10

Applicant: FOB SYNTHESIS ,  CHOI, Woo-Baeg ,  MENALDINO, David, S. ,  KIM, Deog-Il ,  BOUYGUES, Martin ,  HAGER, Michael, W.

Inventor： CHOI, Woo-Baeg ,  MENALDINO, David, S. ,  KIM, Deog-Il ,  BOUYGUES, Martin ,  HAGER, Michael, W.

IPC: A61K31/407

CPC classification number: C07D477/14 ,  A61K31/397 ,  A61K45/06 ,  Y02P20/55 ,  A61K2300/00

Abstract: The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

Abstract translation: 本发明提供了用于治疗细菌感染的β-甲基碳青霉烯类化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。 本发明也在合成有机化学领域，并且具体提供了可用作抗菌剂的改进的β-甲基碳青霉烯合成方法。

公开(公告)号：WO2011160020A3

公开(公告)日：2012-04-12

申请号：PCT/US2011040883

申请日：2011-06-17

Applicant: FOB SYNTHESIS ,  CHOI WOO-BAEG ,  KIM DEOG-IL ,  GRUSZECKA-KOWALIK EWA ,  JOO HYUNG-YEUL ,  LIU SHUANGPEI ,  MAO SHULI ,  LI YONGFENG

Inventor： CHOI WOO-BAEG ,  KIM DEOG-IL ,  GRUSZECKA-KOWALIK EWA ,  JOO HYUNG-YEUL ,  LIU SHUANGPEI ,  MAO SHULI ,  LI YONGFENG

IPC: C07D477/14 ,  A61K31/407 ,  A61P31/04 ,  C07D403/06 ,  C07D487/04

CPC classification number: A61K31/407 ,  A61K45/06 ,  C07D477/10 ,  C07D477/16

Abstract: The present invention provides ß-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Abstract translation: 本发明提供了用于治疗细菌感染的β-甲基碳青霉烯化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。

公开(公告)号：US20200155508A1

公开(公告)日：2020-05-21

申请号：US16619495

申请日：2018-06-11

Applicant: FOB Synthesis, Inc.

Inventor： Woo-Baeg Choi ,  Takashi Tomioka ,  Hyung-Yeul Joo ,  Phong Truong ,  Brian Min

IPC: A61K31/407 ,  A61K45/06 ,  A61P31/04 ,  C07D477/14

Abstract: The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

公开(公告)号：US09937151B2

公开(公告)日：2018-04-10

申请号：US14692973

申请日：2015-04-22

Applicant: FOB Synthesis, Inc.

Inventor： Woo-Baeg Choi ,  Ewa Gruszecka-Kowalik ,  Hyung-Yeul Joo ,  Shuangpei Liu ,  Shuli Mao ,  Yongfeng Li ,  Deog-Il Kim

IPC: A61K31/407 ,  C07D477/10 ,  A61K45/06 ,  C07D477/16

CPC classification number: A61K31/407 ,  A61K45/06 ,  C07D477/10 ,  C07D477/16

Abstract: The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

公开(公告)号：US20130172313A1

公开(公告)日：2013-07-04

申请号：US13713520

申请日：2012-12-13

Applicant: FOB Synthesis, Inc.

Inventor： Woo-Baeg CHOI ,  Ewa GRUSZECKA-KOWALIK ,  Hyung-Yeul JOO ,  Shuangpei LIU ,  Shuli MAO ,  Yongfeng LI ,  Deog-Il KIM

IPC: A61K31/407 ,  A61K45/06 ,  C07D477/16

CPC classification number: A61K31/407 ,  A61K45/06 ,  C07D477/10 ,  C07D477/16

Abstract: The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Abstract translation: 本发明提供了用于治疗细菌感染的β-甲基碳青霉烯化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。

公开(公告)号：US10933051B2

公开(公告)日：2021-03-02

申请号：US16619495

申请日：2018-06-11

Applicant: FOB Synthesis, Inc.

Inventor： Woo-Baeg Choi ,  Takashi Tomioka ,  Hyung-Yeul Joo ,  Phong Truong ,  Brian Min

IPC: C07D477/14 ,  A61K31/407 ,  A61P31/04 ,  A61K45/06

Abstract: The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

公开(公告)号：US20150306071A1

公开(公告)日：2015-10-29

申请号：US14692973

申请日：2015-04-22

Applicant: FOB Synthesis, Inc.

Inventor： Woo-Baeg Choi ,  Ewa Gruszecka-Kowalik ,  Hyung-Yeul Joo ,  Shuangpei Liu ,  Shuli Mao ,  Yongfeng Li ,  Deog-II Kim

IPC: A61K31/407 ,  A61K45/06

CPC classification number: A61K31/407 ,  A61K45/06 ,  C07D477/10 ,  C07D477/16

Abstract: The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Abstract translation: 本发明提供了用于治疗细菌感染的碳青霉烯类化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。

公开(公告)号：US09149461B2

公开(公告)日：2015-10-06

申请号：US13713520

申请日：2012-12-13

Applicant: FOB Synthesis, Inc.

Inventor： Woo-Baeg Choi ,  Ewa Gruszecka-Kowalik ,  Hyung-Yeul Joo ,  Shuangpei Liu ,  Shuli Mao ,  Yongfeng Li ,  Deog-Il Kim

IPC: A61K31/407 ,  A61K45/06 ,  C07D477/16 ,  C07D477/10

CPC classification number: A61K31/407 ,  A61K45/06 ,  C07D477/10 ,  C07D477/16

Abstract: The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Abstract translation: 本发明提供了用于治疗细菌感染的碳青霉烯类化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。

公开(公告)号：WO2018227178A1

公开(公告)日：2018-12-13

申请号：PCT/US2018/036872

申请日：2018-06-11

Applicant: FOB SYNTHESIS, INC.

Inventor： CHOI, Woo-Baeg ,  TOMIOKA, Takashi ,  JOO, Hyung-Yeul ,  TRUONG, Phong ,  MIN, Brian

IPC: A61K38/45

Abstract: The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

公开(公告)号：WO2011160020A2

公开(公告)日：2011-12-22

申请号：PCT/US2011/040883

申请日：2011-06-17

Applicant: FOB SYNTHESIS ,  CHOI, Woo-Baeg ,  KIM, Deog-Il ,  GRUSZECKA-KOWALIK, Ewa ,  JOO, Hyung-Yeul ,  LIU, Shuangpei ,  MAO, Shuli ,  LI, Yongfeng

Inventor： CHOI, Woo-Baeg ,  KIM, Deog-Il ,  GRUSZECKA-KOWALIK, Ewa ,  JOO, Hyung-Yeul ,  LIU, Shuangpei ,  MAO, Shuli ,  LI, Yongfeng

IPC: C07D477/14 ,  C07D403/06 ,  C07D487/04 ,  A61K31/407 ,  A61P31/04

CPC classification number: A61K31/407 ,  A61K45/06 ,  C07D477/10 ,  C07D477/16

Abstract: The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Abstract translation: 本发明提供了用于治疗细菌感染的β-甲基碳青霉烯化合物和药物组合物，以及使用这些化合物和/或组合物治疗这种感染的方法。 本发明包括将有效量的碳青霉烯化合物或其盐和/或前药给予需要这种治疗的宿主。